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Neutrophils in Cancer

Being viewed as the most preliminary parts of the essential immunity cells that moves in

the direction of tumor tissues, studies shows that neutrophils has a very high likelihood to

destroy any cell that appears way not in form at the same time work on establishing a survival

mechanisms in which the immunity will use to react or provide responses.in the case where the

bacterium dependent growth of the ROS (reactive oxygen species)guided by the neutrophils

becomes very much of hopes as a plan especially in the treatment of cancer. As the essay unfolds

we try to establish on the specific outcomes of CPO (Chloroperoxidase) and SOD (Superoxide

dismutase) together on the ROS in the cancerous cells and also if this form of bacterial treatment

is viable in the cancer treatment.

It’s very important to note that cancer has been declared as one of the major causes of

death in the current times, some of the most common clinical treatment procedures include; one

having to undergo an open surgery, constant chemotherapy and radiotherapy which are

associated with one of the worst after effects to other parts of the individual’s body, affects one’s

ability to properly respond to other drugs and also allows for the new growth of the tumor.

Studies show that cells that are depend on neutrophils getting passive will for sure be co-related

to the neutrophil lysosome (Mishalian, Granot, and Zvi, 85). In a more generalized perspective,

we have oxygen (O2) which is crucial component of the biomedical treatment methodologies, we

also have the clinical photodynamic therapy (PDT) and the SDT (sonodynamic therapy) which in
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common forms the excitation of the sensitizers using the ultrasound technology where we have a

molecular oxygen that helps in the formation of superior 1O2 in the regions having tumor cells to

ensure there is a permanent destructions o such cells.

Motivated by the manner in which neutrophil lysosomes produces the 1O2, the bacteria,

SOD makes up the most crucial anti-oxidation bacterial that is among other applications its used

in the food anti-oxidations in manufacturing to speed up the whole process of changing O2 into

another compound component called H2O2 (Ocana, et al, 137). With this revelations, most

scientists have gone farther to suggestions or any bearer good enough ensnare CPO as well as

the SOD ought to take the shape of the walls of the neutrophil lysosomes, that are said to be

hundreds of nanometers in number and size. However, farther stud also reveals that Nanogels,

estimated to contain a range of nanometers from a few tens to a hundreds of the same, to be

coming up as the most flexible, adaptive and befitting avenues for different biomedical

applications and to be specific the biocatalytic body builders. This has been in most instance

been attributed to the gel matrix which is said to be able to provide protections to the bacteria or

rather the enzymes from the deterioration of the enzyme body structure as well as the subsequent

failure and thus provide room for a more packaging together movement of the substrates made

easier. This farther helps in achieving a speeded up most reliable catalytic results.

Therefore, a proposition could be made that; enzyme dynamic therapy (EDT), a process

that puts into consideration the enzyme involved activities around the region containing a

cancerous cell, will for sure take charge of production of 1O2 to help in the treatment of cancer.

EDT having both the SOD and CPO have been found to avail a form of 1O2 that is friendly and

could be altered whenever need to, mechanisms that aims at improving its performances

provided by the catalytic reactions processes with ROS (. O2- and H2O2). It involves the process
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of catalyzing .O2- into another version of O2 and H2O2 using the SOD. The more enzymes

involved effectively and more specificity involved in the process that relate to EDT, the high

likelihood that the output will be most efficient with utmost secured, more advantageous. looking

at the conclusions made by the researchers in this same categories, this EDT has a very good

chance becoming the most efficient instrument of treatment specifically for the hypoxic tumor

cancer type given its O2 that is able to conduct a self catalyzation, that does not require any form

of external energy for the activations to take place.

The efficiency of how 1O2 is produced has been termed as the major attribute to how

effective EDT is likely to be. Also this same efficiency of the production of 1O2 could as well be

evaluated by the use of the fluorescent probations that could involve Singlet Oxygen Sensor

Green reactors (SOSG). Emissions from the fluorescence have been found to directly go up as

the time taken increase (Shaul, Merav, and Zvi, 610). In farther analysis the features of 1O2 from

being just a mere treatment factor was conducted on HepG2 cell structure with the denial of

therapeutic process. Adding more of fluorescent SOSG, the live HepG2 cell structure was

observed to grow more stronger and vibrant green fluorescence. Also testing on the efficiency of

EDT could involve use of vitro on a hepatoma carcinoma HepG2 cell structures together with

hepatic cells HL-7702. in summary, to ascertain the topic of research, randomization of

neutrophil lysosomes by use of AP-activated self-combined core-shell nanogel , with SOD and

CPO in the production of 1O2 in a more efficient and fast way to destroy the abnormal cells just

like hypothesized by the EDT.

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Work Cited

Mishalian, Inbal, Zvi Granot, and Zvi G. Fridlender. "The diversity of circulating neutrophils in

cancer." Immunobiology222.1 (2017): 82-88.

Ocana, Alberto, et al. "Neutrophils in cancer: prognostic role and therapeutic

strategies." Molecular cancer 16.1 (2017): 137.

Shaul, Merav E., and Zvi G. Fridlender. "Tumour-associated neutrophils in patients with

cancer." Nature reviews Clinical oncology 16.10 (2019): 601-620.