Rajiv Gandhi University of Health Sciences, Karnataka

III Year B.Pharm Degree Examination – NOV 2016

Time: Three Hours Max. Marks: 70 Marks

MEDICINAL CHEMISTRY - I
(Revised Scheme 3)
Q.P. CODE: 2611
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Define and classify local anaesthetics. Discuss their structure activity relationship giving
examples. Outline the synthesis of procaine and dibucaine.
2. What are sympathomimetic agents?discuss their structure activity relationship. Outline the
synthesis of isoproterenol and clonidine.
3. Give the classification of antihistaminic agents with examples. Describe the synthesis of
diphenhydramine. Add a short note on gastric proton pump inhibitors.

SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks

4. Discuss structure activity relationship of cholinergic agents.
5. Classify non-steroidal anti inflammatory drugs with examples and give the synthesis of
acetaminophen.
6. Name the various physicochemical properties influencing biological activity of drugs. Discuss
any one physiochemical parameter in detail.
7. Explain the drugs employed in the management of epilepsy giving examples. Give structural
requirements for anti epileptic action of the drugs.
8. Write a note on cholinesterase inhibitors. Give the synthesis of physostigmine.
9. Outline the synthesis and uses of piroxicam and dicyclomine.
10. Discuss biosynthesis of adrenergic agents.
11. What are barbiturates? Give the SAR of barbiturates.

SHORT ANSWERS 10 x 2 = 20 Marks

12. Classify general anaesthetics with examples.
13. Write the structure and uses of any two benzodiazepine derivatives.
14. Write the synthesis and uses of chloral hydrate.
15. Write a note on skeletal muscle relaxants.
16. Define neuromuscular blocking agents with examples.
17. Give the synthesis of propranolol.
18. Add a note on narcotic antagonists.
19. Give the structure and uses of any two antitussive agents.
20. Write a brief note on salicylic acid derivatives and their uses.
21. Give the biological significance of prostaglandins.
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