Archive of SID

Laboratory & Diagnosis Vol.3, No14, Suplememt Issue

P112

Evaluation of Vascular adhesion protein-1 (VAP-1)and Lp(a) levels in psoriatic patients from Kermanshah
Houshang Nemati 1 * , Reza Khodarahmi 1, Ameneh Rahmani 2, Homayon Entezami 2

1- pharmacy school,medical university of kermanshah, 2- Medical University of Kermanshah,

hnemati@kums.ac.ir

Background: Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication.Vascular adhesion protein
(VAP)-1 is an adhesion molecule with an enzymatic activity that partakes in the migration process of lymphocytes. Objectives: The
aim of this study was to investigate the Lp(a) levels and VAP-1 in serum of psoriatic patients. Material and methods: Eighty patients
suffering from psoriasis aged between 23 and 89 years and Eighty sex- and age-matched healthy volunteers were included in the
study. The soluble VAP-1 serum concentration was evaluated by ELISA method and serum Lp(a) levels was assessed by turbidometry
method. Results: The mean serum concentration of soluble VAP-1 was significantly higher in psoriatic patients than in healthy
controls (289.8 ± 134 ng/mL vs. 192.7 ± 41 ng/mL; P < 0.001), and the mean levels of Lp(a) in psoriatic patients were higher than that
of the control group but not significant (19.2± 16.5 mg/dl vs. 17.1 ± 15.1 ng/mL; P > 0.05). No significant relationships were found
between sVAP-1 concentration and studied clinical parameters, except the presence of pruritus. In psoriatic patients, elevation of
VAP-1 correlated with elevation of Lp(a)(p=0.025). Conclusions: This study shows that high serum Lp(a) level and VAP-1, is
significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic
patients. It may be useful to do early screening and treatment of hyperlipidaemia in psoriasis to prevent the atherosclerosis and its
complications.

Keywords: Psoriasis,VAP-1, Lp(a)

124 The 5th International & 10th National Congress on Quality Improvement in Clinical Laboratory April 23-26, 2012

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