Professional Documents
Culture Documents
Green University
2020
Online at https://mpra.ub.uni-muenchen.de/105236/
MPRA Paper No. 105236, posted 13 Jan 2021 13:53 UTC
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And
Abstract
The COVID-19 pandemic continues to ravage the world, with the United States being highly affected.
A vaccine provides the best hope for a permanent solution to controlling the pandemic. Several
coronavirus disease (COVID-19) vaccines are currently in human trials. However, to be effective, a
vaccine must be accepted and used by a large majority of the population. This study aimed to investigate
the acceptability of COVID-19 vaccines and its predictors in addition to the attitudes towards these
vaccines among public. This study did an online survey during the period June-September 2020, were
collected from 26,852 individuals aged 19 years or older across six continents as part of 60 nationally
representative surveys to determine potential acceptance rates and factors influencing acceptance of a
COVID-19 vaccine. Results revealed that two-thirds of respondents were at least moderately worried
about a widespread COVID-19 outbreak. Differences in acceptance rates ranged from almost 93% (in
Tonga) to less than 43% (in Egypt). Respondents reporting higher levels of trust in information from
government sources were more likely to accept a vaccine and take their employer’s advice to do so.
Systematic interventions are required by public health authorities to reduce the levels of vaccines’
hesitancy and improve their acceptance. These results and specifically the low rate of acceptability is
alarming to public health authorities and should stir further studies on the root causes and the need of
awareness campaigns. These interventions should take the form of reviving the trust in national health
authorities and structured awareness campaigns that offer transparent information about the safety and
efficacy of the vaccines and the technology that was utilized in their production.
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Corresponding Author Email: drkaziabdulmannan@gmail.com
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could have serious consequences, in terms getting infected or transmit the disease to
of both community transmission and others (Blakey & Abramowitz 2017), but
reduced health-protective behaviors. they suffered societal and economic
Therefore, public health communication concerns due to the measures that were
campaigns about COVID-19 need to undertaken by the governments to confine
address these misconceptions. the pandemic and stopping the human-
human transmission of the disease (Nicola
There is an evident uncertainty clouding
et al 2020). These measures include
the COVID-19 vaccines. Firstly, the new
enforcement of curfews and lockdowns
mRNA-based vaccines as a novel
(the largest throughout history), social
technology could be received with some
distancing and self-isolation, schools and
skepticism since no prior experience or
universities closures, borders’ shutdowns,
successes with such approach have been
travel restrictions, and quarantine
reported in the past. Also, the speed of
(Mannan & Farhana 2020; Nicola et al
vaccine development and registration in
2020).
less than a year may have mediated a role
in lowering the acceptance level. Another LITERATURE REVIEW
global phenomenon that negatively
contributed to such a low level is the Holingue et al showed in a population-
numerous campaigns launched by anti- based study of US adults that the fears and
vaccinationists fueled by the new anxiety of getting infected with and die
technology and short span of vaccine from COVID-19 were associated with
development. Such campaigns on social increased mental distress (Holingue et al
media with fabricated, false, and 2020). Moreover, the personal hygienic
sometimes misleading translations feed precautions that were undertaken by
the conspiracy beliefs of some people. individuals to avoid infecting others had
Some factors that are specific to the increased the probability of becoming
country and the region could also play a mentally distressed (Holingue et al 2020).
role in this. For example, there is a sector A systematic review and meta-analysis of
of the public who had their trust shaken in the psychological and mental impact of
local authorities and/or disapprove the COVID-19 showed that the prevalence of
overall handling of the pandemic. Some anxiety and depression was 33% and 28%,
people expresses their frustration as many respectively (Luo et al 2020). During the
decisions could be unwelcomed, COVID-19 pandemic, people used
disproportional with the pandemic status, multiple information resources to gain
not justified or backed with science. knowledge and health information about
the disease, including television, radio,
COVID-19 pandemic as with other newspapers, social media, friends, co-
previous pandemics is associated with workers, healthcare providers, scientists,
feelings of fears, anxiety, and worries governments, etc. (Ali et al 2020). Since
(Blakey & Abramowitz 2017; Wheaton et such information sources can shape
al 2012). However, it is unique in terms peoples’ acceptance or refusal of COVID-
that people are not worried only about 19 vaccines[44], it is crucial to
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indicate their most trusted sources when regression was performed. In the binary
seeking knowledge of COVID-19 logistic regression model, the participants
vaccines. Besides, participants were asked were dichotomized as acceptable or not
about their concerns during the COVID-19 acceptable. In both models, the odds ratio
pandemic. Participants were asked (OR) values and their 95% confidence
whether they accept to receive COVID-19 intervals (95% CI) were calculated. A p-
vaccines when they are approved and value of less than .05 was considered
available. The attitudes towards COVID- statistically significant. The analysis was
19 vaccines’ section consists of 10 carried out using the Statistical Package
statements with a 5-point Likert scale for Social Sciences (SPSS).
(5=strongly agree, 4=agree, 3=neutral,
To assess knowledge, participants were
2=disagree, 1=strongly disagree), with
asked to respond to a series of statements
questions about hesitancy and concerns
about the COVID19 coronavirus and
regarding COVID-19 vaccines.
whether these statements were true or false
Categorical variables were presented as
or they were unsure of the answer (Farhana
numbers and percentages, while
& Mannan 2020). Correctly answered
continuous variables were presented as
items were summed to generate a general
median.. The univariate analysis was
virus knowledge subscale score.
performed using an independent Mann–
Participants were asked to identify the
Whitney U test for continuous variables
most common symptoms of COVID-19
and Chi-square test for categorical
infection, based on information provided
variables as appropriate. For analysis,
to the public at the time: fever, cough, sore
responses to the attitudes section were
throat, and shortness of breath. More
combined.
recent information includes fatigue or
The main outcome of the study was the tiredness, which were not included in the
public acceptance of COVID-19 vaccines. survey. Three uncommon symptoms were
To determine the factors that affect the included: diarrhea, vomiting, and nausea
acceptance of the population to receive (Guan et al 2020). The number of correctly
COVID-19 vaccines, both multinomial answered items was summed to generate a
and binary logistic regressions were symptoms knowledge subscale score.
performed. At first, potential predictors for Transmission knowledge items asked
COVID19 vaccines were screened using about the ways the virus can potentially be
univariable analysis, and variables with spread, including droplets spread through
p<.05 were considered in both coughing or sneezing, touching or shaking
multinomial and binary logistic hands with someone who is infected, and
regression. When the multinomial logistic touching surfaces that have come into
regression was conducted, the acceptance contact with the virus. Three other sources,
outcome was trichotomized as (non- which did not appear to be transmission
acceptance, neutral, and acceptance). For a mechanisms, were also included: water,
simpler interpretation of the analysis, the mosquitoes, and airborne spread (Centers
participants who answered ‘neutral’ were for Disease Control and Prevention, 2020;
then removed and a binary logistic World Health Organization, 2020a,b). One
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item assessed knowledge of recommended complete few questions. Firstly, they were
face mask use, with advice to the public at a single-item measure assessing their self-
that time being that only people who were rated heath (Idler & Benyamini, 1997),
sick should be wearing masks to stop them with responses on Likert scale. Secondly,
spreading the virus. respondents were an item assessing
whether they had received a flu vaccine in
RESULTS AND DISCUSSIONS the previous year (yes, no, don’t know).
Information was collected on participants’ For the purposes of analysis, no and don’t
age group, gender, ethnicity, highest level know responses were combined to form a
of education, and region of residence dichotomous measure. Finally,
around six continents as shown in Table participants were asked whether they, or
1.1. Participants were also asked to any family members or friends, had caught
COVID-19 (yes, no, and don’t know).
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Table 1.2 Percentage of true, false, and unsure responses to general knowledge
Table 1.3 Percentage of yes, no, and don’t know responses to symptoms and
transmission
Further, the trust in the manufacturer that lowest proportion of responses from Egypt
provides effective and noncontaminated (43.55%) when asked if they would take a
products is another important determinant ‘when vaccine will available in your
of confidence. About two-thirds of country’. Participants from Asian
respondents in the current study had continent, China gave the highest
confidence in pharmaceutical companies proportion of positive responses (87.42 %)
to develop safe and effective COVID19 and the lowest proportion of responses
vaccines. However, the source of the from Afghanistan (47.22%) when asked if
vaccine affects the perceived safety, as they would take a ‘when vaccine will
only one-third of the participants in the available in your country’. Respondents
current study perceived that COVID-19 from Australian continent, Tonga gave the
vaccines that were manufactured in highest proportion of positive responses
Europe or America were safer than those (92.88%) and the lowest proportion of
made in other countries. This is rather responses from Fiji (87.21%) when asked
lower than the reported percentage by if they would take a ‘when vaccine will
Pogue and colleagues where ~55% and available in your country’. There was
36% of participants stated that they were considerable variation by country, with
more comfortable with vaccines made in Tonga from Australian continent again
the USA and Europe, respectively (Pogue having the highest proportion of positive
et al 2020). responses (92.88%) and the lowest
proportion of responses in Egypt (43.55
Respondents from African continent,
%) from African continent. The proportion
Mauritius gave the highest proportion of
of positive responses for all three
positive responses (82.76%) and the
continents can be found in Table 1.5
Table 1.5 COVID-19 Vaccine Acceptance in the Scale of Strongly Agreed in Africa,
Asia and Australia Continents
Respondents from North American would take a ‘when vaccine will available
continent, Panama gave the highest in your country’. Participants from South
proportion of positive responses (87.44%) American continent, Brazil gave the
and the lowest proportion of responses highest proportion of positive responses
from Canada (62.55%) when asked if they (86.24%) and the lowest proportion of
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responses from Paraguay (67.66%) when country’. There was considerable variation
asked if they would take a ‘when vaccine by country, with Panama from North
will available in your country’. American continent again having the
Respondents from European continent, highest proportion of positive responses
England gave the highest proportion of (87.44%) and the lowest proportion of
positive responses (69.33%) and the responses in Russia (51.34%) from
lowest proportion of responses from African continent. The proportion of
Russia (51.34%) when asked if they would positive responses for all three continents
take a ‘when vaccine will available in your can be found in Table 1.6
Table 1.6 COVID-19 Vaccine Acceptance in the Scale of Strongly Agreed in North
America, South America and Europe Continents
The current study is strengthened by a and risk variables that predict health
large sample size and a good behaviors and vaccine intentions, they
representation of participants from cannot establish causality and must be
different educational backgrounds from interpreted with caution. Given the large
the world. Respondents were recruited sample, the relationships between some of
through Social Network and as such are the significant predictors are likely to be
not representative of the general small and may not be clinically
population. The pattern of results may be meaningful.
generalize to the broader population. To
The current results provide information on
maximize convenience sampling, we used
the public responses to the COVID-19
solely self-report measures, which may
pandemic, including information sources
lead to biased effects. While the results of
and engagement, knowledge, and vaccine
the regression analyses provide interesting
intentions. The findings show that there
starting points to identify the demographic
was a critical mismatch between expected
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severities of symptoms versus data on how concerns about the vaccine once it being
COVID-19 is experienced, which needs to available as indicated by their concerns
be addressed in government education about related side effects. This is
campaigns. Without a vaccine currently consistent with Pogue and colleagues
available, encouraging widespread and finding where the majority of participants
sustained engagement with hygiene and (~63%) in the USA stated that they were
distancing behaviors is critical to worried about the side effects of the
successfully manage the COVID-19 COVID-19 vaccines (Pogue et al 2020).
pandemic, flatten the curve of infections, Most of the participants in the current
and protect vulnerable individuals and study stated that receiving the vaccine is
overburdened healthcare systems. The important to protect against COVID-19.
results of the current study provide However, almost half of them agreed that
important insights into psychological and most people would refuse to take the
behavioral responses early in the outbreak vaccine. This discrepancy could be due to
of this COVID-19. The findings point to their concerns about the vaccine’s side
types of information that may be effects. Our results supported such
particularly effective and groups that may perceived viewpoints, where those who
benefit from clear and targeted messaging did not believe in a conspiracy behind
to promote engagement with health- COVID-19 were more likely to accept
protective behaviors. COVID-19 vaccines. An important factor
to consider when exploring vaccine
Vaccine hesitancy could threaten the
acceptability is vaccine convenience in
efficiency of COVID-19 vaccines once
terms of its availability and affordability
they become commercially available
(MacDonald 2015).
worldwide (French et al 2020). There are
contrasting reports of gender effects in the CONCLUSION
literature, wherein some males were more
likely to accept the vaccine (Malik et al The determinants of vaccine uptake across
2020), compared to others reporting higher the globe show strong consistency, with
acceptance among females (Lazarus et al being male or having fewer years of
2020; Al-Mohaithef & Padhi 2020). In our education associated with decreased
study, males were more likely to take the chances of uptake. Positive information-
vaccine, in agreement with studies seeking behaviours and trusting health-
reported elsewhere (Malik et al 2020). care workers more than other sources such
Interestingly, males were more likely to as one’s social circle for medical and
participate in COVID-19 vaccine clinical health advice were associated with
trials compared to females in 2020 (Abu- increased chances of uptake. Results from
Farha et al 2020). The low acceptance our survey can inform the need for further
level of COVID-19 vaccines among them research, to explore why certain countries
can be attributed to multi factors, some of might experience sudden increases or
which are shared with the wide global decreases in confidence. We have
community. The current study revealed highlighted countries with marked
that half of the participants had safety decreases in percentages reporting that
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they strongly agree that vaccines are safe comparison is crucial to understanding
and countries with significant increases in these changing trends over time, which
those strongly disagreeing that vaccines can serve as an early warning system to
are safe. These countries are candidates for prompt needed intervention to avert drops
more nuanced follow-up surveys to in vaccine confidence and acceptance.
understand the precise drivers of
confidence and the link between Declaration of Conflicting Interests
confidence and uptake. The author declared no potential conflicts
of interest with respect to the research,
There is a study limitation to note. As not
authorship, and/or publication of this
all surveys used have consistent responses,
article.
we have made a key assumption that,
presented with different options between Funding
the extreme categories of “strongly agree”
and “strongly disagree” (which are Project Funded by Migration Research
consistent across all surveys), respondents Development and Society of Bangladesh
with the strongest sentiment will fall into (MRDSB)
one of these extreme groups regardless of
REFERENCES
additional categories. While this approach
probably allows meaningful comparison Abu-Farha, R. K., Alzoubi, K. H.,
across surveys—although it needs testing Khabour, O. F. (2020). Public
for validation—it pools vaccination beliefs Willingness to Participate in COVID-
among those without the strongest beliefs, 19 Vaccine Clinical Trials: A Study
masking potentially key information. from Jordan. Patient Prefer
Finally, owing to low case counts of Adherence, 14:2451-8.
respondents who have not had their
children vaccinated and the varying Ali, S. H., Foreman, J., Tozan, Y.,
religious groups across countries, religious Capasso, A., Jones, A. M., &
groups were recoded into the largest and DiClemente, R. J. (2020). Trends and
minority groups to extract results from our Predictors of COVID-19 Information
regression analysis. In many settings, Sources and Their Relationship With
more nuanced regression findings are Knowledge and Beliefs Related to the
possible, and a comprehensive regression Pandemic: Nationwide Cross-
analysis could reveal more informative Sectional Study. JMIR Public Health
country-specific determinants of vaccine Surveill, 6(4), e21071.
uptake. Al-Mohaithef, M, & Padhi, B. K. (2020).
Further research should investigate the Determinants of COVID-19 Vaccine
link between political polarisation, Acceptance in Saudi Arabia: A Web-
religious extremism, and populism and Based National Survey. J Multidiscip
vaccination beliefs to better understand Healthc, 13, 1657-63.
these complex ties. Having a common Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D.,
metric of confidence and a baseline for & Chen, L. (2020). Presumed
18
Weinstein, Neil, D., Kwitel, A., McCaul, Zou, L., Ruan, F., Huang, M., Liang, L.,
K. D., Magnan, R. E., & Gerrard, M. Huang, H., & Hong, Z. (2020).
(2007). Risk perceptions: Assessment SARSCoV-2 Viral Load in Upper
and relationship to influenza Respiratory Specimens of Infected
vaccination. Health Psychol, 26, 146– Patients. N E J. Med, 1, 19–21.
151.
Wheaton, M. G., Abramowitz, J. S.,
Berman, N. C., Fabricant, L. E., &
Olatunji, B. O. (2012). Psychological
Predictors of Anxiety in Response to
the H1N1 (Swine Flu) Pandemic.
Cognit Ther Res, 36 (3), 210-8.
Wilson, R. J., Paterson, P., Jarrett, C., &
Larson, H. J. (2015). Understanding
factors influencing vaccination
acceptance during pregnancy globally:
a literature review. Vaccine, 33, 6420–
29.
Wong, L. P., Wong, P. F., & Abu Bakar,
S. (2020). Vaccine hesitancy and the
resurgence of vaccine preventable
diseases: the way forward for
Malaysia, a Southeast Asian country.
Hum Vaccin Immunother; published
online Jan 24.
World Health Organization (2020a).
Coronavirus disease (COVID-19)
advice for the public: Myth busters.
Europe: WHO.
World Health Organization (2020b).
Modes of transmission of virus
causingCOVID-19: implications for
IPC precaution recommendations.
Europe: WHO.
Yufika, A., Wagner, A. L., & Nawawi, Y.
(2020). Parents’ hesitancy towards
vaccination in Indonesia: a cross-
sectional study in Indonesia. Vaccine,
38, 2592–99.