1. Diffusible 2.

Indiffusible Solids
Solids

Take solids Take solids

| |
Take solids + tragacanth Triturate in pestle
Triturate in pestle mortar powder
| mortar + tragacanth
| mucilage
Add sufficient vehicle to form Triturate in pestle mortar
smooth cream |
|
| Add sufficient vehicle to form smooth
Add more solvent to make cream
pourable |
| Add more solvent to make pourable
Examine carefully for foreign |
particles Examine carefully for foreign particles
| |
Rinse the mortar and pestle Rinse the mortar and pestle
| |
Add liquid ingredient if any Add liquid ingredient if any
| |
Make up volume Make up volume
3. PRECIPITATE FORMING LIQUIDS
• Certain liquid preparation on addition to water forms precipitate
• Ex: Banzoin tincture, Tolu tincture etc
• Insoluble and indiffusible precipitate
Take solids
Take solids + tragacanth powder |
| Triturate in pestle mortar + tragacanth
Triturate in pestle mortar mucilage
| |
Add sufficient vehicle to form smooth cream, add more vehicle to make pourable
|
Add precipitate forming liquid with slow stream in centre with rapid stirring
|
Carefully Examine for foreign particle
|
Rinse the mortar and pestle
|
Add liquid ingredient if any
|
Make up volume
Suspension prepared by chemical reaction

In this type of suspension highly diluted solutions are mixed together

so as to form very finely divided precipitates

that can be easily distributed throughout the liquid by shaking

Example
Rx
Sulphorated potash 5.0gm
Zinc sulphate 5.0g
Concentrated camphor water 2.5ml
Water add upto 100.0ml
Make a mixture

Method:
Dissolve the potash Dissolve zinc sulphate
in small quantity of water in small quantity of water
| |
Add potash solution to zinc sulphate solution with constant stirring
|
Add camphor water then volume is make up
Packaging and Storage of Suspensions:

1) Should be packaged in wide mouth containers having

adequate air space above the liquid.

2) Should be stored in tight containers protected from: freezing,

excessive heat & light.

3) Label: "Shake Before Use" to ensure uniform distribution of solid

particles and thereby uniform and proper dosage.

4) Stored in room temperature if it is dry powder (25 0C).

Note: It should be stored in the refrigerator after opening or

reconstitute (freezing should be avoided to prevent aggregation)

5) Parental suspension must be packed in amber color ampoule or vial.

STABILITY OF SUSPENSION

A stable suspension can be redisperse homogeneously

with moderate shaking.

Can be easily pourable through its shelf life

If suspension is flocculated suspension can be

redisperse easily at anytime with moderate shaking.

If suspension is deflocculated so particles should not

get settle and can be made stable by decreasing
particle size, increasing density and viscosity.