What is amifostine?

Amifostine (also called Ethyol®) is a medicine that may help reduce some
side effects that can occur after chemotherapy or radiation therapy, such
as:

 Hearing loss and kidney problems caused by cisplatin;

 Skin breakdown and inflammation (swelling, heat, redness, and
pain);
 Low blood counts; and
 Dry mouth caused by radiation therapy.

Amifostine is a liquid given by the vein (IV) for 5-15 minutes. It can also be
injected just under the skin (called a subcutaneous injection).

Possible side effects of amifostine

Early

 Low blood pressure

 Feeling drowsy
 Nausea and vomiting
 Anxiety
 Warm or flushed feeling
 Sneezing
 Low calcium levels in the blood
 Allergic-type reactions (rare)

Later (usually more than a day after treatment starts)

 Low calcium levels in the blood (may last for up to a week)

 Low magnesium levels in the blood

These are the most common side effects, but there may be others. Please
report all side effects to the doctor or nurse.
In case of a severe side effect or reaction, call the doctor, nurse, or
pharmacist at 595-3300. If you are outside the Memphis area, dial
toll-free 1-866-2STJUDE (1-866-278-5833), and press 0 once the call is
connected.

Special instructions for amifostine

 If you are taking medicine for high blood pressure, you should stop
taking it 24 hours before you receive amifostine. Your doctor will tell
you when you should restart your blood pressure medicine.
 Your doctor or nurse will ask you to lie down while you receive IV
amifostine and for one (1) hour after receiving the drug. Lying down
will help you avoid low blood pressure episodes.
 The nurse will check your blood pressure while you are receiving IV
amifostine. If your blood pressure drops below a certain level, the
medicine may be stopped for a short time or stopped completely, or
the dose may be decreased. Your doctor will decide what to do.
 You need to drink plenty of fluid throughout the day if you are
receiving IV amifostine, at least one (1) liter of fluid a day. You should
drink at least 2 cups of fluid before receiving the subcutaneous
injection. Drinking large amounts of fluid will help you feel better
while you receive amifostine.
 Your doctor will give you medicine to reduce nausea while you
receive amifostine.
 The staff will check calcium and magnesium levels in the blood
throughout the day and for up to one (1) week after you receive
amifostine. Your doctor may want you to take calcium or
magnesium by mouth or by vein (IV) to keep those levels normal.
 Call your doctor right away if you notice any signs of low calcium or
low magnesium levels, such as tremors, muscle spasms, muscle
twitching, muscle cramps, or feeling confused.
 The staff will take blood samples to check for changes in blood
counts and kidney function.