CABAZITAXEL

ACTION- INDICATION- In combination with CONTRAINDICATION- Neutrophil count

As a microtubule inhibitor, cabazita prednisone for the treatment of ≤1,500cells/mm3. Allergy to polysorbate 80.
xel binds to tubulin and promotes it metastatic castration-resistant Severe hepatic impairment (total bilirubin
s assembly into microtubules while  prostate cancer previously treated >3xULN). Pregnancy.
simultaneously inhibiting disassem with a docetaxel-containing
bly. This leads to the stabilization of  NURSING INTERVENTION- Patient monitoring
microtubules, which results in the i •Monitor CBC with differential and renal and hepatic function tests 
nhibition of mitotic and interphase  closely.• Be aware that the incidence of Grade 3 to 4 hematologic a
cellular functions. dverse reactions, .☞ Be aware that cabazitaxel is extensively metab
olized in the liver and hepatic impairment is likely to increase cabaz
itaxel concentration, 
SIDE EFECTS- numbness, burning pain, or tingly
feeling in your hands or feet; sudden chest pain or ☞ Continue to closely monitor patents for hypersensitivity reaction
discomfort, wheezing, dry cough, feeling short of s, • Watch for dehydration if patient has nausea, vomiting, or sever
breath; stomach pain or tenderness, severe e diarrhea; ☞ Be aware that renal failure may occur in association 
vomiting or diarrhea, ongoing constipation; blood with sepsis, dehydration, or obstructive uropathy. 
in your urine, urinating more often, pain or burning Patient teaching
when you urinate; low blood cell counts--fever,
chills, tiredness, flu-like symptoms, mouth sores, • Explain the importance of taking oral prednisone as prescribed.
skin sores, easy bruising, unusual bleeding, pale
• Explain the importance of routine blood cell counts and instruct p
skin, cold hands and feet, feeling light-headed or
atient to monitor temperature frequently.
short of breath;
☞ Instruct patient to immediately contact prescriber if signs and sy
signs of stomach bleeding
mptoms of hypersensitivity reactions occur, including rash or itchin
signs of a kidney problem g, skin redness, dizziness or faintness, chest or throat tightness, faci
al swelling, or breathing problems.