Feel Good Biochemistry is a book that allows you to take control and chart your own path

to health and wellness. Unlike my other books, it is not a book that you read all the way
through once, garner the necessary information, and set aside. This book is meant to be an
interactive guide that you refer to frequently, more like a dictionary or the GPS in your car.
It is intended to help you and your doctor know how to proceed when you get a test result
back. It explains what I would do if I were commenting on your tests, and gives you the
science and the rationale that is behind my thinking.
Your unique DNA, and the traits defined by the genes in that DNA is something that has
been inherited from your biological parents. While your DNA does not change over time,
the ability to turn on or off the genes within your DNA is affected by external factors
including diet, toxins, and nutrients.
Nutrigenomics includes the study of how nutrients may turn on or off specific genes to alter
the risk of health issues. Nutrigenomic testing is a measure of imbalances, or mutations in
the DNA of these nutritional pathways, that in turn influence the ability to turn on or off your
genes.
Nutrigenomic SNP testing is something you run only once in your lifetime. The Feel Good
Nutrigenomics book that I have written, describes in detail the value of nutrigenomic
testing, and approaches supplementation based on nutrigenomic data. I have also shared a
computer based program for looking at SNPs that is available online at no cost
through www.knowyourgenetics.com. Additional information about nutrigenomics, as well
as biochemical testing, is available in the DVD series that covers both of these topics
comprehensively.
Nutrigenomic data is just one piece of a larger puzzle that relates to health. The
comprehensive program that I introduced assumes that underlying genetic susceptibility,
infectious agents (virus, bacteria, yeast), environmental toxins (mercury, aluminum,
cadmium, lead, etc.), and stress, all impact your health. The idea behind the program is not
only to look at SNPs, but also to work with your own doctor to run a variety of non-invasive
tests that are designed to detect imbalances in your biochemical pathways, and to address
those imbalances with natural supports and dietary choices. The goal is to address
underlying issues, not just band aid symptoms.
I view biochemical tests as signs along a highway. They let you know where you are in your
journey towards optimal function, and how much further you need to go to reach your goal.
Many individuals run nutrigenomic testing to see where the imbalances are in their
Methylation Cycle. They then add what appears to be appropriate supplementation based
on those nutrigenomic results to support the short cut and the long route around the cycle.
Then they ask me on the discussion group what they should add next. My question to them
is always, “What are your biochemical tests looking like?” Asking me what to do next
without running biochemical testing is like being on your way from your hometown to my
rural town in Maine, and calling me to ask what route to take. How can you ask which route
to take if you cannot answer where you are located? How can you ask how much longer
your trip will take if you don’t know where you are on the Roadmap? This program can help
you to plot your Roadmap to Health, but you need to have a sense of where you are in
order to know what step to take next.
Nutrigenomic testing is a wonderful place to begin as it indicates specific supplementation
to bypass mutations that are identified by SNP testing. But the next critical piece is to be
sure you are running biochemical tests to be sure the support you are adding is sufficient
and having the impact you desire. Biochemical tests are the signposts along the highway
on your Roadmap to Health. You can get started on your journey without nutrigenomic
testing, however, it is virtually impossible to know where you are on the path to health
without running biochemical testing.
The purpose of biochemical testing is to follow up on the supplementation you are using
based on nutrigenomic testing. While you would not want to try to get along without
nutrigenomic testing, especially if your illness is significant, biochemical testing might be
considered even more clarifying than nutrigenomic testing. If you have not run a
nutrigenomic test, you can still get a sense of where you are on your Roadmap to Health by
running biochemical tests. Regardless of whether or not you have nutrigenomic SNP data,
regular biochemical testing lets you know where you are and what supplements may make
a positive impact for you. Nutrigenomic SNP testing gives you an idea about your
underlying genetic weaknesses, but sequential biochemical testing gives you indispensable
feedback on how well your current nutritional support is working.
Unlike DNA based SNP testing, follow up biochemical testing is something you should run
routinely to check that the supplementation you are using is actually making a difference.
The tests I work from are noninvasive in nature and can be run from the privacy of your
own home. I find that there is much better compliance when you have control over when
and where you take a test. You can also run additional blood tests with your own doctor to
supplement the results from urine, hair and fecal testing.
The information contained in this book represents an approach to interpreting test results
that is based upon a significant background in molecular biology and genetics. It is
reflective of my conviction that physical manifestations, such as symptoms and behavior,
have their origins in biochemistry. Those origins can be discovered and addressed, giving
you greater control over your own health and overall sense of wellbeing.
This book systematically goes through the various biochemical tests that I use for my
protocol. It steps you through how to use these tests to guide your supplement choices.
This program is designed to be implemented in conjunction with your doctor, to help you
and your doctor understand how to use biochemical test data to guide supplementation
choices in order to customize this program for your optimal health.
My hope for this book is that it helps each one of you achieve your maximum possible
health and wellness. Many of the adults looking toward this protocol have been sick for ten
or twenty years, having tried most of the options available, and come to this program on
only a very thin thread of hope. Others reading this book have children on the autism
spectrum and have been depleted emotionally and financially without significant progress.
My goal is to give all of you hope, and the guidance necessary so that you can implement
this program with the help of your own doctor.
For those of you reading this book merely looking to increase your lifespan or for
prevention, I am thrilled that you are not dealing with chronic illness, and I expect this book
will help you and your doctor to choose supplements based on biochemical testing to
address longevity and overall health.
At this point, we have almost 70 thousand individuals on my facebook page worldwide, and
almost 20 thousand following the program on the chat group. Those individuals include
adults with a range of health problems including CFS, FM, POTS, MS, ALS, Lupus, and
depression, as well as younger individuals with autism, ADD, ADHD, bipolar disorder and
schizophrenia. I am filled with love and hope for health for all of you, and I extend those
wishes to anyone reading this book. It is my hope that by sharing my rationale behind
supplement suggestions based on biochemical testing, it will enable you with your doctor to
achieve the health you desire.
With love and hope for health always,
Dr. Amy
Purpose of running this test:
An ideal starting point for testing is to run a Hair Elements Analysis. I abbreviate this test to
the acronym HMT. The HMT gives you a sense of the long term status of both toxic and
essential minerals in your body. While the urine and fecal metal tests described in Chapters
2 and 3 are useful, the HMT gives you a broader time view of what is going on with the
minerals in your system. It takes about three months for the one inch of hair that is closest
to your scalp to grow. This is the sample of hair that is tested, so you get a measurement of
the amount of the element that was excreted in your hair over that time period.
I look at a HMT the same way you would view counting the rings on a cross section of a
tree to know how old the tree is. While fecal and urine testing give you up to the moment
data, the amount of an element excreted on the day you collected the sample,
the HMT gives you a historical sense of the major areas of mineral balance to focus on. An
example of the centrality and the value of the HMT data I have been accumulating over the
past decade is my finding that low lithium is a key feature for adults as well as children with
a range of health issues.
Lithium plays a role in B12 transport into the cell. B12 functions at a very critical juncture in
the process of making methyl groups, as well as a range of other functions in your body.
You want to be certain that you have adequate lithium in your body prior to adding high
doses of B12 because of the interaction of lithium with B12 transport. If you add B12 and
other supplements that activate what I call the long route around the methylation cycle, the
route that uses Methionine Synthase (MTR) and Methionine Synthase Reductase
(MTRR), prior to being sure that you have enough lithium in your body, then you run the
risk of further depleting your lithium levels, which can cause symptoms and consequences.
It is also important to be sure that potassium is in balance and well supported when adding
lithium. Addressing both minerals at the same time is useful, as low levels of both lithium
and potassium can induce aggressive and anti-social behavior. Energy supplements can
also impact lithium levels, as well as a number of other minerals, including potassium. If
there is not sufficient energy being generated by the mitochondria in your cells, this can
cause low lithium, low potassium, and problems maintaining adequate levels of other
minerals. Mitochondrial support can be a help in these cases.
The HMT also gives you a sense of the balance between calcium and magnesium, as well
as zinc and copper. Ideally magnesium should be higher than calcium, because calcium
works with glutamate to cause over excitation of nerves. Excess copper relative to zinc can
be a factor in attention problems. Correct copper and zinc levels are also important for
neurotransmitter balance, since copper is a cofactor for the enzymes that break down
dopamine and serotonin.
The HMT is also useful in determining molybdenum balance. Molybdenum and B12 work
together with the enzyme sulfite oxidase to detoxify sulfate from your body. Sulfur levels on
the HMT can be seen as a secondary measure of your need for molybdenum and B12
support. If the sulfur on your HMT is high, you want to be sure that your body has adequate
levels of molybdenum and B12.
Those who are SHMT +, or who have significant bacterial imbalances, should limit iron
supplementation, or use nutrients to help balance iron if the levels are high on
a HMT or UTM/UEE. Iron can increase bacterial virulence, and it increases the activity of
the SHMT pathway, so ideally, serum iron levels should be checked. Consider also
checking Ferritin, Total Iron Binding Capacity (TIBC), % Saturation, and your Reticulocyte
Count for a complete reading on iron if you are concerned about your iron levels.
The HMT gives you useful information on additional essential minerals, as well as a sense
of the level of toxic metal excretion from your body. When you know what toxins are being
excreted, you can supplement with compounds that may help escort them from your body.
Different ‘escorts’ are applicable for different toxic metals. Aluminum requires different
escorts than mercury or nickel. I suggest running a HMT at least twice a year, and for those
individuals who are MTR +, or who show very low lithium levels on a HMT, then running
a HMT every 3 to 4 months to be certain that essential elements stay in balance is a good
idea.
Finally, when there is a high level of excretion of many essential minerals at the same time,
meaning if you are seeing black lines to the right for multiple essential minerals, this can be
a sign that more mitochondrial support is needed. In this case, running a MAP test to look
at energetic markers, as well as adding additional mitochondrial support, can be
considered. Extremely low potassium and lithium, in the absence of an MTR + status, may
also be a sign that more mitochondrial support is needed.

This table contains the rationale behind my suggestions. These

TOXIC
suggestions are for your consideration. Defer your choices to your own
METALS
health care practitioner, as always.

Aluminum can impact the Krebs energy cycle, so consider

a Metabolic Analysis Profile (MAP test) if high levels are seen on
a HMT. Also, aluminum can negatively impact tetrahydrobiopterin
Aluminum
(BH4) levels, which in turn affects dopamine, serotonin and
melatonin levels. A Neopterin / Biopterin Profile Urine Test can be run
to help evaluate BH4 levels. Consider adding MetalAway, or
 selenium, horsetail grass, low dose EDTA, and malic acid. Also,
you can use additional EDTA and EDTA soap or soak as tolerated. IF
you do not have shellfish allergies, consider using BactiSolve.
Use MTHFR A1298C Liver Support capsules and/or BH4 to help
support BH4 levels. Consider Vitamin E succinate if succinate levels
are low on the MAP test. You can also run a UAA test to look at
phenylalanine, tyrosine, and tryptophan levels as another means to
determine the need to consider BH4 support. If you and your
doctor want to push harder on excretion of toxins including
aluminum, you can consider the DetoxAway supplement, but as
always work with and defer to your own doctor.
Antimony can bind to ‘thiol’, which means SH groups. These SH
groups are needed to help escort mercury from your system. Also,
antimony may inhibit the MAO enzymes, which may interfere with
the natural breakdown of dopamine and serotonin. Antimony can
accumulate in your adrenals and thus play a role in fatigue.
Antimony
Consider adding sources of ‘thiol’ groups, such
as Selenium, MetalAway, or DetoxAway. Consider low dose Wasabi,
low dose Selenocysteine, and/or low dose Ion Transport compound,
which has both Wasabi and Selenocysteine. Broccoli and Garlic are
also options. Also, consider OraAdrenal for adrenal support.
Methylation cycle function is needed for arsenic excretion. If
arsenic is consistently high, consider running a Water Elements
Test to test your home water supply that is used for bathing, as well
as your drinking water. Arsenic can bind both to thiol, which are
SH groups, as well as phosphate groups. It can cause vitamin A
deficiency. Symptoms of arsenic toxicity can include white
streaked nails, a garlic odor emanating from your body, and/or
under pigmentation. Arsenic toxicity may also cause hair loss,
problems with folate uptake, or weakness, among other
symptoms.At the very least, use short cut methylation support,
support for the pathway that goes from homocysteine to
Arsenic
methionine using the BHMT enzyme. All in One, Phosphatidyl Serine
Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend all
support the short cut. If lithium is in balance, also support the long
route, the route that uses the MTR and MTRR enzymes. These
supports include low dose Methylmate A, Methylmate B, and B12.
Also, thiol supports may be useful, such as Selenium, MetalAway,
orDetoxAway; low dose Wasabi, low dose Selenocysteine, or low
dose Ion Transport compound, which has
both Wasabi and Selenocysteine. Broccoli may also be helpful. To
support phosphate, use phospholipids such as Phosphatidyl Serine
Complex (PS/PE/PC) and Riboflavin-5-Phosphate, ATP and MitoForce.

Barium can displace potassium, and may cause an increase in

stress hormones. It may also cause tingling and weakness of
Barium
muscles.Consider potassium support with Potassium Citrate. If Krebs
intermediates are low on a MAP test, then use Krebs Magnesium-
 Potassium Chelates. If gut pH is very low then consider Potassium
Bicarbonate. Also, Stress Foundation nucleotide blend and low
dose Muscle Support nucleotide blend may be a help. In
addition, Padma Basic may help with weak muscles and restless leg
syndrome if they are issues.
High levels of beryllium may affect lymphocyte proliferation and
respiratory function, as well as cause adrenal insufficiency and
fatigue. Consider T cell and B cell support capsules for immune
Beryllium support. OraAdrenal may also be used for additional support.
The Muscle Fatigue Support compound supplement can be considered
if fatigue is an issue. Low dose Respiratory Support nucleotide
blend may also be helpful.

High level excretion of bismuth, in the absence of any bismuth

supplementation, may be an indicator for H. pylori, so testing to rule
out H. pylori should be considered. Since high level bismuth
Bismuth
excretion in the absence of any support can lead to depletion of
bismuth over time, consider low level bismuth support
with Peptimycin or its equivalent. Rule out H. pylori.
High levels of cadmium can cause significant symptoms. Your
body uses zinc as a cofactor for over 50 critical enzymes.
However, if zinc is deficient, your body will replace it with
cadmium. Cadmium is just below zinc in the periodic table, so it
fits perfectly into zinc binding sites. Enzymes that make protein,
such as RNA transferase, and alcohol dehydrogenase, the enzyme
involved in alcohol processing, are impacted by this problem.
Other important enzymes are also negatively impacted. Cadmium
may also bind to glutathione (GSH) making it ineffective. It may
also negatively impact bone health and cause respiratory
symptoms. Consider supporting with Zinc Lozenges. Krebs Zinc can
be added if your Krebs intermediates are low on a MAP test. Also,
consider MetalAway and/or EDTA and EDTA soap to help escort
Cadmium cadmium from your system. Since cadmium can bind GSH,
consider supporting with GSH. Low dose Bone Support nucleotide
blend may also be helpful. Cadmium may decrease the Cytochrome
P450 enzyme system, so consider Indole-3-carbinol to support CYP
450. Since cadmium replaces zinc in arteries, adults may want to
consider low dose Heart Support nucleotide blend and Hawthorn Extract.
Also, consider Vitamin E and low dose Ion Transport support
capsules for high cadmium, to help prevent the cadmium induced
suppression of the CFTR enzyme. Also, work on supporting
methylation, as weak methylation capacity is related to
susceptibility to cadmium.In addition, lithium, which is in
both BeCalm Spray and All in One, may help to protect against the
negative impacts of cadmium, especially with respect to hormones
such as testosterone, LH, and FSH.
Lead can deposit in bone and replace calcium there. Lead can also
Lead
affect ATPase, which reduces the production of this energy
 molecule. This negatively impacts both sodium and potassium
levels, as well as energy production. Lead can bind melatonin,
tryptophan, and serotonin. Consider a MAP test and
a Neurotransmitter Urine Test to look at energy markers, as well as
neurotransmitter levels. Lead excretion can cause pica, teeth/jaw
grinding & aggression. Eating inedible objects may be a sign that
lead is being excreted. You may need to consider support to help
escort it from your system. Elevated 5-amino levulinic acid
(ALA) due to lead toxicity can inhibit Gamma amino butyric acid
(GABA), so consider extra GABA if needed. Since lead replaces
calcium in bones, consider low dose Bone Support nucleotide blend.
Vitamin D and K impact calcium absorption, so add a mineral
combination that includes vitamin D and K, such
as Cal/Mag/VitD/VitK. Also, for bone health, watch strontium and
boron levels. Consider MTR/MTRR/SUOX capsules to support
strontium and boron. Also, consider EDTA and MetalAway (or
selenium + horsetail grass + low dose EDTA + malic acid) to help
escort lead from your system. Also, use additional EDTA in EDTA
soap or soak as tolerated. Consider using BactiSolve if you have no
shellfish allergies, as another source of EDTA.
Consider ATP and/or MitoForce to support ATPase.
In addition to a wide range of neurological symptoms, mercury can
also cause increased salivation, rashes, and metallic taste in your
mouth. It can impact cytochrome P450, and may replace selenium
in the T4 to T3 reaction, thus causing thyroid hormone
imbalances.Consider support with Selenium or MetalAway. If more
detox is desired, consider DetoxAway. Also, GSH and Indole-3-
carbinol may be used. Ultimately, you can support re-myelination
with Sphingolin. Work on methylation cycle support to allow the
Mercury
natural detox of mercury. Also, the use of low dose Ion Transport
compound may help support detox because it
contains Selenocysteine and Wasabi to aid in escorting mercury from
your system. Basic methylation support includes All in
One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation
Support nucleotide blend. Once lithium is shown to be in balance on
a HMT, then consider low dose Methylmate A and Methylmate B,
along with extra B12.
Platinum can cause wheezing, excessive mucous in your nose, and
dermatitis. Consider Zinc Lozenges and low dose Respiratory Support
Platinum
nucleotide blend. Also, Serraflazyme and Air Power and the Muscle
Fatigue Support compound can help with mucous.

Thallium inhibits mitochondrial energy and ATP. It also inhibits

DNA and RNA synthesis. It may cause hair loss and anorexia.
Thallium can also cause riboflavin to be sequestered in the body,
Thallium
so Riboflavin-5-Phosphate support should be considered, especially
if MAP test results show imbalances in the Krebs energy cycle.
Consider support with ATP, Riboflavin-5-Phosphate,
 and/or MitoForce to address the impact of thallium on energy. Also,
use All in One for low dose DNA and RNA support,
and AHCY/SHMT compound or direct addition of nucleotides.
Thorium can bind to digestive enzymes. Consider Special Digestive
Thorium
Enzymes. Run a CSA test and GI Effects test to check on digestion.

Uranium can readily combine with nucleotides in your body and

can deposit in your bones. It can also cause chronic fatigue. Test
your home water supply with a Water Elements Test, and do a radon
air test if you continue to excrete high levels of uranium over time.
Consider All in One for low dose nucleotide support.
Consider AHCY/SHMT compound for nucleotide support, or direct
Uranium
nucleotide supplementation. Consider using Muscle Fatigue Support
compound and low dose Bone Support nucleotide blend.
Consider Cal/Mag/VitD/VitK so that vitamin D and K are present to
help with calcium absorption. To support your DNA in the
presence of high levels of uranium, also
consider Ultifend and Quercetin.
Nickel can cause significant skin rashes, allergies, dermatitis and
inflammation. Consider Riboflavin-5-Phosphate, especially when
phosphorus is low and nickel toxicity is present. Consider
Nickel
nucleotide blends such as General Support nucleotide
blend and Cytokine Balance nucleotide blend to help with itching. Clear
Skin spray may be used for topical skin support.

Excess silver may cause a blue gray color to your skin.

Consider MTHFR A1298C Liver Support capsules and low dose Liver
Silver
Support nucleotide blend to support your liver, as well as GSH to help
with toxin excretion.
Tin may cause liver pain, and may be more of an issue if your
system tends to be acidic. Check your pH on a CSA test or GI Effects
test, and/or use pH strips on first morning urine samples. Work to
get pH to around 7 with Buffer pH, VitaOrgan, and/or Stomach pH
Balancing nucleotide blend. If your potassium is low, then
Tin
consider Potassium Bicarbonate. Also, consider Indole-3-carbinol to
support cytochrome P450 enzymes that may be decreased due to
tin. Also, consider Special Digestive Enzymes. Consider MTHFR
A1298C Liver Support capsules, and low dose Liver Support nucleotide
blend for liver support.

Titanium may be a factor in respiratory issues. Consider GSH and

Titanium
low dose Respiratory Support nucleotide blend.
This table contains the rationale behind my suggestions. These
ESSENTIAL
suggestions are for your consideration. Defer your choices to your own
ELEMENTS
health care practitioner, as always.

Ideally, your test will show more magnesium relative to calcium.

Calcium
Excess calcium can work with glutamate to cause excitotoxicity, so
 high levels of calcium may cause symptoms if glutamate is also
high. Your goal for calcium is to be in the low range of normal,
with magnesium in the high range of normal. Since vitamin D and
K help with calcium absorption, less calcium support may be
needed if vitamin D and K are supplemented. Check to see if boron
is being dumped, as boron is often dumped with low vitamin D.
So, high level calcium and boron dumping may indicate a need
for Vitamin D. If calcium is higher than 650ppm or 65%, it may
indicate copper toxicity. There may be a greater need for calcium
support with a high protein diet. Guaifenisen, which is used for
chronic fatigue, may help pull down high calcium. Guaifenisen is
low dose in Muscle Fatigue Support compound, or in Air Power. Other
supplements used to help control high calcium
include Vinpocetine, Boswellia, ATP and/or MitoForce. These may
support better calcium balance because they support mitochondrial
function, and mitochondria may act as sinks to buffer the effects of
calcium overload. Potassium, and the phosphorus in Riboflavin-5-
Phosphate, may reduce high level calcium dumping in urine. If
calcium levels are too low, consider herbs that support calcium in a
complexed form, such as Nettle, Chamomile, or Chervil. The use
of Cal/Mag/VitD/VitK compound also supports calcium in a
balanced fashion. Low calcium can play a role in back pain,
menstrual cramps, and brittle nails. Boron deficiency may cause
dumping of calcium and magnesium in urine, in which case
consider the Bone Support capsules.
Magnesium can help if you have excess glutamate in your system.
It is preferable to have higher magnesium relative to calcium in
your body, because calcium works with glutamate to cause over
excitation of nerves, and magnesium helps to balance this. Boron
deficiency may cause dumping of calcium and magnesium in
urine. Check boron to be sure that it is not causing low magnesium
levels. Low taurine can cause magnesium dumping, so be sure
methylation support is in place to support healthy taurine levels.
You do not want very high taurine levels, nor do you want low
levels. The goal is taurine in a normal range. This can be measured
on a UAA test. Low dietary magnesium may contribute to
Magnesium aluminum-induced degenerative conditions. Consider support
with Magnesium Citrate, Magnesium Oxide, or Magnesium Malate.
Magnesium glycinate is non-optimal, as glycine can exacerbate
glutamate toxicity if your levels of glutamate are high. Amino acid
chelates of minerals are not always ideal, especially if you have
symptoms of excitotoxicity, because they include glutamate and
aspartate. I occasionally recommend them, and we do stock them,
so just be aware of this when you are ordering minerals.Basic
methylation support includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide blend. Once
lithium is shown to be in balance on a HMT, then consider low
dose Methylmate A, Methylmate B, and extra B12.
 Your goal is to keep sodium in the normal range, without its being
too low or excreted to a high degree. The use of Ion Transport
compound and low dose Ion Transport Support nucleotide blend may be
a help. Sodium is co-absorbed with a range of other nutrients, such
as amino acids, glucose and peptides, so supporting healthy ion
transport can be useful.Since sodium and potassium transport
Sodium across your cell membrane uses energy, consider ATP, Riboflavin-5-
Phosphate, and/or MitoForce to support sodium/potassium ATPase.
Also, consider using low dose Ion Transport compound and low
dose Ion Transport Support nucleotide blend. In addition, the use of
Sodium or Potassium Bicarbonate may be considered if your pH is
low on a CSA test or GI Effects test, as a way to support both sodium
and a more balanced pH.
Potassium levels drop coordinately with low lithium, so support
potassium when you are taking lithium. Low potassium can cause
rubidium levels to drop. Your body replaces potassium with
rubidium when potassium is deficient. This can create a rubidium
deficit, which is a factor in aggressive behavior. Use potassium to
support rubidium. Potassium levels that are less than 50ppm or 5%,
may indicate copper toxicity. Barium and cesium may displace or
interfere with potassium function. Additional potassium support
may be needed if you have high levels of barium or cesium
excretion. Also, low levels of potassium may be caused by
hydrogen sulfide (H2S) triggering efflux of potassium, so check
sulfur levels on the HMT and UEE, as well as taurine levels on
a UAA. High levels of taurine on a UAA may indicate higher than
ideal H2S levels in your system, which can then cause low
Potassium potassium levels. Low levels of potassium can be a factor in the
production of acne. Potassium Citrate can be used along with food
sources of potassium to support potassium. If your pH is low on
a CSA test or GI Effects test, then Potassium Bicarbonate can be used
both to support potassium and to help balance pH. If Krebs
intermediates are low on a MAP test, consider Potassium Krebs
Intermediates if you do not have glutamate/ GABA imbalance.
Potassium transport across the cell membrane is an energetic
process, so consider ATP, Riboflavin-5-Phosphate, and/or MitoForce to
support sodium/potassium ATPase if your potassium is low.
Arginine may have a positive impact on potassium levels. Those
who struggle with consistently low potassium, especially athletes,
may consider low dose Arginine support if your levels of arginine
are low on a UAA test. AminoAssist is one source of low dose
arginine.
Ideally, your copper levels should be lower than zinc to favor a
higher zinc to copper ratio. High copper has been implicated in
ADD. Copper is the cofactor that works with the enzymes MAO A
Copper
and MAO B to break down dopamine and serotonin, so high
copper may engender a higher degree of degradation of these two
neurotransmitters. Running a Neurotransmitter Urine Test and a MAP
 test gives you an indication of both the levels of serotonin and
dopamine, and a measure of their breakdown. Excess copper has
also been reported to cause fearful thoughts. If copper replaces zinc
in your brain, it may be a factor in migraines, so zinc support may
help you with this, as well as bring your copper into better balance.
Much less frequently, the issue is actually low copper. Low copper
may cause high histamine. The enzyme that breaks down histamine
is a copper containing MAO type of enzyme, so if your copper is
low, check to see if your histamine is high. Quercetin will help pull
down histamine but inhibits COMT, so use quercetin in
moderation. A natural source of quercetin is cherries. Cherries are
also a source of melatonin. Tart Cherry Extract is reported to be
helpful for gout. Low copper may also be a factor in de-
pigmentation of hair and skin. Ways to help bring copper into
better balance include the use of Molybdenum, Zinc, Carnosine, and
increased EDTA. EDTA is found in MetalAway, EDTA soap or soak,
and DetoxAway. You can also use BactiSolve if you have NO
shellfish allergies. Check molybdenum levels, because often
copper will be high when molybdenum is too low. Molybdenum
can be low due to high taurine, which is measured on a UAA test.
When taurine is processed via sulfite oxidase, molybdenum can
become depleted. In addition, high levels of sulfur can have the
same effect of depleting molybdenum. Molybdenum may also be
depleted due to chronic yeast infections, which can be checked on
a Vaginosis Test, or in the gut via a CSA test or a GI function test. An
alkaline environment limits copper, so work to get pH in balance,
meaning having a pH close to 7. You can use Buffer pH, Stomach pH
Balancing nucleotide blend, Potassium Bicarbonate or sodium
bicarbonate, depending on your need for either sodium or
potassium. VitaOrgan also helps to balance your pH.
As with magnesium, zinc helps to control the calcium and
glutamate interaction that can lead to over excitation of nerves.
Doses of zinc above 40 mg per day can actually stimulate
excitotoxin activity, so your goal is to keep zinc in the high range
of normal with under 40 mg of supplementation per day. A
deficiency of zinc may cause poor wound healing, poor ability to
smell or taste, and night blindness. Iron interferes with zinc
absorption, so keeping iron in proper balance is an important factor
in achieving proper zinc levels. When iron replaces zinc, it may
Zinc cause blood sugar imbalances, so consider support for the pancreas
and pancreatic enzymes such as SDE when zinc is low. Your body
uses zinc as a cofactor for over 50 critical enzymes. It prefers it.
However, if zinc is deficient, your body will replace it with
cadmium or lead, both of which are toxic metals. Cadmium is just
below zinc in the periodic table of the elements, so it fits perfectly
into zinc binding sites. Cadmium may replace zinc in enzymes that
make important proteins, such as RNA transferase and alcohol
dehydrogenase, the enzyme involved in alcohol processing. These
enzymes do not function properly with cadmium replacing zinc.
 Cadmium may also replace zinc in metallothionein, an important
heavy metal binding agent. When zinc is low, lead can replace zinc
in heme enzymes and impact the formation of red blood cells. So it
is important to keep zinc in the high normal range. Some studies
suggest that low zinc may increase the activity of the enzyme
methionine synthase (MTR). This could in turn lead to lower
lithium levels and exacerbate MTR + status. Low dose methionine
support, which is contained in AminoAssist, may be helpful in these
cases, along with lithium support as indicated on this HMT. Zinc
Lozenges are the form of zinc that is particularly helpful and well
absorbed. Consider Zinc Krebs Intermediates if your levels of Krebs
intermediates are low on a MAP test, and you do not have
glutamate/GABA symptoms. If your iron is high on a HMT or UEE,
consider AHCY/SHMT compound and/or Lactoferrin to help keep iron
in better balance. Support your pancreas with VDR/FOK Pancreatic
Support capsules, Ora-Pancreas, and/or Special Digestive Enzymes if your
zinc is low and iron is high, to help with blood sugar balance.
When your zinc is low, consider Heart Support nucleotide
blend and Hawthorn Extract if you are an adult. Cadmium can replace
zinc in the atrial wall of your heart and may cause decreased
flexibility and strength. Coffee may impair zinc uptake and may
lead to a need for increased zinc support.
Manganese is important for helping to process arginine, so
consider supporting with low dose Manganese if arginine is high on
a UAA test. However, high levels of manganese are a concern for
the reasons described below. Ideally, your manganese levels
should be in the lower range of normal so that they are sufficient to
support reactions that require manganese without allowing levels
to climb too high. Proper manganese levels are important to
preserve acetylcholine, an important neurotransmitter. Low
manganese can also impair the function of your Krebs energy
cycle. Low levels of manganese can cause hearing loss and low sex
drive. Low manganese can cause low cholesterol, imbalances in
alkaline phosphatase levels, and decreased T cells. Most bacteria
use iron for growth, but Borrelia burgdorferi uses manganese, so low
Manganese manganese may be seen in Lyme disease. Manganese levels may
also drop with H. pylori infection. Consider ruling out H. pylori or
Lyme disease if you have chronically low levels of manganese.
Iron can compete with manganese for uptake, so be sure iron is in
balance. To support low levels of manganese,
consider MTR/MTRR/SUOX capsules, Manganese Drops,
and Glucosamine/Chondroitin Plus. Consider T cell and B cell support
capsules immune support. AHCY/SHMT compound or Lactoferrin may
help to get iron in better balance. Conversely, excessively high
levels of manganese can cause psychosis as well as seizures.
Excessive accumulation of manganese causes a neurological
condition called “manganism” that is characterized by psychosis
and eventually followed by symptoms similar to those seen in
Parkinson’s disease. High levels of manganese have also been
 associated with ALS and biochemical changes similar to
Alzheimer’s and Huntington’s disease (Sidoryk-Wegrzynowicz,
2013). High levels of manganese can cause increases in reactive
oxygen species, (consider Ultifend), impair glutathione levels
(consider GSH) and increase inflammatory mediators
(consider General Support nucleotide blend and low dose TNF
nucleotide blend). High dose manganese may also decrease
dopamine levels. Toxic doses of manganese can impact both
GABA and taurine levels and affect their transport. If an individual
is intolerant to GABA supplementation in spite of symptoms that
suggest a need for GABA, then check manganese levels to be sure
they are not exceedingly high. The use of valerian root in
conjunction with low dose GABA may be a consideration for you
and your doctor, as valerian may aid in GABA transport. If high
manganese is the issue, consider increased EDTA support. Working
with and deferring to your own doctor, consider the use
of MetalAway , DetoxAway, EDTA soap and soak, and
additional EDTA capsules.If very high levels are seen, rule out high
manganese in your home water supply by using the Water Elements
Test. Some defective water filtration systems may be a source of
higher than ideal levels of manganese in your drinking and bathing
water supply.
Low levels of chromium can be factors in ADD and anxiety. Low
levels of chromium may also be associated with blood sugar
Chromium
imbalances. Support can include Chromium Picolinate and VDR/FOK
Pancreatic Support capsules.

High levels of vanadium may be related to bipolar symptoms.

Vanadium can bind to iron complexes, so be sure iron is in
balance. Consider AHCY/SHMT compound or Lactoferrin to help with
Vanadium
iron balance. Low vanadium levels may be an issue for blood sugar
balance. Consider using Vanadyl Sulfate, depending on your sulfur
levels, and VDR/FOK Pancreatic Support capsules for low vanadium.
Molybdenum is critical for sulfite oxidase function, the enzyme
that processes sulfite to sulfate. Those who are sulfur sensitive
should keep a close eye on molybdenum levels. Sulfite oxidase
follows CBS in the transsulfuration pathway, so excess CBS
activity can put more pressure on sulfite oxidase and generate a
need for molybdenum. Molybdenum is also needed to help keep
copper in balance. High copper has a number of non-optimal
Molybdenum effects, including allowing the increased breakdown of dopamine
and serotonin. Molybdenum is also needed for xanthine oxidase
function. Significant xanthine oxidase may be present in
homogenized milk, so those drinking milk may have a need for
molybdenum support. Those who have high levels of tungsten may
need molybdenum support, as tungsten competes with
molybdenum. Those who are MTR + often show lower levels of
molybdenum, so more frequent HMT and UEE should be run to be
 sure molybdenum stays in balance. Molybdenum can be supported
with Molybdenum Capsules, MTR/MTRR/SUOX capsules, Black Bear
Spray, or Black Bear Drink. Molybdenum Drops can also be used,
although the liquid form is complexed with ammonia so this is not
the preferred form of support.
Low vitamin D levels may relate to low boron levels, so additional
boron support may be needed in areas of low sunlight during the
winter. Also, those who are MTR + may tend to have lower boron
levels. Low boron may cause dumping of calcium and magnesium
Boron
in urine. Check boron levels when there is high level excretion of
magnesium and calcium in your urine. Bone Support
capsule and/or MTR/MTRR/SUOX capsules can be added to help
balance boron levels.
Low iodine can negatively impact your thyroid gland’s ability to
produce thyroid hormone, and cause bulging eyes, goiter, and a
whole host of other symptoms. Low iodine can cause excessive
sweating, hair loss, dry skin and hair, as well as hand tremors.
High levels of iodine support may interfere with lithium levels.
Since lithium is important for B12 transport, be sure your lithium
is in the normal to high normal range, while keeping iodine in
balance. Ideally, lithium should be higher than iodine with both
within normal range. Iodoral can be used to support iodine. A
topical iodine test can be used both to test and to support iodine
Iodine levels. The topical iodine test is done as follows: apply a 2%
solution of iodine in a circular area about the size of silver dollar
on your abdomen. The spot should be allowed to dry completely
before putting clothing over it, because iodine can permanently
stain clothes. The spot should remain visible for 12 to 24 hours. If
the iodine disappears within 12 hours, it may indicate iodine
deficiency, which can be confirmed with this HMT. The skin
absorbs iodine at the rate at which it is needed, so applying iodine
topically replaces it, as well as gives you a broad stroke idea of its
internal levels. Iodine levels can also be checked using the Urine
Iodine Test.

The role of lithium in B12 transport into the cell is potentially critically
important. Peer reviewed work by Tisman, Herbert, and Rosenblatt
published in the British Journal of Haematology was the first to illustrate
that ingestion of lithium is related to B12 binding. Continuing this research,
Lithium Vanyo and coworkers (Lithium in Biology and Medicine) discuss the finding
that lack of lithium and B12 deficiency share physiological features, and that
support with lithium enhances B12 transport into cells. According to these
researchers, lithium is associated with elevated levels of serum B12 binding
capacity. Furthermore, this group was able to show that lithium increases the
transport of folate into the cell, as well as that of B12.
Additional peer reviewed work by Schrauzer (Biological Trace Element
Research) also supports the role of lithium in B12 transport. The addition of
lithium was shown by Cervantes et al to lower elevated serum B12 levels,
again illustrating lithium’s effecting B12 transport into cells.
Based on this research, it is important to look at lithium levels. I use the
HMT and the UTMEE in combination with each other to assess both lithium
as well as cobalt levels (as a measure of B12). You may also want to look at
serum lithium and B12. In cases in which lithium is low and/or serum B12 is
particularly high, use lithium support prior to the addition of high dose B12.
Lithium support is in All in One, Be Calm Spray, and Lithium Orotate.
Use these with the consent of your doctor. The rationale behind this is to
ensure that you have adequate lithium prior to adding high dose B12,
because increasing B12 in the absence of lithium support may further
deplete lithium levels due to the use of lithium to aid in the transport of the
added B12. Ideally, lithium should be in balance prior to adding excess B12
so as not to create lithium depletion. Low dose maintenance nutritional
levels of lithium support are available in All in One and Be Calm Spray.
Lithium plays a range of additional roles in your body aside from B12 and
folate transport into your cells, so it is important not to deplete this pivotal
trace mineral. Lithium’s impact on mood stabilization has been known and
used clinically for many years, despite the fact that the mechanism by which
this occurs has not been fully elaborated. Norepinephrine imbalances have
been implicated in attention disorders, and Sastre and coworkers have
illustrated an impact of lithium on balancing norepinephrine levels.
Researchers have noted and published effects from lithium on neurological
conditions. Beta amyloid may play a role in Alzheimers Disease and lithium
has been shown to have neuroprotective effects against beta amyloid.
Research from Spain illustrates that lithium has a positive impact on neural
repair after traumatic injury. Maurer (2009) showed that lithium can enable
mitochondrial function, which may be particularly useful in the presence of
toxic metals. Increases in the grey matter of the brain have been tied to
lithium support (Moore) and research from the National Institute of Health
 (NIH) showed the induction of brain derived neurotrophic factor (BDNF) by
lithium. Especially relevant to this program, lithium was reported by
Hashimoto (2002) to protect against glutamate excitotoxity.
In addition, lithium has been implicated in Lyme disease, as well as having
an impact on Herpes virus (Amsterdam et al).
Lithium may also help to support healthy tetrahydrobiopterin (BH4) levels.
Lithium stimulates white cells and platelets, so low levels of lithium may
cause low white cells. Myrrh may help for low white cells.
Those who are MTR + tend to have lower lithium levels.
Ideally, lithium should be in balance before adding extra B12, MethylMate
A, or MethylMate B. MethylMate B is low dose 5-methylTHF.
For general lithium support, consider All in One and Be Calm Spray.
Always support potassium when supplementing lithium.
For levels that are particularly low, consider Lithium Orotate plus some form
of potassium, usually Potassium Citrate. Run regular HMT to assess lithium
levels when adding lithium orotate. Those who are MTR + should do a HMT
every 3 to 4 months.
High level excretion of lithium in the absence of any lithium
supplementation suggests that excretion will lead to future depletion. Thus,
lithium should be added when lithium is either very low, or when high level
excretion is seen in the absence of any lithium supplementation.
Low lithium may also be an issue secondary to a need for mitochondrial
energy support. A MAP test can be run to look at energy markers. Support
for mitochondrial energy can include MitoForce, ATP, Riboflavin-5-
Phosphate, NADH, Krebs minerals.

If your phosphate is low, then your leucine may be high.

According to published literature, if phosphate is low, then leucine
may be increased, which in turn may increase glutamate and alpha
KG. This can potentially cause hypoglycemia. Your level of
leucine can be checked on a UAA. Consider phosphate support
when phosphate is low, when hypoglycemia is an issue, when
Phosphorus
glutamate and leucine are high on a UAA test, or when alpha
ketoglutarate is either very high or very low on a MAP test. Cross
referencing between these tests is helpful when problem solving.
Supplementing phosphorus may help with excessive dumping of
calcium in your urine. Copper toxicity may be a factor when
phosphorus is low. Check your copper levels. Riboflavin-5-
 Phosphate can help support phosphorus, especially if nickel toxicity
is present. Also ATP and/or MitoForce help to support phosphorus.
Phospholipids such as Phosphatidyl Serine Complex (PS/PE/PC) and
nucleic acids such as RNA can also support phosphorus. Vitamin
D may help with phosphorus absorption. Pumpkin seeds are a
natural source of phosphorus.
Selenium may become depleted with high level mercury excretion,
as well as with the excretion of a number of other toxic metals.
Consider extra selenium support when toxic metal excretion is
observed. If selenium levels are low on a HMT, consider additional
support.Selenium is essential for the conversion of T4 to T3, T3
being the active form of thyroid hormone. The de-iodinase
enzymes that remove iodine atoms from T4 during its conversion
to T3 are selenium-dependent. So, consider selenium when you
have low thyroid symptoms. PABA, found in Ultimate B,
and Niacinamide can be considered as additional support for those
who have indications of autoimmune thyroid issues. Very high
levels of selenium are toxic, so the goal is to be within normal
range for this mineral. Methylation cycle function is needed to
remove excess selenium, so until methylation support is in place,
Selenium and you know you have good methylation pathway function, do
not use high dose selenium. Consider support with MetalAway or
other sources of Selenium. Low dose Ion Transport compound is a
source of selenocystene, or consider low
dose Selenocysteine. GSH and Vitamin E succinate can aid in
maintaining selenium levels. Excretion of mercury, antimony,
arsenic, and/or thorium may lead to a greater need for selenium
support. DetoxAway can be considered for higher dose support
during detox once effective methylation support is in place. As
always, work with your doctor. Basic methylation support
includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide blend. Once
lithium is shown to be in balance on a HMT, then add low
dose Methylmate A, Methylmate B, and extra B12 in the appropriate
form.
Strontium levels tend to be lower for those who are MTR +.
Strontium Consider MTR/MTRR/SUOX capsules if your strontium is low, or
being excreted excessively in the face of no supplementation.
High levels of sulfur can put excessive pressure on SUOX, the
sulfite oxidase enzyme, which appears below the cystathionine
beta synthase (CBS) enzyme in the transsulfuration pathway
portion of the methylation cycle. Increased CBS activity can free
Sulfur excessive sulfur groups that use SUOX, which may then become
depleted. The SUOX enzyme needs B12 and molybdenum for
activity. So, high sulfur can result in increased usage of B12 and
molybdenum that are needed for other functions in your body. Low
molybdenum can mediate an increase in copper, and unbalance
 your zinc/copper ratio, which can then affect attention, reduce
heavy metal detox, and cause other symptoms. Depletion of B12
can limit enzyme activity in the long route, the reaction in your
methylation cycle that uses the MTR and MTRR enzymes. If your
sulfur levels are high, consider using
additional Molybdenum and B12 once your lithium is in balance on
a HMT. You may also consider using Black Bear Spray or Black Bear
Drink, which is a combination form of molybdenum and B12. Do
a UAA test to be sure that your taurine levels are not high, as high
taurine can also put excessive pressure on the sulfite oxidase
enzyme. For low levels of sulfur support, use healthy sulfur donors
that have other positive attributes such
as Garlic, Broccoli, Wasabi, SAM-e, or N-Acetyl Cysteine.
All forms of B12, hydroxyl, adenosyl, methyl, and cyano, contain
the element cobalt. It is possible to follow cobalt levels on
a HMT and UEE as a method for tracking B12 ingestion. Blood B12
levels can also be directly measured. If cobalt is low, first check
that lithium is in balance before adding high dose B12. As you
increase B12 support, follow with regular HMT testing to be sure
lithium stays in balance. There are several forms of B12. Hydroxy
Cobalt
B12 is usually well tolerated and is used by everyone on this
protocol. Adenosyl B12 is also usually well tolerated. It is often a
help for high methylmalonic acid (MMA) levels on a MAP test, as
well as to help process fats when used in conjunction
with Biotin. MethylB12 may be tolerated by those who are COMT –
and some who are COMT + -. It is used in limited ways in my
protocol.
Excess iron is pro-oxidant and drives bacterial virulence, so high
iron on this test may indicate issues with bacterial imbalances. If
your iron is above the 50th percentile, consider a CSA test and GI
function test to check for unbalanced, non-optimal organisms in
your gut. Adult females may want to run a Vaginosis Test in
addition, to check for bacteria and yeast. Iron helps to increase
SHMT activity, which diverts methylation intermediates from both
the MTR/MTRR enzyme reaction, what I call the long route
around the methylation pathway, and the BHMT enzyme reaction,
the short cut. Limiting iron is particularly important for those who
Iron are SHMT +. Iron can bind tryptophan, so it may reduce serotonin
levels. H2S frees up iron, so check taurine and sulfur levels. If
taurine and sulfur are high, then consider that excess iron may be
an issue. Levels of iron are increased with humic acid, which is in
part why humic acid is not a part of this program. Humic acid may
cause lipid peroxidation. High iron levels may be related to high
methionine, so if your methionine is high on a UAA test, check your
iron levels. Lactoferrin and/or AHCY/SHMT compound may help bind
and transport iron to where it is needed in your body. Also, if your
iron is high, work to shift acidic environments to alkaline
environments, because acid increases iron. So, consider Buffer
 pH, VitaOrgan, and/or Stomach pH Balancing nucleotide blend. Either
sodium bicarbonate or Potassium Bicarbonate can be used to help
balance pH depending on your need for sodium or potassium.
Check pH on a CSA test, GI function test, or by testing urine with pH
strips. Also, consider VDR/FOK Pancreatic Support capsules, because
iron can cause blood sugar issues when it replaces zinc.If you need
iron support, then complexed herbal forms may cause less excess
iron in your system. Dandelion greens are an excellent source of
iron that also may be supportive for your kidneys.
Germanium aids in oxygen utilization and helps support your
Germanium immune system. If your germanium levels are low, consider T
cell and B cell support capsules for immune support.

Low levels of rubidium are a sign of low potassium. Low rubidium

can cause aggression. Consider potassium support if your rubidium
is low. Potassium Citrate can be used, along with food sources of
potassium. If your pH is low on a CSA test or GI function test, then
Rubidium
use Potassium Bicarbonate to both support potassium and help
balance pH. If Krebs intermediates are low on a MAP test, and you
do not have problems with glutamate GABA imbalances, then
consider Potassium Krebs Intermediates.
High levels of zirconium may cause lung irritation, so consider low
dose Respiratory Support nucleotide blend. Low zirconium may
Zirconium suggest a need for more liver support. Consider Liver Support
nucleotide blend. The liver may be a source of zirconium, so
consider Ora-Liv and MTHFR A1298C Liver Support capsules.
Purpose of running this test:
Looking at the Hair Elements Analysis (HMT) to determine the toxic and essential element
content of your body is something like looking at the rings on a cross section of a tree. It
gives you a longer term, more historical view of the toxic and essential metals in your body.
The urine test, on the other hand, gives you a measurement of what is being excreted on
the day the test was taken, the level of excretion for that day. It is useful to run the Urine
Toxic Metals and Urine Essential Elements Test (UTM/UEE) at the same time as a HMT, at
least initially, to get a baseline level of metals from both the immediate as well as the
historic vantage point.
When detox is suspected because of behavioral changes or other issues in a child, or
symptoms characteristic of detox in an adult, it is useful to have immediate feedback from a
UTM/UEE or Fecal Metals Test (FMT), rather than waiting until the toxins causing the
disturbance become evident in a hair sample. Environmental toxins are a risk factor in
multi-factorial conditions, including the many adult and pediatric chronic illnesses evident at
present. Urine toxic metal excretion data is also useful because the environmental toxic
load in your body impacts your capacity to produce methyl groups and methylate
appropriately. Impaired capacity to methylate affects multiple systems’ function, not the
least of which are your immune and nervous systems. Additionally, methyl groups are
important epigenetic regulators of genetic function, so impaired methylation has a global
impact. See the Feel Good Nutrigenomics book for a more comprehensive discussion of
epigenetics.
This urine test is particularly useful for looking at cobalt levels as a measure of B12 status
secondary to methylation cycle support. Lithium is reported to impact B12 transport into the
cell. Comparing data on lithium levels in urine as opposed to hair helps to determine how
your body is handling this important trace element, and in so doing helps you to support the
methylation cycle optimally.
The current financial climate has impacted the testing I ask for, however, I really like to see
an initial UTM/UEE along with a HMT to get a baseline sense of toxic and essential
minerals. Then, over time, the UTM/UEE can be rotated with a FMT and a HMT, so
that one test is run every two or three months. In this way, over the course of a year, two of
each of these tests is run. This gives me a sense of what is being excreted via all three
routes, as well as a measure of essential elements.
If a certain essential element is particularly low, for example cobalt, or its excretion is
particularly high, for example lithium, then running a HMT along with a UTM/UEE more
often is worth considering, at least until you are certain that these critical minerals are in
balance.

This table contains the rationale behind my suggestions. These

TOXIC
suggestions are for your consideration. Defer your choices to your own
METALS
health care practitioner, as always.

Aluminum can impact the Krebs energy cycle, so consider

a Metabolic Analysis Profile (MAP test) if high levels are seen on
a HMT. Also, aluminum can negatively impact tetrahydrobiopterin
(BH4) levels, which in turn affects dopamine, serotonin and
melatonin levels. A Neopterin / Biopterin Profile Urine Test can be run
Aluminum
to help evaluate BH4 levels. Consider adding MetalAway, or
selenium, horsetail grass, low dose EDTA, and malic acid. Also,
you can use additional EDTA and EDTA soap or soak as tolerated. If
you do not have shellfish allergies, consider using BactiSolve.
Use MTHFR A1298C Liver Support capsules and/or BH4 to help
 support BH4 levels. Consider Vitamin E succinate if succinate levels
are low on the MAP test. You can also run a UAA test to look at
phenylalanine, tyrosine, and tryptophan levels as another means to
determine the need to consider BH4 support.
Antimony can bind to ‘thiol’, which means SH groups, which are
needed to help escort mercury from your system. Also, antimony
may inhibit the MAO enzymes, which may interfere with the
natural breakdown of dopamine and serotonin. Antimony can
accumulate in your adrenals and thus play a role in fatigue.
Antimony
Consider adding sources of ‘thiol’ groups, such
as Selenium, MetalAway, or DetoxAway. Consider low dose Wasabi,
low dose Selenocysteine, and/or low dose Ion Transport compound,
which has both Wasabi and Selenocysteine. Broccoli and Garlic are
also options. Also, consider OraAdrenal for adrenal support.
Methylation cycle function is needed for arsenic excretion. If
arsenic is consistently high, consider running a Water Elements Test.
Arsenic can bind both to thiol, which are SH groups, as well as
phosphate groups. It may cause vitamin A deficiency. Symptoms
of arsenic toxicity can include white streaked nails, a garlic odor
emanating from your body, and/or under pigmentation. Arsenic
toxicity may also cause hair loss, problems with folate uptake, or
weakness, among other symptoms. At the very least, consider short
cut methylation support, support for the pathway that goes from
homocysteine to methionine using the BHMT enzyme. All in
Arsenic
One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation
Support nucleotide blend all support the short cut. If lithium is in
balance, also support the long route, the route that uses the MTR
and MTRR enzymes. These supports include low dose Methylmate
A, Methylmate B, and B12. Also, thiol supports may be useful, such
as Selenium, MetalAway, or DetoxAway; low dose Wasabi, low
dose Selenocysteine, or low dose Ion Transport compound, which has
both Wasabi and Selenocysteine. Broccoli may also be helpful. To
support phosphate, use phospholipids such as Phosphatidyl Serine
Complex (PS/PE/PC) and Riboflavin-5-Phosphate, MitoForce or ATP.

Barium can displace potassium, and may cause an increase in

stress hormones. It may also cause tingling and weakness of
muscles. Consider potassium support with Potassium Citrate. If
Krebs intermediates are low on a MAP test, then consider Krebs
Barium Magnesium-Potassium Chelates. If gut pH is very low then
consider Potassium Bicarbonate. Also, Stress Foundation nucleotide
blend and low dose Muscle Support nucleotide blend may be a help. In
addition, Padma Basic may help with weak muscles and ginkgo along
with Padma Basic if restless leg syndrome if they are issues.
High levels of beryllium may affect lymphocyte proliferation and
respiratory function, as well as cause adrenal insufficiency and
Beryllium
fatigue. Consider T cell and B cell support capsules for immune
support. OraAdrenal may also be used for additional support.
 The Muscle Fatigue Support compound supplement can be considered
if fatigue is an issue. Low dose Respiratory Support nucleotide
blend may also be helpful.

High level excretion of bismuth, in the absence of any bismuth

supplementation, may be an indicator for H. pylori, so testing to rule
out H. pylori should be considered. Since high level bismuth
Bismuth
excretion in the absence of any support can lead to depletion of
bismuth over time, consider low level bismuth support
with Peptimycin or its equivalent. Rule out H. pylori.
High levels of cadmium can cause significant symptoms. Your
body uses zinc as a cofactor for over 50 critical enzymes.
However, if zinc is deficient, your body will replace it with
cadmium. Cadmium is just below zinc in the periodic table, so it
fits perfectly into zinc binding sites. Enzymes that make protein,
such as RNA transferase, and alcohol dehydrogenase, the enzyme
involved in alcohol processing, are impacted by this problem.
Other important enzymes are also negatively impacted. Cadmium
may also bind to glutathione (GSH) making it ineffective. It may
also negatively impact bone health and cause respiratory
symptoms. Consider supporting with Zinc Lozenges, or Krebs Zinc, if
your Krebs intermediates are low on a MAP test. Also,
consider MetalAway and/or EDTA to help escort cadmium from
Cadmium your system. Since cadmium can bind GSH, consider supporting
with GSH. Low dose Bone Support nucleotide blend may also be
helpful. Cadmium may decrease the Cytochrome P450 enzyme
system, so consider Indole-3-carbinol to support CYP 450. Since
cadmium replaces zinc in arteries, adults may want to consider low
dose Heart Support nucleotide blend and Hawthorn Extract. Also,
consider Vitamin E and low dose Ion Transport support capsules for
cadmium, as it may help prevent the cadmium induced suppression
of the CFTR enzyme. Also, work on supporting methylation, as
weak methylation capacity is related to susceptibility to cadmium.
In addition, lithium, which is in both BeCalm Spray and All in One,
may help to protect against the negative impacts of cadmium,
especially with respect to hormones such as testosterone, LH, and
FSH.
Cesium inhibits potassium currents, so it can cause fatigue and
palpitations, as well as muscle weakness. Use a form of potassium
support that compliments your other biochemistry, ie, Potassium
Citrate, Krebs Magnesium-Potassium Chelates, or Potassium
Cesium Bicarbonate can be considered depending on other test values, such
as a MAP test for Krebs minerals or pH levels in the gut may
indicate Potassium Bicarbonate. Consider low dose Muscle Support
nucleotide blend, and, if needed, Muscle Fatigue Support
compound supplement.

Gadolinium is a contrast dye used for MRIs. High levels in your

Gadolinium
system may cause kidney problems, skin rashes, and joint and
 muscle weakness. While gadolinium does not always cause these
problems, if high levels of this mineral are excreted, consider
support for your organ systems. Consider T cell and B cell support
capsules for immune support. In addition, MTHFR A1298C Liver
Support capsules, Gymnema, Ora-Kidney, Ora-Liv, Kidney Support
nucleotide blend, Liver Support nucleotide blend, and Indole-3-
carbinol can all be considered to support other organ systems.

Lead can deposit in bone and replace calcium there. Lead can also
affect ATPase, which reduces the production of this energy
molecule. This negatively impacts both sodium and potassium
levels, as well as energy production. Lead can bind melatonin,
tryptophan, and serotonin. Consider a MAP test and
a Neurotransmitter Urine Test to look at energy markers, as well as
neurotransmitter levels. Lead excretion can cause pica, teeth/jaw
grinding & aggression. Eating inedible objects may be a sign that
lead is being excreted. You may want to consider support to help
escort it from your system. Elevated 5-amino levulinic acid
(ALA) due to lead toxicity can inhibit Gamma amino butyric acid
Lead (GABA), so consider extra GABA if needed. Since lead replaces
calcium in bones, consider low dose Bone Support nucleotide blend.
Vitamin D and K impact calcium absorption, so consider a mineral
combination that includes vitamin D and K, such
as Cal/Mag/VitD/VitK. Also, for bone health, watch strontium and
boron levels. Consider MTR/MTRR/SUOX capsules to support
strontium and boron. Also, consider EDTA and MetalAway (or
selenium + horsetail grass + low dose EDTA + malic acid) to help
escort lead from your system. Also, consider
additional EDTA in EDTA soap or soak as tolerated. Consider
using BactiSolve if you have no shellfish allergies, as another source
of EDTA. Consider ATP and/or MitoForce to support ATPase.
In addition to a wide range of neurological symptoms, mercury can
also cause increased salivation, rashes, and metallic taste in your
mouth. It can impact cytochrome P450, and may replace selenium
in the T4 to T3 reaction, thus causing thyroid hormone imbalances.
Consider support with Selenium or MetalAway. If more detox is
desired, consider DetoxAway. Also, GSH and Indole-3-carbinol may
be used. Ultimately, you can support re-myelination
with Sphingolin. Work on methylation cycle support to help allow
Mercury
the natural detox of mercury. Also, the consider low dose Ion
Transport compound as it may help support detox because it
contains Selenocysteine and Wasabi to aid in escorting mercury from
your system. Basic methylation support includes All in
One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation
Support nucleotide blend. Once lithium is shown to be in balance on
a HMT, then consider low dose Methylmate A and Methylmate B,
along with extra B12.
Nickel Nickel can cause significant skin rashes, allergies, dermatitis and
 inflammation. Consider Riboflavin-5-Phosphate, especially when
phosphorus is low and nickel toxicity is present. Consider
nucleotide blends such as General Support nucleotide
blend and Cytokine Balance nucleotide blend to help with itching. Clear
Skin spray may be used for topical skin support.

Palladium may impact your liver and kidneys. It can cause free
radical damage to DNA, and allergic reactions, especially for those
with nickel allergies. Consider Kidney Support nucleotide blend, Liver
Support nucleotide blend, Ora-Kidney, Ora-Liv and/or MTHFR A1298C
Palladium
Liver Support capsules. Consider Riboflavin-5-Phosphate to help with
nickel, Quercetin in low doses if COMT status is not an issue,
and General Support nucleotide blend. You can also consider
an Oxidative Damage test to assess damage.
Platinum can cause wheezing, excessive mucous in your nose, and
dermatitis. Consider Zinc Lozenges and low dose Respiratory Support
Platinum
nucleotide blend. Also, Serraflazyme and Air Power may help with
mucous, along with Muscle Fatigue Support compound.
Tellurium is chemically similar to selenium, so consider extra
selenium support when tellurium levels are high. Some options
Tellurium
include MetalAway, low dose Selenocysteine, low dose Ion Transport
compound or other low dose forms of selenium.

Thallium inhibits mitochondrial energy and ATP. It also inhibits

DNA and RNA synthesis. It may cause hair loss and anorexia.
Thallium can also cause riboflavin to be sequestered in the body.
So Riboflavin-5-Phosphate support should be considered, especially
Thallium if MAP test results show imbalances in the Krebs energy cycle.
Consider support with ATP, Riboflavin-5-Phosphate,
and/or MitoForce to address the impact on energy. Also, All in
One for low dose DNA and RNA support, and AHCY/SHMT
compound, or direct addition of nucleotides.

Thorium can bind to digestive enzymes. Consider Special Digestive

Thorium Enzymes, and run the CSA test and GI function test to check on
digestion.
Tin may cause liver pain, and may be more of an issue if your
system tends to be acidic. Check your pH on a CSA test or GI Effects
test, and/or use pH strips on first morning urine samples. Work to
get pH to around 7 with Buffer pH, VitaOrgan, and/or Stomach pH
Balancing nucleotide blend. If your potassium is low, then
Tin
consider Potassium Bicarbonate. Also, consider Indole-3-carbinol to
support cytochrome P450 enzymes that may be decreased due to
tin and consider Special Digestive Enzymes. MTHFR A1298C Liver
Support capsules, and low dose Liver Support nucleotide blend can be
considered for liver support.
Tungsten interferes with molybdenum, may cause DNA damage,
Tungsten
and may be a factor in impaired sense of smell. Tungsten can
 interfere with SUOX, so consider B12, provided that lithium is in
balance. Also, watch levels of molybdenum, boron, and
manganese. Provided that lithium is in balance, consider support
with B12 formulas like Hydroxy B12 spray, Methyl B12
MegaDrops, Hydroxy B12 MegaDrops, or Adenosyl B12 MegaDrops.
Consider MTR/MTRR/SUOX capsules to help support molybdenum,
boron and manganese. Consider a DNA oxidation test, and if DNA
damage/oxidation is a concern, then
consider Ultifend and/or Quercetin. High dose quercetin may be an
issue for those who are COMT ++.
Uranium can readily combine with nucleotides in your body and
can deposit in your bones. It can also cause chronic fatigue. Test
your home water supply with a Water Elements Test, and do a radon
air test if you continue to excrete high levels of uranium over time.
Consider All in One for low dose nucleotide support.
Use AHCY/SHMT compound for nucleotide support, or direct
Uranium
nucleotide supplementation. Consider using Muscle Fatigue Support
compound and low dose Bone Support nucleotide blend.
Consider Cal/Mag/VitD/VitK so that vitamin D and K are present to
help with calcium absorption. To support your DNA in the
presence of high levels of uranium, also
consider Ultifend and Quercetin.
A high level of creatinine means that your urine is very
concentrated. This may indicate that your kidneys are under stress.
For this issue, consider Kidney Support nucleotide blend, Ora-
Kidney, Dandelion Leaf, Rhodiola, SHMT Spray, AHCY/SHMT
compound, and Zinc Lozenges. If your pH is low, consider using
sodium bicarbonate to both help with pH as well as to help with
high creatinine. If your creatinine is chronically high, also check
Creatinine your blood sugar levels. Creatinine levels that are low suggest
insufficient methylation and a need for SAM-e. Low levels of
creatine have been associated with limited language development.
You can consider using Creatine plus SAM-e. Basic methylation
support includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide blend. Once
lithium is shown to be in balance on a HMT, then consider low
dose Methylmate A and Methylmate B, along with extra B12.
This table contains the rationale behind my suggestions. These
ESSENTIAL
suggestions are for your consideration. Defer your choices to your own
ELEMENTS
health care practitioner, as always.

Your goal is to keep sodium in the normal range, without its being
too low or excreted to a high degree. The use of Ion Transport
compound and low dose Ion Transport Support nucleotide blend may be
Sodium a help. Sodium is co-absorbed with a range of other nutrients, such
as amino acids, glucose and peptides, so supporting healthy ion
transport can be useful. Since sodium and potassium transport
across your cell membrane uses energy, consider ATP, Riboflavin-5-
 Phosphate, and/or MitoForce to support sodium/potassium ATPase.
Also, consider using low dose Ion Transport compound and low
dose Ion Transport Support nucleotide blend. In addition, the use of
Sodium or Potassium Bicarbonate may be considered if your pH is
low on a CSA test or GI Effects test, as a way to support both sodium
and a more balanced pH.
Potassium levels drop coordinately with low lithium, so support
potassium when you are taking lithium. Low potassium can cause
rubidium levels to drop. Your body replaces potassium with
rubidium when potassium is deficient. This can create a rubidium
deficit, which is a factor in aggressive behavior. The approach this
program uses is to consider support with potassium for either low
potassium or low rubidium. Potassium levels that are less than
50ppm or 5%, may indicate copper toxicity. Barium and cesium
may displace or interfere with potassium function. Additional
potassium support may be needed if you have high levels of
barium or cesium excretion.Also, low levels of potassium may be
caused by hydrogen sulfide (H2S) triggering efflux of potassium,
so check sulfur levels on the HMT and UEE, as well as taurine
levels on a UAA. High levels of taurine on a UAA may indicate
higher than ideal H2S levels in your system, which can then cause
low potassium levels.Low levels of potassium can be a factor in
the production of acne.
Potassium Potassium Citrate can be used along with food sources of potassium to
support potassium. If your pH is low on a CSA test or GI Effects test,
then Potassium Bicarbonate can be considered to both support potassium and
to help balance pH. If Krebs intermediates are low on a MAP test,
consider Potassium Krebs Intermediates if you do not have glutamate/
GABA imbalance.
Potassium transport across the cell membrane is an energetic process, so
consider ATP, Riboflavin-5-Phosphate, and/or MitoForce to support
sodium/potassium ATPase if your potassium is low.
Arginine may have a positive impact on potassium levels. Those who
struggle with consistently low potassium, especially athletes, may consider
low dose Arginine support if your levels of arginine are low on a UAA
test. AminoAssist is one source of low dose arginine.

If your phosphate is low, then your leucine may be high.

According to published literature, if phosphate is low, then leucine
may be increased, which in turn may increase glutamate and alpha
Phosphorus
KG. This can potentially cause hypoglycemia. Your level of
leucine can be checked on a UAA. Consider phosphate support
when phosphate is low, when hypoglycemia is an issue, when
 glutamate and leucine are high on a UAA test, or when alpha
ketoglutarate is either very high or very low on a MAP test. Cross
referencing between these tests is helpful when problem solving.
Supplementing phosphorus may help with excessive dumping of
calcium in your urine. Copper toxicity may be a factor when
phosphorus is low. Check your copper levels.Riboflavin-5-
Phosphate can help support phosphorus, especially if nickel toxicity
is present. Also ATP and/or MitoForce may help to support
phosphorus. Phospholipids such as Phosphatidyl Serine Complex
(PS/PE/PC) and nucleic acids such as RNA can also support
phosphorus. Vitamin D may help with phosphorus absorption.
Pumpkin seeds are a natural source of phosphorus.
Ideally, your test will show more magnesium relative to calcium.
Excess calcium can work with glutamate to cause excitotoxicity, so
high levels of calcium may cause symptoms if glutamate is also
high. Your goal for calcium is to be in the low range of normal,
with magnesium in the high range of normal. Since vitamin D and
K help with calcium absorption, less calcium support may be
needed if vitamin D and K are supplemented. Check to see if boron
is being dumped, as boron is often dumped with low vitamin D.
So, high level calcium and boron dumping may indicate a need
for Vitamin D. If calcium is higher than 650ppm or 65%, it may
indicate copper toxicity. There may be a greater need for calcium
support with a high protein diet.Guaifenisen, which is used for
chronic fatigue, may help pull down high calcium. Low dose
support can be considered in the Muscle Fatigue Support compound, or
in Air Power. Other supplements used to help control high calcium
Calcium include Vinpocetine, Boswellia, ATP and/or MitoForce. These may
support better calcium balance because they support mitochondrial
function, and mitochondria may act as sinks to buffer the effects of
calcium overload.
Potassium, and the phosphorus in Riboflavin-5-Phosphate, may reduce high
level calcium dumping in urine.
If calcium levels are too low, consider herbs that support calcium in a
complexed form, such as Nettle, Chamomile, or Chervil. The use
of Cal/Mag/VitD/VitK compound also supports calcium in a balanced
fashion. Low calcium can play a role in back pain, menstrual cramps, and
brittle nails.
Boron deficiency may cause dumping of calcium and magnesium in urine.

Magnesium may be calming and have a positive impact if you have

excess glutamate in your system. It is preferable to have higher
Magnesium magnesium relative to calcium in your body, because calcium
works with glutamate to cause over excitation of nerves, and
magnesium helps to balance this. Boron deficiency may cause
 dumping of calcium and magnesium in urine. Check boron to be
sure that it is not causing low magnesium levels. Low taurine can
cause magnesium dumping, so be sure methylation support is in
place to support healthy taurine levels. You do not want very high
taurine levels, nor do you want low levels. The goal is taurine in a
normal range. This can be measured on a UAA test. Low dietary
magnesium may contribute to aluminum-induced degenerative
conditions. Consider support with Magnesium Citrate, Magnesium
Oxide, or Magnesium Malate. Magnesium glycinate is non-optimal, as
glycine can exacerbate glutamate toxicity if your levels of
glutamate are high. Amino acid chelates of minerals are not always
ideal, especially if you have symptoms of excitotoxicity, because
they include glutamate and aspartate. I occasionally recommend
them, and we do stock them, so just be aware of this when you are
ordering minerals.Basic methylation support includes All in
One, Phosphatidyl Serine Complex (PS/PE/PC), DHA and Methylation
Support nucleotide blend. Once lithium is shown to be in balance on
a HMT, then consider low dose Methylmate A, Methylmate B, and
extra B12.
As with magnesium, zinc helps to control the calcium and
glutamate interaction that can lead to over excitation of nerves.
Doses of zinc above 40 mg per day can actually stimulate
excitotoxin activity, so your goal is to keep zinc in the high range
of normal with under 40 mg of supplementation per day. A
deficiency of zinc may cause poor wound healing, poor ability to
smell or taste, and night blindness. Iron interferes with zinc
absorption, so keeping iron in proper balance is an important factor
in achieving proper zinc levels. When iron replaces zinc, it may
cause blood sugar imbalances, so consider support for the pancreas
and pancreatic enzymes when zinc is low. Your body uses zinc as a
cofactor for over 50 critical enzymes. It prefers it. However, if zinc
is deficient, your body will replace it with cadmium or lead, both
of which are toxic metals. Cadmium is just below zinc in the
Zinc periodic table of the elements, so it fits perfectly into zinc binding
sites. Cadmium may replace zinc in enzymes that make important
proteins, such as RNA transferase and alcohol dehydrogenase, the
enzyme involved in alcohol processing. These enzymes do not
function properly with cadmium replacing zinc. Cadmium may
also replace zinc in metallothionein, an important heavy metal
binding agent. When zinc is low, lead can replace zinc in heme
enzymes and impact the formation of red blood cells. So it is
important to keep zinc in the high normal range.Some studies
suggest that low zinc may increase the activity of the enzyme
methionine synthase (MTR). This could in turn lead to lower
lithium levels and exacerbate MTR + status. Low dose methionine
support, which is contained in AminoAssist, may be helpful in these
cases.
Zinc Lozenges are the form of zinc that is particularly helpful and well
 absorbed. Consider Zinc Krebs Intermediates if your levels of Krebs
intermediates are low on a MAP test, and you do not have symptoms of
glutamate/ GABA imbalances.
If your iron is high on a HMT or UEE, consider AHCY/SHMT
compound and/or Lactoferrin to help keep iron in better balance. Consider
pancreatic support with VDR/FOK Pancreatic Support capsules, Ora-
Pancreas, and/or Special Digestive Enzymes if your zinc is low and iron is
high, to help with blood sugar balance.
When your zinc is low, consider Heart Support nucleotide
blend and Hawthorn Extract if you are an adult. Cadmium can replace zinc
in the atrial wall of your heart and may cause decreased flexibility and
strength.
Coffee may impair zinc uptake and may lead to a need for increased zinc
support.

Ideally, your copper levels should be lower than zinc to favor a

higher zinc to copper ratio. High copper has been implicated in
ADD. Copper is the cofactor that works with the enzymes MAO A
and MAO B to break down dopamine and serotonin, so high
copper may engender a higher degree of degradation of these two
neurotransmitters. Running a Neurotransmitter Urine Test and a MAP
test gives you an indication of both the levels of serotonin and
dopamine, and a measure of their breakdown. Excess copper has
also been reported to cause fearful thoughts. If copper replaces zinc
in your brain, it may be a factor in migraines, so zinc support may
help you with this, as well as bring your copper into better
balance.Much less frequently, the issue is actually low copper.
Low copper may cause high histamine. The enzyme that breaks
Copper down histamine is a copper containing MAO type of enzyme, so if
your copper is low, check to see if your histamine is
high. Quercetin may help pull down histamine but inhibits COMT,
so use quercetin in moderation. A natural source of quercetin is
cherries. Cherries are also a source of melatonin. Tart Cherry
Extract is reported to be helpful for gout.
Low copper may also be a factor in de-pigmentation of hair and skin.
Ways to help bring copper into better balance include the use
of Molybdenum, Zinc, Carnosine, and increased EDTA. EDTA is found
in MetalAway, EDTA soap or soak, and DetoxAway. You can also
consider BactiSolve if you have NO shellfish allergies.
Check molybdenum levels, because often copper will be high when
 molybdenum is too low. Molybdenum can be low due to high taurine, which
is measured on a UAA test. When taurine is processed via sulfite oxidase,
molybdenum can become depleted. In addition, high levels of sulfur can
have the same effect of depleting molybdenum. Molybdenum may also be
depleted due to chronic yeast infections, which can be checked on
a Vaginosis Test, or in the gut via a CSA test or a GI function test.
An alkaline environment limits copper, so work to get pH in balance,
meaning having a pH close to 7. You can consider Buffer pH, Stomach pH
Balancing nucleotide blend, Potassium Bicarbonate or sodium bicarbonate,
depending on your need for either sodium or potassium. VitaOrgan may also
help to balance your pH.

High levels of sulfur can put excessive stress on SUOX, the sulfite
oxidase enzyme, which appears below the cystathionine beta
synthase (CBS) enzyme in the transsulfuration pathway portion of
the methylation cycle. The SUOX enzyme needs B12 and
molybdenum for activity. So, high sulfur can result in increased
usage of B12 and molybdenum that are needed for other functions
in your body. Low molybdenum can mediate an increase in copper,
and unbalance your zinc/copper ratio, which can then affect
attention, reduce heavy metal detox, and cause other symptoms.
Depletion of B12 can limit enzyme activity in the long route, the
Sulfur
reaction in your methylation cycle that uses the MTR and MTRR
enzymes. If your sulfur levels are high, consider using
additional Molybdenum and B12 once your lithium is in balance on
a HMT. You may also consider using Black Bear Spray or Black Bear
Drink, which is a combination form of molybdenum and B12.
Consider a UAA test to be sure that your taurine levels are not high,
as high taurine would also put increased pressure on sulfite oxidase
activity.For low levels of sulfur support, use healthy sulfur donors
that have other positive attributes such
as Garlic, Broccoli, Wasabi, SAM-e, or N-Acetyl Cysteine.
Manganese is important for helping to process arginine, so
consider supporting with low dose Manganese if arginine is high on
a UAA test. However, high levels of manganese are a concern for
the reasons described below. Ideally, your manganese levels are in
the lower range of normal so that they are sufficient to support
reactions that require manganese without allowing levels to climb
Manganese
too high. Proper manganese levels are important to preserve
acetylcholine, an important neurotransmitter. Low manganese can
also impair the function of your Krebs energy cycle. Low levels of
manganese can cause hearing loss and low sex drive. Low
manganese can cause low cholesterol, imbalances in alkaline
phosphatase levels, and decreased T cells.Most bacteria use iron
 for growth, but Borrelia burgdorferi uses manganese, so low
manganese may be seen in Lyme disease. Manganese levels may
also drop with H. pylori infection. Consider ruling out H. pylori or
Lyme disease if you have chronically low levels of manganese.
Iron can compete with manganese for uptake, so be sure iron is in balance.
To support low levels of manganese, consider MTR/MTRR/SUOX
capsules, Manganese Drops, and Glucosamine/Chondroitin Plus. Consider T
cell and B cell support capsules immune support. AHCY/SHMT
compound or Lactoferrin may help to get iron in better balance.
Conversely, excessively high levels of manganese can cause psychosis as
well as seizures. Excessive accumulation of manganese causes a
neurological condition called “manganism” that is characterized by
psychosis and eventually followed by symptoms similar to those seen in
Parkinson’s disease. High levels of manganese have also been associated
with ALS and biochemical changes similar to Alzheimer’s and Huntington’s
disease (Sidoryk-Wegrzynowicz, 2013). High levels of manganese can cause
increases in reactive oxygen species (so consider Ultifend), impair
glutathione levels (consider GSH) and increase inflammatory mediators
(consider General Support nucleotide blend and low dose TNF nucleotide
blend). High dose manganese may also decrease dopamine levels.
Toxic doses of manganese can impact both GABA and taurine levels and
affect their transport. If an individual is intolerant to GABA supplementation
in spite of symptoms that suggest a need for GABA, then check manganese
levels to be sure they are not exceedingly high. The use of valerian root in
conjunction with low dose GABA may be a consideration for you and your
doctor, as valerian may aid in GABA transport. If high manganese is the
issue, consider increased EDTA support. Working with, and deferring to
your own doctor consider the use of MetalAway, DetoxAway, EDTA
soap and soak, and additional EDTA capsules can be considered.
If very high levels are seen, rule out high manganese in your home water
supply by using the Water Elements Test. Some defective water filtration
systems may be a source of higher than ideal levels of manganese in your
drinking and bathing water supply.

Molybdenum is critical for sulfite oxidase function, the enzyme

Molybdenum
that processes sulfite to sulfate. Those who are sulfur sensitive
 should keep a close eye on molybdenum levels. Sulfite oxidase
follows CBS in the methylation cycle, so excess CBS activity can
put more pressure on sulfite oxidase and generate the need for
molybdenum. Molybdenum is also needed to help keep copper in
balance. High copper has a number of non-ideal effects, including
allowing the increased breakdown of dopamine and serotonin.
Molybdenum is also needed for xanthine oxidase
function. Significant xanthine oxidase may be present in
homogenized milk, so those drinking milk may have a need for
molybdenum support. Those who have high levels of tungsten may
need molybdenum support, as tungsten competes with
molybdenum. In addition, those who are MTR + often show lower
levels of molybdenum, so more frequent HMT and UEE can be run
to be sure molybdenum stays in balance. Molybdenum can be
supported with Molybdenum Capsules, MTR/MTRR/SUOX
capsules, Black Bear Spray or Black Bear Drink. Molybdenum Drops can
also be used, although the liquid form is complexed with ammonia
so this is not the preferred form of support.
Low vitamin D levels may relate to low boron levels, so additional
support may be needed in areas of low sunlight during the winter.
Also those who are MTR + may tend to have lower boron levels.
When boron is low, this deficiency may cause dumping of calcium
Boron
and magnesium in urine. So check boron levels when there is high
level excretion of magnesium and calcium in urine. Consider
support with either Bone Support capsules or MTR/MTRR/SUOX
capsules to help balance boron levels.

Low levels of chromium can be factors in ADD and anxiety. Also

low levels of chromium may be associated with blood sugar
Chromium
imbalances. Consider Chromium Picolinate support and VDR/FOK
Pancreatic Support capsules.

The role of lithium in B12 transport into the cell is potentially critically
important. Peer reviewed work by Tisman, Herbert, and Rosenblatt
published in the British Journal of Haematology was the first to illustrate
that ingestion of lithium is related to B12 binding. Continuing this research,
Vanyo and coworkers (Lithium in Biology and Medicine) discuss the finding
that lack of lithium and B12 deficiency share physiological features, and that
Lithium
support with lithium enhances B12 transport into cells. According to these
researchers, lithium is associated with elevated levels of serum B12 binding
capacity. Furthermore, this group was able to show that lithium increases the
transport of folate into the cell, as well as that of B12.
Additional peer reviewed work by Schrauzer (Biological Trace Element
Research) also supports the role of lithium in B12 transport. The addition of
lithium was shown by Cervantes et al to lower elevated serum B12 levels,
again illustrating lithium’s effecting B12 transport into cells.
Based on this research, it is important to look at lithium levels. I use the
HMT and the UTMEE in combination with each other to assess both lithium
as well as cobalt levels (as a measure of B12). You may also want to look at
serum lithium and B12. In cases in which lithium is low and/or serum B12 is
particularly high, use lithium support prior to the addition of high dose B12.
Lithium support is in All in One, Be Calm Spray, and Lithium Orotate.
Use these with the consent of your doctor. The rationale behind this is to
ensure that you have adequate lithium prior to adding high dose B12,
because increasing B12 in the absence of lithium support may further
deplete lithium levels due to the use of lithium to aid in the transport of the
added B12. Ideally, lithium should be in balance prior to adding excess B12
so as not to create lithium depletion. Low dose maintenance nutritional
levels of lithium support are available in All in One and Be Calm Spray.
Lithium plays a range of additional roles in your body aside from B12 and
folate transport into your cells, so it is important not to deplete this pivotal
trace mineral. Lithium’s impact on mood stabilization has been known and
used clinically for many years, despite the fact that the mechanism by which
this occurs has not been fully elaborated. Norepinephrine imbalances have
been implicated in attention disorders, and Sastre and coworkers have
illustrated an impact of lithium on balancing norepinephrine levels.
Researchers have noted and published effects from lithium on neurological
conditions. Beta amyloid may play a role in Alzheimers Disease and lithium
has been shown to have neuroprotective effects against beta amyloid.
Research from Spain illustrates that lithium has a positive impact on neural
repair after traumatic injury. Maurer (2009) showed that lithium can enable
mitochondrial function, which may be particularly useful in the presence of
toxic metals. Increases in the grey matter of the brain have been tied to
lithium support (Moore) and research from the National Institute of Health
(NIH) showed the induction of brain derived neurotrophic factor (BDNF) by
lithium. Especially relevant to this program, lithium was reported by
Hashimoto (2002) to protect against glutamate excitotoxity.
 In addition, lithium has been implicated in Lyme disease, as well as having
an impact on Herpes virus (Amsterdam et al).
Lithium may also help to support healthy tetrahydrobiopterin (BH4) levels.
Lithium stimulates white cells and platelets, so low levels of lithium may
cause low white cells. Myrrh may help for low white cells.
Those who are MTR + tend to have lower lithium levels.
Ideally, lithium should be in balance before adding extra B12, MethylMate
A, or MethylMate B. MethylMate B is low dose 5-methylTHF.
For general lithium support, consider All in One and Be Calm Spray.
Always support potassium when supplementing lithium.
For levels that are particularly low, consider Lithium Orotate plus some form
of potassium, usually Potassium Citrate. Run regular HMT to assess lithium
levels when adding lithium orotate. Those who are MTR + should do a HMT
every 3 to 4 months.
High level excretion of lithium in the absence of any lithium
supplementation suggests that excretion will lead to future depletion. Thus,
lithium should be added when lithium is either very low, or when high level
excretion is seen in the absence of any lithium supplementation.
Low lithium may also be an issue secondary to a need for mitochondrial
energy support. A MAP test can be run to look at energy markers. Support
for mitochondrial energy can include MitoForce, ATP, Riboflavin-5-
Phosphate, NADH, Krebs minerals.

Selenium may become depleted with high level mercury excretion,

as well as with the excretion of a number of other toxic metals.
Consider extra selenium support when toxic metal excretion is
observed. If selenium levels are low on a HMT, use additional
support. Selenium is essential for the conversion of T4 to T3, T3
being the active form of thyroid hormone. The de-iodinase
enzymes that remove iodine atoms from T4 during its conversion
to T3 are selenium-dependent. So, consider selenium when you
Selenium
have low thyroid symptoms. PABA, found in Ultimate B,
and Niacinamide can be considered for those who have indications
of autoimmune thyroid issues. Very high levels of selenium are
toxic, so the goal is to be within normal range for this mineral.
Methylation cycle function is needed to remove excess selenium,
so until methylation support is in place, and you know you have
good methylation pathway function, do not use high dose
selenium. Consider support with MetalAway or other sources
 of Selenium. Consider low dose Ion Transport compound as a source of
selenocystene, or low dose Selenocysteine. GSH and Vitamin E
succinate may aid in maintaining selenium levels. Excretion of
mercury, antimony, arsenic, and/or thorium may lead to a greater
need for selenium support. DetoxAway can be considered for higher
dose support during detox once effective methylation support is in
place. As always, work with your doctor.Basic methylation support
includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide blend. Once
lithium is shown to be in balance on a HMT, then add low
dose Methylmate A, Methylmate B, and extra B12 in the appropriate
form.
Strontium levels tend to be lower for those who are MTR +.
Strontium Consider MTR/MTRR/SUOX capsules if your strontium is low, or
being excreted excessively in the face of no supplementation.
High levels of vanadium may be related to bipolar. Low levels may
be an issue for blood sugar balance. Vanadium can bind to iron
complexes, so be sure iron is in balance. Consider vanadyl
Vanadium
sulfate (depending on sulfur levels) and VDR/FOK Pancreatic Support
capsules for low vanadium. Also, you can use AHCY/SHMT
compound or Lactoferrin to help with iron balance.

All forms of B12, hydroxyl, adenosyl, methyl, and cyano, contain

the element cobalt. It is possible to follow cobalt levels on
a HMT and UEE as a method for tracking B12 ingestion. Blood B12
levels can also be directly measured. Be sure lithium is in balance
before adding high dose B12. As you increase B12 support, follow
with HMT testing to be sure lithium stays in balance. There are
Cobalt several forms of B12. Hydroxy B12 is usually well tolerated and is
used by everyone on this protocol. Adenosyl B12 is also usually well
tolerated. It is often a help for high methylmalonic acid (MMA)
levels on a MAP test, as well as to help process fats when used in
conjunction with Biotin. MethylB12 may be tolerated by those who
are COMT – and some who are COMT + -. It is used in limited
ways in my protocol.
Excess iron is pro-oxidant and drives bacterial virulence, so high
iron on this test may indicate issues with bacterial imbalances. If
your iron is above the 50th percentile, consider a CSA test and GI
function test to check for unbalanced, non-optimal organisms in
your gut. Adult females may want to run a Vaginosis Test in
addition, to check for bacteria and yeast. Iron helps to increase
Iron SHMT activity, which diverts methylation intermediates from both
the MTR/MTRR enzyme reaction, what I call the long route
around the methylation pathway, and the BHMT enzyme reaction,
the short cut. Limiting iron is particularly important for those who
are SHMT +. Iron can bind tryptophan, so it may reduce serotonin
levels.H2S frees up iron, so check taurine and sulfur levels. If
taurine and sulfur are high, then consider that excess iron may be
an issue.
Levels of iron are increased with humic acid, which is in part why humic
acid is not a part of this program. Humic acid may cause lipid peroxidation.
High iron levels may be related to high methionine, so if your methionine is
high on a UAA test, check your iron levels.
Lactoferrin and/or AHCY/SHMT compound may help bind and transport
iron to where it is needed in your body. Also, if your iron is high, work to
shift acidic environments to alkaline environments, because acid increases
iron. So, consider Buffer pH, VitaOrgan, and/or Stomach pH Balancing
nucleotide blend. Either sodium bicarbonate or Potassium Bicarbonate can
be used to help balance pH depending on your need for sodium or
potassium. Check pH on a CSA test, GI function test, or by testing urine
with pH strips.
Also, consider VDR/FOK Pancreatic Support capsules, because iron can
cause blood sugar issues when it replaces zinc.
If you need iron support, then complexed herbal forms may cause less
excess iron in your system. Dandelion greens are an excellent source of iron
that also may be supportive for your kidneys.
Purpose of running this test:

A number of individuals tend to excrete toxins more readily through their stool rather than in
urine or via hair. Particularly when there are imbalances in gut microbes and you are working
to address the gut, you may see more excretion of toxins in the stool than in urine.

Unfortunately, the Fecal Toxic Metals Test (FMT) does not include aluminum. Since aluminum
retention may be an issue with non-ideal gut microbes, if this is a concern, you should also run
either a UTM/UEE or a HMT to follow aluminum excretion. Aluminum can negatively impact
BH4 levels, so it is important to know what is happening with aluminum in your system to
determine proper support for BH4 levels.

This table contains the rationale behind my suggestions. These suggestions

TOXIC
are for your consideration. Defer your choices to your own health care
METALS
practitioner, as always.

In addition to a wide range of neurological symptoms, mercury can also

cause increased salivation, rashes, and metallic taste in your mouth. It can
impact cytochrome P450, and may replace selenium in the T4 to T3 reaction,
thus causing thyroid hormone imbalances.Consider support
with Selenium or MetalAway. If more detox is desired, consider DetoxAway.
Also, GSH and Indole-3-carbinol may be used. Ultimately, you can support re-
myelination with Sphingolin. Work on methylation cycle support to help
Mercury
allow the natural detox of mercury. Also, the use of low dose Ion Transport
compound may help support detox because it
contains Selenocysteine and Wasabi to aid in escorting mercury from your
system.Basic methylation support includes All in One, Phosphatidyl Serine
Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend. Once
lithium is shown to be in balance on a HMT, then consider low
dose Methylmate A and Methylmate B, along with extra B12.

Antimony can bind to ‘thiol’, which means SH groups, which are needed to
help escort mercury from your system. Also, antimony may inhibit the MAO
enzymes, which may interfere with the natural breakdown of dopamine and
serotonin. Antimony can accumulate in your adrenals and thus play a role in
Antimony fatigue. Consider adding sources of ‘thiol’ groups, such
as Selenium, MetalAway, or DetoxAway. Consider low dose Wasabi, low
dose Selenocysteine, and/or low dose Ion Transport compound, which has
both Wasabi and Selenocysteine. Broccoli and Garlic are also options. Also,
consider OraAdrenal for adrenal support.

Methylation cycle function is needed for arsenic excretion. If arsenic is

Arsenic consistently high, consider running a Water Elements Test. Arsenic can bind
both to thiol, which are SH groups, as well as phosphate groups. It can cause
 vitamin A deficiency. Symptoms of arsenic toxicity can include white
streaked nails, a garlic odor emanating from your body, and/or under
pigmentation. Arsenic toxicity may also cause hair loss, problems with folate
uptake, or weakness, among other symptoms. At the very least, use short cut
methylation support, support for the pathway that goes from homocysteine
to methionine using the BHMT enzyme. All in One, Phosphatidyl Serine
Complex (PS/PE/PC), DHA and Methylation Support nucleotide blend all
support the short cut. If lithium is in balance, also support the long route, the
route that uses the MTR and MTRR enzymes. These supports include low
dose Methylmate A, Methylmate B, and B12. Also, thiol supports may be
useful, such as Selenium, MetalAway, or DetoxAway; low dose Wasabi, low
dose Selenocysteine, or low dose Ion Transport compound, which has
both Wasabi and Selenocysteine. Broccoli may also be helpful. To support
phosphate, use phospholipids such as Phosphatidyl Serine Complex
(PS/PE/PC) and Riboflavin-5-Phosphate.

High levels of beryllium may affect lymphocyte proliferation and respiratory

function, as well as cause adrenal insufficiency and fatigue. Consider T
cell and B cell support capsules for immune support. OraAdrenal may also be
Beryllium
used for additional support. The Muscle Fatigue Support
compound supplement can be considered if fatigue is an issue. Low
dose Respiratory Support nucleotide blend may also be helpful.

High level excretion of bismuth, in the absence of any bismuth

supplementation, may be an indicator for H. pylori, so testing to rule out H.
pylori should be considered. Since high level bismuth excretion in the
Bismuth
absence of any support can lead to depletion of bismuth over time, consider
low level bismuth support with Peptimycin or its equivalent. Rule out H.
pylori.

High levels of cadmium can cause significant symptoms. Your body uses zinc
as a cofactor for over 50 critical enzymes. However, if zinc is deficient, your
body will replace it with cadmium. Cadmium is just below zinc in the periodic
table, so it fits perfectly into zinc binding sites. Enzymes that make protein,
such as RNA transferase, and alcohol dehydrogenase, the enzyme involved in
alcohol processing, are impacted by this problem. Other important enzymes
Cadmium are also negatively impacted. Cadmium may also bind to glutathione (GSH)
making it ineffective. It may also negatively impact bone health and cause
respiratory symptoms. Consider supporting with Zinc Lozenges, or Krebs
Zinc, if your Krebs intermediates are low on a MAP test. Also,
consider MetalAway and/or EDTA to help escort cadmium from your system.
Since cadmium can bind GSH, consider supporting with GSH. Low dose Bone
Support nucleotide blend may also be helpful. Cadmium may decrease the
 Cytochrome P450 enzyme system, so consider Indole-3-carbinol to support
CYP 450. Since cadmium replaces zinc in arteries, adults may want to
consider low dose Heart Support nucleotide blend and Hawthorn Extract.
Also, consider Vitamin E and low dose Ion Transport support capsules for
cadmium, as it may help to prevent the cadmium induced suppression of the
CFTR enzyme. Also, work on supporting methylation, as weak methylation
capacity is related to susceptibility to cadmium.In addition, lithium, which is
in both BeCalm Spray and All in One, may help to protect against the
negative impacts of cadmium, especially with respect to hormones such as
testosterone, LH, and FSH.

Ideally, your copper levels should be lower than zinc to favor a higher zinc to
copper ratio. High copper has been implicated in ADD. Copper is the cofactor
that works with the enzymes MAO A and MAO B to break down dopamine
and serotonin, so high copper may engender a higher degree of degradation
of these two neurotransmitters. Running a Neurotransmitter Urine Test and
a MAP test gives you an indication of both the levels of serotonin and
dopamine, and a measure of their breakdown. Excess copper has also been
reported to cause fearful thoughts. If copper replaces zinc in your brain, it
may be a factor in migraines, so zinc support may help you with this, as well
as bring your copper into better balance.

Much less frequently, the issue is actually low copper. Low copper may cause
high histamine. The enzyme that breaks down histamine is a copper
containing MAO type of enzyme, so if your copper is low, check to see if your
histamine is high. Quercetin may help pull down histamine but inhibits
COMT, so use quercetin in moderation. A natural source of quercetin is
Copper cherries. Cherries are also a source of melatonin. Tart Cherry Extract is
reported to be helpful for gout.

Low copper may also be a factor in de-pigmentation of hair and skin.

Ways to help bring copper into better balance include the use
of Molybdenum, Zinc, Carnosine, and increased EDTA. EDTA is found
in MetalAway, EDTA soap or soak, and DetoxAway. You can also
use BactiSolve if you have NO shellfish allergies.

Check molybdenum levels, because often copper will be high when

molybdenum is too low. Molybdenum can be low due to high taurine, which
is measured on a UAA test. When taurine is processed via sulfite oxidase,
molybdenum can become depleted. In addition, high levels of sulfur can
have the same effect of depleting molybdenum. Molybdenum may also be
depleted due to chronic yeast infections, which can be checked on
a Vaginosis Test, or in the gut via a CSA test or a GI function test.

An alkaline environment limits copper, so work to get pH in balance,

 meaning having a pH close to 7. You can use Buffer pH, Stomach pH
Balancing nucleotide blend, Potassium Bicarbonate or sodium bicarbonate,
depending on your need for either sodium or potassium. VitaOrgan also
helps to balance your pH.

Lead can deposit in bone and replace calcium there. Lead can also affect
ATPase, which reduces the production of this energy molecule. This
negatively impacts both sodium and potassium levels, as well as energy
production. Lead can bind melatonin, tryptophan, and serotonin. Consider
a MAP test and a Neurotransmitter Urine Test to look at energy markers, as
well as neurotransmitter levels.Lead excretion can cause pica, teeth/jaw
grinding & aggression. Eating inedible objects may be a sign that lead is being
excreted. You may need to consider support to help escort it from your
system. Elevated 5-amino levulinic acid (ALA) due to lead toxicity can
inhibit Gamma amino butyric acid (GABA), so consider extra GABA if
Lead
needed.Since lead replaces calcium in bones, consider low dose Bone
Support nucleotide blend. Vitamin D and K impact calcium absorption, so
add a mineral combination that includes vitamin D and K, such
as Cal/Mag/VitD/VitK. Also, for bone health, watch strontium and boron
levels. Consider MTR/MTRR/SUOX capsules to support strontium and boron.
Also, consider EDTA and MetalAway (or selenium + horsetail grass + low dose
EDTA + malic acid) to help escort lead from your system. Also, consider
additional EDTA in EDTA soap or soak as tolerated. Consider
using BactiSolve if you have no shellfish allergies, as another source of EDTA.
Consider ATP and/or MitoForce to support ATPase.

Nickel can cause significant skin rashes, allergies, dermatitis and

inflammation. Consider support with Riboflavin-5-Phosphate, especially
when phosphorus is low and nickel toxicity is present. Consider nucleotide
Nickel
blends such as General Support nucleotide blend and Cytokine Balance
nucleotide blend to help with itching. Clear Skin spray may be used for
topical skin support.

Platinum can cause wheezing, excessive mucous in your nose, and

Platinum dermatitis. Consider Zinc Lozenges and low dose Respiratory Support
nucleotide blend. Also, Serraflazyme and Air Power may help with mucous.

Thallium inhibits mitochondrial energy and ATP. It also inhibits DNA and RNA
synthesis. It may cause hair loss and anorexia. Thallium can also cause
Thallium riboflavin to be sequestered in the body. So Riboflavin-5-Phosphate support
should be considered, especially if MAP test results show imbalances in the
Krebs energy cycle. Consider support with ATP, Riboflavin-5-Phosphate,
and/or MitoForce to address the impact on energy. Also, All in One for low
 dose DNA and RNA support, and AHCY/SHMT compound, or direct addition
of nucleotides.

Tungsten interferes with molybdenum, may cause DNA damage, and may be
a factor in impaired sense of smell. Tungsten can interfere with SUOX, so
consider B12, provided that lithium is in balance. Also, watch levels of
molybdenum, boron, and manganese. Provided that lithium is in balance,
support with B12 formulas like Hydroxy B12 spray, Methyl B12
Tungsten MegaDrops, Hydroxy B12 MegaDrops, or Adenosyl B12
MegaDrops. Consider MTR/MTRR/SUOX capsules to help support
molybdenum, boron and manganese. Consider a DNA oxidation test, and if
DNA damage/oxidation is a concern, then
consider Ultifend and/or Quercetin. Keep in mind that high dose quercetin
may be an issue for those who are COMT ++.

Uranium can readily combine with nucleotides in your body and can deposit
in the bones. Also, it can cause chronic fatigue. Consider testing your home
water supply using a Water Elements Test, and do a radon air test if you
continue to excrete high levels of uranium over time. Consider All in One for
Uranium low dose nucleotide support. Use AHCY/SHMT compound for nucleotide
support, or direct nucleotide supplementation. Consider using Muscle
Fatigue Support compound and low dose Bone Support nucleotide blend.
Use Cal/Mag/VitD/VitK so that vitamin D and K are present to help with
calcium absorption.
Purpose of running this test:
The Metabolic Analysis Profile (MAP test) gives information about intermediates in a
number of biochemical pathways in your body. Important methylation cycle markers such
as FIGLU, a marker for folate, and methylmalonic acid, a marker for B12, are included in
this test.
Additionally, the MAP test gives information about the turnover and/or breakdown products
of several neurotransmitters, including serotonin and dopamine. These are useful in
conjunction with neurotransmitter testing to determine the causes of problems such as
mood instability, depression, obsessive compulsive disorder (OCD), or the need for
nutritional neurotransmitter support.
The MAP test also generates data about critical energy intermediates and your
mitochondrial function. Mitochondrial disorder is being recognized as a factor in the
declining health of increasing numbers of both adults and children. MAP testing is useful for
assessing the level of mitochondrial energy intermediates including intermediates in the
mitochondrial Krebs cycle. Oxalate is part of the Krebs energy cycle along with other
compounds such as malate and fumarate.
In conjunction with a CSA and GI test, the MAP test can reveal problems with the
breakdown of fats in your body and show intermediates that indicate ketosis. In addition,
these three tests contain information about bacterial or yeast infestations or infections.
In general, the MAP test helps you determine areas you need to focus on for additional
testing and/or treatment. As noted in the ‘related tests’ section below, high values for
specific intermediates on this test help you target which additional tests and/or
supplementation may be needed.

This table contains the rationale behind my suggestions.

Marker These suggestions are for your consideration. Defer your
choices to your own health care practitioner, as always.

An increased indoleacetic acid marker can be due to

bacterial breakdown of unabsorbed tryptophan. This
may be due to lack of BH4 which converts
Indoleacetic acid tryptophan to serotonin, or a need for vitamin B3
(niacin) that helps to process tryptophan. There are
several forms of B3, and supplementing with a
variety of types of B3 may be helpful. Also, rule out
 bacterial issues as a cause of high indoleacetic acid.
You can use Niacinamide and/or NADH, MTHFR
A1298C Liver Support capsules, or Ultimate B Complex.
Depending on your levels of hippuric or benzoic
acids, and the levels of tyrosine, tryptophan, and/or
phenylalanine on a UAA test, as well as aluminum
on HMT and/or UEE , you can consider using BH4.
Run a CSA test and GI Effects test to look for bacterial
issues.
Phenylacetic acid is formed from bacterial
degradation of phenylalanine. Phenylalanine is
processed by BH4. So, a lack of BH4, excessive
bacteria in your GI tract, excessive ingestion of
NutraSweet, supplementation of phenylalanine, or
aluminum in your system which impairs BH4
formation, may cause this marker to be high. MTHFR
Phenylacetic acid A1298C Liver Support capsules and MetalAway can be
used to support natural BH4, as well as to help with
aluminum in your system. Depending on your levels
of hippuric or benzoic acids, and the levels of
tyrosine, phenylalanine, and/or tryptophan on a UAA
test, as well as aluminum on HMT and/or UEE, you
can consider using BH4. Run a CSA test and GI Effects
test to rule out bacterial issues.

Increased 3 hydroxyphenylacetic acid and/or 4

hydroxyphenylacetic acid may be due to bacterial
imbalances in your gut, or a need for BH4 so that
tyrosine can be processed more fully. Lack of
functional BH4 can be related to bacterial issues.
Bacteria, in particular Staphylococci, sequester
aluminum. Aluminum interferes with the activity of
the DHPR enzyme needed to turn BH2 into BH4.
Running a CSA test and GI Effects test helps to rule out
3Hydroxyphenylacetic bacterial issues. Also, use a UAA to check on
Acid4Hydroxyphenylacetic tyrosine levels and the need for BH4. Consider
Acid addressing aluminum if HMT and UTM suggest
elevated levels. Consider natural supports for BH4,
including Royal Jelly if you have NO bee
allergies, MTHFR A1298C Liver Support capsules,
and BH4. Also consider support with gut herbs such
as Naturomycin Spray, Naturomycin capsules, and
grapefruit seed extract (GSE capsules or GSE
liquid) along with probiotics. If aluminum is high,
then use MetalAway, EDTA soap or EDTA soak. Run
a CSA test and GI Effects test.
Dihydroxphenylpropionic Dihydroxphenylpropionic acid (DHPPA) can be due
Acid (DHPPA) to Clostridia, Pseudomonas, E.coli or Klebsiella. In
 order to specifically supplement based on particular
organisms, run a CSA test & GI Effects test. General
microbial support includes Naturomycin
Spray plus Naturomycin capsules and grapefruit seed
extract (GSE capsules or GSE liquid). You can
consider BactiSolve if you have NO shellfish allergies
to help address biofilm, along with EDTA
soap /soak daily. Run a CSA test and GI Effects test to
determine which microbes are the issue. If Clostridia
is the greater concern based on testing or prior data,
then consider using the full Clostridia support
program.
Benzoic and hippuric acids are breakdown products
from phenylalanine. Excess tyrosine and tryptophan
also feed into the pathway to hippuric acid.
Phenylalanine, tyrosine, and tryptophan are all
processed by BH4. If BH4 levels are not sufficient,
or if excess aluminum is present, BH4 production
may be impaired. This can drive up benzoic and
hippuric acid levels. Check glycine levels on a UAA,
because high glycine, in some cases secondary to
SHMT +, can react with benzoic acid to form
Benzoic & Hippuric Acids hippuric acid. High levels of support with TMG or
betaine may increase both glycine and sarcosine,
which can in turn increase hippuric acid levels and
porphyrins. Consider natural supports for BH4, as
well as addressing excess aluminum. Include MTHFR
A1298C Liver Support capsules and MetalAway, as well
as EDTA soap or EDTA soak. In addition, depending
on your levels of phenylalanine, tyrosine, or
tryptophan on a UAA, the aluminum on
a HMT and UEE, or the values on a Neopterin /
Biopterin Profile Urine Test, you can also consider BH4.

Arabinose and citramalic acid are general indicators

of excess yeast in your system. In order to determine
if this is due to normal flora (Saccharomyces) or
imbalanced flora, consider a CSA test and GI Effects
test. If behavior or clinical presentation suggests that
yeast or fungus are the issue, then consider support
to address these issues. For adult females, the in-
Arabinose & Citramalic
home Comprehensive Vaginosis Profile can also be run.
Acid
To help address yeast imbalances, you can
consider Candisol alternating
with Lactoferrin, Mycology Support nucleotide
blend, Naturomycin Spray, Naturomycin capsules, SHMT
Spray and/or AHCY/SHMT compound and grapefruit
seed extract (GSE capsules or GSE liquid). You may
also consider BactiSolve if you do not have shellfish
 allergies.
High tartaric acid can be due to yeast or fungal
issues, or may result from a lack of B12.
A HMT and UEE can help to determine if lack of B12
is the issue. You may also use a blood test for B12
levels. A high level of corpuscular hemoglobin
(MCH) in your red blood cells is a marker for low
B12. Be sure your lithium is in balance prior to
adding extra B12, and determine the optimal form of
B12 support based on your Nutrigenomic testing. If
Nutrigenomic data is not available, use Hydroxy
B12 and low dose Adenosyl B12. Consider a CSA
test or GI Effects test to determine if the issue is yeast
or fungal rather than a need for B12. If a CSA
test and GI Effects test determine that yeast or fungus
Tartaric Acid
are the issues, then you can
consider Candisol alternating
with Lactoferrin, Mycology Support nucleotide
blend, Naturomycin Spray, Naturomycin capsules, SHMT
Spray, and/or AHCY/SHMT compound and grapefruit
seed extract (GSE capsules or GSE liquid). You may
also consider BactiSolve if you do not have shellfish
allergies. If a lack of B12 is the issue, then consider
low dose lithium support such as All in
One and BeCalm Spray along with appropriate forms
of B12. If Nutrigenomics are not known, then focus
on Hydroxy B12 and Adenosyl B12, or Black Bear
Spray or Black Bear Drink, which is a combination of
hydroxy and adenosyl B12.
The MAP test has a helpful diagram that shows where
lactic and pyruvic acids feed into the Krebs energy
cycle. Pyruvic feeds into the Krebs energy cycle and
is formed from carbohydrate via glucose, or can be
from fats. Pyruvic acid is also formed from lactic
acid with O2 and zinc. So, zinc will help you to
cycle between lactic and pyruvic acids. The
conversion of lactic or pyruvic acids into Krebs
energy cycle substrates requires B vitamins. If lactic
Lactic Acid & Pyruvic
and/or pyruvic acids are building up, it would
Acid
suggest that insufficient B vitamins are in
place. Ultimate B Complex is a source of B complex
that uses the most readily available forms of the B
vitamins. Ultimate B Complex can be added, or add
each of the B vitamins individually, such
as Pantothenic Acid, Benfotiamine, Riboflavin-5-
Phosphate and NADH or Niacinamide. Also, consider
additional energetic support, since a buildup of lactic
and pyruvic acids suggests that energy is not being
 generated appropriately from ingested food sources.
Consider direct energy support with MitoForce, or
add Carnitine, CoQ10, and/or Idebenone individually.
Consider using Zinc, because when lactic acid gets
too high, it can recycle to pyruvic acid with O2 and
zinc. Some reports suggest the use of Yerba Mate to
help with high levels of lactic acid due to exercise,
so that lactic acid does not build up in your muscles
and cause that painful, after-exercise soreness. Those
who are ACAT+ may have particular issues
converting food into energy. The individual
components in the ACAT cap can be added one at
time, or simply add ACAT/BHMT capsules.
The buildup of beta-hydroxy-butyric acid (BHBA) is
an indication that fats are not being processed
ideally. It is a sign of possible ketosis. Often, higher
levels of BHBA are seen in those who have H. pylori,
or who do not have sufficient biotin and adenosyl
B12 to process fats. Lack of pancreatic enzymes can
also be a factor in high BHBA. Running a CSA
test and GI Effects test to look at fatty acid processing
may be useful. If there are other signs of low B12,
such as high methylmalonic acid (MMA), low cobalt
on a HMT and UEE, low lithium on a HMT, or low
serum lithium, then supporting lithium and Adenosyl
B12 may address high BHBA. If the issue is fat
processing, then Biotin and digestive enzymes that
are higher in pancreatin or bile salts may be a help.
Beta-Hydroxy-Butyric
When high BHBA is a sign of possible ketosis,
Acid (BHBA)
consider a UAA to check amino acid levels and a
need for additional nutritional support. Consider
using Biotin and Adenosyl B12 to help process fats.
Also check to see if lithium support is needed.
Consider using All in One and/or BeCalm Spray for low
dose lithium support. Consider Special Digestive
Enzymes as a source of enzymes high in pancreatin,
and ACAT/BHMT capsules for low dose bile salt
support. Also, consider MitoForce to help compensate
for diminished energy components for the Krebs
cycle. Certain diets may cause a greater tendency
toward ketosis, such as the Specific Carbohydrate
Diet or the Paleolithic Diet. A more balanced diet
can be considered if these are factors in ketosis that
do not resolve with supplement support.
Citric acid, cis-aconitic acid, and isocitric acid are
the first three metabolites in the Krebs Citric Acid
Citric Acid
energy production cycle, which operates in the
mitochondria of your cells. Mitochondria are the
 structures within your cell that are your main source
of energy. The terms citric acid, cis-aconitic acid, and
isocitric acid can be used interchangeably with citrate,
cis-aconate and isocitrate. They are just different forms
of the same molecule. The same is true for any other
organic acid. They have two names for two different
forms of the substance, for example alpha ketoglutaric
acid or alpha keto-glutarate, succinic acid or succinate,
etc. These terms are used interchangeably throughout
this chapter for the organic acids discussed. Aluminum
has a particularly destructive effect on many steps of
the Krebs Citric Acid Cycle. Aluminum interferes
with the enzymes that convert citrate to isocitrate, so
high levels of citrate and isocitrate may indicate that
aluminum is high in your body. Additionally, lack of
B12 can cause the Krebs energy cycle to run in the
reverse direction leading to elevated citric acid. If a
HMT and UEE indicate a need for more B12, then
supplement the appropriate form of B12 for your
genetics, after you are sure that your lithium is in
balance. Lithium helps to transport B12 into your
cells. If levels of lithium are low in hair, urine or
serum, consider low dose lithium support. If citric
acid is too low, consider increasing supports that
help feed into the Krebs energy cycle, such
as MitoForce and Ultimate B Complex. You can also
consider supplements that supply citrate, such
as Magnesium Citrate, Potassium Citrate, etc. Consider
supporting with MitoForce or the individual
components in MitoForce. Check HMT and UEE, and
add B12 as needed once lithium is in balance. Use
the low dose lithium support in All in
One and/or BeCalm Spray when needed. Look for
evidence of aluminum toxicity and
consider MetalAway, EDTA soap or EDTA soak if
aluminum is present. Consider natural supports for
BH4, such as BH4 itself and MTHFR A1298C Liver
Support capsules. You can also consider
using Lactoferrin, Glutathione (GSH), and Vitamin K.
High citric acid can be a sign of acidosis IF citric
acid is high but cis-aconitic acid is NOT as high.
Acidosis can occur from lack of bicarbonate due to
decreased pancreatic enzymes, in which case
consider Special Digestive Enzymes (SDE) which are
high in pancreatin. If potassium is low on mineral
tests, you can also consider low dose Potassium
Bicarbonate.

Aluminum interferes with the enzymes that convert

Cis-Aconitic Acid citrate to isocitrate as well as the next step which
converts isocitrate to alpha ketoglutarate (alpha KG),
 so high levels of cis-aconitate and isocitrate may
indicate that your aluminum is high. Lack of B12
can cause the Krebs energy cycle to run in the
reverse direction, potentially leading to elevated
levels of citric acid, cis-aconitic acid, and isocitric
acid. If a HMT and UEE indicate a need for more
B12, then supplement B12 when you are sure that
your lithium is in balance. Lithium helps to transport
B12 into your cells. If levels of lithium are low in
hair, urine or serum, use low dose lithium support. If
citric acid is low, consider increasing supports that
help feed into the Krebs energy cycle, such
as MitoForce and Ultimate B Complex. Since iron
and GSH play a role in the conversion of citric acid
to cis-aconitic and isocitric acids, the use of
supplements that help to move iron or support
glutathione may also be a help when cis-aconitic
acid levels are low. Consider supporting
with MitoForce or the individual components
in MitoForce. Check HMT and UEE, and add B12 as
needed. Consider the low dose lithium support in All
in One and/or BeCalm Spray when lithium is needed.
Look for evidence of aluminum toxicity and
consider MetalAway, EDTA soap or EDTA soak if it is
present. Aluminum inhibits the DHPR enzyme that
is necessary to convert BH2 into BH4. Consider
natural supports for BH4, such as BH4 itself
and MTHFR A1298C Liver Support capsules. You can
also consider Lactoferrin, Glutathione (GSH),
and Vitamin K.
Aluminum interferes with the enzymes that convert
citrate to isocitrate as well as the next step which
converts isocitrate to alpha KG, so high levels of cis-
aconitate and isocitrate may indicate that your
aluminum is high. Lack of B12 can cause the Krebs
energy cycle to run in the reverse direction,
potentially leading to elevated levels of citric acid,
cis-aconitic acid, and isocitric acid. If a HMT and
UEE indicate a need for more B12, then supplement
Isocitric Acid B12. Lithium helps to transport B12 into your cells.
If levels of lithium are low in hair, urine or serum,
consider low dose lithium support. Manganese,
magnesium and vitamin B3 (ie. niacin, Niacinamide,
or NADH) play a role in the conversion of isocitrate
to alpha KG, so the use of these supplements may
help if isocitric is high and alpha KG is lower.
Conversely, if isocitrate levels are too low, consider
increasing supports that help feed into the Krebs
energy cycle, such as MitoForce and Ultimate B.
 Check HMT and UEE, and add B12 as needed.
Consider the low dose lithium support in All in
One and/or BeCalm Spray when needed. Look for
evidence of aluminum toxicity and
consider MetalAway, EDTA soap or EDTA
soak. Consider natural supports for BH4, such
as BH4 itself and MTHFR A1298C Liver Support
capsules. You can also consider Ultimate B Complex,
and Niacinamide or NADH. Check manganese and
magnesium on a UEE and a HMT, and add as needed.
Consider MitoForce or the individual components
in MitoForce.
Aluminum can inhibit the reaction that converts
glutamate to alpha KG, so low levels of alpha KG
may be an indication of high aluminum. Check
aluminum on a HMT and UEE, and support to address
aluminum and BH4. If alpha KG is very low it may
be due to high aluminum or a lack of B12. You may
suspect that B12 is low especially if threonine,
glycine and asparagine are high on a UAA. If the
level of phosphate is low on a HMT or UEE, leucine
may be increased. High leucine may also negatively
impact alpha KG levels. Low alpha KG may cause
hypoglycemia. Check leucine levels on a UAA.
Determine if leucine is high in the absence of high
isoleucine or high valine. If this is the case, consider
using ATP and Riboflavin-5-Phosphate for phosphate
support. If ammonia is very high on a UAA, and
glutamate is also high, then much of the alpha KG
may have been converted to glutamate. Work on
Alpha-Ketoglutaric Acid
high ammonia levels with CBS/NOS Kidney Support
(alpha KG)
capsules. Check that sulfates are not too high, and
check molybdenum levels. High levels of T4 thyroid
hormone, thyroxine, inhibits the enzyme glutamate
dehydrogenase, which then can increase glutamate
levels and decrease alpha KG. Check a CSA
test and GI Effects test, because imbalances in gut
microbes can affect thyroid hormones. PABA, found
in Ultimate B and Niacinamide can be considered for
those who have concerns about thyroid
autoimmunity. In addition, Coleus may be a help to
support the thyroid. Look for evidence of aluminum
toxicity and consider MetalAway, EDTA soap or EDTA
soak if aluminum is present. Aluminum inhibits the
DHPR enzyme that is necessary to convert BH2 into
BH4, so consider natural supports for BH4, such
as BH4 itself and MTHFR A1298C Liver Support
capsules. If lack of B12 is an issue, consider All in
One, BeCalm Spray, Hydroxy B12, Adenosyl B12, Black
 Bear Spray or Black Bear Drink. If alpha KG levels are
too high, consider Ultimate B. If leucine is also high,
consider ATP and Riboflavin-5-Phosphate.
Low succinic acid can be due to excess aluminum in
your system. Look for other signs of aluminum
excess, such as high aluminum on a HMT and UEE,
imbalances in other Krebs cycle intermediates on
the MAP, or a need for BH4 as evidenced by high
phenylalanine, tyrosine, or tryptophan on a UAA. If
these indicators suggest that aluminum and BH4 are
issues, then consider MetalAway, EDTA soap, or EDTA
soak, and BH4 supports, such as BH4 itself
and MTHFR A1298C Liver Support capsules. In addition,
succinate helps to limit the enzyme urocanase, which
plays a role in increasing FIGLU and glutamate. So,
low levels of succinate may be a factor in high
Succinic Acid FIGLU and high glutamate. If succinic acid is too
low, consider Vitamin E succinate and Adenosyl B12.
Low B2 (riboflavin) and B3 (niacin) generally lead
to extremely high levels of succinic acid. If succinic
acid is high, consider Riboflavin-5-
Phosphate and MTHFR A1298C Liver Support capsules. In
addition, consider NADH, Niacinamide or Ultimate B to
support vitamin B3. Thallium can cause issues with
riboflavin levels, so if thallium is present on
the UTM or HMT, consider additional Riboflavin-5-
Phosphate to help convert succinate to fumarate. High
succinate may combine with excess glycine to
increase porphyrins. Check glycine on a UAA, and
use AHCY/SHMT compound if needed.
Excess urea cycle function can generate high levels
of fumarate, because fumaric acid is one of the urea
cycle products. To see if excess urea cycle activity is
causing high fumarate, look at a UAA to check
arginine, ammonia, citrulline, and ornithine levels.
High ammonia may drive your system to more urea
cycle activity, so check ammonia on a UAA and
support to address high ammonia if needed. Be sure
the Krebs cycle is supported so that fumarate can be
Fumaric Acid
processed through the cycle. Specific nutrients such
as Riboflavin-5-Phosphate, NADH , and/or MTHFR
A1298C Liver Support capsules may be a help in
processing fumarate. Support with MitoForce and
sources of BH4 may help to shift the emphasis
toward the Krebs energy cycle rather than on the
urea cycle. A lack of B12 may cause the Krebs
energy cycle to run in a reverse direction and cause
increased levels of intermediates, including
 fumarate. Check markers for B12 levels, such as
cobalt on a HMT and UEE, as well as methylmalonic
acid (MMA) on a MAP test. Blood testing for B12
includes serum B12 levels and MCV. Be sure that
lithium levels are in balance. In addition, check for
and address high aluminum. Aluminum can interfere
with the formation of BH4 that is needed for optimal
urea cycle function. If BH4 appears to be low,
consider supplementing BH4 or Royal Jelly if you
have no bee allergies. For low levels of fumarate,
consider Carnitine fumarate.
Low levels of malic acid have been implicated in
fatigue. Check a MAP test for tartaric and citramalic
acid levels. These acids can inhibit malic acid.
Address those as needed if malic acid levels are low.
When malic acid levels are low, consider support
Malic acid
with Muscle Fatigue Support compound as well as eating
apples. If levels of malic are high,
consider Riboflavin-5-Phosphate, NADH, and/or MTHFR
A1298C Liver Support capsules to help with the
processing of malic acid.
A number of programs and tests focus on high oxalic
acid, also called oxalate. In my program, the issue of
high oxalate is integrated into my larger concern
about overall biochemical balance. Aside from diet,
there are a number of factors that may contribute to
high oxalate levels. A determination if the trigger is,
for example, high yeast or fungi, a lack of B12, or
low ATP, is made through interpretation of testing.
The reason for the high oxalate then guides your
decisions as to how you address the problem. High
oxalate may be due to yeast and fungal infestation.
These factors can be investigated with a CSA
test and GI Effects test, among others. Several chapters
Oxalic Acid in this book contain suggestions for what to do when
these issues are found.High oxalate can also be
caused by low B12. Low B12 makes the Krebs cycle
run in a reverse direction, which increases oxalate.
Check cobalt levels on a UEE and HMT. Lithium
transports B12 into your cells. Be sure that lithium is
in balance with these two tests as well. The Krebs
cycle is the energy/ATP generating portion of the
mitochondria in your cells. Your level of B12
impacts enzymes in the Krebs cycle, and the levels
of Krebs intermediates are affected. Adequate levels
of B12 increase fumarate reductase, which then aids
in processing oxalate and fumarate (Kurumada and
Labbe Science Vol 151 page 1228).Conversely, lack
of B12 leads to increases in citrate lyase and
succinate dehydrogenase (Frenkel et al JBC Vol 251
page 2147). The net effect of these enzymatic
changes is to increase oxalate and fumarate levels.
While fumarate is generally converted to malate, it
may happen that when fumarate levels are high
enough, some of it is converted to tartarate.
Feedback inhibition by high oxalate in addition to
high fumarate may control the flow into malate, such
that fumarate and oxalate are converted to tartarate.
The pathway that leads to formation of tartarate
from oxalate has been defined (Nakamura and
Ogata, JBC Vol 248 page528 and Shreeve and
Meuter JBC Vol 239 page 729), as has as the path
from fumarate to tartarate (Kuni and Hernandez JBC
page 201 and Finkle JBC page 349).Conditions of
B12 deficiency, coming either as a result of
mutations in the methylation cycle, and/or by high
level depletion of B12 through endurance training or
sports, can lead to increased levels of tartarate,
fumarate, and oxalate. High levels of tartarate in the
absence of high arabinose, or high levels of
fumarate, should lead you to consider supplementing
with multiple forms and routes of B12. This includes
chewable hydroxyl, adenosyl, and methyl B12. The
relative amounts depend on your Nutrigenomics.
If you have high oxalate levels, you should consider
increasing your B12 support for an additional reason.
Relative B12 deficiency increases the conversion of citrate
to oxalate via citrate lyase. Consider Lactoferrin, Vitamin
K, Pantothenic Acid, Riboflavin-5-
Phosphate, Curcumin, Benfotiamine, and GSH to increase
the flow from pyruvate through citrate and onto isocitrate as
another way to decrease high oxalate. The use
of MitoForce may also support this conversion.
High leucine in the absence of high valine or isoleucine can
occur secondary to low phosphate. This can also cause
increases in oxalate, so check to determine if leucine is high
on a UAA. If so, consider ATP and Riboflavin-5-
Phosphate to support phosphate.
High oxalate may also be due to excess glycine secondary to
SHMT + or excess iron. Glycine can be checked on a UAA,
and iron levels are on a UEE and HMT. As discussed in
the UAA chapter, high glycine can be addressed with
supports for SHMT.
If threonine is high on a UAA test, this may be an indication
of high oxalic acid.
High levels of oxalates may increase ACE activity. The use
of anxiety support and progesterone may be helpful.
(Umekawa et al J. Am Soc Nephrol Vol 15, 2004).
High levels of citrate or high levels of the intermediates that
precede acetyl CoA on the MAP diagram, i.e., pyruvate,
lactate, etc., may be an indirect indication of high oxalate, as
the cycle is not incorporating at 11:00 (oxalate) well enough
to be moving around to 1:00 (citrate) properly.
Also, a build up at 1:00 (citrate) may be causing a backup in
the cycle, which may be an indirect indication of high
oxalate. Consider MitoForce or Lactoferrin, Vitamin
K, Riboflavin-5-Phosphate, Pantothenic Acid,
and Benfotiamine to get the portion of the cycle from 11:00
to 1:00 moving.
Those who are ACAT + may also have problems converting
nutrients from food into the Krebs energy cycle, and the use
of ACAT/BHMT capsules may be a help in this regard.
Research articles illustrate a relationship between B12 and
ATP which seems to present a catch 22. ATP, the fuel
generated by your body to drive its biochemical reactions, is
created by your Krebs energy cycle. The Krebs cycle needs
B12 in order to function optimally. If your Krebs cycle is
not functioning optimally, ATP production is reduced. Yet,
ATP is needed to transport B12 into your cells. However,
lithium also plays a role in B12 transport, so lithium levels
should be checked and supported as
needed. MitoForce or ATP, NADH, Vitamin E succinate,
and Malic Acid also play a role in B12 transport and may be
 supplemented as needed.
High levels of sulfur in your system can have a negative
impact on the regeneration of ATP and NADH. This may be
a particular issue for those who are SUOX + – or CBS
++. MitoForce or ATP, NADH, Vitamin E succinate,
and Malic Acid help to regenerate these important
intermediates also.
The supplements suggested for consideration to reduce high
oxalate depend upon its cause. If low B12 is the issue,
consider a source of low dose lithium, such as All in
One and/or BeCalm Spray, in addition to B12 itself.
If high glycine and/or high iron are the issues,
consider SHMT support.
If leucine alone is elevated on a UAA, without concurrent
increases in isoleucine and valine, then
consider ATP and Riboflavin-5-Phosphate .
Aluminum and thallium can impair the function of the Krebs
cycle, so address thallium and aluminum if they are found to
be elevated on HMT, UTM or FMT.
Rule out yeast and fungal issues on a CSA test and GI
Effects test.

Similar to BHBA, high levels of HMG suggest

problems processing nutrients to convert them into
energy via the Krebs cycle. Studies suggest
that Carnitine may be a particular help. To help
convert nutrients into energy, consider MitoForce and
additional Carnitine. If you are not using MitoForce,
then individually add the other ingredients in
Beta-Hydroxy-Beta-
the MitoForce compounded supplement, such
Methylglutaric Acid
as CoQ10, Benfotiamine, Riboflavin-5-
(HMG)
Phosphate, Pantothenic Acid, Policosanol,
and Cholacol or ACAT/BHMT capsules to help process
fats.Also, rule out excessively high leucine on
a UAA. If high leucine is present in the absence of
elevated valine or isoleucine, then
consider Riboflavin-5-Phosphate and ATP to support
phosphate levels.
Adipic Acid High adipic acid suggests fat processing
 problems. Biotin, low dose Adenosyl B12, and Special
Digestive Enzymes (SDE) may be a help. Consider
a CSA test and GI Effects test to look at short chain
fatty acids. To help process fats,
consider Carnitine and SDE. Also,
consider MitoForce or add the other ingredients in
the MitoForce compounded supplement, such
as CoQ10, Benfotiamine, Riboflavin-5-
Phosphate . Pantothenic Acid, Policosanol,
and Cholacol or ACAT/BHMT capsules to help process
fats.
High suberic acid suggests a strong need for
carnitine. High suberic acid is often seen with H.
pylori. This organism may deplete carnitine. Consider
ruling out H. pylori with a breath test, or running
a CSA test and GI Effects test to look at other possible
markers for H. pylori, including gut
pH. Carnitine support is the key approach to high
suberic acid. Also, consider MitoForce or add the
other ingredients in the MitoForce compounded
supplement, such as CoQ10, Benfotiamine, Riboflavin-5-
Suberic Acid
Phosphate , Pantothenic Acid, Policosanol,
and Cholacol or ACAT/BHMT capsules to help process
fats. If you are concerned that H. pylori may be the
cause of your high suberic acid because of other
markers as well as clinical presentation, then you and
your doctor can consider the more complete H.
pylori protocol used in this program. A more
mainstream approach to H. pylori is a triple
prescription therapy, including minocycline,
augmentin, and proton pump inhibitors.
VMA is a breakdown product from both epinephrine
and norepinephrine. This MAP test also measures
MHPG, which is a reflection of primarily the
breakdown of norepinephrine. So, comparing VMA
to MHPG gives you a sense of whether there is
excessive breakdown of both, or only increased
breakdown of norepinephrine. It has been suggested
that higher norepinephrine activity relative to
Vanilmandelic Acid
epinephrine is a factor in ADD/ADHD. This is a
(VMA)
reason to pay attention to the ratio of VMA to
MHPG. If the values are very elevated, consider
a Neurotransmitter Test (NT test) to look directly at
epinephrine and norepinephrine levels in addition to
their breakdown products. If MHPG levels are
higher than VMA, consider using Vitamin C, because
ascorbic acid may shift the balance to higher levels
of epinephrine relative to norepinephrine. Also,
 consider Phosphatidyl Serine Complex (PS/PE/PC) and
low dose Attention Support nucleotide blend. SAM-e may
also be helpful, depending on your Nutrigenomics.
For very high levels of VMA, also consider low
dose Mood D nucleotide blend. Recent studies suggest
that Yohimbe may be a help in shifting to higher
levels of epinephrine relative to norepinephrine.
Yohimbe is also reported to help with fat digestion
and healthy insulin levels. However, Yohimbe has
also been suggested to help with erectile
dysfunction; for this reason, it should be used with
caution in children and teens. When your main
concern is attention, focus, depression, ADD, ADHD
or OCD, then consider looking at neurotransmitters
in several ways. In addition to looking at the
breakdown products on a MAP test, also consider
a Neurotransmitter Test (NT Test) to get the level of the
NT, as well as a UAA to assess the level of starting
material to make NT and, if needed, a Neopterin /
Biopterin Profile Urine Test. In this way, you look at
breakdown on a MAP, the levels of
neurotransmitters on a NT test, and the level of the
starting material for producing neurotransmitters on
a UAA and biopterin test.
HVA is the breakdown product of dopamine. If your
values are very low, then some additional support for
dopamine production may be a help. Alternately,
support for the process that breaks down dopamine
via Mao B may be needed. Additional testing can
help to differentiate between these options. Consider
a NT test to be sure that dopamine is in the normal
range. Use a UAA to see if there is sufficient tyrosine
to produce dopamine, and if there is evidence of
sufficient BH4 to convert tyrosine into dopamine. If
dopamine is high on a neurotransmitter test, yet the
HVA is low on a MAP, copper levels may be too
Homovanillic Acid (HVA) low. Dopamine is processed by the enzyme MAO B.
This enzyme requires copper to function. In addition,
MAO B may be inhibited due to high levels of
hydrogen sulfide, which can decrease MAO activity.
If levels of HVA are very low, run a UAA to look at
tyrosine levels to be sure there is sufficient material
for the body to produce dopamine. In addition, MAO
B may be inhibited due to high levels of hydrogen
sulfide, which can decrease MAO activity. In this
case, looking at taurine levels and certain
transulfuration markers, such as cysteine,
cystathionine, cystine, and glutathione on
the UAA may also be helpful. Also consider sulfur
 levels on a HMT and UEE to determine if this may be
a cause of low HVA. Licorice may inhibit MAO
enzymes, so limit the use of licorice if levels of HVA
are very low. If low HVA is ALSO associated with
low dopamine on an NT test, then ascertain that
there is sufficient tyrosine and BH4 to make
dopamine. You may need to consider direct, low
dose, natural supports for dopamine. These include
low dose Ginkgo Biloba, Mucuna Pruriens, Mycoceutics,
low dose Mood D nucleotide blend, and low dose Mood
Focus nucleotide blend, depending on your
nutrigenomics. As always, work with and defer to
your own doctor, especially when addressing
imbalances in neurotransmitters. Conversely, if
values of HVA are high, run a HMT and UEE to
check copper levels. Be sure that copper is not
higher than zinc. The use
of Molybdenum, Manganese and low dose EDTA may
help if copper levels are high. This may help to get
copper into better balance, and to slow down
excessive dopamine breakdown, which would lead to
high HVA levels. When your main concern is
attention, focus, depression, ADD, ADHD or OCD,
then consider looking at neurotransmitters in a range
of ways, not just the breakdown products on a MAP
test. Also consider a NT test, as well as a UAA, and, if
needed, a Neopterin / Biopterin Profile Urine Test. In this
way, you look at breakdown on a MAP, levels of
neurotransmitters on a NT test, and starting material
for producing neurotransmitters on a UAA and
biopterin test.
5 HIAA is a breakdown product of serotonin.
Serotonin is broken down by the enzyme MAO A.
This enzyme requires copper to function. If 5 HIAA
is high, run a HMT and UEE to check copper levels.
Be sure that copper is not higher than zinc. The use
of Molybdenum, Manganese and low dose EDTA may
help if copper levels are high. If levels of 5HIAA are
very low, yet serotonin is high on a NT test, then
5-OH-Indoleacetic Acid MAO A may be inhibited due to high levels of
(5-HIAA) hydrogen sulfide, which can decrease MAO activity.
In this case, run a UAA to look at taurine levels and
certain transulfuration markers, such as cysteine,
cystathionine, cystine, and glutathione. Look at
sulfur on a HMT and UEE to determine if this may be
a cause of low 5HIAA.Also, if serotonin is high on a
NT test, and 5HIAA is low, be sure that copper
levels are not too low. Licorice also may inhibit
MAO enzymes, so limit the use of licorice if levels
 of 5HIAA are very low. Low levels of serotonin
have been associated with OCD and perseverative
behavior, as well as depression. I suggest that you
look at neurotransmitters in a range of ways, not just
the breakdown products on a MAP test. So consider
a NT test, as well as a UAA, and, if needed, a Neopterin
/ Biopterin Profile Urine Test. In this way, you look at
breakdown on a MAP, levels of neurotransmitters on
a NT test, and starting material for producing
neurotransmitters on a UAA and biopterin test.For
high levels of 5HIAA, consider low dose Mood S
nucleotide blend and low dose SeroMood. Be sure that
copper levels are not high, and that molybdenum and
manganese are not low. Check tryptophan on
a UAA and serotonin on a NT test. Check for signs
that BH4 needs support or that excess aluminum is
impacting BH4.Serotonin levels can be impacted by
bacterial issues. Especially if the bacterial markers
on a MAP are elevated, you should do a CSA
test and GI Effects test. Also, in the case of high
bacterial markers, consider support for vitamin B3,
niacin, with Ultimate B and MTHFR A1298C Liver
Support capsules.

MHPG is the breakdown product from

norepinephrine, but it may also be produced from
epinephrine to a lesser extent. Still, comparing VMA
to MHPG gives you a sense of whether there is
excessive breakdown of both, or only increased
breakdown of norepinephrine. When norepinephrine
is too high relative to epinephrine, it may cause
decreased ability to focus and attend. High levels of
norepinephrine may decrease BH4, so consider other
testing to be sure that sufficient BH4 is available.
When your main concern is attention, focus,
depression, ADD, ADHD or OCD, then consider
3-Methyl-4-OH- looking at neurotransmitters in a range of ways, not
phenylglycol (MHPG) just the breakdown products on a MAP test. So,
consider a NT test, as well as a UAA, and, if needed,
a Neopterin / Biopterin Profile Urine Test. In this way,
you look at breakdown on a MAP, levels of
neurotransmitters on a NT test, and starting material
for producing neurotransmitters on a UAA and
biopterin test. Supplements that may help with
attention include low dose Attention Support nucleotide
blend, NADH, MTHFR A1298C Liver Support
capsules, BH4, Royal Jelly if you have NO bee
allergies, DMG, SAM-e, Phosphatidyl Serine Complex
(PS/PE/PC) and Zinc. If MHPG levels are higher than
VMA, consider using Vitamin C. Ascorbic acid may
 shift the balance to higher levels of epinephrine
relative to norepinephrine. Recent studies suggest
that Yohimbe may be a help in shifting to higher
levels of epinephrine relative to norepinephrine.
Yohimbe is also reported to help with fat digestion
and with healthy insulin levels. However, Yohimbe
has also been suggested to help with erectile
dysfunction. For this reason, it should be used with
caution in children or teens.
Kynurenic acid is a breakdown product of
tryptophan. Use a UAA to check that tryptophan
levels are in balance, and neopterin/biopterin testing to
determine if sufficient BH4 is present to convert
tryptophan into serotonin. Also, use a NT test to
check NT levels. Kynurenic acid is a calming
compound, but it will convert to quinolinic acid in
the presence of B6. This is a concern because
quinolinic acid is an excitotoxin. High kynurenic
and/or quinolinic acids may be due to bacterial
issues. Use a CSA test and a GI Effects test to rule out
excess non-ideal microbes. Support for high
kynurenic acid includes MTHFR A1298C Liver Support
Kynurenic Acid
capsules to help natural levels
of NADH, Niacinamide and healthy BH4. Consider
adding BH4 depending on the UAA, and a Neopterin /
Biopterin Profile Urine Test if it appears that high
kynurenic acid is due to lack of BH4 and decreased
serotonin. If both kynurenic and quinolinic acids are
high, then limit B6 and Pyridoxal-5-phosphate (P5P)
to attempt to shift the balance to kynurenic rather
than quinolinic acid. If bacterial issues are suspected,
you can consider Naturomycin Spray, Naturomycin
capsules, grapefruit seed extract (GSE capsules or GSE
liquid) and BactiSolve if you have NO shellfish
allergies.
Kynurenic acid, which is derived from the
processing of tryptophan, is converted to quinolinic
acid in the presence of B6 or P5P. While kynurenic
is calming, quinolinic is an excitotoxin that can over
stimulate nerves. Excitotoxins can cause seizure
activity, problems sleeping, heart palpitations,
Quinolinic Acid nervous twitches, among other symptoms.
Consider GABA Balance capsules, BeCalm Spray,
and Nerve Calm nucleotide blend. Consider a CSA
test and GI Effects test to check for bacterial issues that
may be involved with breaking down tryptophan,
and to look at which specific microbes may need to
be addressed. For high levels of quinolinic acid from
 bacterial breakdown, consider BactiSolve if you have
NO shellfish allergies, Naturomycin Spray, Naturomycin
capsules, and grapefruit seed extract (GSE
capsules or GSE liquid). Limit B6 and P5P.

As with any of the keto acids, ketosis may be an

issue when high AKAA is present. Ketosis can be a
factor in lack of growth or poor weight gain. If you
are using a diet that can increase ketosis such as the
Specific Carbohydrate Diet or Paleolithic Diet, be
aware that they may be a factor in high keto acids.
The use of Biotin and low dose Adenosyl B12 may be a
help for ketosis. AKAA is formed from tryptophan
and lysine, so be sure that excess lysine is not being
added to your diet. See that there is sufficient BH4 to
process tryptophan into serotonin. You may also
check serotonin levels on a NT test and tryptophan
and lysine levels on a UAA. To support healthy
a-Ketoadipic Acid levels of BH4, consider supplementing BH4 itself if
(AKAA) other tests indicate a need. You can also use MTHFR
A1298C Liver Support capsules. In addition, use Ultimate
B to help support B vitamin cofactors. AKAA is a
precursor to glutaric acid, so also consider
supplementing with Carnitine, as Carnitine is reported
to help mitigate the effects of glutaric acid. Run
a CSA test and GI Effects test to rule out bacterial
production of AKAA. If bacterial issues are a
concern, use gut herbs, including Naturomycin
Spray, Naturomycin capsules, and grapefruit seed
extract (GSE capsules or GSE liquid). Rule out H.
pylori if other markers or clinical presentations for
that bacteria are present, such as history of acid
reflux, etc.
As with any of the keto acids, ketosis may be an
issue when high AKAA is present. Ketosis can be a
factor in lack of growth or poor weight gain. If you
are using a diet that can increase ketosis such as the
Specific Carbohydrate Diet or Paleolithic Diet, be
aware that they may be a factor in high keto acids.
AKIV is specifically due to breakdown of valine.
a-Ketoisovaleric Acid Excess levels of the branched chain amino acids
(AKIV) (BCAA) of valine, leucine and isoleucine can cause
a maple syrup smell to your urine. Decreasing the
use of BCAA can help.The use of Biotin and low
dose Adenosyl B12 may be a help for ketosis. Ultimate
B can be used to help support B vitamin cofactors for
the processing of fats. Also, consider
using MitoForce and additional Carnitine. This is
important, because high levels of BCAA and their
 respective ketoacids have been implicated in
depletion of mitochondrial energy, which has
significant negative effects on your system. Consider
support with SDE to help with fat digestion,
and ACAT/BHMT capsules if needed to help get fatty
acids into a normal, healthy range.Rule out H.
pylori. With any case of suspected ketosis, run a CSA
test and GI Effects test to check on the processing of
fats. Check a UAA to see that nutrients are in fact
being absorbed. You can also run an Intestinal
Permeability test. The Celiac test can also be run if
desired.
As with any of the keto acids, ketosis may be an
issue when high AKAA is present. Ketosis can be a
factor in lack of growth or poor weight gain. If you
are using a diet that can increase ketosis such as the
Specific Carbohydrate Diet or Paleolithic Diet, be
aware that they may be a factor in high keto acids.
AKIC is specifically due to breakdown of leucine.
Excess levels of the branched chain amino acids
(BCAA) of valine, leucine and isoleucine can cause
a maple syrup smell to your urine. A body odor that
smells like “sweaty feet” may be an indication of
leucine breakdown issues. Decreasing the use of
BCAA can help.The use of Biotin and low
dose Adenosyl B12 may be a help for ketosis. Support
with Ultimate B to supplement B vitamin cofactors.
Also, consider using MitoForce and
additional Carnitine. This is important, as high levels
of BCAA and their respective ketoacids have been
a-Ketoisocaproic Acid
implicated in depletion of mitochondrial energy that
(AKIC)
has significant negative effects on your system.
Support with SDE to help fat digestion and
use ACAT/BHMT capsules if needed to get fatty acids
into a normal, healthy range. If only AKIC is
elevated without an elevation in AKIV or AKBM,
then consider that low phosphate may be increasing
leucine levels. Check phosphate levels on
a HMT and UEE and support with ATP and Riboflavin-
5-Phosphate if the levels of phosphate are low. Rule
out H. pylori as with any case of suspected ketosis,
and run a CSA test and GI Effects test to check on the
processing of fats. Check a UAA to see that nutrients
are being absorbed. Conversely, low levels of AKIC
may be a factor in absence seizures, along with low
levels of leucine in particular and BCAA in general.
If levels of AKIC are very low, along with low levels
of BCAA on a UAA, then consider BCAA support
and AminoAssist. Be sure that no maple syrup smell
 comes to your urine due to too much support. This is
important, as high levels of BCAA and their
respective ketoacids are an issue as described above.
However, extremely low levels are a risk factor for
other health conditions.
As with any of the keto acids, ketosis may be an
issue when high AKAA is present. Ketosis can be a
factor in lack of growth or poor weight gain. If you
are using a diet that can increase ketosis such as the
Specific Carbohydrate Diet or Paleolithic Diet, be
aware that they may be a factor in high keto acids.
AKBM is specifically due to breakdown of
isoleucine. Excess levels of the branched chain
amino acids (BCAA) of valine, leucine and
isoleucine can cause a maple syrup smell to your
urine. Decreasing the use of BCAA can help. The
use of Biotin and low dose Adenosyl B12 may be a
a-Keto-b-Methylvaleric help for ketosis. In addition, Ultimate B may help to
Acid (AKBM) support B vitamin cofactors. Also,
consider MitoForce and additional Carnitine. This is
important, as high levels of BCAA and their
respective ketoacids have been implicated in
depletion of mitochondrial energy that has
significant negative effects on your system. Support
with SDE to help with fat digestion and
use ACAT/BHMT capsules if needed to help get fatty
acids into a normal, healthy range. Rule out H.
pylori as with any case of suspected ketosis, and run
a CSA test and GI Effects test to check on the
processing of fats. Check a UAA to be sure that
nutrients are being absorbed.
High FIGLU suggests that adequate folate is not in
place. All in One supplies low doses of folic acid,
folinic acid, and 5 methyl THF. There are two key
reasons to support with low doses of folate/folic acid,
in addition to the use of specific types of folate such
as 5 methyl THF that help to bypass mutations like
MTHFR C677T. First, since 1959 it has been known
that “folic acid deficiency results in inability to
Formiminoglutamic Acid
degrade formiminoglutamic acid (FIGLU) to
(FIGIU)
glutamic acid, so that FIGLU accumulates in
excessive amounts and is excreted in the urine”.
(Luhby, Am J Clin Nutr). FILGU levels are
measured on this MAP test, and high levels suggest a
need to use low dose folate/folic acid support. The
second reason to look at low dose folic acid/folate is
the pathway that involves MTHFS. A low dose form
of plain folate or folic acid is supplemented in part to
address possible MTHFS mutations, especially since
they are not generally identified on most
nutrigenomic tests. MTHFS is another enzyme in the
methylation pathway. It functions at 11:00 in the
folate cycle, between 5 formyl THF (folinic) on the
way to produce tetrahydrofolate at 12:00. MTHFS
functions to address SHMT and the formation of the
purines guanine and adenine for DNA and RNA
formation. If there is a mutation that impacts the
ability of MTHFS to function, it can increase folinic
acid to high levels and limit the synthesis of purines,
as well as decrease the THF level. In this program,
my policy is to use only low dose folinic acid, to add
nucleotides to support DNA and RNA production,
and to use low dose folic acid along with probiotics as
a secondary way to make THF. In this way, I bypass
the impact of any possible MTHFS mutation, even if
I do not have nutrigenomic data regarding this gene.
This again highlights why I want to think
about all aspects of the pathway when adding
support. I choose to add only low dose folinic acid to
help keep SHMT in balance without allowing the
levels of folinic to climb, which might happen if you
are adding high dose folinic and have a MTHFS
mutation. I add nucleotides to supply purines and
pyrimidines in case the pathway for their formation
is not fully functional. I add low dose folic acid to have
a secondary route for making THF that consumes
excess glutamate in doing this. The rationale behind
also adding low dose 5 methyl THF is that the way
to bypass an MTHFR C677T mutation is with 5
methyl THF. If you look at the biochemical diagrams
you can see this. No amount of folinic, folate, or
folic acid is going to bypass a MTHFR C677T
mutation. So, the whole conversation about folic acid
or folate is actually misplaced, as the real issue is 5
methyl THF. There is some sort of misconception
out there that folate will bypass MTHFR. To be
clear, 5 methyl THF is the only way to bypass
MTHFR C677T. I have it in low dose form in
both All in One as well as Methylmate B. If you are
C677T ++, using high dose 5 methyl THF can
trigger more detox than you can handle, especially if
you are an adult. This is why All in One uses low
dose 5 methyl THF, and my stand alone source of 5
methyl THF, Methylmate B, is a liquid, so you have
exquisite control over increasing or decreasing its
dose. MOST of the folate that is used for this
program is 5 methyl THF, with some low dose folinic
acid. Folinic is useful for those who are SHMT + or
have iron levels that may increase SHMT activity.
Some low dose folic acid/folate is helpful for other
aspects of the pathway, and that is why some very,
very low dose folic acid is included in the
formulation.To summarize, I do feel that some low
dose folinic acid is needed to help to control SHMT,
which is why All in One also has some low dose
folinic. I do not like high dose folinic as those with
MTHFS mutations can have a problem with it.
Finally, for adequate processing of FIGLU, I want
some low dose folate/folic acid in your system.
Because the various forms of folate compete with
each other for transport into your cells, the ratio in
the All in One is mostly 5 methylTHF, with a lesser
amount of folinic, and finally the least amount of
folic acid.Now I am going to be very specific with
regard to why I use low dose folic acid rather than
folate. Folate is basically a chain of glutamates. The
difference between folic acid and folate is the
stability and the length of their glutamate chains. So,
if you are MTHFR C677T++ and you take high dose
folate, you potentially have a chain of unused
glutamate molecules left in your system. You cannot
process it efficiently to 5 methyl THF because of
your SNPs. You run the risk of folate breaking down
to release glutamate into your system. STEP 1 of this
program is focused on glutamate/GABA balance. I
have made significant progress for some individuals
merely by getting their glutamate and GABA into
balance. Thus, I am not choosing to add high doses
of a form of folate that could break down into
glutamate, especially in the population I work with.
One of the main differences between folic acid and folate is
that folic acid has a shorter glutamate chain than folate.
Folic acid is also more stable, so it is less likely to break
down into glutamate. I am using only a tiny bit of folic acid,
to allow FIGLU to convert to glutamic acid. I am not using
high dose folic acid, as that is not going to bypass MTHFR
in any event. I understand there are other programs out there
that use higher doses of plain folate. Perhaps those programs
are less concerned with the glutamate issue.
I have specific reasons for the choices I make in terms of
supplements and the forms that I use. Natural folate has
more glutamate residues and can break down more easily to
release those glutamate molecules into your system, so I
prefer to use a VERY low dose of folic acid. There are only
approximately 15 micrograms of folic acid in All in One and
about 25 micrograms in Ultimate B. This program uses
some very, very low dose folic acid for the reactions that
need it, but the focus is more heavily on the use of 5 methyl
THF and low dose folinic acid.
The use of LOW dose folic acid is a choice, to limit the risk
of increased glutamate in your system. The RDA for
folate/folic acid is 300 micrograms for a child that is 1 year
old, up to 1,000 micrograms daily for an individual 19 years
of age or older. Thus the 15 to 40 micrograms used for this
program is not an issue, especially since the body does need
some folate/folic acid aside from the need for 5 methyl THF
and folinic. To put this in an easily understandable
perspective, a bowl of cheerios has 400 micrograms of folic
acid, as compared to the 15 to 40 micrograms used in this
program.
In addition to making rational choices in terms of folic acid
versus folate, and only using low dose folinic out of
consideration for possible MTHFS mutations, I am already
taking into account the need to balance the production of
purines, thymidine levels, controlling SHMT, and producing
methionine from homocysteine with the supplementation I
have in place for the methylation cycle.
To reiterate the approach: (1) get the BHMT pathway
moving with Phosphatidyl Serine Complex
(PS/PE/PC) plus DHA, SAM-e if tolerated, All in
One, Ultimate B, and low dose methylation RNA; (2) add
some low dose lithium support with BeCalm Spray, and run
a HMT to be sure you have checked lithium to see if you
need low dose Lithium Orotate. If aggression is an issue,
 pay close attention to potassium and rubidium on
your HMT. If your lithium is very low, run a HMT every 3
to 4 months to keep an eye on levels; (3) once lithium is in
balance, you can add extra B12; (4) add Methylmate
A and Methylmate B to be sure you have the cycle fully
supported; (5) if you have SHMT + status or high iron
on HMT and UEE, use SHMT support along with step 1 and
2 above; (6) be sure you have probiotics in place, focusing
on Lactobacillus and Bifidobacter; (7) run a HMT to check
lithium every few months once you have extra B12 in place.
High levels of the enzyme urocanase will also increase
FIGLU. Urocanase is produced by certain bacteria,
including Pseudomonas, so consider a CSA test and GI
Effects test when high FIGLU is noted on a MAP.
Urocanase is limited by succinate. Be sure that succinate
levels on a MAP test are in balance, because a lack of
succinate combined with bacterial increases in urocanase
can be factors in high FIGLU in addition to a need for folate.
In terms of support for high levels of FIGLU, the use of All
in One supplies specialized forms of folate. Also, once it is
clear that lithium is in balance on a HMT, consider low
dose Methylmate A and Methylmate B for comprehensive
methylation support. Use Vitamin E succinate if succinate
levels are low. Also, consider a CSA test and GI Effects
test to rule out Pseudomonas. Consider the use of gut herbs
including Naturomycin Spray, Naturomycin capsules, and
grapefruit seed extract (GSE capsules or GSE liquid) when
necessary.

Glutaric acid is a breakdown product of lysine and/or

tryptophan, so limit lysine support. Run a UAA to be
sure that tryptophan is being converted properly to
Glutaric Acid serotonin, that adequate BH4 is present, as well as
checking serotonin levels on a NT test. Glutaric acid
is also produced by bacteria, so consider a CSA
test and GI Effects test. Carnitine is reported to help
 mitigate the effects of glutaric acid, so consider
extra Carnitine support. If bacterial issues are a
concern, then use grapefruit seed extract (GSE
capsules or GSE liquid), Naturomycin Spray,
and Naturomycin capsules.
Isovalerylglycine is a breakdown product of leucine.
As with AKIC, it may be a sign of ketosis, so
consider using Biotin and Adenosyl B12. Limit leucine
and BCAA, increase Carnitine, CoQ10 spray, and low
dose GABA Calm. Also, consider Ultimate
B and MitoForce. Add carbohydrates from well
thought out sources if ketosis is present. A body odor
that smells like “sweaty feet” may be an indication
of leucine breakdown issues. If only
isovalerylglycine and AKIC are elevated without
increases in AKIV or AKBM, then low phosphate
may be the issue. You can support with Riboflavin-5-
Phosphate, ATP and MitoForce. Rule out H. pylori with
Isovalerylglycine
any case of suspected ketosis. Run a CSA test and GI
Effects test to check on the processing of fats. To help
with fat digestion, consider SDE and ACAT/BHMT
capsules if needed. Run a UAA to be sure that
nutrients are being absorbed. Also, check glycine
levels on a UAA and iron on a HMT and UEE. If
glycine and/or iron are elevated,
consider AHCY/SHMT compound and SHMT Spray for
support.In cases of very high isovalerylglycine
levels, seizures may be present. In these cases,
consider support for glutamate and GABA balance,
such as GABA Balance capsules, Nerve Calm nucleotide
blend, and BeCalm Spray.

MMA is most often considered to be a sign of low

B12, which it is. However, it is also related to the
breakdown of the branched chain amino acids
(BCAA) of leucine, isoleucine, and valine. If high
methylmalonic acid is seen on a MAP and high
leucine on a UAA, consider using low dose Adenosyl
B12 and Biotin. High levels of MMA may be
associated with a maple syrup smell from your urine.
Methylmalonic Acid
MMA may enhance the impact of excess glutamate,
(MMA)
so consider supports to balance glutamate, such
as GABA Balance capsules, Nerve Calm nucleotide blend,
and BeCalm Spray. Excess MMA can react with high
glycine to increase porphyrins. Check glycine on
a UAA. Use SHMT Spray and AHCY/SHMT
compound as needed to help keep glycine in balance.
When MMA is high, limit BCAA support, and
use Adenosyl B12 and Biotin to help with its
 processing.
Xanthurenic acid is related to the processing of
tryptophan. Use a UAA to check that tryptophan
levels are in balance, and consider testing to
determine if sufficient BH4 is present to help convert
tryptophan to serotonin. Also, use a NT test to check
NT levels. Compare the level of xanthurenic acid on
a MAP test to serotonin on a NT test and tryptophan on
a UAA, as this may help indicate if BH4 support is
needed.Xanthurenic acid also suggests a need for
Xanthurenic Acid
more B vitamins, including B6, so consider
using Ultimate B. Xanthurenic acid may increase the
impact of glutamate, so consider supplements to
calm glutamate, including GABA Balance
capsules, Nerve Calm nucleotide blend, and BeCalm Spray.
Consider support for BH4 if the composite of tests
suggest a need for BH4 support. These
include MTHFR A1298C Liver Support capsules, BH4,
and Royal Jelly if you do not have any bee allergies.
3HPA is a precursor to MMA. Excess MMA is due
to the breakdown of branched chain amino acids
(BCAA) of leucine, isoleucine and valine. Limit
BCAA support. Also, consider Adenosyl
B12 and Biotin to help with processing them. See
3-Hydroxyproprionic Acid
additional suggestions listed under MMA above.
(3HPA)
High levels of MMA may be associated with a maple
syrup smell from the urine. MMA may enhance the
impact of excess glutamate, so consider supports to
balance glutamate. These include GABA Balance
capsules, Nerve Calm nucleotide blend, and BeCalm Spray.

Ketosis of any type can cause a non specific

elevation in hydroxyisovaleric acid. With high
hydroxyisovaleric acid, consider support
with Biotin and Adenosyl B12 to help with ketosis, and
run a CSA test and GI Effects test to check on the
processing of fats. Rule out H. pylori as with any case
of suspected ketosis. Use a UAA to be sure that
nutrients are being absorbed. Biotin, Adenosyl
3-Hydroxyisovaleric Acid
B12, MitoForce, and extra Carnitine can be used for
ketosis. Consider BeCalm Spray, GABA Balance
capsules and Nerve Calm nucleotide blend for glutamate
issues related to ketosis. Consider SDE to help with
fat digestion and ACAT/BHMT capsules if needed. If
you are using a diet that can increase ketosis such as
the Specific Carbohydrate Diet or Paleolithic Diet,
be aware that they may contribute to high keto acids.
α-Ketophenylacetic Acid When high levels of these two toxic breakdown
(from styrene) &α- products are found, the function of support systems
Hydroxyisobutyric Acid such as the liver and kidneys may be impaired by
(from MTBE) excess toxin exposure. B12 may play a role in
processing these compounds, so use low dose B12,
and be sure lithium is in balance to help with B12
transport into the cells. Check lithium on
a HMT and UEE prior to adding more B12 than the
low levels found in All in One. Consider Liver Support
nucleotide blend, and MTHFR A1298C Liver Support
capsules. Consider GSH and Quercetin to help with
possible DNA damage, along with the use
of Ultifend, SHMT Spray and AHCY/SHMT
compound supply nucleotides. Also, consider Ora-
Kidney and Kidney Support nucleotide blend.

Orotic acid lies along the biochemical route for

making DNA building blocks. When levels of orotic
acid are high, use ATP to convert the orotic that has
built up into pyrimidines. Also, use SHMT
Spray, AHCY/SHMT compound, and All in One to
supply nucleotides to your system. Excess orotic
acid may be a sign of increased ammonia, so
consider a UAA and address excess ammonia if
needed. Consider CBS/NOS Kidney Support capsules to
Orotic Acid
help ammonia detox.Be sure that methylation
support is in place so that you can produce thymidine
from uridine, which is the next step after orotic acid.
Basic methylation support includes All in
One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide
blend. Once lithium is shown to be in balance on
a HMT, then use low dose Methylmate
A and Methylmate B, along with extra B12.

Pyroglutamic acid is an intermediate

in GSH recycling. There may be too much emphasis
on the BHMT pathway, what I call the short cut, of
the methylation cycle, or not enough entry into the
transulfuration portion when high levels of
pyroglutamic are seen. A UAA can be run to assess
this balance. Ultimate B may be a help in this regard.
Increased gamma glutamyl transferase (GGT) may
Pyroglutamic Acid
also generate pyroglutamic acid. This can be due
to H. pylori, so rule out H.pylori with testing. Be sure
both the long route, the MTR/MTRR pathway, and
the short cut, the BHMT pathway, around the cycle
are supported, as well as using Ultimate B. You can
consider adding low dose GSH. Basic methylation
support includes All in One, Phosphatidyl Serine
Complex (PS/PE/PC) , DHA and Methylation Support
 nucleotide blend. Once lithium is shown to be in
balance on a HMT, then use low dose Methylmate
A and Methylmate B, along with extra B12.

Homogentisic acid is a breakdown product of

tyrosine. Check that BH4 levels are sufficient to
process tyrosine to dopamine. Look at tyrosine on
a UAA and compare that result to the level of
dopamine on a NT test. This may indicate whether or
not tyrosine is being converted efficiently to
dopamine. Without sufficient BH4, excess tyrosine
Homogentisic Acid
may be forming homogentisic acid rather than
dopamine. Decrease Vitamin C, as this may cause a
buildup of homogentisic acid. Also, consider that
BH4 may need to be supplemented, and if so,
support with Royal Jelly if you have NO bee
allergies, MTHFR A1298C Liver Support capsules,
and BH4.
Processing from phenylalanine can cause increases
in 2-hydroxyphenylacetic acid. This can be due to a
lack of BH4, or excess phenylalanine or tyrosine.
Consider a UAA to look at phenylalanine, tyrosine
and the potential need for more BH4. Also, excess
aluminum in your system may be impairing BH4
production. Running a HMT and UTM may indicate if
2-Hydroxyphenylacetic
your aluminum is high. In addition, aluminum may
Acid
be sequestered secondary to bacterial issues, so
consider a CSA test and GI Effects test to look at
microbial balance. A Neopterin / Biopterin Profile Urine
Test should also be considered. If natural support for
BH4 is indicated, consider including Royal Jelly if
you have NO bee allergies, MTHFR A1298C Liver
Support capsules and BH4.
Purpose of running this test:
The Urine Amino Acids Test (UAA) gives you information about amino acids, the building
blocks for the proteins in your body. Essential amino acids are those which must be in your
diet. Your body cannot synthesize these. Non-essential amino acids are those which can
be synthesized from other constituents, given that the substrates necessary for their
formation are present in your body.
The genetic information that is stored and transmitted in the four-letter alphabet and
language of DNA is ultimately expressed in the twenty-letter language of proteins. All
proteins, whether from the most ancient lines of bacteria or from the most complex forms of
life, are constructed from the same ubiquitous set of twenty amino acids, linked in
characteristic sequences. These amino acids are precursor molecules to protein structures
with strikingly different properties and activities. From these building blocks, these relatively
simple subunits, your body makes such widely diverse structures as enzymes, hormones,
antibodies, transporters, muscle fibers, and the lens portion of the eye.
UAA testing gives you a sense of the overall nutrient absorption from your gastrointestinal
tract (GI tract), as well as shows you how well you are doing with the compounds in your
methylation cycle. It measures homocysteine, an important indicator of cardiac health and
pro inflammatory status in your body, and a component of the methylation cycle. It also
measures methionine, taurine, phospholipids, and other compounds which are indicators of
methylation cycle status. It gives you a sense of your ability to make methyl groups by
measuring the level of molecules that need methyl groups to be processed.

This table contains the rationale behind my suggestions.

Amino Acid These suggestions are for your consideration. Defer your
choices to your own health care practitioner, as always.

A high level of creatinine means that your urine is very

concentrated. This may mean that your kidneys are
under additional stress. In this case consider the use
of Kidney Support nucleotide blend, Ora-Kidney, Dandelion
Leaf, Rhodiola, SHMT Spray, AHCY/SHMT compound,
and Zinc Lozenges. If your pH is low, consider using
sodium bicarbonate to help balance the ph as well as to
Creatinine
normalize creatinine levels.Creatinine levels that are
low suggest insufficient methylation and a need for
SAM-e. Low levels of creatine have been associated
with limited language development, so you can
consider using Creatine plus SAM-e. If your creatinine is
chronically high, consider checking your blood sugar
levels.
 High ammonia is closely associated with imbalanced or
abnormal microorganisms in your body, most often in
your GI tract. See Chapter 6 on CSA and GI testing for
approaches you and your doctor can consider in terms
of assessing and addressing microbial imbalances. To
help your body to deal with high ammonia,
consider CBS/NOS Kidney Support capsules, as well
Ammonia
as Carnitine. Consider using Magnesium Citrate, charcoal
flushes, and low dose Yucca as needed.For low
ammonia, increase the protein in your diet.
Use AminoAssist spray and/or AminoAssist capsules. Other
options for increased protein support are the use of Egg
Protein Powder, if you have no egg allergy, or Royal Jelly,
if you have no bee allergy.
For low overall amino acids, either you are not eating
enough protein and/or your GI tract is not absorbing
them well. Consider appropriate diet and supplements
to address amino acid support. Consider a CSA
test and GI Effects test to address digestive issues. You
can also consider running an Intestinal Permeability
Overall Amino Acids test and a Celiac test. Also consider a MAP test to look for
ketosis. For low overall amino acids, consider Egg
Protein Powder, AminoAssist capsules, and AminoAssist
spray for three routes of administration of amino acids.
Also, consider Bowel Support nucleotide blend, VitaOrgan,
and Royal Jelly, if you have no bee allergies. Ora-
Placenta may also be a help to support amino acids.

Methionine is a critical part of your methylation cycle.

Low levels of methionine suggest a need to support
both the long route, the pathway that uses the
MTR/MTRR enzymes, and the short cut, the BHMT
pathway. Methylmate A and short cut support can be
added even if lithium is low. Check that lithium is in
balance on a HMT before adding
extra B12 and Methylmate B for the long route. If you are
adding methionine, be sure you have support for the
methylation cycle in place so you can process the
Methionine methionine and homocysteine that is generated as a
result of methionine support. AminoAssist
spray or AminoAssist capsules can be added for low levels
of methionine. The Muscle Fatigue Support
compound supplement is also a source of low dose
methionine. For methylation cycle support,
consider Phosphatidyl Serine Complex (PS/PE/PC), DHA,
and All in One. This supports the short cut pathway.
Then, Methylmate A can be added, and finally, once
lithium is in balance, add extra B12 and Methylmate B. If
methionine remains low, you can add sprinkles
 of Methionine. Check lithium on a HMT prior to adding
extra B12 or higher levels of Black Bear Spray or Black
Bear Drink, which is a source of B12 and molybdenum.
Alternately, high methionine is sometimes seen in those
who are ACAT+. The use of ACAT/BHMT capsules may
help to restore methionine to healthy, balanced levels.
High levels of methionine have been reported to cause
increased tryptophan levels, as well as lower serotonin
and GABA. Theoretically, this is due to competition for
B vitamins, in particular B6 or P5P. Therefore, if
methionine levels are high, consider using Ultimate B,
and check tryptophan on a UAA, as well as the relative
levels of glutamate to GABA.
Lysine is often used to help with Herpes cold sores.
Alternate supports for this can include alternating IMF
1, IMF 2, and IMF 6, or topical Clear Skin spray, to help
lower the level of lysine support needed. In addition,
some studies suggest that lithium may be a help for
Herpes (Amsterdam, 1996). Lysine can impact calcium
absorption and retention. Consider a UEE and HMT to
look at calcium levels when lysine is being
supplemented, or when lysine levels are significantly
out of balance. AKAA may lead to high Lysine, so
check AKAA levels on a MAP test. If lysine levels are
high, yet alpha amino adipic acid is low,
consider Ultimate B and/or low dose P5P, as lysine
intermediates that build up prior to alpha amino adipic
acid can inhibit P5P. If ornithine, cysteine, and
carnosine are high along with lysine, then rule out
dibasic-aminoaciduria. The use of low dose Citrulline as
well as adequate methylation support may help in this
Lysine
case. Rerun a UAA after 4 to 8 weeks to be sure that
these dibasic amino acids are in better balance. High
oxaloacetate can convert to high lysine and high
threonine. If both lysine and threonine are high,
consider a MAP test and addressing oxalates. Pay
attention to B12 levels and lithium for B12 transport if
oxalate issues are suspected. B vitamins can be a help
in processing lysine. Consider Ultimate B and/or add
each of the B vitamins individually
including NADH, Riboflavin-5-Phosphate, B12, and Vitamin
PQQ. Vitamin PQQ is a new B vitamin and is included
in Ultimate B. Ultimate B includes a natural support for
PQQ. For energy, consider CoQ10, Carnitine,
and MitoForce. Chervil is another possible source of PQQ
as well as a source of vitamin A.For low overall amino
acids, support with diet and supplements, and consider
a CSA test and GI Effects test to look for imbalances in
your digestive tract and fatty acid processing.For low
 overall amino acids, consider Egg Protein
Powder, AminoAssist capsules, and AminoAssist spray for
three routes of administration of amino acids. Also,
consider Bowel Support nucleotide blend, VitaOrgan,
and Royal Jelly if you have no bee allergies. Ora-
Placenta may also be a help to support amino acids.

High threonine may be associated with high oxalates,

so consider running a MAP test. Because high
oxaloacetate can convert to both lysine and threonine if
both lysine and threonine are high, a MAP test would
be suggested, as well as addressing oxalates if they are
an issue. Pay attention to B12 levels and lithium for
B12 transport if oxalate issues are present. See the
suggestions for addressing high oxalate and oxalic acid
in Chapter 4. Low threonine may be associated with
Clostridia, Pseudomonas, E.coli or Klebsiella. You can
consider ruling out these microbial issues with a MAP
test, CSA test, and a GI Effects test. Threonine can be
supportive for your immune system. If threonine levels
are low, use T cell and B cell support capsules for immune
support. If your threonine is high, decrease any added
threonine support. Increase B12 once lithium is checked
on a HMT because low B12 may be a factor. Also,
Threonine
check leucine levels on this UAA, as high leucine in the
absence of high isoleucine or valine, may indicate a
need for phosphate. Low phosphate, in turn, can impact
alpha KG and oxalates. This is discussed in Chapter 4 on
the MAP test in the section on oxalates. High threonine
is indirectly related to high oxalate, so
consider ATP and B12. Increased threonine can also
raise 3 methylhistidine. If microbes are an issue,
consider herbal microbial support such as Naturomycin
Spray, Naturomycin capsules, and grapefruit seed
extract (GSE capsules or GSE liquid). Bay
leaf, Paradex, Mycoceutics can also be considered,
depending upon the organisms found. You can also
consider the full Clostridia program for these
organisms. BactiSolve can be considered if you have NO
shellfish allergies, EDTA soap or soak daily, along
with Malic Acid.
Leucine, isoleucine and valine are all branched chain
amino acids. Generally the levels of all three will track
together, so if one is high all three will generally be
high, if one is low all three will generally be low. If the
Leucine
three BCAAs, leucine, isoleucine, and valine, are all
high, then consider Adenosyl B12 and Biotin to help
process them, or use Black Bear Spray and Biotin. There
are certain instances in which the level of only one of
 the three is impacted. If phosphate is low, then only
leucine may be increased, but not isoleucine or valine.
High leucine, in turn, may increase glutamate, which
may increase alpha KG, which may cause
hypoglycemia. So, check phosphate levels
on UEE and HMT, and check alpha KG on a MAP. If
leucine alone is high, then consider ATP and Riboflavin-
5-Phosphate to support phosphate levels. Also, check for
signs of ketosis on a MAP test when high levels of
leucine, isoleucine or valine are noted, as the ketoacids
of these amino acids are present on the MAP test. The
combination of high levels of one or more of the BCAA
on this UAA with high levels of ketoacids on a MAP
would suggest possible ketosis and the need to adjust
diet as well as consider supporting with Adenosyl
B12, Biotin and Special Digestive Enzymes. Specific issues
with the breakdown of leucine may cause an overall
body odor that smells like “sweaty feet”. Low levels of
leucine, its ketoacid AKIC, and low levels of BCAAs in
general, may be a factor in absence seizures. If levels of
AKIC on a MAP are very low, along with low levels of
leucine or BCAAs on this UAA, then consider BCAA
support and AminoAssist capsules, again being sure there
is no maple syrup smell in your urine due to too much
support. This is important because high levels of
BCAAs and their respective ketoacids have been
implicated in depletion of mitochondrial energy which
has significant negative effects. If all three BCAAs are
low, then consider low dose BCAA support. Be sure
there is no maple syrup smell coming from your urine.
If a maple syrup smell is present, then discontinue
BCAA support. Be sure that you have
sufficient Adenosyl B12 and Biotin in place before adding
any BCAAs back. Lack of BCAAs can be a factor in a
number of neurological symptoms, including some
cases of Bell’s Palsy.For overall low amino acids,
consider Egg Protein Powder, AminoAssist
capsules and AminoAssist spray for three routes of
administration. Also Bowel Support nucleotide
blend, VitaOrgan, and if you have no bee allergies, Royal
Jelly. Ora-Placenta may also help to support amino acids.

Leucine, isoleucine and valine are all branched chain

amino acids. Generally the levels of all three will track
together, so if one is high all three will be high, if one is
low all three will be low. If the three BCAAs, leucine,
Isoleucine
isoleucine, and valine, are all high, then
consider Adenosyl B12 and Biotin to help process them,
or use Black Bear Spray and Biotin. However, there are
certain instances in which the level of only one of the
 three is outside of the normal range. If only isoleucine
is high, and not leucine or valine, it may be due to high
oxaloacetate, which may indicate a need for more B12.
Also look at suggestions for oxalates in Chapter 4 on the
MAP test. If all three BCAAs are low, then use low
dose BCAA support. Be sure there is no maple syrup
smell coming from your urine. If a maple syrup smell is
present, then discontinue BCAA support. Be sure that
you have sufficient Adenosyl B12 and Biotin in place
before adding any BCAAs back. Lack of BCAAs can
be a factor in a number of neurological symptoms,
including some cases of Bell’s Palsy. Low levels of
BCAAs, in particular low levels of leucine, may be a
factor in absence seizures. If levels of BCAAs are very
low, along with low levels of isoleucine, then
consider BCAA support and AminoAssist, again being
sure there is no maple syrup smell coming from your
urine due to too much support. This is important
because high levels of BCAAs and their respective
ketoacids have been implicated in depletion of
mitochondrial energy which has significant negative
effects. For overall low amino acids, consider Egg
Protein Powder, AminoAssist capsules and AminoAssist
spray for three routes of administration. Also Bowel
Support nucleotide blend, VitaOrgan, and if you have no
bee allergies, Royal Jelly. Ora-Placenta may also help to
support amino acids.
Leucine, isoleucine and valine are all branched chain
amino acids. Generally the levels of all three will track
together, so if one is high all three are high, if one is
low all three are low. However, there are certain
instances in which the level of only one of the three is
outside of the normal range. If only valine is high, it
may be due to high pyruvate, so
consider MitoForce and Ultimate B. In addition, if only
valine is high, consider using ACAT/BHMT capsules to
help with processing Co A, because valine is not
moving to leucine and Isoleucine. If all three BCAAs
Valine
are high, then consider Adenosyl B12 and Biotin to help
process them. Alternately, you can use Black Bear
Spray and Biotin. If all three BCAAs are low, then
consider low dose BCAA support. Lack of protein in the
diet leads to a general lack of all amino acids. Certain
neurological syndromes may indicate low BCAAs, such
as trigeminal neuralgia, Bell’s Palsy, and TMJ, among
others. Be sure there is no maple syrup smell coming
from your urine. If a maple syrup smell is present, then
discontinue BCAA support. Be sure that you have
sufficient Adenosyl B12 and Biotin in place before adding
 any BCAAs back.For overall low amino acids,
consider Egg Protein Powder, AminoAssist
capsules and AminoAssist spray for three routes of
administration. Also Bowel Support nucleotide
blend, VitaOrgan, and if you have no bee allergies, Royal
Jelly. Ora-Placenta may also help to support amino acids.

A “musty odor” emanating from your body can be a

sign of excess phenylalanine. High levels of
phenylalanine have a range of neurological
consequences, so limit your ingestion of aspartame
even if your phenylalanine is not high. High
phenylalanine may signal a need for more BH4,
because BH4 helps to convert phenylalanine to tyrosine
and then to dopamine. Especially if tryptophan,
tyrosine, and phenylalanine are all high,
consider MTHFR A1298C Liver Support capsules, along
Phenylalanine with BH4. If you have no bee allergies, you can also
consider Royal Jelly. You can consider running
a Neopterin / Biopterin Profile Urine Test to get your
biopterin level as an additional indicator for a need for
BH4 support. Pay special attention to aluminum on
a HMT and a UEE, because aluminum has a negative
impact on BH4 levels. Check that bacterial imbalances
are not an issue, as this may cause increased aluminum
levels, which in turn may reduce BH4. Also, consider
using MetalAway to help with healthy BH4 levels and to
address aluminum.
High tryptophan, along with phenylalanine and
tyrosine, may signal a need for more BH4, because
BH4 helps to convert phenylalanine, tyrosine, and
tryptophan into dopamine and serotonin respectively.
Consider using MTHFR A1298C Liver Support
capsules along with BH4. If you have no bee allergies,
you may use Royal Jelly. If tryptophan is either too high
or too low, consider running a NT test to check on
serotonin, and a MAP test to look at the breakdown
products from serotonin, such as 5HIAA. The approach
Tryptophan I use when looking at tryptophan is to look at the
balance between the available starting material for
serotonin production, i.e., tryptophan, in conjunction
with the actual levels of serotonin on a NT test,
counterbalancing these two values with the level of
serotonin breakdown products on a MAP. This gives
me a picture of what is going on with serotonin, the
serotonin turnover, as opposed to just looking at the
level of tryptophan or of its neurotransmitter, serotonin.
Low serotonin has been implicated in OCD behaviors,
as well as depression. When niacinamide levels are too
 low, it can cause the breakdown of tryptophan, so
consider using Ultimate B, NADH and/or Niacinamide.
There is a delicate balance with respect to tryptophan
breakdown and vitamin B3 levels which can be affected
by bacteria. One of the breakdown products from
tryptophan, kynurenic acid, is calming, but in the
presence of B6 or pyridoxal-5-phosphate, kynurenic
acid will convert to quinolinic acid, which is an
excitotoxin. I have suggestions for dealing with high
quinolinic acid in the quinolinic acid section of the
MAP test description in Chapter 4. Conversely, high
levels of methionine may deplete B6 and cause high
levels of tryptophan with less conversion to
serotonin. Ultimate B is a low dose source of B6 that can
be used for support. Also, a Neopterin / Biopterin Profile
Urine Test can be run, as well as looking for indicators
for BH4 support on a MAP test. High methionine is often
seen for those who are ACAT +, in these cases the use
of ACAT/BHMT capsules may also help to get methionine
in better balance, which in turn can impact tryptophan.
Pay special attention to aluminum on a HMT and a
UEE, as aluminum may further reduce BH4 levels.
Check that bacterial imbalances are not an issue, as they
may relate to high aluminum, which in turn reduces
BH4 production. Also, consider using MetalAway to
help enhance BH4 levels and to address aluminum.For
low tryptophan, you can consider Egg Protein
Powder, AminoAssist capsules, AminoAssist spray, and low
dose SeroMood as needed.

For low taurine, be sure full methylation cycle support is in

place. Basic methylation support includes All in
One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide blend.
You may also use low dose Methylmate A while working to get
lithium in balance. Once lithium is shown to be in balance on
Taurine a HMT, then consider low dose Methylmate B, along with
extra B12. High taurine may affect body temperature. High
taurine, along with high levels of alanine and serine, have been
implicated in lowering body temperature. The mechanism by
which this temperature lowering effect occurs is not well
defined. Theories put forth include the inhibitory impact of high
taurine on the hypothalamus, on inhibitory properties that may
play a positive role in seizure regulation, or because high
taurine may inhibit GABA transport. It is also possible that
hydrogen sulfide, which is generated from high taurine, is the
pathway by which it lowers body temperature. High levels of
taurine can put pressure on the remainder of the transulfuration
pathway, creating a need for Molybdenum and B12 in order to
process toxic sulfur groups. If taurine levels are high, stop any
added high dose taurine. The amount of taurine in All in One is
not high dose. Some low level taurine is important in terms of
helping to balance your system and aid in reducing possible
seizure activity. If you are not adding taurine, yet levels are
above the 84th percentile, then consider low dose CBS+
nucleotide blend. Those who are CBS C699T, CBS A360A, or
CBS 212 may tend toward high taurine levels. This can cause
problems with sulfur processing and potentially deplete B12
and molybdenum. High levels of taurine also can cause low
levels of GSH. So, in addition to low dose CBS+ nucleotide
blend, also consider using GSH. Rerun a UAA 6 to 8 weeks
after starting CBS+ nucleotide blend to be sure your taurine is
in the normal range. As always, work with and defer to your
own doctor when working on taurine levels. Also consider
checking zinc levels, because increased taurine may lead to low
zinc. Low zinc can throw off your zinc/copper ratio and may
affect your ability to pay attention. Also, low zinc is a particular
issue for adolescent males, as that group needs more zinc. Low
zinc is also an issue for those with high levels of cadmium, as
cadmium can replace zinc in important reactions in your
body.Taurine may also be elevated due to infection. TNF alpha,
an important inflammatory mediator, can increase CBS enzyme
activity, which in turn may increase taurine. If you are not
adding taurine, and you have no specific CBS SNPs (A360A,
C699T, or 212), yet taurine is still high, then infection may be
the cause. In this case your GI tract is the first place to look, so
consider running a CSA test and a GI Effects test.Excess
taurine may increase hydrogen sulfide (H2S) that is also
produced in the in the transsulfuration pathway. H2S increases
NMDA receptor responses which may cause over excitation of
nerves. You can consider using Nerve Calm nucleotide
blend, BeCalm Spray, and GABA Balance capsules if needed.
H2S is catabolized by thiosulfate reductase in the mitochondria.
The sulfite generated is then oxidized to sulfate by sulfite
oxidase (SUOX), which can be helped
by B12 and Molybdenum support. Low dose Ion Transport
compound and/or low dose Wasabi may be helpful for
thiosulfate processing.H2S can trigger potassium dumping, so
consider checking a HMT and UEE, especially because low
potassium can be a factor in aggression.Potassium needs to be
supported when you are taking lithium.H2S can also cause
direct DNA damage, so if taurine is very high, consider a 8-
hydroxydeoxyguanosine (8-OHdG) test for DNA damage.
Support with Quercetin and Ultifend may be helpful if DNA
damage is a concern. H2S can also deplete glutathione, which
may already be low because of high taurine. Low glutathione
can free up iron, which may increase problem gut bugs because
iron drives bacterial virulence. So, consider SHMT support for
iron issues. High levels of H2S have also been found in Down’s
syndrome.Increased H2S can be found in Postural Orthostatic
Tachycardia Syndrome (POTS), so consider addressing H2S, as
well as support for nitric oxide. The nitric oxide supports can
include Arginine and/or Citrulline, depending on their levels on
your UAA test. You also can consider BH4 support for optimal
nitric oxide cycle function. Low nitric oxide has been
implicated in some cases of POTS.High taurine may also have
an inhibitory effect on GABA transport.For those with the more
rare condition of Huntington’s Disease (HD), consider that HD
genes interact with the CBS gene and may cause high taurine
because of this. Also, trehalose may help with the glutamate
that is produced secondary to HD. BeCalm Spray and Nerve
Calm nucleotide blend may also be helpful.
Again, work with your doctor on taurine levels that are too
high. Consider the use of low dose CBS+ nucleotide blend. It is
important to rerun a UAA 6 to 8 weeks after starting CBS to
check that taurine levels are in a normal range.
Finally, I want to take a few moments to explain more
thoroughly the science behind these CBS SNPs. This can be
such a critical SNP that it is important to understand the logic
regarding increased CBS activity from these mutations (C699T,
A360A and CBS 212), as they have the capacity to ‘drain’
intermediates from the methylation cycle, put pressure on
sulfite processing, as well as decrease glutathione levels.
There has been some confusion regarding CBS “upregulations”.
This may be in part because many SNPs impair the function of
an enzyme. In the case of these particular CBS SNPs, these
mutations increase the activity of the enzyme, rather than
impairing it, as is the case with many mutations.
When someone is CBS C699T + or ++, it is easy to see the
impact of that “upregulation” by methionine loading and then
running a UAA test. You will see taurine levels that are very,
very high. Many of those who are CBS C699T + will actually
show extremely high taurine even in the absence of methionine
loading, or with simple basic methylation support. I do not use
or recommend methionine loading, but I mention this if you
want to see for yourself the impact of that SNP.
According to published, peer reviewed literature, the C699T
mutation is what is known as a silent mutation. The change at a
molecular level from a C to a T, does not cause a change in the
amino acid sequence, so it is considered a synonymous or silent
mutation. Often silent mutations either have no impact or are
regulatory in nature. Part of the reason I choose this SNP, as
well as A360A and CBS 212 for my panel, is that I am most
interested in regulatory mutations. Clearly CBS C699T has an
impact which is very obvious in terms of taurine levels on a
UAA after methylation support or methionine loading. The
methionine loading effect may not be observed for those who
are MTHFR C677T + or ++, and in this case 5 methyl THF
loading would show the effect.
Studies looking at the C699T and A360A SNPs, suggest that
they are in fact changes that increase CBS activity. “…The
699C–>T and 1080C–>T (A360A) polymorphisms may be in
linkage disequilibrium with regulatory elements
that upregulate CBS gene transcription.” (Aras, et al Clinical
Genetics, 58: 455–459, 2000). Additional literature reinforces
the concept that CBS C699T+ or ++ has the ability to increase
enzyme activity because CBS C699T+ is in “strong linkage
disequilibrium” with regulatory elements, which is logical since
it is located in the gene’s promoter region. More specifically,
CBS C699T+ is suggested by articles to be in strong linkage
disequilibrium with the 68 bp insert that causes an increase in
CBS activity. According to Fredrikson et al, “Our observation
that the 68 bp insertion is in strong linkage disequilibrium with
the CBS c699T is in accordance with earlier reported
data…Thus the metabolic phenotype of the CBS c699T
polymophism is similar to that of the 68 bp insertion” (Hum.
Mutat., 28: 856–865, 2007).
Studies state that the 68bp insert causes alternate splicing of the
gene such that a shorter final product is produced. The shorter
construct has been stated to be “constitutively” active, which
means it is constantly active. (Shan Hum Mol Genet. Mar
15;10(6):635-43,2001). Thus, increased activity would be
expected to result in higher taurine and lower homocysteine,
which is what is observed for the 68 bp insert, as well as the
C699T mutation. (Kruger et al, Mol Genet Metab.
 May;70(1):53-60, 2000)
Furthermore, literature indicates that the 68bp insert counteracts
the increase in homocysteine due to the MTHFR C677T
mutation. This fits with an increase in CBS activity for those
with the 68bp insert that in turn is in linkage disequilibrium
with the C699T mutation. (De Stefano, Ann Hum Genet. 1998
Nov;62(Pt 6):481-90.

If only cysteine is high, be sure there is sufficient

support in the transsulfuration pathway for the
processing of sulfur groups. These supports consist
of B12 and Molybdenum, Black Bear Spray or Black Bear
Drink. Check that lithium is in balance on a HMT before
building up the dose of B12.Cysteine processing can
ultimately produce pyruvate that feeds into the Krebs
cycle. Be sure that sufficient B complex, such
as Ultimate B, is in place to allow pyruvate to enter the
Krebs cycle. This can be followed on a MAP test. If
ornithine, lysine, and carnosine are all high in addition
to cysteine, then consider and rule out dibasic
Cysteine
aminoaciduria. The use of low dose Citrulline, as well as
adequate methylation support, may help in this case.
Rerun a UAA after 4 to 8 weeks of support to be sure
that these dibasic amino acids are in better balance. If
cysteine is low, then consider methylation cycle
support. Basic methylation support includes All in
One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide
blend. Methylmate A can also be added before lithium is
in balance. Once lithium is shown to be in balance on
a HMT, then use low dose Methylmate B, along with
extra B12.
Excess arginine can be generated from urea cycle
activity. If this is the case and arginine levels are high,
then consider MTHFR A1298C Liver Support capsules, as
well as BH4. Also, excess arginine excretion can be
seen in some cases of H. pylori infection. Rule out H.
pylori with testing, and look for other symptoms of H
pylori, including high levels of suberic on a MAP test,
Arginine
wide swings in pH on a CSA test and GI Effects test, and
direct H. pylori testing. If lysine is being supported, as is
often the case in the presence of Herpes, then balance
any lysine support with an equal amount of arginine
support, as lysine can antagonize arginine levels. Look
at creatinine levels if arginine is high, because arginine
from the urea cycle is available to produce creatinine. If
 creatinine is very high, then consider kidney support:
low dose Kidney Support nucleotide blend, Ora-Kidney, and
dandelion leaf. Include SHMT support and Rhodiola.
Increased urea cycle activity can cause increased levels
of aspartate. Aspartate can then feed into the Krebs
cycle to increase the level of oxaloacetate, which
converts into oxalic acid. High aspartate can also result
in elevated beta alanine. Beta alanine leads to increased
levels of carnosine and anserine. Elevated histidine due
to decreased tetrahydrofolate (THF) also increases the
formation of anserine. See notes on Chapter 4, the MAP
test, for suggestions for high oxalate. Arginine may
have a positive impact on potassium levels. Those who
struggle with consistently low potassium, especially
athletes, may consider low dose arginine support if
levels of arginine are low. Arginine and citrulline both
can help to produce nitric oxide in your body, provided
that there is sufficient BH4 present in your system.
Extremely low levels of nitric oxide have been
associated with aggressive behavior in animal models,
and nitric oxide can impact blood pressure, so maintain
normal, healthy levels, as opposed to extremely high or
low levels. Using 5-methyl THF as in Methylmate B has
been reported to help with healthy nitric oxide levels by
helping to support nitric oxide synthase (NOS). Low
nitric oxide has been implicated in some cases of
Postural Orthostatic Tachycardia Syndrome (POTS). In
addition, the combination of low nitric oxide and
increased H2S is found in POTS, so consider
addressing both H2S as well as nitric oxide.Lack of
arginase activity can also elevate arginine levels.
Arginase requires manganese for activity, so check
manganese levels on
a UEE and HMT. Glucosamine/Chondroitin Plus is a good
source of manganese, as well as a source of support for
your GI tract lining.High levels of arginine may be
associated with muscle stiffness, and in extreme cases,
developmental delay and mental retardation. Some
articles suggest a see saw relationship between arginine
and alpha KG. If arginine is very high or low, check
that alpha KG is in balance on a MAP test.
Low tetrahydrofolate (THF) levels can cause elevated
histidine. Elevations in histidine, in turn, cause
increased levels of anserine and carnosine. So, high
histidine along with high anserine and carnosine may
Histidine
indicate a need for THF. Consider using All in
One or Ultimate B. In addition, check FIGLU levels on
a MAP test, as FIGLU will also climb If there is not
sufficient THF. Thus, high FIGLU may be an indirect
 sign of excess histidine. High levels of histidine may
depress the levels of other amino acids, as well as be
related to high cholesterol. A GI function test can be run
to look at cholesterol levels. In addition, high histidine
can translate to increased histamine, which is a factor in
allergic reactions and inflammation. This can be
exacerbated by low copper, because copper is needed
for mono amine oxidase (MAO) activity, which breaks
down histamine. Also, check taurine, because high
taurine may indicate increased CBS enzyme activity.
Increased CBS activity can generate excess H2S, which
may decrease MAO enzyme activity and the breakdown
of histamine. This may increase histamine
levels. Quercetin can help with high histamine, but
quercetin can inhibit COMT, so this can be non-optimal
for those who are COMT ++ who have slow COMT
activity. Cherries are a natural source of quercetin, but
while cherries may help with inflammation and some
forms of arthritis, high quercetin levels may cause
problems for those who are COMT ++. Licorice can
also inhibit MAO, so along with low copper and high
H2S, licorice may reduce the breakdown of histamine,
allowing higher levels to accumulate. If allergic
reactions are an issue, low dose Hyper-Balancing
nucleotide blend can be considered.

High alanine may be due to lack of ATP, NADH, and/or

B complex to move it along in its conversion to
pyruvate for entry into the Krebs cycle. See Chapter 4 on
MAP testing for more on this topic. Consider
using MitoForce, Ultimate B, and/or Riboflavin-5-Phosphate.
High alanine may also be due to excess 5HTP or
tryptophan support, as tryptophan can breakdown to
alanine. Alanine feeds into pyruvate for the Krebs
Alanine
energy cycle, so if pyruvate is low on a MAP test, it
may be related to low levels of amino acids in general,
and alanine in particular. Alanine may be useful support
for ketosis, especially post exercise ketosis. Markers for
ketosis can be checked on a MAP test. In some cases, a
sweet, fruity smell to the breath is an indicator of
ketosis. AminoAssist includes alanine in its propriety
blend of amino acids.
In the presence of ammonia, aspartate converts to
asparagine. So, if aspartate is low and asparagine is
high, consider support to address ammonia. Low
Aspartate & Asparagine dose CBS/NOS Kidney Support capsules (NOT the
nucleotide blend) may be helpful. With low levels of
ammonia, aspartate may increase. Aspartate can then
feed into the Krebs cycle to increase the level of
 oxaloacetate and oxalic acid. If aspartate, asparagine
and threonine are all high, this suggests high
oxaloacetate/oxalic acid, which in turn suggests that
you may need B12 support. Check cobalt and lithium
on a UEE and a HMT. Support B12 and lithium as
needed, using All in One, BeCalm Spray, and a source of
B12. High aspartate can also result in elevated beta-
alanine. Elevated beta-alanine leads to increased levels
of carnosine and anserine. So high levels of beta-
alanine, carnosine and anserine on a UAA may be
related to a need to address aspartate. Along with
glutamate, aspartate is an excitotoxin that can over
excite nerves. Aspartame, the artificial sweetener,
increases your levels of aspartate. Supplementation to
address high aspartate is similar to that for high levels
of glutamate. Consider support to address aspartate as
an excitotoxin, such as Nerve Calm nucleotide blend, Be
Calm Spray, and GABA Balance capsules. High asparagine
or aspartate may be due to a lack of ATP, NADH, and
B complex. Consider
using ATP and NADH or MitoForce, along with Ultimate
B. Also, eliminate sources of aspartate and
aspartame. Supplement to decrease glutamate and increase
GABA if they are unbalanced.

Excess glutamate can over excite your nerve cells,

causing excitotoxicity. I have spoken and written about
this in many places. The levels of both glutamine and
glutamate need to be considered when looking for
causes of excitotoxicity, because they convert into one
another. The enzyme glutaminase converts glutamine
into glutamate, and in the presence of ammonia and
ATP, glutamate is converted back into glutamine. The
supplements that may help with glutamate/GABA
balance are Nerve Calm nucleotide blend, Be Calm Spray,
and GABA Balance capsules. Valerian root may be helpful
in conjunction with GABA. Pycnogenol, Grape Seed
Glutamine & glutamate Extract and Resveratrol may also be used.
Support Carnosine if your levels are low,
because carnosine may decrease glutamate transport into
the cells. Jujube & CoQ10 may also help control excess
glutamate. KuShen tea is also reported to help with
excess glutamate. Eliminate sources of glutamate and
excitotoxins. Also, check a HMT and UEE for the levels
of minerals that help with glutamate and calcium
balance, such as Zinc, Magnesium, and Lithium.
According to the literature, creatine may help pull down
glutamate, so consider Creatine support if your
creatinine levels are low. If your level of phosphate is
low, then leucine may be increased, which, in turn, may
 increase glutamate and alpha KG, and be associated
with hypoglycemia. Check hydroxyproline levels. High
hydroxyproline can increase glycine and glutamate.
When glutamate is high, then glycine can exacerbate
the effects of glutamate, so check glycine levels.
Use SHMT support as needed to help with glycine
balance. H2S increases NMDA receptor responses, so it
is important to check taurine levels to be sure there is
not too much generation of H2S from taurine. See
suggestions for balancing high taurine levels if this is
an issue. Be sure there is
sufficient Molybdenum and B12 to process sulfites. You
can use Black Bear Spray or Black Bear Drink for low dose
molybdenum and B12 support. Check lithium before
adding high dose B12.High levels of thyroxine (T4)
inhibit glutamate dehydrogenase, which turns glutamate
into alpha KG. This can increase glutamate levels and
decrease alpha KG. T4 is contained in Synthroid and
other prescription thyroid. Consider a CSA test and GI
Effects test because imbalances in gut microbes can also
affect thyroid hormone production.
Cystine is the oxidized form of cysteine, so high cystine
may indicate both high levels of cysteine and pro
oxidant conditions in your body.
Consider Ultifend and NADH, as well as other anti-
oxidants such as Spirulina and Pycnogenol to help with
Cystine oxidation. Less cystine or cysteine relative to serine has
been noted in some cases of psychosis. A high serine to
cysteine ratio, 1.5 to 1 versus 1 to 1, was noted in the
literature to be associated with psychosis. Consider
running an Oxidative Damage test when high levels of
cystine are seen.
If either serine or glycine are higher than most other
amino acids, consider SHMT support. Also, limit iron,
and consider using All in One as a low dose source of
nucleotides. When high glycine is observed it is also
important to check the levels of methylmalonic acid
(MMA), succinate, and benzoic acid on a MAP
test. Excess levels of glycine can combine with benzoic
to form hippuric acid (benzoic acid is used as a food
Glycine
preservative and is naturally found in a number of foods
especially berries). While increased hippuric acid in the
urine is generally accepted to be due to microbial
issues, it can also be due to reactions that can occur
secondary to high glycine (combining with benzoic in
the system) to produce excess hippuric acid. MMA
converts to succinate in the presence of B12. When
succinate combines with glycine it generates
 porphyrins. Thus increased levels of MMA and/or
succinate can ultimately lead to increases in
biochemical porphyrin products after reaction with
excess glycine. If high levels of porphyrins are seen on
a porphrin test it is important to check glycine levels to
determine if high glycine along with high citric acid
intermediates (ie succinate) are the actual source of the
high porphyrins. Keep in mind that certain nutritional
supports will also increase glycine levels which in turn
may influence the levels of biochemical products such
as hippuric and prophryrins. High levels of support with
trimethylglycine (TMG), or the direct supplementation
with glycine may increase both glycine and sarcosine,
which can in turn increase porphyrin and hippuric acid
levels. TMG is also called betaine, which is contained
in the digestive support Betaine HCl.
Tyrosine is important in the formation of dopamine, a
NT which plays a critical role in attention, focus,
reward motivated behavior, as well as mood. Cross
check your levels of tyrosine with dopamine on a NT
test, and with the break down products of dopamine on
a MAP test for an overall sense of the status of the
pathway from tyrosine to dopamine. For low tyrosine
levels, consider AminoAssist support. If needed, you can
Tyrosine
consider low dose support for dopamine. High levels of
tyrosine may generate a smell of “cabbage” from your
body. High levels of tyrosine may indicate a lack of
BH4 which is needed to convert tyrosine to dopamine.
Suspect a lack of BH4 particularly if tryptophan and
phenylalanine are also elevated. Low dose BH4 as well
as MTHFR A1298C Liver Support capsules may be a help
when this is the case.
If either serine or glycine are higher than most other
amino acids, consider SHMT support. Also, limit iron,
and consider All in One as a low dose source of
nucleotides. High levels of 5,10methylene THF may
Serine cause increases in serine. This should be kept in mind,
because imbalances in serine may be a factor in some
cases of psychosis. Less cysteine or cystine relative to
serine has been observed in psychosis. A serine to cysteine
ratio of 1.5 to 1 versus 1 to 1 was noted in the literature to
be associated with psychotic thought disorder.

Excess proline can convert to glutamate, so be sure you

are not using excessive proline support. If glutamate is
high along with proline, consider Nerve Calm nucleotide
Proline
blend, Be Calm Spray, and/or GABA Balance capsules. Also,
be sure that magnesium is higher than calcium and zinc
is higher than copper on a UEE or HMT. Both zinc and
 magnesium can help to balance calcium, which can
exacerbate glutamate toxicity. Also, check that lithium
is in balance on a HMT.
Often the levels of ethanolamine are high for those who
are ACAT+, so consider ACAT/BHMT capsules and/or
low dose Cholacol when this is the case. Also, you can
consider using Policosanol, Riboflavin-5-
Ethanolamine
Phosphate, ATP, SAM-e, and/or MitoForce when
ethanolamine is high.For low levels,
consider Phosphatidyl Serine Complex (PS/PE/PC) as well
as SAM-e.
High levels of lysine, too much lysine support, or not
enough alpha KG, may cause high alpha
aminoadipate. Ultimate B may help in balancing this
pathway. Check alpha KG levels on a MAP test and see
suggestions for alpha KG support if indicated by the
values found there. Also, Ultimate B serves as a source
of low dose vitamin PQQ, which may help with
lysine/alpha aminoadipate balance. Alpha aminoadipate
may inhibit the enzymes glutamine synthetase and
gamma-glutamylcysteine synthetase. Thus, high levels
Alpha Aminoadipate of alpha aminoadipate may cause increases in glutamate
and decreases of GSH. It may also cause tryptophan to
rise. In addition, alpha aminoadipate has been reported
to decrease the level of kynurenic acid, which is
calming and helps to modulate excitotoxins, as well as
to help with seizure activity. Since alpha aminoadipate
may lower kynurenic acid levels, consider using Nerve
Calm nucleotide blend and Be Calm Spray when alpha
aminoadipate levels are high. If lysine levels are high, yet
alpha aminoadipate is low, consider using Ultimate
B and/or low dose P5P, because lysine intermediates that
build up prior to alpha amino adipate can inhibit P5P.

High levels of aspartate may cause increases in beta-

alanine. High levels of beta-alanine may also be due to
too much carnosine. A high ratio of uridine to
thymidine in your body may also lead to high levels of
beta-alanine. Lack of methylation capacity in your body
results in your having too few methyl groups. This may
generate more uridine relative to thymidine in your
Beta-alanine system. Thymidine is 3-methyl uracil, uracil that has
been methylated at the 3 position. Use methylation
cycle support to address this.Basic methylation support
includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA, and Methylation Support nucleotide blend.
Low dose Methylmate A can be added before lithium is
in balance. Once lithium is shown to be in balance on
a HMT, then use low dose Methylmate B along with
 extra B12. Beta-alanine may compete with GABA
transport, so consider using Be Calm Spray and GABA
Balance capsules, particularly if GABA levels are low
along with high beta-alanine. Low levels of beta-
alanine may indicate a need for low dose Carnosine, as
well as low dose Muscle Support nucleotide blend.
Beta-aminoisobutyrate is a breakdown product of
thymidine. Excess thymidine may be secondary to
SHMT imbalance, and can also lead to high levels of
beta aminoisobutyrate. SHMT enzyme activity may be
increased due to iron, so check iron levels on
a HMT and UEE. Consider using SHMT
Spray and AHCY/SHMT compound. Also use basic
Beta-aminoisobutyrate
methylation support, which includes All in
One, Phosphatidyl Serine Complex (PS/PE/PC), DHA,
and Methylation Support nucleotide blend. Low
dose Methylmate A can be added before lithium is in
balance. Once lithium is shown to be in balance on
a HMT, then use low dose Methylmate B along with
extra B12.
Increased levels of carnosine and anserine may be due
to high beta-alanine. High beta-alanine may be due to
excess aspartate. So, check to see if aspartate is high
when you have high carnosine or anserine. Consider
support to help address aspartate if it is high. Supports
can include Nerve Calm nucleotide blend, Be Calm Spray,
and GABA Balance capsules. High aspartate may also be
due to a lack of ATP, NADH, and B complex. Consider
using ATP and NADH or MitoForce, along with Ultimate
B. Also, eliminate sources of aspartate and
aspartame. Supplement to decrease glutamate and increase
GABA if they are unbalanced. A high ratio of uridine to
thymidine in your body may also lead to high levels of
beta-alanine. Lack of methylation capacity in your body
Anserine & Carnosine
results in your having too few methyl groups. This may
generate more uridine relative to thymidine in your
system. Thymidine is 3-methyl uracil, uracil that has
been methylated at the 3 position. Use methylation
cycle support to address this. Basic methylation support
includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA, and Methylation Support nucleotide blend.
Low dose Methylmate A can be added before lithium is
in balance. Once lithium is shown to be in balance on
a HMT, then use low dose Methylmate B along with
extra B12. If carnosine is low, support with Carnosine, as
carnosine may help with glutamate issues. In addition,
be sure sufficient methylation support is in place, along
with low dose THF. THF is found in All in
 One and Ultimate B.A lack of THF can cause increases in
histidine. The breakdown of histidine then may cause
higher levels of beta alanine, methylhistidine, anserine,
and carnosine.If anserine and carnosine are excessively
high, while FIGLU on a MAP test is very low, consider
that histidase may not be functioning optimally. Be sure
copper is not low, as histidase needs copper to function.
Rule out a histidase deficiency if levels do not balance
with methylation support as well as the supports
suggested above. Recall that excess histidine can
increase cholesterol levels, and cause issues with
histamine and sensitivity.If carnosine is high along with
high ornithine, lysine and cysteine, rule out dibasic
aminoaciduria. High carnosine may also reflect a need
for more muscle support, especially if beta-alanine is
also high. If this is the case, consider low dose Muscle
Support nucleotide blend as well as Muscle Fatigue Support
compound.

If gamma-aminobutyrate (GABA) levels are low,

support with GABA, such as GABA Balance
capsules and Be Calm Spray. Also, look at glutamate
levels and work to balance high glutamate with GABA
as needed. Toxic doses of manganese can impact both
GABA and taurine levels, and affect their transport into
Gamma-aminobutyrate
the cell. If an individual is intolerant to GABA
supplementation in spite of symptoms that suggest a
need for GABA support, then check manganese levels
to be sure they are not high. If very high manganese
levels are present, run a Water Elements Test to look for
the source of manganese.
Hydroxyproline plays a role in collagen formation and
is produced from proline by vitamin C. If levels are
low, consider Vitamin C with rose hips. High levels of
hydroxyproline may be due to high levels of sulfur
amino acids. This may also indicate a need to support
with Molybdenum and B12 to process sulfur groups. You
can also use Black Bear Spray or Black Bear Drink for low
Hydroxyproline dose molybdenum and B12 support. Check lithium
before adding high dose B12. Check sulfur on
a HMT and UEE. High hydroxyproline can increase both
glycine and glutamate, so check the levels of these two
substrates. High levels of hydroxyproline excretion may
be related to bone or collagen processing, so consider
low dose Bone nucleotide blend, Bone Support capsules,
and the addition of Riboflavin-5-Phosphate.
If levels of citrulline are low be sure that dibasic
Citrulline
aminoaciduria is not an issue. Consider support
 with AminoAssist and low dose additional Citrulline. If
levels are high, then check to see if arginine is also
high. Both amino acids being high may indicate a need
to support arginase with low dose Manganese. If
ornithine is high, along with high citrulline and
arginine, there may be aluminum present in your body
that is blocking the function of the Krebs Citric Acid
Cycle. The Krebs cycle may be shunting substrates into
the urea cycle. A MAP test can be run to look at Krebs
cycle intermediates. In this case, consider support to
address aluminum. There is a list of suggestions on
the HMT and UTM for addressing aluminum. In
addition, consider BH4, as well as MTHFR A1298C Liver
Support capsules, to help to support urea cycle production
of less pro oxidant species. Arginine and citrulline both
can help produce nitric oxide in your body, provided
that there is sufficient BH4 present. Extremely low
levels of nitric oxide have been associated with
aggressive behavior in animal models. Nitric oxide can
impact blood pressure. Maintain normal, healthy levels,
as opposed to extremely high or low levels. Using 5-
methyl THF, Methylmate B, has been reported to help
with healthy nitric oxide levels by helping to support
nitric oxide synthase (NOS). Low nitric oxide has been
implicated in some cases of Postural Orthostatic
Tachycardia Syndrome (POTS). In addition, the
combination of low nitric oxide and increased H2S is
found in POTS, so consider addressing both H2S as
well as nitric oxide if POTS is a concern.
For low levels, consider Phosphatidyl Serine Complex
Phosphoethanolamine
(PS/PE/PC) as well as SAM-e.

For low levels, consider Phosphatidyl Serine Complex

Phosphoserine
(PS/PE/PC) as well as Riboflavin-5-Phosphate.

High levels of methionine sulfoxide may indicate a

need for additional ATP, or MitoForce. Also,
consider Ultifend, NADH, and GSH to help with
Methionine Sulfoxide oxidative stress, disulfides such as H2S, and to lower
the levels of methionine sulfoxide in your body. It has
been suggested that methionine sulfoxide is a factor in
aging. Levels do increase with age.
Homocysteine is converted to cystathionine by
Cystathionine Beta Synthase (CBS). Cystathionine is,
in turn, converted into cysteine. Both reactions are
Cystathionine increased with B6, and the overall pathway, called the
Transsulfuration Pathway, is a reflection of CBS
activity. Those who have an up regulation in CBS
enzyme activity by virtue of a mutation in the genes
 that encode for this enzyme, or who are using high
levels of B6, or who have high levels of TNF alpha,
tend to have higher levels of cystathionine, cysteine,
and/or taurine. High TNF alpha can be caused by
infection, such as those that are commonly found in the
GI tract. Look at the overall balance of cystathionine,
cysteine, and taurine in determining if a decrease in B6
support is indicated, or if CBS+ nucleotide blend is
needed. Also, consider a CSA test and GI Effects test to
address bacterial issues that may be impacting
cystathionine levels. Cystathionine is an intermediary
step on the way to cysteine. As such, it may or may not
be high. This is the reason that you look at
cystathionine, plus cysteine and taurine, for an overall
sense of whether or not this pathway is over active. If
cysteine levels get too high due to over activity, you
may also see high taurine and low GSH. See
information regarding taurine levels in this chapter for
additional support suggestions.
1 methylhistidine can climb secondary to high aspartate
levels. There are many reasons why aspartate may be
elevated, and many suggested supports for it in the
aspartate section of this chapter. 3 methyl histidine may
increase because of high threonine, which may be
secondary to high oxalate, which in turn is related to a
need for B12. Additional information about oxalates
1-Methylhistidine &3- and addressing high levels of oxalates can be found
Methylhistidine in Chapter 4, the chapter describing the MAP test. If
levels of both 1 and 3 methylhistidine are low, and if
the use of AminoAssist is not sufficient to cause levels to
get into better balance, then consider low dose histidine
support. A high level of both 1 and 3 methylhistidine
may reflect a need for muscle support. You and your
doctor can consider using low dose Muscle Support
nucleotide blend and Muscle Fatigue Support compound.

Homocystine is the oxidized form of homocysteine.

High levels suggest both a need for antioxidants, as
well as a need for methylation support to process
homocysteine to methionine via the long and short cut
around the cycle. Consider Ultifend and NADH for
antioxidant support. Basic methylation support
Homocystine includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA, and Methylation Support nucleotide blend.
Low dose Methylmate A can be added before lithium is
in balance. Once lithium is shown to be in balance on
a HMT, then use low dose Methylmate B along with
extra B12. Also, consider running the Oxidative Damage
test to see how problematic the pro oxidant conditions
 are.
Sarcosine levels may climb with the use of
trimethylglycine (TMG), as well as when glycine is an
issue. High levels of support with TMG may increase
both sarcosine and glycine, which can in turn increase
porphyrin and hippuric acid levels. TMG is also called
betaine, which is contained in the digestive support
Betaine HCl. Consider SHMT support, Phosphatidyl Serine
Sarcosine Complex (PS/PE/PC), and DHA, rather than TMG, to
support the pathway between homocysteine and
methionine in the methionine cycle. TMG is a methyl
donor and should be avoided especially in people who
are COMT+. When rhodiola is used to balance high
creatinine, the levels of sarcosine may climb as
creatinine levels fall. If too much choline support is in
place, it may also cause sarcosine to climb.

Related Tests to Run

The MAP test discussed in Chapter 4 gives useful information in conjunction with a UAA
about methylation cycle support, as well as the balance of the Krebs Citric Acid cycle.
Amino acids feed into the Krebs energy cycle. The combination of MAP data along with
UAA data gives a more complete picture of amino acid balance and how they are entering
into the energy cycle.
Looking at tryptophan and tyrosine levels on a UAA, in conjunction with having the levels of
their respective neurotransmitters from neurotransmitter testing, in addition to having
information about the breakdown products of dopamine and serotonin from a MAP test,
gives a much more comprehensive picture of neurotransmitter balance than you get from
any one test in isolation.
In a similar fashion, the levels of lithium, potassium and manganese on
a HMT and UEE can be considered with respect to one another, uncovering much more
information than either test alone. Having accurate and comprehensive information about
the levels of these minerals helps you to interpret data from a UAA. For example, you will
be able to discern very quickly if elevated arginine is due to a lack of manganese, or if you
must continue to look for other factors. It is very helpful to be able to rule in or rule out
single causes of what otherwise may be complex conditions.
Metabolic Analysis Profile Test

Hair Elements Analysis

Neurotransmitter Test

Urine Toxic Metals and

Essential Elements Test
Purpose of running this test:
A key factor in multi-factorial conditions is the infectious disease burden you have in your
body. In addition to blood testing for antibody titers for a range of bacterial and viral
conditions, there are stool tests that can detect what organisms, normal and pathogenic,
are present in your gastrointestinal (GI) tract.
Stool analysis tests can give you an indication of the bacterial and yeast load in your GI
tract. My preference is to run more than one GI stool test simultaneously because various
tests give related but non-identical information. The Comprehensive Stool Analysis does
not limit the organisms it allows to grow. It reports any organisms that grow in a given
amount of time. This is a useful tool for detecting a range of non-optimal organisms that
may be growing in your gut.
But a Comprehensive Stool Analysis may not pick up very slow growing or oxygen
sensitive organisms. Tests that use a DNA probe or include saliva based antibody screens
often detect very small numbers of slow growing organisms. This is excellent for
determining if slow growing organisms are an issue even if they did not grow on the
Comprehensive Stool Analysis. However, DNA probe tests or saliva antibody markers only
look for a limited number of organisms. It can identify only those organisms for which their
specific DNA probe or the particular antibody assayed is included in the test. For this
reason, the combination of a Comprehensive Stool Analysis along with a second GI
panel that includes saliva antibody markers and/or DNA probe testing for microorganisms
yields more comprehensive data.
The GI Health Panel determines bacterial, parasitic as well as food related issues using a
combination of saliva based antigen testing along with the growth of organisms to look for
very specific organisms as well as specific toxins or antibodies to individual microbes. This
test is useful for slow growing organisms like anaerobes or Clostridia and also looks at
Helicobacter pylori antibodies in saliva.
While the H.pylori test that is included in the GI Health Panel is not a DNA based test it
does measure antibodies in saliva that the body has produced in response to the presence
of H.pylori. When there are concerns about H.pylori (such as chronic acid reflux), I prefer to
run this saliva test for H.pylori antibody along with the H.pylori antigen test in stool from
DDI. These two tests work well together as one looks at the antibody in saliva produced in
response to H.pylori and the stool test from DDI measures evidence of antigens from
H.pylori in stool.
The expanded GI Health Panel would make sense if an individual was particularly
concerned about parasites or wanted another mechanism to check sensitivity to milk and
wheat/gluten rather than the Celiac test.
In addition to looking at specific organisms that are present the idea is to look at BOTH
the gut environment as well as specific microbes. In terms of the gut environment, the
goal is to have a balanced pH; sufficient elastase; balanced levels of fatty acids reflecting
appropriate fatty acid digestion; low levels of inflammatory markers; lack of blood, mucous,
or muscle in the stool; and normal ranges of lactoferrin, cholesterol, and triglycerides. A
healthy gut environment is more conducive to the growth of appropriate flora rather than
non-optimal microbes.
Imbalances in gut microbes can affect your thyroid hormones. Instead of using thyroid
peroxidase to make thyroid hormone, your body uses this enzyme to combat abnormal GI
organisms. Fluctuating levels of thyroid hormone can result. High levels of T4, the thyroid
hormone thyroxine, inhibit glutamate dehydrogenase, which can increase your glutamate
levels, reduce alpha keto-glutarate, and give you the symptoms of excitotoxicity.

This table contains the rationale behind my suggestions.

Marker These suggestions are for your consideration. Defer your
choices to your own health care practitioner, as always.

Gut Environment
For imbalances in the levels of elastase and long
chain fatty acids, consider 1 or 2 Special Digestive
Enzymes (SDE) with each meal, along with 1 or
more FOK capsules daily for pancreatic support, and
Elastase Long chain fatty support for pancreatin and digestive enzymes. If this
acids is not sufficient to get elastase levels into the normal
range, then also consider an ACAT/BHMT
capsules with each meal. Run a HMT and UTM to rule
out high thorium, since thorium can bind and inhibit
digestive enzymes.
Imbalances in the levels of these compounds suggest
problems with fat digestion and carbohydrate
absorption. If these are out of balance, consider 1 or
Short chain fatty acids 2 Special Digestive Enzymes (SDE) with each meal. In
(SCFA)Fat addition, Biotin and low dose Adenosyl B12 help with
StainTriglyceridesCarbohy fat digestion and are key nutrients for imbalances in
drates SCFA. Order a MAP test to rule out ketosis, as well as
a UAA to look at overall nutrient absorption. If high
levels of carbohydrate are seen and/or there are low
amino acids on a UAA, then consider Bowel Support
 nucleotide blend /or Leaky Gut nucleotide blend, as well
as VitaOrgan, AminoAssist and Ora-Placenta. SCFA also
play a regulatory role with respect to T cells and
inflammation, so consider T cell and B cell support
capsules for immune support if SCFA are out of
balance.
High levels of propionate, or propionic acid, may be
produced by intestinal bacteria, such as
Propionate Propionibacterium, after the use of antibiotics, in
particular clindamycin. Carnitine and Carnosine may
offset the impact of high levels of propionic acid.
Increased butyric acid, or butyrate, may be due to
Butyrate Fusobacterium or Roseburia. Consider Goldenseal, a
component of Naturomycin, to address butyrate.
When acetate is high, check the CSA / GI for signs of
yeast infection, as the acetaldehyde produced by
Candida can be converted to acetate, or acetic acid.
This conversion uses Molybdenum, so be sure
Acetate
molybdenum is supported, or that Black Bear Spray is
in place. The processing of acetaldehyde also may
use the cofactor PQQ, so consider Ultimate B as a
natural source of PQQ.
High vegetable and muscle fibers suggest poor
digestion. Consider 1 or 2 Special Digestive
Enzymes(SDE) with each meal. Not all digestive
enzymes are equal, and many do not have sufficient
pancreatin. The reason I recommend SDE is that they
are higher in pancreatin, along with a more complete
Vegetable fibers and
range of additional digestive enzymes. Consider low
Muscle fibers
dose Muscle Support nucleotide blend and low dose Ion
Transport nucleotide blend. The Muscle Support nucleotide
blend may help keep muscle breakdown in a more
normal range. The Ion Transport nucleotide blend may
aid in balancing excess mucous in the gut that can
contribute to digestive issues.
If your cholesterol levels are high, you can consider
low dose Red Rice Yeast. When using any supplement
Cholesterol
or medication that helps to keep cholesterol in a
normal range, also use CoQ10.
These compounds are all markers of inflammation,
and may also indicate infection. When they are high,
LysozymeLactoferrinWhit
consider AHCY/SHMT compound, SHMT Spray, and/or
e blood cellsMucus Red
extra Lactoferrin to take the pressure off of your body
blood cells Occult blood
to produce lactoferrin, and to prevent its depletion in
your system. To help with inflammation, and to have
 these markers stay in the normal range,
consider Inflammatory Pathway Support
capsules and/or Inflammove, as well as Bowel Support
nucleotide blend, Cytokine Balance nucleotide blend, as
well as General Support nucleotide blend. For the
presence of red blood cells, consider Vitamin
K and Mastica Gum. Rule out Helicobacter pylori and
hemolytic E.Coli as causes of blood in your stool. For
excess white cells, consider Myrrh. Also, check
lithium levels on a UEE and HMT, because lithium
can be stimulating for white cells. If lithium is low,
consider Be Calm Spray, All in One, and, if
needed, Lithium Orotate. For excess mucus,
consider Ion Transport nucleotide blend, Muscle Fatigue
Support compound and Serraflazyme.

Ideally, your gut pH should be around 7. Levels that

are too low may grow the non-optimal microbes that
are able to thrive at a low pH, such as H.pylori,
E.coli and Streptococci. In addition, a low gut pH
makes it difficult for healthy, normal flora such as
Lactobacillus and Bifidobacter to colonize the area.
Low pH may mask the growth of other non-ideal
organisms, so a full picture of your microbial
imbalances may not be seen until your gut pH is
closer to 7. For this reason, even if no dysbiotic flora
are noted, if your GI pH is at 5, there may still be a
range of imbalanced flora that are simply not being
identified. In these cases, it is suggested that another
set of stool tests, CSA and GI Effects, be run once the
low pH has been addressed. Wide swings in pH, for
instance a pH of 5 on a CSA, and a pH of 7 or 8 on a
GI Effects test, when both samples have been taken
Gut pH
during the same time period, may indicate H. pylori.
While H. pylori is attracted to a low pH, it then
produces urease, which increases the gut pH so that
it can thrive. Separate tests for H. pylori can be run to
rule out this possibility. In addition, a breath test for
urease produced by H.pylori can be run by your
doctor and may be the most sensitive test for this
organism. pH strips can be used at various points
throughout the day to check your progress in
balancing gut pH prior to rerunning GI tests. Check
pH in the morning, mid or late day, and again before
bed. Alternately, supplements can be added for 6 to 8
weeks. Once your pH is close to 7, you can rerun GI
tests to both reassess your gut environment, as well
as get a more complete picture of your gut microbes.
Supplements to help address low gut pH
include VitaOrgan, Stomach pH Balancing nucleotide
 blend, Buffer pH, and/or low dose Potassium
Bicarbonate or sodium bicarbonate, depending on
your need for sodium or potassium on a HMT and
UEE. Lack of B12 may also be a factor in causing a
low gut pH. Consider a HMT and UEE to assess
cobalt levels as an indicator of B12 levels, and
support B12 as needed. Because lithium plays a role
in B12 transport, be sure both lithium and potassium
are in balance prior to adding extra B12. Support for
lithium can include Be Calm Spray, All in
One and Lithium Orotate. Tin may also cause an acidic
pH, so rule out high tin on a HMT and UTM. Also,
acidic conditions may increase iron levels, and iron
increases bacterial virulence. A HMT and UEE can be
run to check iron. Consider SHMT
support and/or Lactoferrin to help with high iron.
Acidosis can occur secondary to mitochondrial
dysfunction, so consider a MAP test to rule out
mitochondrial concerns. Acidosis can lead to
pancreatic issues, in which case you can
consider SDE, FOK capsules, and VitaOrgan. If the pH
is very high, above pH 7, rule out non-optimal
anaerobes as an issue. They can be the cause of
increased pH. Consider Anaerobic X nucleotide
blend, IgY Immune capsules and the appropriate
antibiotic herbs and other support listed later in this
chapter. High pH conditions in your GI tract may
limit copper uptake, which can impact the processing
of serotonin, dopamine and histamine, so consider
a neurotransmitter test, as well as a MAP test, to check
on neurotransmitter levels and their breakdown.
Secretory IgA is a marker for immune response in
your gut. It is produced by the mucosal lining of your
gut. High Ig A may be due to inflammation or
indicate infection. Inflammation can be
supplemented into a healthy normal range with Bowel
Support nucleotide blend, Cytokine Balance nucleotide
blend, Inflammatory Pathway Support capsules,
or Inflammove. Your immune system can be
sIgA supported with T cell and B cell support capsules. Your
gut lining can be supported with Colostrum,
specifically colostrum that is high in sIgA, to take
the pressure off of your GI tract to either produce or
deplete its own IgA stores. In addition, if your sulfur
levels are not high on a HMT or UEE, consider
using Glucosamine/Chondroitin Plus to support your gut
lining. VitaOrgan may also be helpful for the GI
mucosa.
 Natural herbs can be used to help limit growth of
undesired organisms, along with probiotics and
supplements that address biofilms. Consider the use
of BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
Overall basic approach to
seed extract (GSE capsules or GSE liquid) along with
imbalanced and dysbiotic
these herbs adds another level of broad spectrum
flora
support and may help balance the microbes in your
gut. In addition to the two Naturomycins and
grapefruit seed extract (GSE capsules or GSE liquid),
consider BactiSolve to aid with biofilm if you have no
shellfish allergies. If you have shellfish allergies,
then consider low dose sources
of EDTA including MetalAway, EDTA capsules, EDTA
soap and/or EDTA soak. In addition to these more
general suggestions for imbalanced flora, consider
the use of specific RNA Microbial nucleotide blends
and specific immunfactors (IMF). Since iron
increases bacterial virulence,
consider Lactoferrin, AHCY/SHMT compound,
and/or SHMT Spray to help with iron.
Rotating specific probiotics lays the groundwork for
normal flora in your gut. A healthy gut environment
helps normal flora proliferate. In turn, healthy
normal flora makes it more difficult for imbalanced
or dysbiotic flora to grow. The probiotics that can be
rotated include Suprema dophilus, NutriClean,
and Lactobacillus. These products have a range of
Lactobacillus species, including L.acidophilus,
L.reuteri. L.rhamnosus, L.johnsonii, as well as
Rotate probiotics Bifidobacter. Also, include normal yeast flora, such
as Saccharomyces boulardii. Eliminate Streptomyces,
Streptococcus, Enterococcus and Prevotella in
probiotic supports. Lactobacillius species ferment
sugars to lactic acid, which provides an environment
in the large bowel that protects against infection.
Bifidobacter species assist digestion, and protect
against the development of allergies and cancer.
Other bacteria will flourish if numbers of
Lactobacilli and Bifidobacter decline for any reason.

Specific Microbes listed alphabetically
Specific herb suggestions are derived in part from Buhner, Stephen Harrod. Herbal
Antibiotics: Natural Alternatives for Treating Drug-resistant Bacteria. North Adams, MA: Storey
Pub., 2012. Print.
Anaerotruncus colihominis
Akkermansia muciniphila
Bacteroides
Barnesiella
Butyrivibrio crossotus
Diet has a huge influence on the gut flora, as well as
gut pH. For instance, a diet high in sugar can
contribute to high levels of yeast. Certain diets may
cause a greater tendency toward ketosis, such as the
Specific Carbohydrate Diet or the Paleolithic Diet.
Diets that are too high in protein can cause excess
ammonia. Diets that are high in glutamate, glutamine
or high levels of fermented food, can increase
excitotoxins. Diets high in sulfur may increase your
need for molybdenum and B12. Work with your
health care provider on a healthy, balanced diet.
This organism is an anaerobe related to Clostridia.
Consider Naturomycin and IgY Immune capsules.
This organism may be a beneficial probiotic that can
help with obesity and aid in breaking down excess
mucus in your gut. Indirectly, this may be a help
for H. pylori and those who are CFTR+.
Rhubarb and IgY Immune capsules may be a help for
anaerobes, particularly for Bacteroides. Consider the
use of BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Barnesiella may have a protective effect against
certain drug resistant organisms.
This organism is an anaerobe related to Clostridia.
Consider Naturomycin and IgY Immune capsules.
Consider the use of BOTH Naturomycin
Spray and Naturomycin capsules because they contain
 different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
Consider Garlic, an ingredient in Naturomycin, along
with IgY Immune capsules for bacteria that grow
anaerobically. Certain Campylobacter species induce
antibodies that react with neuromuscular junctions.
This can create ‘molecular mimicry’ such that your
immune system can produce antibodies that cross
react with neuromuscular junctions. It is important to
eradicate this organism. Campylobacter is related
to H.pylori, so the use of HELX nucleotide
blend and Peptimycin may be considered.Consider
BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
Campylobacter work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism is an anaerobe. Clostridia has been
implicated in a range of behavioral and language
issues. It is critical to address this organism.
Use Microbial CLX nucleotide blend, Peptimycin, IgY
Immune capsules and Bay leaf. Consider
Clostridia
BOTH Naturomycin Spray and Naturomycin
capsulesbecause they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
 lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism is an anaerobe.
Use Naturomycin and IgY Immune capsules. Consider
BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Collinsella aerofaciens and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism is an anaerobe related to Clostridia.
Consider Naturomycin and IgY Immune
capsules. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Coprococcus eutactus and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism can produce hydrogen sulfide which
Desulfovibrio piger can inhibit mitochondrial function directly. A
positive Hydrogen Sulfide Urine Test may indicate
 severe gut dysbiosis, which can be due to overgrowth
of Desulfovibrio or Prevotella. Hydrogen sulfide is
known to inhibit mitochondria and block the oxygen
carrying capacity of hemoglobin. It also greatly
increases the toxicity of heavy metals by enhancing
their absorption. Hydrogen sulfide can also affect
neurotransmitter levels, so consider a NT test and
a MAP test if consistently high levels of Desulfovibrio
or Prevotella are noted on a CSA test and GI Effects
test. This organism is an anaerobe.
Consider Naturomycin and IgY Immune capsules, be
sure levels of Molybdenum and B12 are adequate, or
consider the use of Black Bear Spray or Black Bear
Drink. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism is an anaerobe.
Consider Sage, Naturomycin, and IgY Immune capsules.
Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Enterobacter and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
Enterococcus is the cause of a number of hospital
Enterococcus acquired infections or issues in individuals with
compromised immune systems. The concern with
 Enterococcus is that it is resistant to many standard
antibiotics. Natural herbs that have been reported to
act on Enterococcus include Sage and Oregano.
Consider the use of ECX nucleotide
blend, Cranberry*, Goldenseal*, Garlic*, Juniper
Berry*, Sage, Mastica Gum, grapefruit seed
extract (GSE capsules or GSE
liquid), Mycoceutics and IMF 5 and IgY Immune capsules.
*The starred items are ingredients in Naturomycin.
Certain E. coli species have a capsule that is identical
to human neuronal tissue. This can create ‘molecular
mimicry’ such that the immune system can also
induce antibodies that cross react with neuronal
tissue. It is important to work with your doctor to
address high levels of this organism. Consider
BOTH Naturomycin Spray and Naturomycin
Escherichia coli capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This may be a helpful organism, but if its levels are
high, it may be associated with symptoms and health
problems. This organism is an anaerobe.
Consider Naturomycin and IgY Immune capsules.
Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
Faecalibacterium herbs: Echinacea, Cranberry, Elderberry,
prausnitzii lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
 gut.
These organisms have been associated with
numerous problematic health conditions.
Fusobacterium ultimately increases TNF-alpha, so it
may play a role in mucosal inflammation.
Fusobacterium may also be the cause of high butyric
acid (butyrate) on CSA and GI tests. Because TNF-
alpha can increase the activity of CBS, consider
a UAA to check that taurine levels are not too high.
See the section on taurine in Chapter 5.
Consider Goldenseal, Naturomycin, IgY Immune capsules,
and low dose TNF nucleotide blend. Consider
BOTH Naturomycin Spray and Naturomycin
capsulesbecause they contain different herbs that
Fusobacterium
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism is an anaerobe. A number of species
of Haemophilus cause significant infections and so
the presence of this organism should be taken
seriously.
Consider Naturomycin, Garlic*, Goldenseal*, Sage,
grapefruit seed extract (GSE capsules or GSE liquid),
thyme, Oregano*, Mycoceutics, and IgY Immune
capsules. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
Haemophilus results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
 gut.
This organism is an anaerobe. H.pylori plays a role in
acid reflux, as well as gastric ulcers. It has also been
linked to duodenal ulcers and gastric cancer. The
presence of H.pylori should be taken seriously and
addressed. See the DVD by Dr. Yasko,
and Gastrointestinal Balance and Neurotransmitter
Formation by Drs. Yasko and Mullan. Consider HELX
nucleotide blend, Peptimycin, Carnitine, Potassium
Bicarbonate or sodium bicarbonate, TNF nucleotide
blend, Oregano, Cranberry, Magnesium, and IgY Immune
capsules. Consider BOTH Naturomycin
Spray and Naturomycin capsulesbecause they contain
Helicobacter pylori different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
Species of Klebsiella can cause serious infection and
thus should be addressed. Consider KLX nucleotide
blend, Juniper Berry, Uva
Ursi, Goldenseal, Sage, Wormwood,
thyme, Oregano, Echinacea, and Mycoceutics. Consider
BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
Klebsiella
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
Methanobrevibacter This organism is an anaerobe. High levels of this
Smithii bacterium are often found in people with multiple
health conditions. It is often high in those with
anorexia, however,it may actually help process
polysaccharides. Consider Naturomycin and IgY
Immune capsules. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism may reflect the use or overuse of
antibiotics. It can play a role in urinary tract and
other infections. It can break down tryptophan, so it
may be involved with serotonin imbalances. Check
tryptophan levels on a UAA and serotonin on a NT
test. Consider Sage and BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
Morganella morganii
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
This organism is an anaerobe. Mycoplasma can
cause pneumonia and has been associated with
Mycoplasma neurological and psychiatric problems.
Consider Anaerobic X nucleotide blend, IMF 9 and IgY
Immune capsules.

Odoribacterspp. Consider oral Naturomycin Spray.

High levels of Oxalobacter may be due to high
Oxalobacter formigenes
oxalate in your system. Consider a MAP test and work
 on oxalate if it is high. See the Oxaloacetic acid
section of Chapter 4 for more information on this.
High oxalate may be due to yeast and fungal
infestation. These factors can be investigated with
a CSA test and GI Effects test, among others.
Although some probiotic mixes include Prevotella,
or consider it normal flora, this program does not.
Prevotella species ferment to produce hydrogen
sulfide. Hydrogen sulfide inhibits mitochondrial
function directly. So, a positive Hydrogen Sulfide Urine
Test may indicate severe gut dysbiosis, which can be
due to overgrowth of Prevotella. Hydrogen sulfide is
known to inhibit mitochondria and block the oxygen
carrying capacity of hemoglobin. It also greatly
increases the toxicity of heavy metals by enhancing
their absorption. There does not appear to be an
antibiotic to which Prevotella is sensitive, but it is
purported to be reduced by taking bile salts such as
ursodeoxycholic acid as in Cholacol or ACAT/BHMT
capsules. Neem can also be used and is extremely safe.
Neem works by making microbes less sticky so they
cannot adhere to the lining of the gut. Hydrogen
sulfide can also affect neurotransmitter levels, so
consider a NT test and a MAP test if consistently high
levels of Prevoltella are noted on CSA and GI tests.
Prevotella
In extreme cases, Prevotella species have been found
in brain and lung abscesses.Consider Anaerobic X
nucleotide blend, Neem, Cholacol or ACAT/BHMT
capsules, Molybdenum and B12 or Black Bear Spray.
Consider IgY Immune capsules for anaerobes. Consider
BOTH Naturomycin Spray and Naturomycin
capsulesbecause they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
Consider Garlic, Sage, and IgY Immune capsules.
Proteus Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
 work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs adds another level of broad spectrum
support and may help balance the microbes in your
gut.
Rhubarb and IgY Immune capsules may be a help.
Consider the use of BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
Pseudoflavonifractor spp.
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Pseudomonas species can cause serious infection, so
this organism should be addressed, working with
your doctor as always. Pseudomonas may be
inhibited by hypothiocyanite and thiocyanate, so you
can consider using Ion Transport compound, which
contains sources of these compounds.
Consider Microbial PSX nucleotide blend, Juniper
Berry, Garlic, grapefruit seed extract (GSE
capsules or GSE liquid), thyme, Oregano, Uva
Pseudomonas Ursi, Goldenseal, Cranberry, Mycoceutics, aloe, Ion
Transport nucleotide blend, and IgY Immune capsules.
Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
 leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Along with Fusobacterium, Roseburia may be a
source of butyric acid or butyrate. This organism is
an anaerobe. Consider Naturomycin, IgY Immune
capsules and Goldenseal. Consider BOTH Naturomycin
Spray and Naturomycin capsulesbecause they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Roseburia spp.
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
This organism is related to Clostridia. It is an
anaerobe. Consider Naturomycin and IgY Immune
capsules. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Ruminococcus spp and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Salmonella is associated with significant infection in
the gut and should be taken seriously.
Salmonella Consider Microbial SALX nucleotide
blend, Ashwagandha, Juniper Berry, AHCY/SHMT
compound, SHMT Spray or Lactoferrin to help with iron,
 and IgY Immune capsules. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Shigella can cause significant infections and should
be taken seriously. Consider Goldenseal, Garlic,
grapefruit seed extract (GSE capsules or GSE
liquid), Sage, Mycoceutics, AHCY/SHMT
compound and SHMT Spray or Lactoferrin to help with
iron. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain
different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
Shigella
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Certain species of Staph, for example Staph aureus,
have an outer protein that inhibits the ability of
immunoglobulins to function optimally. Staph may
be inhibited by hypothiocyanite and thiocyanate, so
you can consider Ion Transport compound, which
contains sources of these compounds. To support the
Staphylococcus immune system, consider T cell and B cell support
capsules. Consider STAX nucleotide
blend, Garlic, Goldenseal, Wormwood, Juniper Berry,
grapefruit seed extract (GSE capsules or GSE liquid),
thyme, Oregano, Mycoceutics, aloe, Ion Transport
nucleotide blend, IMF 5 and IgY Immune capsules.
Consider BOTH Naturomycin Spray and Naturomycin
 capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Aside from species of Strep that are known to cause
infection, some species of Strep are often included in
probiotic mixes. This program eliminates the use of
these probiotics because Streptococcus fermentation
produces large amounts of lactic acid. This may
incline you to acidosis. Lactic acid is metabolized in
your liver by lactate dehydrogenase. High levels of
lactic acid may indicate bowel overgrowth with
Streptococcus. Fermentation produces two isomers
of lactic acid, L-lactate and D-lactate. D-lactate is the
problem. The body cannot metabolize D-lactate. It
accumulates in mitochondria and may cause
inhibition of mitochondrial energy production. For
this reason, consider using MitoForce when your
levels of Strep are high. Some Strep species, such as
Strep pyogenes, contain components that are similar
to those of human cardiac, skeletal, and smooth
Streptococcus muscle, heart valve fibroblasts, and neuronal tissues.
This can create ‘molecular mimicry’ so that your
immune system may produce antibodies that cross
react with heart, joints and brain leading to
movement disorders. It is important to eliminate this
organism. Strep infection also increases your levels
of TNF alpha. High TNF alpha has been implicated
in Tourettes syndrome, OCD behavior, “stims”,
PANDAS (Pediatric Autoimmune Neuropsychiatric
Disorders Associated with Streptococcal Infections),
perseverative speech, rheumatoid arthritis and leaky
gut. Consider STRX nucleotide
blend, Garlic, Echinacea, rosemary, Sage, barberry, Golden
seal, Oregon Grape, grapefruit seed extract (GSE
capsules or GSE liquid), Mycoceutics, Juniper Berry, IMF
5 and IgY Immune capsules. Also,
consider AHCY/SHMT compound for DPPIV and as a
source of lactoferrin. Consider TNF nucleotide blend.
 Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
This is an anaerobic bacterium. Consider Anaerobic X
nucleotide blend and IgY Immune capsules. Consider
BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Streptomyces and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
This organism is an anaerobe and is resistant to a
number of antibiotics, so use an herbal combination.
Consider Naturomycin and IgY Immune capsules.
Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
Veillonella spp.
lomantium, Dandelion Root, Skullcap,
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
 support and may help balance the microbes in your
gut.
Consider Garlic, Candisol, Mycology Support nucleotide
blend, Goldenseal, Juniper Berry, IMF 7 and grapefruit
seed extract (GSE capsules or GSE liquid). Consider
BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Candida
and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Consider Naturomycin Spray, Naturomycin capsules,
and Paradex. Consider De Witt’s syrup if needed.
Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that
work together for optimal results. Naturomycin
Spray is a source of the following
herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap,
Parasites and Goldenseal. Naturomycin capsules are a source of
the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive
leaf, Oregano, black walnut, Juniper Berry, Garlic, Uva
Ursi, Wormwood and pumpkin. The use of grapefruit
seed extract (GSE capsules or GSE liquid) along with
these herbs creates additional broad spectrum
support and may help balance the microbes in your
gut.
Additional Considerations

Studies indicate that bacteria can hold on to toxic

metals, including aluminum. Running
a UTM and HMT to check aluminum, especially as
you begin to work on non-ideal microbes, gives you
BH4 levels
a sense of the level of retention of aluminum in your
Aluminum
body, as well as the rate of its excretion. Aluminum
is known to compromise tetrahydrobiopterin (BH4)
formation. BH4 is needed to produce serotonin and
dopamine. Consider a Neopterin / Biopterin Profile Urine
Test, as well as a MAP test and a UAA. These tests can
indicate issues with BH4 levels. Supplements should
include a source of EDTA which may help with
aluminum, such as MetalAway, EDTA soap or soak,
or EDTA capsules. Also, support for natural healthy
levels of BH4 can include MTHFR A1298C Liver
Support capsules and BH4.
Purpose of running this test:
This test examines your stool for the antigenic components of the bacteria H. pylori that
may be detected when you have an active H. Pylori infection.
H.pylori has been associated with ulcers, acid reflux and cancer. My experience has been
that there is a particularly high incidence of H. Pylori infection in children with autism, and
that up to one third of the adult population may also be infected. If you have acid reflux,
consistently low gut pH, high suberic acid on a MAP test, along with high arginine on a
UAA, high level bismuth excretion on mineral tests in the absence of any bismuth support,
then you should consider an H. Pylori Stool Antigen Test.
Wide swings in gut pH on either contemporaneously run or repeat CSA/GI Effects tests,
such as a pH of 5 on one test and pH of 7.5 or 8 on another, may be an indirect indication
of H. Pylori infection. While H. Pylori is initially attracted to low pH conditions in your GI
tract, once it becomes firmly established, it produces the compound urease, which
increases gut pH so it can thrive. This may cause wide swings in the pH of your GI tract on
testing.
Pylori is able to sequester itself between the mucosal cells lining your stomach. There it is
given additional protection by the thick layer of mucus that lines the inside of your stomach.
As a result, the antigenic components of H. Pylori may not be detected. If active H.
Pylori infection is present, it should be possible to identify these antigens with this test.
Therefore, a positive antigen test is significant; however, a negative test does not rule
out the presence of this organism.
A urease breath test can also be run through your doctor that indirectly indicates the
presence of H.pylori. If H.pylori infection is established, and the organism is making urease
in sufficient amounts, then the breath test will indicate its presence.
Ideally, a DNA probe test should also be run. This test would rule out the presence of H.
Pylori that has not stimulated antigen formation by your immune system, but from which the
DNA is able to be detected. I continue to search for a DNA test to be run in conjunction with
this antigen test in order to offer you a comprehensive assessment of the H. Pylori that your
body may harbor.

This table contains the rationale behind my suggestions. These suggestions are
Result for your consideration. Defer your choices to your own health care practitioner,
as always.

H.pyl The approach I suggest for consideration with your doctor is designed to
ori interfere with a number of aspects of H. pylori function. This approach
positi addresses the excess mucus that enables H. pylori to remain undetected in
ve your GI tract, and makes the organism more accessible to anti-infective
antige agents. It includes supplements that may limit H. pylori growth, those that
n test generate a healthy level of inflammatory mediators, and balancing
nutrients such as carnitine that H. pylori may compromise. Suggestions for
consideration for supplementation with natural supports can
include HELX nucleotide blend, Bowel Support nucleotide blend, cycling on
and off Peptimycin, and Potassium Bicarbonate or sodium bicarbonate. The
choice of sodium or potassium is dependent upon your levels of these
minerals on a HMT and UEE. Consider low dose Hydroxy B12 and Adenosyl
B12 once lithium is in balance, in addition to Potassium, Magnesium,
and Biotin. Stomach pH Balancing nucleotide blend, Buffer pH,
and VitaOrgan work to balance the gut pH. Also consider Carnitine, and low
doses of both Ion Transport compound and Ion Transport nucleotide blend.
Although the natural H.pylori approach presented above suggests the use
of multiple supplements/herbs simultaneously, the same is true for a
traditional medical approach to this organism. H.pylori is difficult to
eradicate, so it requires a number of compounds over time, and a
concerted effort to address this microbial imbalance. Standard medical
approaches can be employed with the help of your doctor. These
traditional approaches involve the use of multiple antibiotics and
additional pharmaceuticals, including proton pump inhibitors and a
source of bismuth and bicarbonate. For standard approaches
see: http://www.globalrph.com/antibiotic/hpylori.htm and http://www.uptodate.co
m/contents/treatment-regimens-for-helicobacter-pyloriIt has been observed that
the number of individuals with autism testing positive for the
bacterium Helicobacter pylori is much higher than would be expected. One
third of the adult population is reported to harbor H.pylori. In contrast, this
number is generally not as high in the pediatric population. I have found
that the autistic population is as high as 50 percent and that has been
found by others to be in that range too. Changes in the mucous layer
environment in children with autism may be a predisposing factor that
accounts for this observed increase in H. pylori in that
population.Helicobacter pylori is a Gram-negative, spiral-shaped bacterium
that lives in the mucous layer of the stomach and duodenum. This ulcer-
causing gastric pathogen is able to colonize the harsh acidic environment
of the human stomach. Although the stomach is protected from its own
gastric juice by a thick layer of mucus that covers the stomach lining, H.
pylori takes advantage of this protection by living in the mucus lining
itself. In the mucus lining, H. pylori survives the stomach’s acidic
conditions by producing urease, an enzyme that catalyzes hydrolysis of
urea into ammonia and bicarbonate. As strong bases, ammonia and
bicarbonate produce a cloud of alkalinity around the bacterium, making it
impossible for the body’s normal defenses such as T cells, natural killer
cells, and other white blood cells, to get to it in the gastric mucus layer.
Because H. pylori burrows into the mucus layer of the stomach and is very persistent
there, it is difficult to get a positive test for it even when it is present. In addition, H.
pylori can remain for long periods of time and is extremely difficult to eradicate.
Many factors that have been identified as playing a role in autism are related to H.
pylori, including problems with gluten and casein, breakdown of glutathione, excess
stomach acid, and the high norepinephrine seen in ADD and ADHD. H.
pylori affects neurotransmitters and brain neurochemistry. H. pylori infection
increases the incidence of food allergy by facilitating the passage of intact proteins
across the gastric epithelial barrier. H. pylori depletes secretin, which has previously
been reported to have positive impacts in some cases of speech delay.
Arginine makes urea to neutralize stomach acid, or, alternately, makes an
intermediate such as nitric oxide that relaxes blood vessels. When H.
pylori infection is present, it induces arginine to produce urea as opposed to nitric
oxide because urea provides the alkalinity necessary for its survival. In this way, H.
pylori depletes arginine through its overuse of the enzyme arginase. The depletion of
arginine impacts the mitochondria, reducing mitochondrial energy production from
glucose.
When H. pylori infection is present, it changes the way important phospholipids are
positioned in the cell membrane. Phospholipid orientation has been described as
playing a role in ADD/ADHD, as well as in immune system signaling. H. pylori also
decreases levels of B12 in the body; decreases iron levels; increases ammonia and
taurine; and can produce glaucoma in young individuals that resolves when the H.
pylori is treated.
H. pylori infection is not just an immediate acute infection. Rather, it is a long-term,
chronic problem that may take months or years to eradicate. Chronic H.
pylori gastritis alters feeding behaviors, delays gastric emptying, alters gastric
neuromuscular function, and impairs acetylcholine release. These effects can persist
for months after the infection has been eradicated. Please watch the H.
pylori DVDs to understand more fully the rationale behind this program and the
magnitude of the impact H.pylori can have on your body.
Purpose of running this test:
Reactive oxygen species (ROS) can damage lipid, protein, and nucleic acid in your cells by
oxidizing them. This increases the chemical stress in your body called oxidative stress. A
result of oxidative stress is damage to your DNA, which produces 8-
hydroxydeoxyguanosine (8-OHdG), which is excreted in your urine. Your level of
oxidative stress can be determined by running an Oxidative Damage Test.
Numerous articles and research studies have indicated that urinary 8-OHdG is not only a
marker for generalized, cellular oxidative stress, but might also be associated with a high
risk for cancer, including bladder and prostate cancer. In addition, it has been associated
with other health conditions, including atherosclerosis, rheumatoid arthritis, cystic fibrosis,
atopic dermatitis, and diabetes. Evidence suggests that higher levels of 8-OHdG are also
seen in cases of chronic fatigue, fibromyalgia and depression.
Elevated levels of urinary 8-OHdG have been detected in patients with various types of
cancers. Increased levels of modified DNA and 8-OHdG have been found in human
atherosclerotic plaque. Elevated urinary 8-OHdG and leukocyte DNA were also detected in
diabetic patients with hyperglycemia, or elevated blood sugar, and the level of urinary 8-
OHdG in diabetes correlated with the severity of diabetic nephropathy and retinopathy.

This table contains the rationale behind my suggestions. These

Result suggestions are for your consideration. Defer your choices to your own
health care practitioner, as always.

Consider using antioxidants such as the comprehensive

antioxidant blend in Ultifend. Also, consider Resveratrol, Pycnogenol,
and NADH. Quercetin has been reported to be of particular help for
DNA damage. However, quercetin can inhibit COMT, so this may
8 OHdG be non-optimal for those who are COMT ++. The use
of BH4 and MTHFR A1298C Liver Support capsules should also be
considered, as healthy levels of BH4 may help to reduce reactive
oxygen species. Ultimate B and Green Tea are a natural way to
supplement low dose vitamin PQQ, as well as Chervil.
Purpose of running this test:
The Drinking Water Analysis Test determines if your drinking water is a source of the toxins
noted on your other toxic metal tests, such as the HMT, UTM or FMT. For instance, if you
are consistently excreting high doses of uranium, arsenic, aluminum, or lead on multiple
toxic metal tests, it is possible that you are being exposed to an ongoing source of toxins.
Your water supply is the first place to look. I have seen situations in which individuals have
been chronically ill for years, trying everything they could to recover, only to find that they
had been consuming high levels of arsenic or some other toxin in their water. Arsenic
requires adequate methylation for excretion. In one individual, the continued ingestion of
arsenic, along with suboptimal methylation, combined to create chronic illness.
Some water systems use potassium permanganate to treat the water. If you have this kind
of system, and your system is not functioning properly, high levels of manganese can be
left in your water supply. High manganese can impact your ability to utilize GABA, which is
needed to balance glutamate. High manganese can impact other neurotransmitters as well,
and cause some types of psychosis.
The balance between copper and zinc is important for attention and focus. High levels of
copper in your water supply may upset this delicate balance. Running a water test on both
your home and work water supplies is something to do earlier as opposed to later in this
health program. It helps you rule out continued exposure to and ingestion of toxins that may
be responsible for all or part of your symptom complex.

This table contains the rationale behind my suggestions. These

Primary METALS suggestions are for your consideration. Defer your choices to
your own health care practitioner, as always.

Antimony can bind to ‘thiol’, which means SH groups,

which are needed to help escort mercury from your
system. Also, antimony may inhibit the MAO enzymes,
which may interfere with the natural breakdown of
dopamine and serotonin. Antimony can accumulate in
your adrenals and thus play a role in fatigue.Consider
Antimony
adding sources of ‘thiol’ groups, such
as Selenium, MetalAway, or DetoxAway. Consider low
dose Wasabi, low dose Selenocysteine, and/or low dose Ion
Transport compound, which has
both Wasabi and Selenocysteine. Broccoli and Garlic are also
options. Also, consider OraAdrenal for adrenal support.
Methylation cycle function is needed for arsenic excretion.
Arsenic can bind both to thiol, which are SH groups, as
well as phosphate groups. It can cause vitamin A
deficiency. Symptoms of arsenic toxicity can include
Arsenic white streaked nails, a garlic odor emanating from your
body, and/or under pigmentation. Arsenic toxicity may
also cause hair loss, problems with folate uptake, or
weakness, among other symptoms. At the very least,
consider short cut methylation support, support for the
 pathway that goes from homocysteine to methionine using
the BHMT enzyme. All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide blend all
support the short cut. If lithium is in balance, also support
the long route, the route that uses the MTR and MTRR
enzymes. These supports include low dose Methylmate
A, Methylmate B, and B12. Also, thiol supports may be
useful, such as Selenium, MetalAway, or DetoxAway; low
dose Wasabi, low dose Selenocysteine, or low dose Ion
Transport compound, which has
both Wasabi and Selenocysteine. Broccoli may also be
helpful. To support phosphate, consider phospholipids
such as Phosphatidyl Serine Complex
(PS/PE/PC) and Riboflavin-5-Phosphate.

High levels of beryllium may affect lymphocyte

proliferation and respiratory function, as well as cause
adrenal insufficiency and fatigue. Consider T cell and B cell
Beryllium support capsules. OraAdrenal may also be used for additional
support. The Muscle Fatigue Support compound supplement
can be considered if fatigue is an issue. Low
dose Respiratory Support nucleotide blend may also be helpful.
Ideally, your copper levels should be lower than zinc to
favor a higher zinc to copper ratio. High copper has been
implicated in ADD.
Copper is the cofactor that works with the enzymes MAO A and
MAO B to break down dopamine and serotonin, so high copper
may engender a higher degree of degradation of these two
neurotransmitters. Running a Neurotransmitter Urine Test and
a MAP test gives you an indication of both the levels of serotonin
and dopamine, and a measure of their breakdown.
Excess copper has also been reported to cause fearful thoughts. If
Copper
copper replaces zinc in your brain, it may be a factor in migraines,
so zinc support may help you with this, as well as bring your
copper into better balance.
Ways to help bring copper into better balance include the use
of Molybdenum, Zinc, Carnosine, and increased EDTA. EDTA is
found in MetalAway, EDTA soap or soak, and DetoxAway. You
can also use BactiSolve if you have NO shellfish allergies.
Check molybdenum levels, because often copper will be high
when molybdenum is too low. Molybdenum can be low due to
 high taurine, which is measured on a UAA test. When taurine is
processed via sulfite oxidase, molybdenum can become depleted.
In addition, high levels of sulfur can have the same effect of
depleting molybdenum. Molybdenum may also be depleted due to
chronic yeast infections, which can be checked on a Vaginosis
Test, or in the gut via a CSA test or a GI function test.

Lead can deposit in bone and replace calcium there. Lead

can also affect ATPase, which reduces the production of
this energy molecule. This negatively impacts both sodium
and potassium levels, as well as energy production.Lead
can bind melatonin, tryptophan, and serotonin. Consider
a MAP test and a Neurotransmitter Urine Test to look at energy
markers, as well as neurotransmitter levels.
Lead excretion can cause pica, teeth/jaw grinding & aggression.
Eating inedible objects may be a sign that lead is being excreted.
You may need to consider support to help escort it from your
system. Elevated 5-amino levulinic acid (ALA) due to lead toxicity
can inhibit Gamma amino butyric acid (GABA), so consider
extra GABA if needed.
Lead Since lead replaces calcium in bones, consider low dose Bone
Support nucleotide blend. Vitamin D and K impact calcium
absorption, so add a mineral combination that includes vitamin D
and K, such as Cal/Mag/VitD/VitK. Also, for bone health, watch
strontium and boron levels. Consider MTR/MTRR/SUOX
capsules to support strontium and boron. Also,
consider EDTA and MetalAway (or selenium + horsetail grass +
low dose EDTA + malic acid) to help escort lead from your
system. Also, use additional EDTA in EDTA soap or soak as
tolerated. Consider using BactiSolve if you have no shellfish
allergies, as another source of EDTA.
Consider ATP and/or MitoForce to support ATPase.

Thallium inhibits mitochondrial energy and ATP. It also

inhibits DNA and RNA synthesis. It may cause hair loss
and anorexia. Thallium can also cause riboflavin to be
Thallium
sequestered in the body. So Riboflavin-5-Phosphate support
should be used, especially if MAP test results show
imbalances in the Krebs energy cycle. Consider support
 with ATP, Riboflavin-5-Phosphate, and/or MitoForce to
address the impact on energy. Also, All in One for low dose
DNA and RNA support, and AHCY/SHMT compound, or
direct addition of nucleotides.
Uranium can readily combine with nucleotides in your
body and can deposit in your bones. It can also cause
chronic fatigue. Consider All in One for low dose
nucleotide support. Consider AHCY/SHMT compound for
nucleotide support, or direct nucleotide supplementation.
Uranium
Consider using Muscle Fatigue Support compound and low
dose Bone Support nucleotide blend.
Ultifend and Quercetin can be considered to help with damage to
DNA nucleotides secondary to uranium.

Barium can displace potassium, and may cause an increase

in stress hormones. It may also cause tingling and
weakness of muscles. Consider potassium support
with Potassium Citrate. If Krebs intermediates are low on
a MAP test, then use Krebs Magnesium-Potassium Chelates. If
Barium
gut pH is very low then consider Potassium Bicarbonate.
Also, Stress Foundation nucleotide blend and low dose Muscle
Support nucleotide blend may be a help. In addition, Padma
Basic may help with weak muscles and restless leg
syndrome if they are issues.
High levels of cadmium will definitely cause symptoms.
Your body uses zinc as a cofactor for over 50 critical
enzymes. However, if zinc is deficient, your body will
replace it with cadmium. Cadmium is just below zinc in
the periodic table, so it fits perfectly into zinc binding
sites. Enzymes that make protein, such as RNA
transferase, and alcohol dehydrogenase, the enzyme
involved in alcohol processing, are impacted by this
problem. Other important enzymes are also negatively
impacted. Cadmium may also bind to glutathione (GSH)
making it ineffective. It may also negatively impact bone
Cadmium health and cause respiratory symptoms. Consider
supporting with Zinc Lozenges, or Krebs Zinc, if your Krebs
intermediates are low on a MAP test. Also,
use MetalAway and/or EDTA to help escort cadmium from
your system. Since cadmium can bind GSH, consider
supporting with GSH. Low dose Bone Support nucleotide
blend may also be helpful.
Cadmium may decrease the Cytochrome P450 enzyme system, so
consider Indole-3-carbinol to support CYP 450. Since cadmium
replaces zinc in arteries, adults may want to consider low
 dose Heart Support nucleotide blend and Hawthorn Extract. Also,
use Vitamin E and low dose Ion Transport support capsules for
cadmium, as it helps to prevent the cadmium induced suppression
of the CFTR enzyme. Also, work on supporting methylation, as
weak methylation capacity is related to susceptibility to cadmium.
In addition, lithium, which is in both Be Calm Spray and All in
One, may help to protect against the negative impacts of cadmium,
especially with respect to hormones such as testosterone, LH, and
FSH.

In addition to a wide range of neurological symptoms,

mercury can also cause increased salivation, rashes, and
metallic taste in your mouth. It can impact cytochrome
P450, and may replace selenium in the T4 to T3 reaction,
thus causing thyroid hormone imbalances. Consider
support with Selenium or MetalAway. Also, GSH and Indole-
3-carbinol may be considered. Ultimately, you can support
re-myelination with Sphingolin.
Work on methylation cycle support to help allow the natural detox
of mercury. Also, the use of low dose Ion Transport
Mercury
compound may help support detox because it
contains Selenocysteine and Wasabi to aid in escorting mercury
from your system.
Basic methylation support includes All in One, Phosphatidyl
Serine Complex (PS/PE/PC), DHA and Methylation Support
nucleotide blend. Once lithium is shown to be in balance on
a HMT, then consider low dose Methylmate A and Methylmate B,
along with extra B12.

Nickel can cause significant skin rashes, allergies,

dermatitis and inflammation. Consider Riboflavin-5-
Phosphate, especially when phosphorus is low and nickel
toxicity is present.
Nickel
Consider nucleotide blends such as General Support nucleotide
blend and Cytokine Balance nucleotide blend to help with itching.
Clear Skin spray may be used for topical skin support.

Very high levels of selenium are toxic, so the goal is to be

Selenium within normal range for this mineral. Methylation cycle
function is needed to remove excess selenium, so until
 methylation support is in place, and you know you have
good methylation pathway function, do not use high dose
selenium. Consider support with MetalAway or other
sources of Selenium. Use low dose Ion Transport compound as
a source of selenocystene, or just use low
dose Selenocysteine. GSH and Vitamin E succinate aid in
maintaining selenium levels. Excretion of mercury,
antimony, arsenic, and/or thorium may lead to a greater
need for selenium support. DetoxAway can be considered
for higher dose support during detox once effective
methylation support is in place. As always, work with
your doctor.
Basic methylation support includes All in One, Phosphatidyl
Serine Complex (PS/PE/PC), DHA and Methylation Support
nucleotide blend. Once lithium is shown to be in balance on
a HMT, then add low dose Methylmate A, Methylmate B, and
extra B12 in the appropriate form.

This table contains the rationale behind my suggestions. These

SecondaryMETALS
suggestions are for your consideration. Defer your choices to
your own health care practitioner, as always.

Aluminum can impact the Krebs energy cycle, so consider

a Metabolic Analysis Profile (MAP test) if high levels are seen
on in the water supply. Also, aluminum can negatively
impact tetrahydrobiopterin (BH4) levels, which in turn
affects dopamine, serotonin and melatonin levels.
A Neopterin / Biopterin Profile Urine Test can be run to help
evaluate BH4 levels. Consider adding MetalAway, or
selenium, horsetail grass, low dose EDTA, and malic acid.
Aluminum
Also, consider additional EDTA and EDTA soap or soak as
tolerated. If you do not have shellfish allergies, consider
using BactiSolve. Use MTHFR A1298C Liver Support
capsules and/or BH4 to help support BH4 levels.
Use Vitamin E succinate if succinate levels are low on
the MAP test. You can consider a UAA test to look at
phenylalanine, tyrosine, and tryptophan levels to see if
additional BH4 support can be considered.
Excess iron is pro-oxidant and drives bacterial virulence.
Iron helps to increase SHMT activity, which diverts
methylation intermediates from both the MTR/MTRR
Iron enzyme reaction, what I call the long route around the
methylation pathway, and the BHMT enzyme reaction, the
short cut. Limiting iron is particularly important for those
who are SHMT +.
 Iron can bind tryptophan, so it may reduce serotonin levels.
H2S frees up iron, so check taurine and sulfur levels. If taurine and
sulfur are high, then consider that excess iron may be an issue.
High iron levels may be related to high methionine, so if your
methionine is high on a UAA test, check your iron levels.
Lactoferrin and/or AHCY/SHMT compound may help bind and
transport iron to where it is needed in your body. Also, if your iron
is high, work to shift acidic environments to alkaline
environments, because acid increases iron. So, consider Buffer
pH, VitaOrgan, and/or Stomach pH Balancing nucleotide blend.
Either sodium bicarbonate or Potassium Bicarbonate can be used
to help balance pH depending on your need for sodium or
potassium. Check pH on a CSA test, GI function test, or by testing
urine with pH strips.
Also, consider VDR/FOK Pancreatic Support capsules, because
iron can cause blood sugar issues when it replaces zinc.

If high manganese is the issue, consider

increased EDTA support. Excessively high levels of
manganese can cause psychosis as well as seizures.
Toxic doses of manganese can impact both GABA and taurine
Manganese levels and affect their transport. If an individual is intolerant to
GABA supplementation in spite of symptoms that suggest a need
for GABA, this may be related to high manganese in the water
supply.
Purpose of running this test:
Healthy levels of iodine are important for optimal thyroid function. Conversely, excess
iodine support may affect lithium levels by interfering with its uptake from your GI tract.
Lithium is important for B12 transport into the cell, so the goal is to get your iodine into the
normal range, with lithium levels higher than iodine levels. The HMT gives you an iodine
level, but the UTM/UEE does not. If your level of iodine on the HMT is out of balance, or if
iodine issues are suspected, then this Urine Iodine Test can be run. Alternately, a topical
iodine test can be done. A 2% solution of iodine is applied topically in a circular area about
the size of silver dollar on your abdomen. The spot should be allowed to dry completely
before putting clothing over it. Iodine can permanently stain clothes. The goal is for the spot
to remain visible for 12 to 24 hours. If the iodine disappears within 12 hours, then it may
indicate iodine deficiency which can be confirmed with this Urine Iodine Test, as well as
a HMT. The topical iodine test indicates body iodine stores due to the fact that your skin
absorbs iodine at the rate at which it is needed. There is some vaporization of iodine into
the air, so this test is approximate.

This table contains the rationale behind my suggestions. These

Result suggestions are for your consideration. Defer your choices to your own
health care practitioner, as always..

Topical iodine is absorbed especially rapidly when your immune

system is active due to infection or stress. In this case, for immune
support consider T cell and B cell support capsules, Phosphatidyl Serine
Complex (PS/PE/PC), Stress Foundation nucleotide blend, and Fenugreek,
in conjunction with low dose iodine. Repeated topical iodine
application as described above, may be sufficient to replenish
iodine, as well as to serve as an indicator of the iodine levels in
your body. Alternatively, low doses of Iodoral can be used,
Iodine
or Potassium Iodide, depending on your potassium levels. High
levels of iodine can have side effects, in addition to impairing
your uptake of lithium, which is critical for B12 transport. For this
reason, the goal of this program is to keep iodine levels in the
normal range without having high levels, or levels that exceed
those of lithium.PABA, found in Ultimate B and Niacinamide, can
be considered if you have concerns about thyroid autoimmunity.
In addition, Coleus may help to support your thyroid.
Purpose of running this test:
Gastrointestinal malabsorption, or leaky gut, can reduce nutrient absorption, lower amino
acid levels, be indicative of infection or inflammation in your gut, and negatively impact
growth. It is very useful to have a sense of the degree to which the integrity of your gut
absorption is compromised.
Unfortunately the Intestinal Permeability Test is not available in all states. While not
identical with the IP test, the Celiac Test described in Chapter 19, does provide some
related information regarding malabsorption, leaky gut, and reactions to gliadin and gluten
as allergens in your system which can contribute to leaky gut. Wherever possible, run both
tests, the Celiac and Intestinal Permeability test, for a more comprehensive sense of gut
permeability and inflammation.

This table contains the rationale behind my suggestions. These

Result suggestions are for your consideration. Defer your choices to your
own health care practitioner, as always.

Elevated values may be a reflection of leaky gut. Consider Leaky

Gut nucleotide blend, Bowel Support nucleotide blend,
and Glucosamine/Chondroitin Plus to help with GI mucosal
integrity. Also, consider General Support nucleotide
blend and Cytokine Balance nucleotide blend, along with Inflammatory
Imbalances in Pathway Support capsules, as well as VitaOrgan.If your amino acids
lactulose and are low on a UAA, consider AminoAssist spray, AminoAssist
mannitol capsules, Egg Protein Powder, and Ora-Placenta.
T cell and B cell support capsules may help support immune function if
your IgG levels are out of balance. Colostrum in particular supports low
IgA levels.
Purpose of running this test:
The Hepatic Detox Profile Test is used to determine the pressure under which your liver is
functioning to address detoxification, and if extra liver support may be useful. In some
cases, it reflects your exposure to toxins and your level of excretion of these toxins. In other
cases, the toxins may be sequestered in your body, or you may have difficulty with the
detox pathways, so your test results may come back normal even though you need liver
support. So, a value that is out of balance is meaningful and suggests a need for additional
support, but a normal level may not rule out your need for liver support, or suggest that
you have no toxins present in your system. Particularly if your toxic metal tests show high
levels of material, and/or a MAP test indicates that organic toxins are present, but this test
does not show elevations, you still need additional support for toxin excretion.
I have seen cases in which values on a Hepatic Detox profile were consistently in the
normal range, yet toxin excretion on HMT, UTM and FMT along with clinical symptoms,
suggested issues with toxic metals. As I have described in the past, chronic viral infection
can allow toxins to be sequestered that are not excreted until those viral infections have
been addressed. Viral antibody titers can be run through your doctor to assess this
possibility.

This table contains the rationale behind my suggestions. These

Result suggestions are for your consideration. Defer your choices to your
own health care practitioner, as always.

Consider Liver Support nucleotide blend and MTHFR A1298C Liver

Support capsules to support your liver. Also consider using GSH.If
your results on this test are within the normal range, yet high
levels of toxins are present on other toxic metal testing or on
a MAP test, then consider MetalAway, Ion Transport
compound and DetoxAway to help to encourage excretion.
However, when you are attempting to increase excretion of
toxins, work with and defer to your own health care
Imbalances in D professional.
glucaric &
mercapturic If viral issues are a concern, consider having your doctor run a range of
acids viral antibody titers that include IgM and IgG levels for Measles,
Mumps, Rubella, Chicken Pox, Herpes Viruses 1, 2 and 6, Hepatitis,
CMV and EBV. Immune support for viral concerns can include T
cell and B cell support capsules, Moducare, and the Metals nucleotide
blends, along with specific IMFs. As always when working on
detoxification, work with and defer to your own doctor.
Purpose of running this test:
The Porphryin Test measures a group of organic compounds that play critical functions in
your body. The best known porphyrin is heme, which gives the red pigment to your red
blood cells. Heme is part of the hemoglobin molecule that has the important function of
transporting oxygen in your blood stream. When the pathway for heme synthesis is
affected, such as in the presence of high doses of lead, then increased levels of porphyrins
can accumulate and be excreted in your urine.
Aside from serving as the oxygen carrying part of your red blood cells, heme also
contributes important components to your mitochondrial energy production system. So,
proper balance with respect to porphyrins in your body is important. Imbalances in
porphyrin levels may reflect oxidative stress, as well as high levels of particular toxins in
your body. Specific urinary porphyrins have been associated with very high levels of toxic
metals such as mercury, lead and arsenic. In addition, a range of medications and other
compounds may affect urine porphyrins, including alcohol, sedatives, analgesics,
antibiotics, estrogens, and oral contraceptives. Anemia, pregnancy, and liver disease can
also impact porphyrin levels.
While toxic metal profiles can be seen on HMT, UTM and FMT, this test also gives
information about imbalances in porphyrins that can explain mitochondrial energy issues,
bruising, bleeding, increased sun sensitivity, and potentially a greater need for B complex
and zinc.
Lead can block an early step in porphyrin synthesis that creates a compound which
competes with GABA. If you are experiencing symptoms that seem to be related to
glutamate/GABA balance, it may be due in part to the impact of lead on your porphyrin
pathway.
Imbalances in glycine levels also cause an increase in urinary porphyrin.
Porphyrins and pyrroles are different chemical structures. Porphrins are made of up
pyrroles, so concerns about kryptopyrrole, pyrrole, pyroluria and
HemoPyrrolLactamUria (HPU) are related to issues with porphyrins. This test looks at
excess porphyrins as an indicator of toxic metals in your body, but high levels on this
test may suggest a need to look more closely at pyrrole levels.
The major pyrrole that is measured on an HPU/pyroluria test is kryptopyrrole. There are a
number of labs that perform this test. However, the Environmental Medicine group in the
Netherlands has pioneered this work, so I prefer to send urine samples directly to them for
assessing kryptopyrroles if needed. Again, the Porphyrin Test is not measuring
kryptopyrroles. Rather it is looking at porphyrin levels as indicators of toxic metals in your
body. However, since porphyrins are made up of pyrroles, high levels of pyrroles on this
test may suggest a need to run a separate urine test looking directly at kryptopyrrole and
possible HPU/pyroluria. The link for the test directly from the Netherlands
is: http://www.hputest.nl/english.htm.
Kryptopyrroles bind B6 and zinc and can therefore cause deficiencies in these nutrients.
HPU or pylouria is essentially a condition of combined B6 and zinc deficiency. Zinc levels
can be assessed on a UEE and HMT and supported as needed. I do not recommend high
dose B6 or P5P support unless it is clearly indicated. B6 can lead to increased levels of
taurine on a UAA, deplete intermediates of the methylation cycle, put excessive pressure
on the transsulfuration pathway, and increase the need for B12 and molybdenum. This is
why administration of high levels of B6 should be used only if there is clear laboratory
indication for B6 support. Low level B6 support is recommended and is included in the All in
One general vitamin as well as Ultimate B.

This table contains the rationale behind my

suggestions. These suggestions are for your
Result
consideration. Defer your choices to your own
health care practitioner, as always.

These porphyrins are reported to reflect excess

pentacarboxyporphyrinogen &
coproporphyrinogen III &
precoproporphyrin
mercury in your body. Suggestions for
consideration are similar to those given when
high mercury is seen on toxic metal tests. Aside
from a wide range of neurological symptoms,
mercury can also cause increased salivation,
rashes, and metallic taste in your mouth. It can
impact cytochrome P450, and may replace
selenium in the T4 to T3 reaction, thus causing
thyroid issues.Consider support
with Selenium or MetalAway. If more detox is
desired, consider DetoxAway.
Also, GSH and Indole-3-carbinol may be used.
Ultimately, you can support re-myelination
with Sphingolin. Work on methylation cycle
support to help allow the natural detox of
mercury. Also, consider low dose Ion Transport
compound to help support detox because it
contains Selenocysteine and Wasabi to aid in
escorting mercury from your system.
Basic methylation support includes All in
One and Phosphatidyl Serine Complex (PS/PE/PC),
along with DHA and Methylation Support nucleotide
blend. Once lithium is shown to be in balance on
a HMT, then consider low dose Methylmate
A and Methylmate B, along with extra B12. Be sure
lithium is in balance on a HMT.

These porphyrins are reported to reflect excess

arsenic in your body. Suggestions for
uroporphyrins and consideration are similar to those given when
coproporphyrin I high arsenic is seen on toxic metal tests.
Methylation cycle function is needed for arsenic
excretion. If arsenic is consistently high,

coproporphyrin III and in some
cases coproporphyrin I
consider running a Water Elements Test. Arsenic
can bind both to thiol, which is an SH group, as
well as to phosphate. It can cause vitamin A
deficiency. Symptoms of arsenic toxicity can
include white streaked nails, a garlic odor
emanating from your body, and/or under
pigmentation. Arsenic toxicity may also cause
hair loss, problems with folate uptake, or
weakness, among other symptoms.At the very
least, consider short cut methylation support,
support for the pathway that goes from
homocysteine to methionine using the BHMT
enzyme. All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support
nucleotide blend all support the short cut. When
lithium is in balance, support the long route, the
route that uses the MTR and MTRR enzymes.
These supports include low dose Methylmate
A, Methylmate B, and B12. Also, thiol supports
may be useful, such as Selenium, MetalAway,
or DetoxAway; low dose Wasabi, low
dose Selenocysteine, or low dose Ion Transport
compound, which has
both Wasabi and Selenocysteine. Broccoli may also
be helpful. To support phosphate, use
phospholipids such as Phosphatidyl Serine Complex
(PS/PE/PC) and Riboflavin-5-Phosphate.
These porphyrins are reported to reflect excess
lead in your body. Suggestions for consideration
are similar to those given when high lead is seen
on toxic metal tests. Lead can deposit in bone
and replace calcium there. Lead can also affect
ATPase, which reduces the production of this
energy molecule. This negatively impacts both
sodium and potassium levels, as well as energy
production.Lead can bind melatonin,
tryptophan, and serotonin. Consider a MAP
test and a Neurotransmitter Urine Test to look at
energy markers, as well as neurotransmitter
levels.
Lead excretion can cause pica, teeth/jaw grinding &
aggression. Eating inedible objects may be a sign that
lead is being excreted. You may need to consider
support to help escort it from your system. Elevated 5-
amino levulinic acid (ALA) due to lead toxicity can
inhibit Gamma amino butyric acid (GABA), so

Uroporphyrin I and III &
coproporphyrin III
Overall elevated porphyrins
consider extra GABA if needed.
Since lead replaces calcium in bones, consider low
dose Bone Support nucleotide blend. Vitamin D and K
impact calcium absorption, so add a mineral
combination that includes vitamin D and K, such
as Cal/Mag/VitD/VitK. Also, for bone health, watch
strontium and boron levels.
Consider MTR/MTRR/SUOX capsules to support
strontium and boron. Also,
consider EDTA and MetalAway (or selenium +
horsetail grass + low dose EDTA + malic acid) to help
escort lead from your system. Also, use
additional EDTA in EDTA soap or soak as tolerated.
Consider using BactiSolve if you have no shellfish
allergies, as another source of EDTA.
Consider ATP and/or MitoForce to support ATPase.
These porphyrins may reflect excess aluminum
in your body. Suggestions for consideration are
similar to when aluminum is seen on toxic metal
tests. Aluminum can impact the Krebs energy
cycle, so consider a Metabolic Analysis Profile
(MAP test). Check aluminum l on a HMT. Also,
aluminum can negatively impact
tetrahydrobiopterin (BH4) formation, which in
turn affects dopamine, serotonin and melatonin
production. A Neopterin / Biopterin Profile Urine
Test can be run to help evaluate BH4
levels.Consider adding MetalAway (or selenium,
horsetail grass, low dose EDTA, and malic
acid). Also, you can use
additional EDTA and EDTA soap or soak as
tolerated. If you have no shellfish allergies,
consider BactiSolve. Use MTHFR A1298C Liver
Support capsules and/or BH4 to help support BH4
levels. Use Vitamin E succinate if succinate levels
are low on the MAP test. You can consider
a UAA test to look at phenylalanine, tyrosine,
and tryptophan levels to see if BH4 needs to be
added.
Consider MitoForce to support healthy
mitochondrial function due to the impact of
toxic metals on energy producing cytochromes
in your body. Also, consider a direct
kryptopyrrole test and assess zinc levels on
a HMT and UEE.
Purpose of running this test:
The Neopterin / Biopterin Profile Urine Test assesses the levels of these important
substrates in your body, biopterin being a breakdown product of tetrahydrobiopterin (BH4).
BH4 is critical for neurotransmitter production and other important functions, including the
processing of intermediates that generate oxygen free radicals. BH4 is a necessary
cofactor for endothelial nitric-oxide synthase (eNOS). Deficiencies in BH4 can therefore
allow for increased levels of the biologically toxic superoxide anion.
When you have an infection, neopterin may be produced preferentially over biopterin in
response to immune system requirements. A shift in the neopterin/biopterin balance away
from biopterin toward neopterin may be an indication of increased immune function in
response to infection. Knowing that this balance has shifted may be critical to your fully
understanding what is going on in your body.
Healthy levels of tetrahydrobiopterin are necessary for the synthesis of dopamine and
serotonin, critical neurotransmitters for executive mental function, mood and other organ
system function. The presence of BH4 also helps mitigate some of the reactive oxygen
species production that can occur secondary to urea cycle function. The levels of biopterin
on this test may or may not reflect biologic BH4 levels, because biopterin is an end product
of the processing of BH4. However, when used in conjunction with other tests that reflect
BH4 levels, this biopterin measurement is useful in assessing the need for supplemental
natural sources to support normal healthy BH4.

This table contains the rationale behind my suggestions.

Result These suggestions are for your consideration. Defer your
choices to your own health care practitioner, as always.

Consider T cell and B cell support capsules for immune

Elevated Neopterin
support. Stress Foundation nucleotide blend may be helpful
in supporting a healthy TH1 to TH2 balance for your
immune system.
To support healthy BH4 levels, consider MTHFR A1298C
Liver Support capsules, BH4, and Royal Jelly, if you have no
allergy to bees. In addition, a CSA test and GI function test can
be run to rule out GI bacterial sources of infection and
inflammation. General Support nucleotide
blend and Inflammatory Pathway Support capsules, along with
 other appropriate interventions for the underlying condition
involved, can be considered for inflammation and/or infection.

Low levels of biopterin may suggest a need to support

BH4. Conversely, very high levels may also indicate a
need for BH4 support. High levels of biopterin may
indicate excessive breakdown or processing of the
available BH4 in your system. In this case, additional
testing to evaluate the status of your BH4 level should
be considered.
Testing to assess your aluminum levels can be run. Aluminum
inhibits the activity of the DHPR enzyme needed to make BH4,
and may deplete BH4 levels. Either low or excessively high
biopterin, in conjunction with high aluminum levels, indicates a
need to consider supplemental natural BH4 support. Bacterial
infection in your body may be a reservoir for aluminum, so high
levels of bacteria are also an indicator for BH4 support.
Lack of or insufficient BH4 can be a factor in diminished levels
of serotonin and dopamine. Tryptophan needs BH4 for its
conversion to serotonin. Likewise, BH4 is needed both to
Biopterin convert phenylalanine to tyrosine and to convert tyrosine to
dopamine. Assess the levels of serotonin and dopamine on a NT
test, in conjunction with tryptophan, phenylalanine, and tyrosine
levels on a UAA, to help define your need for BH4, among
other things.
A “musty odor” coming from your body may be a sign of
phenylalanine excess. High levels of tryptophan, phenylalanine,
and tyrosine on a UAA test may also indicate a need for
additional BH4, such as BH4, MTHFR A1298C Liver Support
capsules, and/or Royal Jelly, if you have no bee allergies. Those
who are MTHFR A1298C + benefit from additional BH4
support. Lithium may also be a help in supporting healthy BH4
levels.
A lack of BH4 may be a factor in an increased level of reactive
oxygen species, so check the levels of methionine sulfoxide,
cystine and homocystine on a UAA as one measure of oxidative
 stress, as well as considering an Oxidative Damage test.

Purpose of running this test:

The Bone Resorption Assay is useful for assessing the need for natural bone support
compounds in older adults, as well as for those of you with high levels of toxic minerals in
your body, especially lead and cadmium. Lead and cadmium impair the integrity of bones
and may indicate the need for additional bone support for those with Ehlers Danlos
Syndrome.
Bone resorption is related to the activity of enzymes that break down bone, as well as
degrade collagen. These enzymes are called matrix metalloproteinases, abbreviated
MMPs. As you age, the level of MMPs increases, which may be related to increased bone
resorption. Studies have shown that decreasing the level of MMPs helps to limit some
types of bone resorption. Therefore, the Bone Resorption Assay may relate to MMP levels.
It is possible that this test indirectly indicates MMP activity.
Collagen is also broken down by MMPs. Ehlers Danlos Syndrome is a condition involving
improper processing of collagen. It is possible that an increase in bone collagen peptides
may be reflecting, in part, the activity of MMPs which are a factor in Ehlers Danlos, making
this test potentially useful for those with this condition.
A recent review by Chopra, Baveja and Kuhad (2015) suggests that excess MMPs play a
role in schizophrenia and brain inflammation.

This table contains the rationale behind my suggestions.

Result These suggestions are for your consideration. Defer your
choices to your own health care practitioner, as always.

Consider low dose Bone Support nucleotide blend,

and Bone Support capsules. Depending on your level of
calcium and magnesium on a HMT and UEE, you can
consider the use of Cal/Mag/VitD/VitK supplement, in
addition to the use of the Bone Support capsules. Recall
that calcium needs vitamin K and vitamin D to be used
effectively. Adding high doses of calcium in the
absence of vitamins D and K may not only be less
effective, but also may increase excitotoxin activity.
High level of bone
Calcium works in conjunction with excess glutamate to
resorption
cause excitotoxicity in your body. More is not always
better when it comes to calcium supplementation. Adult
females may want to consider Calcium Glucarate as the
preferred form of calcium if extra calcium support is
indicated. Calcium glucarate may help to pull excess
estrogen from your body. This can be useful for older
females, especially in conjunction with low dose Indole-
3-carbinol, or Broccoli. If hot flashes become an issue,
low dose Anxiety Balancing nucleotide blend may be used.
Ehlers Danlos Syndrome (EDS) is a condition related to
the processing, the production, and the structure of the
collagen which is ultimately produced, or the proteins
that work in conjunction with that collagen. One of the
hallmarks of this condition is extreme hypermobility. A
number of individuals with this condition have seen
Ehlers Danlos benefits from working on their methylation pathway
Syndrome function. In part, this may be related to studies
indicating that matrix metalloproteinases (MMPs) are
regulated by methylation (Chernov AV, Strongin AY.
2011;2(3):135-147). MMPs are enzymes that break
down collagen. Inadequate methylation may allow
increased activity of MMPs secondary to decreased
regulation of these enzymes. Basic methylation support
 includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide blend.
You may also consider low dose Methylmate A even
before lithium is in balance. Once lithium is shown to
be in balance on a HMT, then consider low
dose Methylmate B, along with extra B12. In addition to
addressing proper methylation cycle function, several
additional supplements may be useful for Ehlers Danlos
Syndrome. These include low dose Bone Support
nucleotide blend and Muscle Support nucleotide blend, as
well as supplements that support healthy collagen such
as Acute Injury. Supporting natural collagen processing
may be particularly helpful for this syndrome.
Elevated MMP levels have been associated with
psychiatric symptoms. Consult with your own doctor on
the use of low dose Bone Support nucleotide blend, TNF
nucleotide blend, Inflammatory Pathway Support
capsules, General Support nucleotide blend, Cytokine Balance
nucleotide blend and Heart Support nucleotide blend. In
addition, specific herbs have been reported to be helpful
for excess MMP activity, including Polygoni Multiflori
Psychological
Caulis, also known by other names in Traditional
conditions related to
Chinese Medicine. Phellodendron amurense and
imbalanced MMP
berberine containing herbs such
as Goldenseal or barberry have also been used. In
addition, extracts of Milk Thistle may be helpful. More
traditional medical approaches to excess MMP activity
include the use of doxycycline or minocycline. As
ALWAYS, work with and defer to your own doctor
before using supplementation and/or medication for any
health condition.
Purpose of running this test:

This Neurotransmitter Test assays neurotransmitters that function in your brain and body in
ways that define your personality and physical abilities. Low serotonin has been implicated in
OCD, perseverative behavior, depression, anxiety, and GI dysfunction. Dopamine is critical for
executive function, attention, focus, goal motivated behavior, and mood. Dopamine is further
converted into nor-epinephrine and epinephrine, neurotransmitters in themselves that may be
associated with hyperactivity and attention deficit. A higher ratio of norepinephrine relative to
epinephrine appears to be associated with ADD/ADHD.

I use several tests to get a complete sense of neurotransmitter formation, balance, and
breakdown. First, I look at the level of the starting material for the neurotransmitteritself. In
the example of serotonin,I am looking atthe level of the amino acid tryptophan. For dopamine,
I am looking at the phenylalanine and tyrosine levels. These are measured on a UAA.

I can then compare how much amino acid is present versus how much of it is converting into
its neurotransmitter, that level being measured by this test. From these two values, I make
inferences concerning the availability of BH4 in your body. BH4 is needed to convert
tryptophan into the neurotransmitter serotonin. It is also needed to convert both
phenylalanine into the amino acid tyrosine, and tyrosine into the neurotransmitter dopamine.
If these conversions are not happening well, I consider that BH4 may be low.

Finally, the level of the breakdown products of these neurotransmitters are measured on the
MAP test, the rate of neurotransmitter breakdown being a decisive factor in the final level of
neurotransmitter present in your body.
So, in order to assess neurotransmitter status and performance, I first look at a UAA to
determine the level of the starting amino acid for the neurotransmitter in question. Then, I
look at the reported neurotransmitter level on this Neurotransmitter Test. Finally, I look at
a MAP test to get the measurement of neurotransmitter breakdown products. From the UAA
and the neurotransmitter test results, I may also draw conclusions about BH4 levels.

This method of evaluating neurotransmitter (NT) status gives me a more complete picture of
the status of neurotransmitter formation, balance, and breakdownin your body, rather than
looking at reported neurotransmitter levels alone.

Finally, remember that all values on a urine test are reported after correcting for the creatinine
level. What this means is that the raw value for a particular NT is divided by the value of
creatinine to give you the final number you see on the test. Sometimes, if a person has
significant physical or psychological stressors in their body or life, the creatinine value can be
very high. This will make your NT values look low. So keep in mind the creatinine number, and
if it is above around 150, realize that your NT values may look lower than they actually are.

Conversely, if you used a very dilute urine sample for the test, then your creatinine may be
very low. This means that all urine sample values are divided by a small number, which will
make your NT values look higher than they actually are. If your creatinine level is below around
50, then be aware that your NT values may appear high.

This table contains the rationale behind my suggestions.

Result These suggestions are for your consideration. Defer your
choices to your own health care practitioner, as always.

5HTP is formed from tryptophan in the process of

synthesizing serotonin. High 5HTP on this NT test, along
with high tryptophan, phenylalanine, and tyrosine on
a UAA, may signal a need for more BH4. BH4 is needed to
convert 5HTP to serotonin, as well as for the conversion of
phenylalanine to tyrosine, and tyrosine to dopamine. For
low BH4, consider natural support to reach a healthy
normal range, including MTHFR A1298C Liver Support
5 Hydroxy Tryptophan capsules, BH4, and Royal Jelly, if you have no bee allergies.
(5HTP) When looking at 5HTP, be sure to look at the levels of the
available starting materials for serotonin, which are
tryptophan and 5HTP, in conjunction with the level of
serotonin on a NT test, and then the level of serotonin
breakdown on a MAP test. The goal is to have a healthy
level of serotonin without levels of its starting materials,
tryptophan or 5HTP, or its breakdown product, 5HIAA,
being either too high or too low. For high 5HTP, use
more BH4 support. For low 5HTP,
consider AminoAssist and low dose SeroMood.Excessive
 breakdown of tryptophan and 5HTP may be due to a need
for niacin or Niacinamide, vitamin B3, so consider
using Ultimate B or extra Niacinamide.

There is a delicate balance in the body between the

serotonin metabolites melatonin, 5HIAA, and tryptamine.
Tryptamine may cause neurologically based symptoms
affecting mood, appetite, emotions, sleep, OCD behaviors,
and psychosis. In fact, the psychosis inducing impact of
tryptamine has been compared to LSD and mescaline.
Elevated tryptamine urinary excretion has been
observed in schizophrenic patients, suggesting that
tryptamine may be involved in the pathophysiology of
schizophrenia. Ketosis increases tryptamine levels in
animal models. Ketosis occurs when the body is breaking
down its own stores of glycogen, stored carbohydrate,
rather than using carbohydrates from food. A low
Tryptamine carbohydrate diet, and/or significant long term exercise
may cause the body to break down glycogen, generating
ketone molecules and ketosis. In addition, lack of digestive
enzyme support or biotin to help process fats for energy,
or ACAT + status may also generate ketosis. Ketosis can be
evaluated on a MAP test.Tryptamine-induced symptoms
include vegetative states, athetoid movements, delusions,
hallucinations, autistic-like behavior, language
disturbances, spatial and temporal perception
disturbances, euphoria, and anxiety.

The use of Yucca, along with GSH support, may help to

process unwanted tryptamine. Also, Feverfew may help to
keep a better balance among serotonin compounds,
including tryptamine.

If your serotonin levels are low, check that copper is not

high on a HMT and UEE, because copper works with the
MAO enzyme to break down serotonin. Also, check 5HIAA
levels on a MAP test, as 5HIAA is a breakdown product of
serotonin. The use of Molybdenum, Manganese, and low
Serotonin/melatonin dose EDTA may help if your copper levels are high and are
thereby causing increased serotonin degradation. A
number of toxic metals can bind to tryptophan or to
serotonin, so if your serotonin levels are particularly low,
run a HMT, UTM/UEE, and/or FMT to check on your levels
of aluminum, lead, and iron. Serotonin is formed from
tryptophan or 5HTP with the help of BH4. Check your
5HTP levels on this NT test, as well as your tryptophan
levels on a UAA, to be sure that you have sufficient
tryptophan to produce serotonin. Also, check the
indicators on a UAA, MAP, and a Neopterin / Biopterin
Profile Urine Test to see that you have sufficient BH4 for
serotonin to be produced from tryptophan. High
tryptophan along with high phenylalanine and tyrosine on
a UAA may signal a need for BH4 support.
Consider MTHFR A1298C Liver Support capsules, BH4,
and Royal Jelly, if you have no bee allergies, to naturally
support healthy levels of BH4. Low serotonin may also be
due to increased breakdown rather than a lack of
synthesis. Consider a MAP test to look at the breakdown
product from serotonin, 5HIAA. The goal is to have
balance among these three: 1) the levels of the available
starting materials for serotonin production, ie, tryptophan
and 5HTP; 2) the level of serotonin on this NT test; and, 3)
the level of 5HIAA, the breakdown product of serotonin on
a MAP.Pay special attention to aluminum on a HMT and a
UEE, because aluminum interferes with the production of
BH4. Check that bacterial imbalances are not an issue, as
this may lead to high aluminum, which in turn decreases
BH4 production. Consider MetalAway and EDTA
soap or soak to help address aluminum.

Tryptophan breakdown can be increased by bacteria.

There is a balance between tryptophan and vitamin B3
levels which helps to support tryptophan. Consider
using Ultimate B, Niacinamide, and /or NADH.

Also, for low levels of serotonin, you can consider using

low dose Mood S nucleotide blend.

Conversely, levels of serotonin that are too high may be

due to decreased breakdown of this neurotransmitter by
the MAO enzyme. Licorice can inhibit the action of MAO
causing serotonin levels to climb. This is not optimal,
because serotonin may then feedback and inhibit itself.

Also, if serotonin levels are high, do a UAA to check for

excess CBS activity, which may be detected from
elevations in taurine. Excess CBS activity can generate
increased levels of H2S, which also inhibits MAO enzyme
activity. Check your levels of sulfur on a HMT and UEE,
because, in conjunction with other data, they may also
 indicate excess H2S.

Lack of copper may limit MAO activity, causing serotonin

levels to climb. Ideally, your level of zinc should be higher
than copper to support attention and focus, as well as for
melatonin production, but it is important for copper to be
available to work with MAO, especially if serotonin levels
are high.

Serotonin converts to melatonin at night to support sleep.

If needed, Melatonin Sleep Spray or other forms of
melatonin can be used. Cherries are a natural source of
melatonin, however cherries are also a source of
quercetin. While quercetin may help with increased
histamine and oxidative DNA damage, it also inhibits
COMT, which may be an issue for those who are COMT ++.
Zinc works with melatonin, so be sure zinc levels are in
balance. Magnesium support can also be assessed as
magnesium may stimulate melatonin release.

Serotonin also plays a role in platelet clotting. If bruising

and bleeding is an issue for those with low serotonin, you
can consider using Vitamin K, Myrrh, and Topical Arnica
Gel as needed, along with supports to help balance low
serotonin levels.

Imbalances in serotonin have been implicated in

perseverative and OCD behaviors. In addition to balancing
serotonin, the use of Fenugreek may also be helpful for
these symptoms, along with TNF Support nucleotide
blend.

L dopa is formed from tyrosine in the process of

synthesizing dopamine. Low L dopa on this NT test, along
with high phenylalanine, tyrosine, and tryptophan on a
UAA, may signal a need for more BH4, since BH4 is needed
to help convert tyrosine to L dopa. For low BH4, consider
natural supports to reach a healthy normal range,
L dopa including MTHFR A1298C Liver Support capsules, BH4,
and Royal Jelly, if you have no bee allergies. When
balancing tyrosine and L dopa, look at the available
tyrosine on a UAA because it is the starting material for
both L dopa and dopamine. Then look at the levels of L
dopa and dopamine on this NT test. Then, finally look at
the level of the breakdown product of dopamine on
 a MAP test. The goal is to have a healthy level of
dopamine without excessive HVA, the dopamine
breakdown product, or levels of tyrosine, the dopamine
starting material, that are either too high or too low. For
high tyrosine but low L dopa, consider more BH4 support.
For low tyrosine and low L dopa, you can
consider AminoAssist or other forms of amino acid
support.

Dopamine is formed from tyrosine in conjunction with

BH4 to first produce L dopa, and then finally dopamine.
Check L dopa levels on this NT test, as well as tyrosine
levels on a UAA, to be sure that there is sufficient tyrosine
to produce L dopa, and ultimately dopamine. Also, check
for indicators on a UAA, MAP test, and a Neopterin /
Biopterin Profile Urine Test that there is sufficient BH4 for
the reaction to proceed. Low dopamine may be due to
increased breakdown rather than a lack of synthesis. If
dopamine levels are low, check that copper is not high on
a HMT and UEE, because copper works with the MAO
enzyme to break down dopamine. HVA represents the
breakdown product of dopamine. Its level can be checked
on a MAP test. The use of Molybdenum, Manganese, and
low dose EDTA may help if copper levels are high and are
causing increased dopamine degradation. Consider
running a MAP test to look at breakdown products from
Dopamine
dopamine such as HVA. The goal is to be sure that there is
balance among the level of tyrosine on a UAA, the
available starting material for dopamine, the reported
levels of L dopa and dopamine on this NT test, and the
level of HVA, the breakdown product of dopamine on a
MAP test. Pay special attention to aluminum on a HMT
and a UEE, as aluminum may reduce BH4 levels. Check
on CSA / GI Effects testing that bacterial imbalances are
not an issue, as this may generate high aluminum levels,
which in turn inhibits the production of BH4.
Consider MetalAway to help address aluminum in order to
support healthy BH4 levels.If values of dopamine are very
low, consider the use of low dose ginkgo biloba, mucuna
pruriens, Mycoceutics, low dose Mood D nucleotide blend,
and Mood Focus nucleotide blend, depending on your
nutrigenomics.

Adequate ATP can support dopamine release. The use

 of MitoForce and/or ATP may help low levels of dopamine,
especially if other markers for ATP indicate a need
for ATP support, such as energy data from a MAP test and
low phosphate levels.

High tryptophan along with high phenylalanine and/or

tyrosine on a UAA may signal a need for more BH4.
Consider MTHFR A1298C Liver Support capsules, BH4,
and Royal Jelly, if you have no bee allergies, to naturally
support healthy levels of BH4 if indicated.

Conversely, levels of dopamine that are too high may be

due to its decreased breakdown. Licorice can inhibit the
action of the MAO enzyme, causing dopamine levels to
climb. This is non-optimal, as dopamine can then feedback
and inhibit itself.

If dopamine levels are too high, consider a UAA to check

for excess CBS activity, which may be indicated by
elevated taurine. Excess CBS activity can generate
increased levels of H2S, which also acts to inhibit the MAO
enzyme. The levels of sulfur on a HMT and UEE may also
indicate excess H2S levels, if this coordinates with other
test data.

Lack of copper may limit MAO enzyme activity causing

dopamine levels to become high. Ideally, the level of zinc
should be higher than copper to enhance attention and
focus, as well as for melatonin production. However, it is
important that copper be available to catalyze MAO
activity, especially if dopamine levels are high.

Finally, lithium may play a role in modulating dopamine

levels, so run a HMT and UEE to be sure that lithium is in
balance.

Some studies indicate that excessive dopamine and high

norepinephrine are factors in Tourette’s Syndrome, which
is characterized by spontaneous vocal and motor tics. TNF
Support nucleotide blend may help in these
circumstances.

3-methoxytyramine is a partial breakdown product of

3 Methoxytyramine dopamine that is formed by the action of COMT. 3-
methoxytyramine is then processed by MAO to HVA. Thus,
checking the level of 3- methoxytyramine on this NT test,
 and HVA on a MAP test, helps to distinguish the steps in
dopamine processing between the step that is achieved by
the action of COMT, and the step that is achieved by the
action of MAO. Some NT tests give a measure of DOPAC,
as opposed to 3-methoxytyramine. DOPAC is formed
when dopamine is first acted on by MAO. Then, in a
second step, COMT converts DOPAC to HVA. The MAP test
reports only HVA, the final breakdown product of
dopamine via either route. This NT test, which looks at 3-
methoxytyramine, is also assessing the activity of COMT
on dopamine. A NT test that looks at DOPAC is assessing
the activity of MAO on dopamine. The combination of
either a DOPAC value or a 3-methoxytyramine value, in
conjunction with the HVA value on a MAP test, gives
composite information about dopamine breakdown, and
enables you to discern which steps in the dopamine
breakdown process may be most active or may need
additional support.

High norepinephrine relative to epinephrine may interfere

with focus and attention. High norepinephrine relative to
epinephrine may be due to toxic lead which inhibits the
enzyme PNMT that converts norepinephrine to
epinephrine. See suggestions in
the UTM/UEE, HMT and FMT chapters about addressing
lead in your system. Supplements that may help with
attention and your norepinephrine to epinephrine balance
include low dose Attention Support nucleotide
blend, NADH, MTHFR A1298C Liver Support
capsules, BH4, DMG, SAM-e, Phosphatidyl Serine Complex
(PS/PE/PC) , Vitamin C with rose hips, Zinc Lozenges,
Norepinephrine and Royal Jelly, if you have no bee allergies. Acute stress
may also increase norepinephrine. Consider
using Phosphatidyl Serine Complex (PS/PE/PC), Stress
Foundation nucleotide blend, and Fenugreek to help with
the stress response. High levels of norepinephrine may
lower BH4, so consider other testing to be sure that you
have sufficient BH4 available. If other tests indicate a need
for BH4 support, and/or you are concerned about your
BH4 levels, use MTHFR A1298C Liver Support
capsules, BH4, and Royal Jelly, if you have no bee
allergies.Some studies indicate that excessive dopamine
and high norepinephrine are factors in Tourette’s
syndrome, which is characterized by spontaneous vocal
 and motor tics. Consider a CSA and GI Effects test to rule
out Streptococcus as a causative factor in Tourette’s
Syndrome. TNF alpha has been definitively associated with
strep infection. Use supports to help balance excess TNF
alpha, such as TNF nucleotide blend.

Normetanephrine is a partial breakdown product of

norepinephrine that reflects the action of COMT on
norepinephrine. Comparing MHPG on a MAP test to
Normetanephrine
normetanephrine on this NT test separates the action of
COMT to form normetanephrine from the action of MAO
that produces MHPG from norepinephrine.

Low epinephrine relative to norepinephrine may interfere

with focus and attention. If relative epinephrine levels are
too low, use Vitamin C with rose hips, as that may
enhance epinephrine levels. Supplements that may help
with attention and norepinephrine to epinephrine balance
Epinephrine
include low dose Attention Support nucleotide
blend, NADH, MTHFR A1298C Liver Support
capsules, BH4, DMG, SAM-e, Phosphatidyl Serine Complex
(PS/PE/PC), Zinc Lozenges and Royal Jelly, if you have no
bee allergies.

Glutamic acid, or glutamate, is an excitatory

neurotransmitter. While I am thinking, talking, processing,
and sharing with you, the glutamate receptors in my
neurons are functioning actively to take glutamate in. You
need glutamate for learning, attending, and functioning. In
fact, the more intelligent you are, the more glutamate
receptors you have on your cells. But too much glutamate
being taken into your nerve cells may damage or destroy
them. It would be like turning a light switch on and off
Glutamic Acid & GABA continuously until it breaks. A number of other substances
related to glutamate will also act as excitatory
neurotransmitters at glutamate receptor sites. They
include glutamine, alpha ketoglutarate, and monosodium
glutamate or MSG. The aspartate family of molecules will
do this also. They include aspartate, aspartic acid, and
aspartame, commonly known as NutraSweet. Cysteine can
also act as a mild excitatory neurotransmitter, but N-acetyl
cysteine does not. However, N-acetyl cysteine contains an
acetyl and a sulfur group and so must be used
thoughtfully. Glycine is also a special case
neurotransmitter. If the balance in your body is towards
glutamate, glycine will be excitatory. If the balance is
toward GABA, it will be inhibitory. So if you tend toward
glutamate excess, avoid glycine. The number of glutamate
receptor sites you have on your neuron surfaces is an
important determinant of the level of glutamate in your
cells. The more glutamate receptor sites you have, the
more glutamate you take in, thus your resting level of
glutamate is higher. In this case your balance tips to favor
excitotoxicity. Glutamate excitotoxicity produces nerve
damage or death by inducing inflammation. Increased
numbers of glutamate receptors have been associated
with neurologic disorders such as Lou Gehrig’s Disease or
Amyotrophic Lateral Sclerosis (ALS), Fragile X,
schizophrenia, and seizure disorder.It was initially thought
that autistic children had fewer glutamate receptors, but
subsequent studies, including one from the prestigious
journal Neurology published in 2001, showed that autistic
children, in fact, have more glutamate receptors than
normal controls. Furthermore, they are genetically
predisposed to have more. So autism is another hyper-
glutamate condition.

If you keep the total amount of glutamate in your body

under control, you can limit neurologic symptoms. One
way you can do this is by eliminating gluten and casein
from your diet. You also want to eliminate glutamate and
anything that sounds like that, and aspartate and anything
that sounds like that, from your supplements. Glutamine is
a frequently recommended supplement, but glutamate
and glutamine change back and forth into each other. This
means that the administration of glutamine, say for gastro
intestinal support, actually increases the level of
glutamate. Increased glutamate may produce insomnia,
decreased eye contact, and too much acetylcholine, which
can lead to bladder contraction and abnormal eye
movements called strabismus. Increased glutamate also
causes an increase in self-stimulatory behavior, commonly
called stims. In adults, too much glutamate may be a
factor in heart palpitations, inability to fall asleep, and
excessive urination.

One of the ways your brain deals with excitotoxin damage

is to increase the level of opioids that are produced.
Opioids are opium-like substances. Obviously, they will
interfere with your ability to function.

Elevated levels of glutamate can deplete your levels of

glutathione (GSH). GSH is a central antioxidant and metal
detox molecule. Depleted GSH leads to increased
inflammatory mediators, including TNF alpha. Depleted
GSH and increased TNF alpha can exacerbate leaky gut,
generate gastrointestinal inflammation, and mediate
allergic intolerance to foods.

GABA is a calming NT that helps to balance out the impact

of glutamate. GABA, gamma amino butyric acid, is an
inhibitory neurotransmitter. Glutamate should convert
into GABA when it is acted on by the enzyme glutamic acid
decarboxylase (GAD), but several factors may interfere
with this conversion, and you get stuck at glutamate. The
rubella virus interferes with the activity of the GAD
enzyme. This is the same virus that is in the MMR
vaccination. It has been shown in Type 1 Diabetes that the
rubella virus can cause the GAD enzyme to stop
functioning. The body makes antibodies against it. In some
studies, enzyme activity was decreased by 50%.

Viral issues are related to methylation. If you are

producing insufficient methyl groups, then you cannot
methylate viral DNA to silence the virus. In addition, the
methylation cycle is involved in new DNA synthesis that
makes immune cells such as T-cells, which deal with viral
infection.

When someone speaks to you and you are not quite

attending, you may turn to them and say, “What did you
say?” Before they can answer you, your mind replays it,
and you can recover what they said. GABA is the
neurotransmitter involved with this function. GABA is very
prominently involved with the neuronal connections of
language. It actually puts the gaps between words.
Decreased GABA leads to increased anxiety, increased
aggressive behavior, decreased social behavior, decreased
eye contact, and decreased bowel function. GABA is
necessary to stimulate bowel contraction. Decreased
GABA also causes eye-focusing problems, like both eyes
focused in toward the nose or vertical or horizontal eye
wavering.
Calcium is another factor in the glutamate GABA story. If
glutamate is like a gun, then calcium is the bullet.
Glutamate creates the scenario for excitotoxicity to
happen, but the factor that actually destroys the nerve cell
is the influx of calcium. The combination of excessive
glutamate from any source and too much calcium is a
major problem.

Evaluate calcium levels using a UEE. Vitamin D and Vitamin

K are fat-soluble vitamins and are important for re-
establishing calcium balance. Your body can store Vitamin
D, but Vitamin K may need to be supplemented on a daily
basis, unless you are eating dark leafy green organic
vegetables and are able to absorb the nutrients from
them.

Supplementing calcium be accomplished by

using Chamomile and/or Nettle rather than by taking
calcium directly. Increasing magnesium relative to calcium,
using zinc to limit glutamate damage, and monitoring
lithium, iodine and boron levels, all aid in reducing
glutamate levels and reversing the flow of calcium into the
neurons and back to the bones and teeth.

You can evaluate glutamate and GABA levels by running

a UAA. The UAA has both of these neurotransmitters on it.
You can supplement GABA directly, and also consider the
glutamate GABA balancing BeCalm Spray.

In the presence of ammonia and ATP, glutamate is

converted to glutamine. Your levels of both glutamine and
glutamate should be considered as they convert into one
another. If your level of phosphate is low, then leucine is
increased, which in turn increases glutamate and alpha
KG, and in addition can cause hypoglycemia.

Consider supplements that help with glutamate/GABA

balance such as Nerve Calm nucleotide blend, BeCalm
Spray, GABA Balance capsules, Pycnogenol, Grape Seed
Extract, and Resveratrol. Consider using Carnosine if your
levels on a UAA are low, as it may decrease glutamate
transport. Jujube & CoQ10 may also help control excess
glutamate. Eliminate sources of glutamate and other
excitotoxins. Also, check a HMT and UEE for the levels of
minerals that can help with glutamate and calcium
balance, such as Zinc, Magnesium and Lithium.

According to the literature, creatine may help reduce

glutamate, so consider Creatine support if your creatinine
levels are low.

Consider checking hydroxyproline levels, as high

hyrdoxyproline can increase glycine and increase
glutamate. When glutamate is high, then glycine can
exacerbate the effects of glutamate, so check glycine
levels and use SHMT Spray and AHCY/SHMT compound as
needed to help with glycine balance.

H2S increases NMDA responses, so it is important to check

taurine levels to be sure there is not too much flow from
taurine to H2S. See suggestions for balancing high taurine
levels if this is an issue, and be sure you have
sufficient Molybdenum and B12 to process sulfur groups.
You can consider Black Bear Spray or Black Bear Drink for
low doses of molybdenum and B12.

Low levels of GABA may play a role in spasticity and

involuntary movement syndromes.

Toxic levels of manganese may impact both GABA and

taurine levels and affect their transport. If an individual is
intolerant to GABA supplementation in spite of symptoms
that suggest a need for GABA support, then check
manganese levels to be sure they are not high. The use of
valerian root in conjunction with low dose GABA may be a
consideration for you and your doctor, as valerian may aid
in GABA transport. If high manganese is the issue, consider
increased EDTA support. Working with, and deferring to
your own doctor consider the use
of MetalAway, DetoxAway, EDTA soap and soak, and
additional EDTA capsules can be considered.

If GABA is not tolerated, consider ruling out high

manganese in your home water supply by using the Water
Elements Test. Some defective water filtration systems
may be a source of higher than ideal levels of manganese
in your drinking and bathing water supply. Since
manganese is important for helping to process arginine,
consider supporting with low dose Manganese if arginine
is high on a UAA test. However, high levels of manganese
are a concern for the reasons described below. Ideally,
 manganese levels should be in the lower range of normal
so that they are sufficient to support reactions that
require manganese without allowing levels to climb too
high.

Excessively high levels of manganese can cause psychosis

as well as seizures. Excessive accumulation of manganese
causes a neurological condition called “manganism” that is
characterized by psychosis and eventually followed by
symptoms similar to those seen in Parkinson’s disease.
High levels of manganese have also been associated with
ALS, and biochemical changes similar to Alzheimer’s and
Huntington’s disease (Sidoryk-Wegrzynowicz, 2013). High
levels of manganese can cause increases in reactive
oxygen species, so consider Ultifend; impair glutathione
levels, so consider GSH; and increase inflammatory
mediators, so consider General Support nucleotide
blend and low dose TNF nucleotide blend. High dose
manganese may also decrease dopamine levels.

The basic components of allergic inflammation include

mast cells, basophils, and eosinophils. Specific IgE
molecules that are generated due to very precise allergens
bind to mast cells, eosinophils, and basophils, causing the
release of histamine, which causes immediate, and
sometimes very intense, hypersensitivity reactions.In
addition to their activity in causing inflammation, mast
cells, basophils, and eosinophils also play a protective role
in immune function. Conversely, excessively high levels of
mast cells, called mastocytosis, or high levels of mast cell
degranulation and release of histamine can cause health
Histamine problems. Mast cells are like water balloons filled with
histamine. When your body reacts to an allergen, it is like
sticking a pin in a water balloon, allowing the histamine to
burst out. Mast Cell Activation Syndrome (MCAS) is a
condition in which there may be excessive numbers of
mast cells that are triggered even in the absence of a
specific allergen. In either case, the goal is to both reduce
the number of mast cells, as well as to mitigate the high
histamine levels.First, realize that there is a relationship
between histamine and the methylation cycle. Low
tetrahydrofolate (THF) levels can cause elevated histidine.
Elevations in histidine in turn cause increased levels of
histamine. So, high histidine along with high histamine
may indicate a need for THF. Consider All in
One or Ultimate B to help support healthy natural THF
levels. In addition, check FIGLU levels on a MAP test, as
FIGLU will also climb If there is not sufficient THF. Thus,
high FIGLU may be an indirect sign of excess histidine.
High levels of histidine may depress the levels of other
amino acids, as well as be related to high cholesterol. A GI
function test can be run to look at cholesterol levels.

In addition to the need for adequate THF, the methylation

cycle is also important in processing the histamine that is
produced secondary to a lack of THF. FIGLU is an indicator
for low THF. When FIGLU is elevated it leads to the
formation of histidine, which can convert to histamine.
You need methyl groups to process histamine. Working on
basic methylation cycle support, as well as the use of SAM-
e, may help you process histamine, because SAM-e may
specifically help to lower histamine. Some reports also
suggest that methionine may have a similar impact;
however, the effect of methionine may be due to its
conversion into SAM-e, which is the active agent in
lowering histamine.

Histamine is broken down by the enzymes diamine

oxidase (DAO) and histamine N-methyltransferase
(HNMT). The HNMT enzyme requires methylation cycle
function in order to break down histamine. The DAO
enzyme needs copper to function. High levels of copper
can be an issue for other NTs, increasing the breakdown of
serotonin and dopamine, as well as negatively impacting
attention. So, the goal is to keep copper in a normal range,
with zinc levels higher than copper. In this way, there is
sufficient copper for DAO function without causing
increased serotonin or dopamine breakdown or causing
issues with attention.

In addition, rule out excess CBS activity on a UAA, as the

high H2S that can be generated due to excess
transulfuration activity can decrease MAO activity.

Licorice can also inhibit MAO enzyme activity, so low

copper, high H2S, and licorice, may slow the breakdown of
histamine and lead to higher levels of histamine. Limit
licorice ingestion in this situation and in general.

Some patients with Postural Orthostatic Hypotension

Syndrome (POTS) have co-existing complaints of episodic
flushing. In about half of these cases there is an associated
mast cell activation disorder. This can be diagnosed by
collecting urine from individual 2-4 hour voids following a
severe flushing spell for determination of
methylhistamines

Acrocyanosis due to POTS is reported to be helped

with Nerve Calm nucleotide blend, BH4 support,
and MTHFR A1298C Liver Support capsules, as well
as CBS/NOS Kidney Support capsules. A striking physical
feature of POTS is the acrocyanosis that occurs in the legs
of 40-50% of these patients. They experience a dark red-
blue discoloration of their legs, which are cold to the
touch.

In addition to supporting healthy histamine breakdown,

and being sure that FIGLU does not climb too high
allowing increased histamine synthesis, it is also important
to pay attention to vitamin B6 levels. Vitamin B6, or P5P
(pyridoxal 5 phosphate) helps to produce higher levels of
histamine. This program uses only low levels of B6/P5P for
reactions that need it, such as converting glutamate to
GABA, without using the excessively high levels of B6/P5P
that are employed by some other programs.

The reason I suggest Ultimate B as the B complex of choice

is that it is specially formulated to have the most active
forms of B vitamins, while at the same time only including
low levels of B6/P5P. The same is true for the general
vitamin this program uses, All in One. It does support B
vitamins, while maintaining only low levels of B6/P5P, as
higher doses of B6/P5P may produce increased levels of
histamine.

You may be able to slow down some of the mast cell

degranulation and histamine release of an IgE reaction by
the use of quercetin. Quercetin is not optimal for those
who are COMT + +. While it may be a help for high
histamine, as well as for oxidative DNA damage, it is not
ideal for those who are COMT ++ because it can inhibit
COMT. Cherries are a natural source of quercetin, so while
cherries may help with inflammation, gout, and some
forms of arthritis, the quercetin levels in cherries may be
an issue for those who are COMT ++.
Also, Butterbur, which is in Petadolex, blocks the action of
histamine. In general, keeping inflammation in check by
using General Support nucleotide blend, Cytokine Balance
nucleotide blend, Nettle, Boswellia,
and Curcumin or Inflammatory Pathway Support capsules,
are other routes to consider.

Working on leaky gut to limit immune responses to food

may also be useful. Bowel Support nucleotide
blend and Leaky Gut nucleotide blend can be considered.
In addition, mast cells are released in H.pylori infection. Be
sure you do not have H.pylori, which may be causing
eosinophilia or sarcoidosis. See Chapter 7 for a more
complete discussion of H.pylori. Low dose Respiratory
Support nucleotide blend may be a help, along with low
dose Hyper-Balancing nucleotide blend, NOT Hypoimmune
nucleotide blend. As always, defer to and work with your
doctor. Cross check supplementation with your doctor.

In addition to the role played by IgE and allergies in

triggering mast cell histamine release, the compound nitric
oxide may also regulate mast cell function. According to
Guzik et al, “Activation of nitric oxide producing cells in
the tissue microenvironment may be important in the
control of mast cell-dependent allergic reactions”. Since
tetrahydrobiopterin (BH4) is important for all NOS
reactions, it is important to support healthy natural BH4
levels with BH4 and MTHFR A1298C Liver Support
capsules.

Finally, more traditional medications may be a help if

natural approaches are not enough to address severe
Mast Cell Activation Syndrome (MCAS). The antibiotic
minocycline has been reported to limit certain
inflammatory reactions and can be used for anti-
inflammatory purposes rather than for its antibiotic
properties. Minocycline has been a help for limiting
excessive microglial activation that plays a role in chronic
neurological inflammation. In addition, minocycline has
been reported to reduce overall levels of IgE. The action of
IgE specific allergens binding to mast cells allows for the
massive release of histamine in allergic conditions.
Limiting IgE levels while identifying and eliminating the
allergy triggers may be a help in extreme conditions in
which natural approaches have not been sufficient.
The combination of Claritin and Pepcid has been reported
to lower the number of mast cells in skin reactions, as well
as to decrease histamine levels. While I generally prefer to
go the more natural route first, to work on the underlying
causes, in extreme conditions of MCAS, the combination
of medication with natural supplements may be
considered. As always, work with and defer to your own
doctor.
Purpose of running this test:
This Vaginosis Test is indicated when yeast and fungal markers are elevated on a MAP
test, a CSA/GI test indicate that you have yeast or fungus, if you are an adult female with
CFS or FM, or if you have symptoms of yeast infection or vaginal odor.

This table contains the rationale behind my suggestions. These

Result suggestions are for your consideration. Defer your choices to your
own health care practitioner, as always.

If your levels of normal flora are low, consider rotating

different forms of normal flora. Concentrate on Lactobacillus,
Lactobacilli as well as rotating in normal yeast flora, such as low
dose Saccharomyces boulardiii. Sources of lactobacillus
include Suprema dophilus, Lactobacillus, and NutriClean.
Gram negative Consider Naturomycin Spray, Naturomycin capsules, grapefruit seed
rods extract (GSE capsules or GSE liquid), and Cranberry.
Diet is important for the eradication of yeast, particularly
limiting sugar intake. Controlling the yeast in your GI tract is
necessary for controlling the growth of vaginal yeast. Work
with your health care provider on diet.You can
consider Garlic, Candisol, Mycology Support nucleotide
blend, Goldenseal, Juniper Berry, and IMF 7.
In addition, you can consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain different herbs
that work together for optimal results. Naturomycin Spray is a source of
the following herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap, and Goldenseal. Naturomycin
Yeast capsules are a source of the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive leaf, Oregano,
black walnut, Juniper Berry, Garlic, Uva Ursi, Wormwood and pumpkin.
The use of grapefruit seed extract (GSE capsules or GSE liquid) along
with these herbs helps to create a more broad based broader spectrum,
and further helps balance these microbes.
Finally, yeast may impact molybdenum levels in your body. Consider
a HMT and UEE to be sure molybdenum is in a normal healthy range
and support with either Molybdenum Capsules or Black Bear
Spray or Black Bear Drink as needed.

Consider Vitamin K, Mastica Gum, and General Support nucleotide

RBC
blend.
 Consider T cell and B cell support capsules for immune support.
WBC Also consider Myrrh, which is an ingredient in Naturomycin. Be
sure lithium is in balance on a HMT.
Consider Garlic and Naturomycin. Consider BOTH Naturomycin
Spray and Naturomycin capsules because they contain different
herbs that work together for optimal results. Naturomycin Spray is
a source of the following herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap, and Goldenseal. Naturomycin
capsules are a source of the following herbs: berberis, Myrrh, Bay
Clue cells
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive leaf, Oregano,
black walnut, Juniper Berry, Garlic, Uva Ursi, Wormwood and
pumpkin. The use of grapefruit seed extract (GSE capsules or GSE
liquid) along with these herbs adds another level of broad
spectrum support and may help balance the microbes in your
gut.
Be sure BH4 is in a normal, healthy range. Consider MTHFR
A1298C Liver Support capsules, BH4, and low dose Respiratory
Eosinophils
Support nucleotide blend. If histamine is also an issue,
consider SAM-e support.
Enterococcus is the cause of a number of hospital acquired
infections or issues in individuals with compromised immune
systems. It can be found in the GI tract as well as in cases of
Enterococcus vaginal discharge, burning and itching. The concern with
Enterococcus is that it is resistant to many standard antibiotics.
Natural herbs that have been reported to act on Enterococcus
include Sage and Oregano.
Consider STAX nucleotide
blend, Garlic, Goldenseal, Wormwood, Juniper Berry, grapefruit seed
extract (GSE capsules or GSE liquid),
thyme, Oregano, Mycoceutics, aloe, Ion Transport nucleotide
blend, IMF 5 and IgY Immune capsules.Consider
BOTH Naturomycin Spray and Naturomycin capsules because they
contain different herbs that work together for optimal
results. Naturomycin Spray is a source of the following
Staphylococcus herbs: Echinacea, Cranberry, Elderberry, lomantium, Dandelion
Root, Skullcap, and Goldenseal. Naturomycin capsules are a source
of the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive leaf, Oregano,
black walnut, Juniper Berry, Garlic, Uva Ursi, Wormwood and
pumpkin. The use of grapefruit seed extract (GSE capsules or GSE
liquid) along with these herbs adds another level of broad
spectrum support and may help balance the microbes in your
gut.
Consider STRX nucleotide
Streptococcus blend, Garlic, Echinacea, rosemary, Sage, barberry, Goldenseal, Oregon
Grape, grapefruit seed extract (GSE capsules or GSE
 liquid), Mycoceutics, Juniper Berry, IMF 5 and IgY Immune capsules.
Also, use AHCY/SHMT compound for DPPIV and as a source of
lactoferrin.Consider BOTH Naturomycin Spray and Naturomycin
capsules because they contain different herbs that work together
for optimal results. Naturomycin Spray is a source of the
following herbs: Echinacea, Cranberry, Elderberry,
lomantium, Dandelion Root, Skullcap, and Goldenseal. Naturomycin
capsules are a source of the following herbs: berberis, Myrrh, Bay
leaf, Cranberry, Neem, Oregon Grape, Elderberry, olive leaf, Oregano,
black walnut, Juniper Berry, Garlic, Uva Ursi, Wormwood and
pumpkin. The use of grapefruit seed extract (GSE capsules or GSE
liquid) along with these herbs adds another level of broad
spectrum support and may help balance the microbes in your
gut.
If compulsive behaviors are a concern, also consider low dose TNF
nucleotide blend.
Aside from species of Strep that are known to cause disease and
infection, some species of Strep are included in probiotic mixes. Do not
use these mixes, as Streptococcus fermentation produces large amounts
of lactic acid. This may make you acidotic. Lactic acid is metabolized in
the liver by lactate dehydrogenase (LDH), so high levels of LDH on a
blood test may indicate bowel overgrowth with streptococcus.
Fermentation produces two isomers of lactic acid, namely L-lactate and
D-lactate. It is D-lactate which is the problem. Your body cannot
metabolize it, it accumulates in your mitochondria, and can cause
inhibition of mitochondrial energy production.
Streptococci are well known to cause autoimmune disorder and have
been implicated in Pediatric Autoimmune Neuropsychiatric Disorders
Associated with Streptococcal infections (PANDAS), as well as to
increase the inflammatory mediator TNF alpha, and to be involved in
some cases of OCD behavior. If your levels of Strep are particularly
high, consider a CSA and GI to be sure Strep levels are not elevated
elsewhere in your system.

Work with your doctor on the use of Flagyl. Natural approaches

to be considered in conjunction can
Trichomonas include Garlic*, Echinacea*, Goldenseal*, Oregon
vaginalis Grape*, berberine*, and tea tree oil.Also work on vaginal pH.
Consider VitaOrgan, Buffer pH, and Stomach pH Balancing
nucleotide blend.
Be sure probiotics that include Lactobacillus are in place. Also,
consider AHCY/SHMT compound as a source of lactoferrin.
*an ingredient in Naturomycin
Purpose of running this test:
While I prefer noninvasive testing, the Plasma Methylation Profile is the one test I
recommend that does require a blood draw ordered by your doctor. This test measures the
levels of intermediates in your methylation cycle that can be integrated with data from a
UAA and a MAP test, as well as with the cobalt levels from a UEE and HMT, to give you a
sense of the overall function of the methylation pathway in your body.
This test may be particularly useful for those who are AHCY +, as that mutation can impact
the SAM-e (S-adenosyl methionine) levels in your body. It may help determine the need for
supplemental SAM-e, not only for those who are AHCY +, but also for those who are
COMT ++, who would not ordinarily add SAM-e because of their COMT status. In addition,
based on studies by Rich Van Konynenburg and Dr. Neil Nathan, those with CFS and FM
may benefit from running this test, as SAM-e may need supplementation in this population
as well.

This table contains the rationale behind my suggestions.

Result These suggestions are for your consideration. Defer your
choices to your own health care practitioner, as always.

MTR and MS are both accepted abbreviations for the

enzyme “methionine synthase”. The indication for
where methionine synthase acts in the above test
diagram is denoted by “MS”. Elsewhere in this book,
methionine synthase is referred to as “MTR”,
reflecting the standard three letter nomenclature that
is used for this gene. Methionine levels are a
reflection of the conversion of homocysteine back
into methionine by both MTR/MTRR and BHMT
enzyme function. High levels of homocysteine and
low levels of methionine suggest a need for support
of the function of these enzymes.Check that lithium is
Methionine in balance before adding extra B12, Methylmate A,
and Methylmate B to support MS/MTR/MTRR
function. If you are adding methionine, be sure you
have support for these enzymes and for overall
methylation cycle function in place to process the
methionine and homocysteine that is generated.To
support BHMT enzyme function and methionine
levels, consider AminoAssist and/or Egg Protein
Powder, Phosphatidyl Serine Complex
(PS/PE/PC), DHA, All in One, and Methylation Support
nucleotide blend. Once lithium is in balance, then add
extra B12 and Methylmate A and Methylmate B. If
methionine is still low, you can use sprinkles
 of Methionine.
Check lithium on a HMT prior to adding extra B12 or higher
levels of Black Bear Spray or Black Bear Drink as a source of
B12 and Molybdenum.
Alternately, high methionine is sometimes seen in those who
are ACAT +. The use of ACAT/BHMT capsules may be a
help to restore methionine to healthy, balanced levels. This is
an important consideration because high levels of methionine
have been reported to have toxic effects in animal models.

If cysteine and cystathionine are high, be sure there is

sufficient transsulfuration pathway support for
processing sulfur groups, such
as B12 and Molybdenum. Check that lithium is in
balance on a HMT before using high dose B12.
Cysteine processing can ultimately produce pyruvate
that feeds into the Krebs cycle. Be sure that sufficient
B complex, such as Ultimate B, is in place to enable
pyruvate to enter the Krebs cycle. This can be seen on
a MAP test.High levels of either or both cysteine or
cystathionine may be due to levels of B6 that are too
high, or to a need to address increased CBS activity.
Increased CBS activity may be due to certain CBS
SNPs, for example CBS C699T, CBS A360A, or
CBS 212. High levels of TNF alpha secondary to
Cysteine & Cystathionine infection in your system, can also increase CBS
activity and lead to elevated levels of cysteine and/or
cystathionine. Excessive CBS activity that leads to
increased cysteine and/or cystathionine may also be
reflected in elevated taurine levels, which can be seen
on a UAA test. Consider GSH support when both
taurine and cysteine levels are elevated. If cysteine or
cystathionine are too low, then consider increased
methylation cycle support, as well as support with a B
complex that includes low dose B6 or low dose P5P,
such as Ultimate B.Basic methylation support
includes All in One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide
blend. Once lithium is shown to be in balance on
a HMT, then use low dose Methylmate A, Methylmate B,
and extra B12.
SAM-e is the single most important methyl donor in
SAM-e ( S adenosyl your body. If levels are low, consider support
methionine) with SAM-e along with B complex. There are two
supplement sources of SAM-e: enteric coated tablets
 that are well protected from oxidation and a foil
wrapped uncoated tablet. When sulfur levels are high
on a HMT or UEE, then the preferred form of SAM-e
to use is the foil wrapped tablets. If sulfur levels are
not an issue, and/or initially the decision is to break
the SAM-e into smaller doses using only ½ or ¼
tablet, then the enteric coated form is preferred.
SAH can inhibit COMT. This can be a particular
issue for those who are COMT ++. High levels of
SAH may also generate increased uric acid via a
pathway that utilizes adenosine deaminase (ADA).
High levels of ADA may be associated with
hemolysis, thus with increased bruising and bleeding
and potentially anemia. High uric acid may be
associated with gout, diabetes, and kidney stones.
Approaches to reducing uric acid include Pantothenic
Acid, which is part of Ultimate B, Quercetin,
SAH ( S adenosyl
and Dandelion Root. Tart Cherry Extract along
homocysteine)
with Advanced Joint Support nucleotide blend may also be
a help for gout or high uric acid. Quercetin is also
helpful for high histamine and oxidative DNA
damage, but it may be problematic for those who are
COMT ++, because it further slows down this
enzyme function. High SAH can drive the methionine
cycle in a reverse direction and reduce the production
of SAM-e. Consider using sodium bicarbonate, if you
can use bicarbonate for low pH, and/or low dose Ion
Transport compound.

High levels of homocysteine are risk factors for a

number of health conditions. Support for both
MS/MTR/MTRR and BHMT enzyme function to
convert homocysteine to methionine should be
considered. Basic methylation support includes All in
One, Phosphatidyl Serine Complex
(PS/PE/PC), DHA and Methylation Support nucleotide
blend. Once lithium is in balance on a HMT, then
consider using low dose Methylmate A, Methylmate B,
and extra B12. Check lithium on a HMT prior to
Homocysteine
adding extra B12 or increased levels of Black Bear
Spray or Black Bear Drink as a source of B12 and
molybdenum.In addition, support to process
homocysteine via the transsulfuration pathway can
also be considered, especially if taurine is low on a
UAA, if sulfur levels are not too high on a UEE or
HMT, and if cysteine and/or cystathionine are low.
To support the transsulfuration pathway,
consider Ultimate B and, if needed, additional low dose
B6 or P5P. However, you do not want taurine to
climb above normal range on a UAA from
transsulfuration support or adding B6/P5P.Also, be
sure that sufficient transsulfuration pathway support
is present to process sulfur groups generated by
supporting the transsulfuration pathway,
including B12, Molybdenum, Black Bear Spray or Black
Bear Drink, which is a source of both B12 and
molybdenum. Be sure lithium is in balance on a HMT
before adding extra B12.
Purpose of running this test:
Malabsorption, or leaky gut, can reduce nutrient absorption, minimize amino acid levels,
reflect infection or inflammation in your gut, and deter growth. The Celiac Test is very
useful for giving you a sense of the degree to which your body may be over reacting to
gliadin and gluten as allergens in your system, as well as the degree to which leaky gut
may be an issue. Although the Intestinal Permeability Test described in Chapter 11 is not
available in all states, wherever possible, run both tests together for a more comprehensive
sense of gut permeability and inflammation.

This table contains the rationale behind my suggestions. These

Result suggestions are for your consideration. Defer your choices to
your own health care practitioner, as always.

Imbalances Eliminate gluten from your diet. Consider Leaky Gut

inDeaminated nucleotide blend, Bowel Support nucleotide blend,
Gliadin Peptide and Glucosamine/Chondroitin Plus to help with GI mucosal
(DGP) integrity. Also, consider General Support nucleotide blend,
IgADeaminated and Cytokine Balance nucleotide blend, along with Inflammatory
Gliadin Peptide Pathway Support capsules and VitaOrgan. If your amino acids
(DGP) IgGGliadin are low on a UAA, consider AminoAssist spray, AminoAssist
IgAGliadin IgG capsules, Egg Protein Powder, and Ora-Placenta. T cell and B cell
support capsules may help support immune function if your
Gluten IgG
IgG levels are out of balance. Colostrum in particular
supports low IgA levels.
Purpose of running this test:
The Vitamin D Blood Spot test may be helpful to assess your need for supplemental
vitamin D, which is a factor in blood sugar balance, as well as bone integrity. Lead or
cadmium are especially damaging to bone. High levels of these toxic metals may impair
bone health and suggest a greater need for bone support, including vitamin D.
If you live in an area with decreased sunshine, or suffer from seasonal affect disorder, you
should also monitor your vitamin D levels. Individuals in low sunshine areas may
experience Seasonal Affect Disorder (SAD). Supporting healthy levels of vitamin D along
with low doses of SAM-e (S-adenosyl methionine) may help. Low levels of vitamin D have
also been associated with certain health conditions including Multiple Sclerosis (MS) and
colon cancer.

This table contains the rationale behind my suggestions. These

Result suggestions are for your consideration. Defer your choices to your
own health care practitioner, as always.

Consider Vita D-Light Spray for enhanced absorption through the

mucous membranes of your mouth. In addition, Vita D-Light
Spray contains a source of Rosemary and Sage that may help
transport the vitamin into your cells. Also, you can
consider Vitamin D softgels. Depending on your levels of calcium
and magnesium on a HMT and UEE, you can
consider Cal/Mag/VitD/VitK. For osteoporosis or osteopenia,
Imbalances in
consider low dose Bone Support nucleotide blend and Bone Support
Vitamin D
capsules. Do regular Bone Resorption Tests to be sure you are
making a difference. If blood sugar imbalances are your issue,
consider the FOK capsules. If you have seasonal affective
disorder, consider SAM-e beginning in late October through
March, or equivalent months in other regions. The use of a B
complex such as Ultimate B is suggested when SAM-e support is
being utilized.