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Volume 32 Number 1 January 2018

Well Maintained
In response to public patient safety concerns, the American
Board of Emergency Medicine (ABEM) developed an
external assessment of cognitive skills to ensure the
highest standards of clinical care. Since 2000, ABEM-
certified physicians have been required to meet rigorous,
specialty-specific standards predicated on Maintenance
of Certification, episodic assessments of performance
that extend beyond licensure and traditional continuing
medical education. As such, it is imperative for every
practicing emergency physician to understand these key
expectations and their impact on patient care.

Clearing the Air


The emergency department observation unit has become
an effective practice environment for the evaluation
and treatment of common respiratory conditions,
including asthma, chronic obstructive pulmonary
disease, and anaphylaxis. Because these presentations
Lumbar puncture (LP) is used in the diagnostic
require multiphasic interventions and re-evaluation, it
evaluation of central nervous system (CNS) processes,
is imperative for emergency clinicians to understand the
most commonly in cases of suspected infection and
tenets of patient selection and be prepared to formulate
subarachnoid hemorrhage. Less commonly, the
a therapeutic strategy for addressing these potentially
procedure is used for therapeutic purposes (eg, in cases
life-threatening pulmonary disorders.
of idiopathic intracranial hypertension).

THE OFFICIAL CME PUBLICATION OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS


IN THIS ISSUE
Lesson 1 n Observation of Asthma, COPD, and Anaphylaxis . . . . . . 3
Critical Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Critical Decisions in Emergency Medicine is the official
Critical Image . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 CME publication of the American College of Emergency
Physicians. Additional volumes are available.
LLSA Literature Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Lesson 2 n ABEM's Maintenence of Certification . . . . . . . . . . . . . . . . . . 13 EDITOR-IN-CHIEF
Michael S. Beeson, MD, MBA, FACEP
Critical ECG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Northeastern Ohio Universities,
CME Questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Rootstown, OH

Drug Box/Tox Box . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 SECTION EDITORS


Andrew J. Eyre, MD
Brigham & Women’s Hospital/Harvard Medical School,
Contributor Disclosures. In accordance with the ACCME Standards for Commercial Boston, MA
Support and policy of the American College of Emergency Physicians, all individuals with Joshua S. Broder, MD, FACEP
control over CME content (including but not limited to staff, planners, reviewers, and Duke University, Durham, NC
authors) must disclose whether or not they have any relevant financial relationship(s) to
learners prior to the start of the activity. These individuals have indicated that they have Frank LoVecchio, DO, MPH, FACEP
a relationship which, in the context of their involvement in the CME activity, could be Maricopa Medical Center/Banner Phoenix Poison
perceived by some as a real or apparent conflict of interest (eg, ownership of stock, grants, and Drug Information Center, Phoenix, AZ
honoraria, or consulting fees), but these individuals do not consider that it will influence the Amal Mattu, MD, FACEP
CME activity. Sharon E. Mace, MD, FACEP; Baxter Healthcare, consulting fees, fees for non- University of Maryland, Baltimore, MD
CME services, and contracted research; Gebauer Company, contracted research; Halozyme,
consulting fees. Joshua S. Broder, MD, FACEP; GlaxoSmithKline; his wife is employed by Lynn P. Roppolo, MD, FACEP
GlaxoSmithKline as a research organic chemist. All remaining individuals with control over University of Texas Southwestern Medical Center,
CME content have no significant financial interests or relationships to disclose. Dallas, TX

Method of Participation. This educational activity consists of two lessons, a post-test, Christian A. Tomaszewski, MD, MS, MBA, FACEP
and evaluation questions; as designed, the activity it should take approximately 5 hours to University of California Health Sciences,
complete. The participant should, in order, review the learning objectives, read the lessons San Diego, CA
as published in the print or online version, and complete the online post-test (a minimum Steven J. Warrington, MD, MEd
score of 75% is required) and evaluation questions. Release date January 1, 2018. Expiration Orange Park Medical Center, Orange Park, FL
December 31, 2020.
Accreditation Statement. The American College of Emergency Physicians is accredited by ASSOCIATE EDITORS
the Accreditation Council for Continuing Medical Education to provide continuing medical Wan-Tsu W. Chang, MD
education for physicians. University of Maryland, Baltimore, MD
The American College of Emergency Physicians designates this enduring material for a
Walter L. Green, MD, FACEP
maximum of 5 AMA PRA Category 1 Credits™. Physicians should claim only the credit
University of Texas Southwestern Medical Center,
commensurate with the extent of their participation in the activity.
Dallas, TX
Each issue of Critical Decisions in Emergency Medicine is approved by ACEP for 5 ACEP
John C. Greenwood, MD
Category I credits. Approved by the AOA for 5 Category 2-B credits.
University of Pennsylvania, Philadelphia, PA
Commercial Support. There was no commercial support for this CME activity.
Danya Khoujah, MD
Target Audience. This educational activity has been developed for emergency physicians.
University of Maryland, Baltimore, MD

Critical Decisions in Emergency Medicine is a trademark owned and published monthly by the American Sharon E. Mace, MD, FACEP
College of Emergency Physicians, PO Box 619911, Dallas, TX 75261-9911. Send address changes and Cleveland Clinic Lerner College of Medicine/Case
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Jennifer L. Martindale, MD, MSc
Copyright 2018 © by the American College of Emergency Physicians. All rights reserved. No part of this
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The American College of Emergency Physicians (ACEP) makes every effort to ensure that contributors to its George Sternbach, MD, FACEP
publications are knowledgeable subject matter experts. Readers are nevertheless advised that the statements Stanford University Medical Center, Stanford, CA
and opinions expressed in this publication are provided as the contributors’ recommendations at the time
of publication and should not be construed as official College policy. ACEP recognizes the complexity of RESIDENT EDITOR
emergency medicine and makes no representation that this publication serves as an authoritative resource
for the prevention, diagnosis, treatment, or intervention for any medical condition, nor should it be the basis
Nathaniel Mann, MD
for the definition of, or standard of care that should be practiced by all health care providers at any particular Massachusetts General Hospital, Boston, MA
time or place. Drugs are generally referred to by generic names. In some instances, brand names are added
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information.
ISSN2325-0186(Print) ISSN2325-8365(Online)
Clearing the Air
Observation of Asthma,
COPD, and Anaphylaxis

LESSON 1

By Sangil Lee, MD, MS; Brooks J. Obr, MD;


and David Gresback, MD
Dr. Lee is an assistant professor and Dr. Obr is chief resident in the Department
of Emergency Medicine at The University of Iowa Carver College of Medicine
in Iowa City. Dr. Gresback is an emergency physician at the Mayo Clinic Health
Systems – Mankato in Mankato, Minnesota.

Reviewed by Jennifer L. Martindale, MD

OBJECTIVES
On completion of this lesson, you should be able to: CRITICAL DECISIONS
1. Appropriately triage cases of asthma, COPD, and
anaphylaxis to the emergency department observation n What criteria can be used for selecting which
unit. patients with asthma, COPD, or anaphylaxis
2. Formulate a strategy for diagnosing and observing should be admitted to the emergency
patients with acute presentations of asthma, COPD,
department observation unit?
and anaphylaxis.
3. Identify when a respiratory complaint warrants inpatient n What is the ideal approach to managing asthma,
hospital admission.
COPD, and anaphylaxis in the emergency
4. Provide safe and effective discharge instructions for
asthma, COPD, and anaphylaxis patients admitted in department observation unit?
the emergency department observation unit.
n What are the treatment endpoints for asthma,
FROM THE EM MODEL COPD, and anaphylaxis prior to discharge from
16.0 Thoracic-Respiratory Disorders the observation unit?
16.4 Obstructive/Restrictive Lung Disease

The emergency department observation unit, which has provided a unique practice environment since the
1990s, was created to address the increasingly complex needs of a growing patient population.1 Several
respiratory conditions, including asthma, chronic obstructive pulmonary disease (COPD), and anaphylaxis are among
the disorders frequently — and effectively — managed in the observation unit.2-4

January 2018 n Volume 32 Number 1 3


CASE PRESENTATIONS
■ CASE ONE ■ CASE TWO respiratory rate remains in the 20s.
The patient reports feeling better;
A 40-year-old black woman A 52-year-old woman with
however, her oxygen saturation
presents with an acute asthma a history of chronic obstructive
remains 88% to 89% on room air.
exacerbation. She is treated with pulmonary disease (COPD) presents
a single nebulizer treatment, but with cough, wheezing, and dyspnea, ■ CASE THREE
which began 1 week ago. Her vital A 12-year-old boy with a history
continues to be tachypneic with
signs are blood pressure 150/115, of a food allergies presents after
a respiratory rate of 30. Her
heart rate 120, respiratory rate 35, accidentally ingesting a sandwich
ECG shows sinus tachycardia,
temperature 37°C (98.6°F), and that contained peanut butter. He is
and her lung examination reveals
oxygen saturation 89%. Her lung flushed, has developed a pruritic rash
diminished lung sounds bilaterally. examination reveals wheezing, and on his torso, and is dyspneic. The
The emergency physician must the patient is subsequently provided patient reports feeling better after
decide if this patient is appropriate a nebulizer treatment. After a total receiving an intramuscular dose of
for admission to the observation of three nebulizer treatments and epinephrine, and his parents ask how
unit. a loading dose of steroids, her long their son needs to be monitored.

While respiratory complaints are quite Due to the advanced age and intramuscular epinephrine (.3 mL of
common, their endpoints are not as comorbidities (eg, hypertension, a 1:1,000 solution). Out of concern
clear as they are for many other acute impaired mobility, etc.) that often for a biphasic reaction, guidelines
conditions such as chest pain, which accompany COPD (Figure 1), as recommend observation for 6 hours.
can be evaluated with laboratory or many as 30% of these patients will Of note, The National Institute of
provocative tests. Asthma, COPD, require hospital admission — a rate Allergy and Infectious Disease and
and anaphylaxis require multiphasic substantially higher than for those the Food Allergy and Anaphylaxis
interventions and particularly careful with asthma exacerbations. If there is Network (NIAID/FAAN) criteria
monitoring, considerations that make any question regarding the appropriate may be a useful diagnostic adjunct
them particularly good candidates for disposition of a patient with COPD, if anaphylaxis is suspected but the
observation management. serial examinations and assessments of diagnosis remains unclear (Table 2). 2
respiratory rate, arterial blood gas, and Patients in active respiratory distress
CRITICAL DECISION venous blood gas can be used to help and those with anaphylaxis, airway
What criteria can be used for gauge the treatment response. edema, or hemodynamic instability
selecting which patients with Patients presenting with signs and require a higher level of care and should
asthma, COPD, or anaphylaxis symptoms of anaphylaxis require bypass the observation unit. 3
should be admitted to the
emergency department TABLE 1. Observation Unit Admission Criteria for Patients with Asthma
observation unit?
Inclusion Criteria
Asthma and COPD patients should, • Stable vital signs (SaO2 >89% and respiratory rate <40)
first and foremost, have stable vital
• Patient must be alert and oriented
signs, clear mentation, and respiratory
• Intermediate response to bronchodilator therapy (improved, but still
improvement with bronchodilator/
wheezing)
steroid therapy to be considered
potential candidates for observation • Patient must receive at least 3 nebulizers plus steroid treatments
unit admission. In contrast, patients Exclusion Criteria
with evidence of respiratory failure, • Impending respiratory failure/fatigue/lethargy
unstable vital signs (including hypoxia), • Unstable vital signs (SaO2 <89%, respiratory rate >40, and temperature
new ECG abnormalities other than >38.5°C)
sinus tachycardia, or a poor response • Inability to perform spirometry
to more than three nebulizer treatments
• New ECG changes (except sinus tachycardia)
(or 1 hour of continuous nebulizer
• Patient requiring continuous nebulizer treatments >3 hours without
treatment) require a higher level of care
improvement
(Table 1). 5

4 Critical Decisions in Emergency Medicine


TABLE 2. NIAID/FAAN Criteria for Anaphylaxis

Anaphylaxis is likely when any one of these three criteria is fulfilled:


1. Acute onset of illness (minutes to several hours) with involvement of the skin, mucosal tissue, or both (eg, generalized
hives, pruritus or flushing, swollen lips, tongue, or uvula)
and at least one of the following:
(a) Respiratory compromise (eg, dyspnea, wheeze or bronchospasm, stridor, reduced peak expiratory flow, hypoxemia)
(b) Reduced blood pressure or associated symptoms of end-organ dysfunction (eg, hypotonia [collapse], syncope, incontinence)
2. Two or more of the following that occur rapidly after exposure to a likely allergen for that patient (minutes to several hours):
(a) Involvement of the skin or mucosal tissue (eg, generalized hives, itch or flush, swollen lips, tongue, or uvula)
(b) Respiratory compromise (eg, dyspnea, wheeze or bronchospasm, stridor, reduced peak expiratory flow, hypoxemia)
(c) Reduced blood pressure or associated symptoms (eg, hypotonia [collapse], syncope, incontinence)
(d) Persistent gastrointestinal tract symptoms (eg, crampy abdominal pain, vomiting)
3. Reduced blood pressure after exposure to known allergen for that patient (minutes to several hours):
(a) Infants and children: low systolic blood pressure (age specific) or >30% decrease in systolic blood pressure*
(b) Adults: systolic blood pressure <90 mm Hg or >30% decrease from that person’s baseline
*Low systolic blood pressure for children is defined as <70 mm Hg from 1 month to 1 year, <(70 mm Hg + [2 × age]) from 1 to 10 years,
and <90 mm Hg from 11 to 17 years.

CRITICAL DECISION de-escalation in frequency to every 4 respiratory reserves. These cases


hours and rescue treatments as needed. often require the involvement of a
What is the ideal approach to
Bronchodilator weaning may be respiratory therapist, who may be
managing asthma, COPD, and possible with concomitant steroid use, best equipped to assess respiratory
anaphylaxis in the emergency and the efficacy of treatment often can function at the bedside and determine
department observation unit? be determined within the first 6 hours the treatment endpoint. Continuous/
of observation. 5 bilevel positive airway pressure may be
Asthma COPD an appropriate next step for patients
The initial management of asthma who display respiratory difficulty/
Although the strategy for
should begin with a bronchodilator fatigue (depending upon mental status),
managing exacerbations of COPD
treatment (ie, inhaled beta-adrenergic and inpatient management might be
(Figure 2) is similar to the approach
agonist) and a loading dose of steroids. warranted.
used for asthma, it can be more
Once placed in the observation unit, challenging owing to coexisting Anaphylaxis
these patients initially may require a medical conditions, the irreversibility Observation unit admission can
dose every 2 hours, with subsequent of bronchoconstriction, and limited be considered for patients with stable
vital signs and symptom improvement.
The options for treating severe allergic
reactions in the observation unit are
the same as those employed in the
emergency department. Epinephrine is
one of a few agents known to prevent
n Asthma exacerbations require treatment with bronchodilators and steroids. the progression of anaphylaxis. 3
While such cases may require up to 6 to 8 hours of observation before
Antihistamines (eg, diphenhydramine)
disposition can be determined, symptom monitoring and peak flow can
and steroids (eg, oral prednisone,
serve as indicators for treatment success or failure.
40-60 mg or IV methylprednisolone,
n COPD exacerbations can be safely monitored in the emergency department 125 mg) also can help provide
observation unit. For continuous observation, it is beneficial to request an symptomatic relief. 3
assessment from a respiratory therapist. Occasionally, a patient will require
n Most patients with anaphylaxis can be monitored safely in the emergency multiple doses of epinephrine; in such
department observation unit. Biphasic reactions are considered rare cases, prompt inpatient admission
(0.4%-14%), and can be effectively treated with epinephrine.3,4 (often to the intensive care unit) is
warranted. A minimum of 10 to 15

January 2018 n Volume 32 Number 1 5


FIGURE 1. COPD Management Protocol for Emergency Department Observation Unit

COPD Management
Presumptive diagnosis of Protocol Exclusion Criteria
“COPD exacerbation” in
• SpO2 <92% on 4 liters-per-
the emergency department
minute oxygen
• Utilization of noninvasive
positive pressure support
or mechanical ventilation
Provider/primary nurse
• Abnormal chest x-ray (eg,
(RN)/triage nurse page
frank pneumonia)
respiratory therapy (RT)

• Patient provided supplemental oxygen by nasal cannula versus titration of existing liters-per-
minute flow rate (goal SpO2 90%)
• Patient provided three sequential nebulized DuoNeb treatments (ipratropium .5 mg/albuterol
2.5 mg in 3 mL 0.9% NaCL)
• Supplemental oxygen may be discontinued if SpO2 >95%
• Venous blood gas measurement obtained while patient is in emergency department

Has the patient’s clinical status deteriorated during emergency department visit?
• Increased work of breathing
• Worsening hypercarbia on arterial blood gas/venous blood gas
• SpO2 <90% on supplemental oxygen
Does the patient exhibit any of the exclusion criteria of the COPD management protocol?

No Yes

• Initiate emergency department observation unit • Consider admission to inpatient floor


COPD management protocol. versus intensive care unit.
• Consider follow-up assessments of venous blood • Provide airway management at provider’s
gas/arterial blood gas. discretion.
• Consider pulmonary service consult.

Observation Unit Hours 0-12


• Nurse monitors/records vital signs every hours for 2 consecutive hours, followed by recording
vital signs every 4 hours
• Nurse administers antibiotics/glucocorticoids per physician orders
• RT/RN administers DuoNeb every 4 hours (scheduled), and every 2 hours as needed
Observation Unit Hours 13-24
• RN monitors vital signs every 4 hours
• RT/RN administers DuoNeb every 4 hours (scheduled), and every 2 hours (as needed)
• COPD specialist consult (if available)

No stabilization/improvement Stabilization/improvement
in clinical condition in clinical condition

• Consider discharge to home.


Consider admission to inpatient
floor unit versus intensive care. • Ensure patient has appropriate home-
going medication regimen and arrange
follow up.

6 Critical Decisions in Emergency Medicine


oxygen saturation for patients with
COPD is 90%; those who require
continuous SpO 2 may necessitate
transfer to an inpatient floor.
A multidisciplinary approach,
especially with the involvement of a
n Overlooking a new ECG finding (other than sinus tachycardia) in a patient respiratory therapist, is particularly
with asthma or COPD. Such findings are a contraindication for observation helpful when determining if a patient
unit admission. with asthma or COPD is appropriate
n Discharging a patient with an epinephrine autoinjector without providing for discharge. Due to the complexity of
clear instructions on proper use. COPD, an admission rate of less than
30% is considered acceptable.8 Most
n Admitting a patient with anaphylaxis, airway edema, or hemodynamic
instability to the emergency department observation unit. These patients patients admitted to the emergency
require a higher level of care. department observation unit for
anaphylaxis become asymptomatic
within 4 to 6 hours. It is imperative
for the clinician to ensure that these
minutes should be allowed prior to CRITICAL DECISION patients are comfortable with the use
providing a second intramuscular of an epinephrine autoinjector prior to
What are the treatment
dose of epinephrine. The duration of discharge.
endpoints for asthma, COPD, and
observation will vary, as there are no
definitive guidelines that delineate anaphylaxis prior to discharge Discharge Process
the appropriate observation periods. from the observation unit? The discharge process for patients
with serious respiratory complaints
While some experts have proposed Treatment goals for any patient
can be rather complex and may take
up to 24 hours of monitoring, most being observed for a respiratory
several hours. A protocol-driven
recommendations suggest 4 to 6 disorder include weaning the patient observation unit can initiate most of
hours.6,7 Importantly, the extra time off oxygen, reducing the frequency of these procedures, which will help save
in the observation unit can be used bronchodilator treatment (maximum time in the emergency department.
to teach patients about allergen every 4 hours), and improving peak For example, when a patient with an
avoidance, and train them in the use flow measurements and reported asthma exacerbation is discharged,
of an epinephrine autoinjector. symptoms. The target supplementary it is prudent for them to be provided

FIGURE 2. Characteristics of Asthma and COPD

ASTHMA COPD
• More intermittent airflow • Progressively worsening airflow
obstruction obstruction
• Improvement in airways • Often presents in sixth decade
obstruction with bronchodilators of life or later in patients
and steroids • More permanent airflow
• Cellular inflammation obstruction; less reversibility
(eg, eosinophils, mast cells, and less normalization of airflow
T-lymphocytes, and neutrophils) obstruction
in more severe disease • Cellular inflammation (eg,
• Broad inflammatory mediator neutrophils, macrophases,
response eosinophils, and mast cells)
• Airway remodeling • Emphysema frequently found

Adapted from Bleecker ER. Similarities and differences in asthma and COPD. The Dutch hypothesis. Chest. 2004;126(2 Suppl):93S-5S; discussion
159S-61S.

January 2018 n Volume 32 Number 1 7


CASE RESOLUTIONS
■ CASE ONE ■ CASE TWO allergic reaction began to feel much
The middle-aged asthmatic was The woman’s COPD-related better. He was admitted to the
treated with oral prednisone (60 mg, symptoms improved after the emergency department observation
0.5 mg/kg) and two additional administration of oxygen, a dose unit, where he received additional
bronchodilator therapies. After 1 hour, of steroids, and three consecutive treatment with dexamethasone and
the patient’s wheezing improved and her bronchodilator treatments in the diphenhydramine. The patient’s
breath sounds became audible; however, emergency department; however,
parents were cautioned about the
her peak flow remained between 50% she remained hypoxic. A chest x-ray
warning signs of anaphylaxis,
and 80% of baseline. She was placed in revealed evidence of pneumonia. After
determining that she was at too high a and given a prescription for an
the observation unit, where she received
risk for treatment in the observation unit, epinephrine autoinjector and
frequent bronchodilator therapy. Her
the clinician admitted her to the hospital instructed on its proper use. The
symptoms resolved within 6 hours, and
for further management. boy was released home after 6 hours
her peak flow increased to above 80%
of baseline. She was given oral fluids, ■ CASE THREE of observation, and an outpatient
and discharged after her tachycardia After the prompt administration follow up with allergist was
resolved. of epinephrine, the boy with the arranged.

with information regarding smoking REFERENCES


cessation, instructions on the proper use 1. Graff LG, Dallara J, Ross MA, et al. Impact on the
care of the emergency department chest pain
of bronchodilators, educational materials patient from the chest pain evaluation registry
(CHEPER) study. Am J Cardiol. 1997;80(5):563-568.
about steroid loading/maintenance
2. Rydman RJ, Isola ML, Roberts RR, et al. Emergency
therapy, and arrangements for timely department observation unit versus hospital
inpatient care for a chronic asthmatic population: a
outpatient follow up. Patients with COPD randomized trial of health status outcome and cost.
also may require a consultation with Med Care. 1998;36(4):599-609.
3. Campbell RL, Li JTC, Nicklas RA, et al. Emergency
a social worker and/or pulmonologist. department diagnosis and treatment of anaphylaxis:
Anaphylaxis patients require a supply of a practice parameter. Ann Allerg Asthma Im.
2014;113(6):599-608.
epinephrine autoinjectors, and a referral 4. Salazar A, Juan A, Ballbe R, Corbella X. Emergency
to either a primary care physician or an short-stay unit as an effective alternative to in-
hospital admission for acute chronic obstructive
allergy specialist. pulmonary disease exacerbation. Am J Emerg Med.
2007;25(4):486-487.
It is important to note that emergency
5. Graff LG. Observation units: implementation and
department observation stays are management strategies. American College of
Emergency Physicians; Dallas, TX: 1998.
billable as a part of observation service.
6. Lee S, Bellolio MF, Hess EP, et al. Time of onset and
The clinician’s rationale for observation predictors of biphasic anaphylactic reactions: a
systematic review and meta-analysis. J Allergy Clin
unit placement and treatment plan Immunol Pract. 2015;3(3):408-416 e1-2.
should be documented. 7. Sampson HA, Munoz-Furlong A, Bock SA, et al.
Symposium on the definition and management
Summary of anaphylaxis: summary report. J Allergy Clin
Immunol. 2005;115(3):584-591.
The emergency department 8. Ross MA, Compton S, Richardson D, et al. The use
and effectiveness of an emergency department
observation unit has become an effective observation unit for elderly patients. Ann Emerg
Med. 2003;41(5):668-677.
practice environment for the evaluation
9. Baugh CW, Venkatesh AK, Hilton JA, et al. Making
and treatment of common respiratory greater use of dedicated hospital observation units
for many short-stay patients could save $3.1 billion a
conditions, including asthma, chronic year. Health Affair. 2012;31(10):2314-2323.
obstructive pulmonary disease, and
anaphylaxis. Because these presentations ADDITIONAL READING
require multiphasic interventions Lee S, Young I, Colletti J. Online module to improve
emergency department observation unit practice.
and re-evaluation, it is imperative for MedEdPORTAL Publications. 2016;12:10423. http://
dx.doi.org/10.15766/mep_2374-8265.10423.
emergency clinicians to understand
the tenets of patient selection and be
prepared to formulate a therapeutic
strategy for patients suffering from these
potentially life-threatening pulmonary
disorders.

8 Critical Decisions in Emergency Medicine


The Critical Procedure
By Steven Warrington, MD, MEd
Dr. Warrington is director of the Emergency Medicine
Residency Program and academic chair of the
Department of Emergency Medicine at Orange Park
Medical Center in Orange Park, Florida.

A needle is inserted at the base of the skull,


Posterior view of the head and neck and the medication is injected around the
origin of the greater occipital nerve.

OCCIPITAL NERVE BLOCK


Occipital nerve blocks have been used successfully for occipital neuralgia, tension headaches, cluster
headaches, migraines, and occipital neuritis. The procedure typically involves an injection of local
anesthetic, which may be combined with a corticosteroid to manage patients with occipital neuritis.

Contraindications
n Overlying infection
inflammatory drugs, triptans, ergots,
and other pharmacological regimens.
TECHNIQUE
(Landmark placement of both greater
n Allergy to component of medication Reducing Side Effects and lesser occipital nerve block)
Benefits and Risks Side effects can be avoided with 1. Gather supplies. The author uses a
The primary benefit of this therapy is standard precautions such as cleansing blunt-fill needle, 25-gauge needle,
its ability to treat the patient’s symptoms the site and aspirating prior to injection alcohol swabs, 10-mL syringe, and
while avoiding systemic medications. In to ensure proper positioning of the 1% lidocaine without epinephrine.
addition, greater and/or lesser occipital needle. The risk of breaking the needle 2. Fill the syringe with 10 mL of lidocaine.
nerve blocks often can be performed tip theoretically can be mitigated by 3. Identify the location for injection.
very quickly, and can provide relief more using a larger 23- or 25-gauge needle • The greater occipital nerve can be
rapidly than many traditional treatment instead of a smaller one, and not fanning found by tracking ≈2-3 cm lateral to
methods. or moving the needle while the tip is the external occipital protruberence,
The procedure poses minimal deep. Ultrasound guidance also may help and palpating for the point of
risks, aside from potential failure or increase the accuracy of the procedure. maximal severity. The nerve lies just
allergic reactions to the medication medial to the occipital artery.
Special Considerations
being used. Possible complications • The lesser occipital nerve can be
Greater and lesser occipital nerve
include the introduction of infection or found ≈2.5-3.5 cm lateral and 1 cm
blocks can be performed independently
unintentional intravascular injection. inferior to the greater occipital nerve.
of each other or simultaneously,
Although uncommon, the needle tip can 4. Cleanse the area, and aspirate and
depending on each patient’s clinical
break during any injection (resulting in a inject 3-5 mL of the anesthetic in
presentation and examination findings.
retained foreign body). a fan pattern (both anteriorly and
The block, which should be placed on
superiorly).
Alternatives the ipsilateral side of the symptoms,
can be performed with lidocaine, Note: Gentle massage over the areas
Depending on the nature of the
of injection may be beneficial to further
patient’s symptoms, alternative bupivacaine, or other mixtures of
distribute the anesthetic.
therapies include systemic anti- medications.

January 2018 n Volume 32 Number 1 9


The Critical Image
A 16-year-old girl presents with 6 days of severe headache, which By Joshua S. Broder, MD, FACEP
began during cheerleading practice. She denies direct trauma to the Dr. Broder is an associate professor and the
residency program director in the Division
head, and has no fever or focal neurological complaints. The headache of Emergency Medicine at Duke University
resolves completely within seconds when the patient lies supine, but is Medical Center in Durham, North Carolina.
severe again within minutes of standing.

The patient has a history of scoliosis and underwent a T3-L2 spinal fusion 6 weeks prior to her emergency department
visit. Her vital signs are blood pressure 110/71, heart rate 64, respiratory rate 18, temperature 36.7°C (98.1°F), and oxygen
saturation 100% on room air.
The patient is lying supine in bed and does not appear to be in any distress. Her fundoscopic and neurological examinations
are normal, as are assessments of her head and neck. She refuses to sit up, anticipating recurrence of her headache.
Magnetic resonance imaging (MRI) of her brain, which was performed before she arrived in the emergency department,
showed no evidence of mass or hemorrhage but demonstrated subtle dural enhancement suggesting intracranial
hypotension. A computed tomography (CT) myelogram scan was performed to assess for cerebrospinal fluid (CSF) leakage.

Contrast contained
within thecal sac Spinal cord

Sharply defined
thecal sac

A. Axial CT myelogram image at the level of T9 shows a normal spinal cord surrounded
by contrast. No contrast escapes the bounds of the thecal sac at this level.

1. Fishman RA, Dillon WP. Dural enhancement and cerebral displacement secondary to .intracranial hypotension. Neurology. 1993;43:609-611.
2. Schoffer KL, Benstead TJ, Grant I. Spontaneous intracranial hypotension in the absence of magnetic resonance imaging abnormalities. Can J Neurol Sci. 2002;29:253-257.
3. Starling A, Hernandez F, Hoxworth JM, et al. Sensitivity of MRI of the spine compared with CT myelography in orthostatic headache with CSF leak. Neurology. 2013;81:1789-1792.

10 Critical Decisions in Emergency Medicine


B

Contrast
outside of
thecal sac Spinal cord

B. Axial CT myelogram image at the level of T10 shows a normal spinal cord
surrounded by contrast. Here, contrast is seen outside of the thecal sac,
confirming a CSF leak.

KEY POINTS
n Spinal CSF can be iatrogenic (as from lumbar puncture or spinal surgery) or spontaneous.
Headache classically is orthostatic, resolving when the patient is in a supine position.
A brain MRI can provide clues to intracranial hypotension from a CSF leak, including
downward displacement of the brain and dural enhancement; however, the test is not
100% sensitive.1,2 CASE
n Imaging of the spine to identify the site of a CSF leak is confirmatory. Modalities include RESOLUTION
CT myelography, MRI, MR myelography, radionuclide cisternography, and fluoroscopic The patient
digital subtraction myelography. Radiography and CT without the injection of contrast into underwent CT-
the subarachnoid space are not useful. guided patching
n MRI has high sensitivity compared with CT myelography (91.7%); however, the test has with autologous
wide confidence intervals due to the rarity of cases for research (the included study found
blood and fibrin
just 12 patients over a 12-year period). The sensitivity of CT myelography itself is uncertain,
glue. Her symptoms
as it is considered the reference standard.3
completely resolved
n Intermittent leaks might be missed on any modality; negative imaging tests should be
repeated if suspicion remains high.
following the
n MRI (without myelography) is less invasive than a CT myelogram scan, which requires
procedure.
lumbar puncture; however, CT myelography also offers the therapeutic option of image-
guided patching, while MRI is purely diagnostic.
n During CT or MR myelography, contrast material is injected into the spinal subarachnoid
space, outlining the spinal cord and spinal nerve roots, which do not enhance. A CSF leak
is confirmed by the presence of contrast in the extradural space, excluding the immediate
vicinity of the injection site. Thecal contrast is necessary for the detection of CSF leak.

January 2018 n Volume 32 Number 1 11


The LLSA Literature Review
Can You Multitask?
Evidence and Limitations of
Task Switching and Multitasking
in Emergency Medicine
By Jason Wong, MD, and Laura Welsh, MD
University of Washington School of Medicine, Department of Emergency
Medicine, Seattle
Skaugset LM, Farrell S, Carney M, et al. Ann Emerg Med. 2016;68:189-195.

Emergency medicine physicians face To accommodate interruptions during optimization, including common order
frequent clinical interruptions and, these tasks, physicians must utilize task sets, alert minimization, and standard
therefore, must be proficient at task switching. This leads to potential errors documentation cues, also can decrease
switching, a skill that enables one to by increasing the time it takes to finish an cognitive load. Finally, the physical
shift between two discrete activities. action, decreasing quality, and preventing space can be designed to clearly label
This skill is different than multitasking, completion of the primary task. quiet spaces in which staff can complete
which requires the simultaneous To minimize the errors that result critical work with minimal distractions.
performance of two separate tasks. When from interruptions, focus should turn
an interruption leads to task switching, to improving task switching at the
the primary task is less likely to be level of the individual provider, and KEY POINTS
completed, which can increase the risk of globally optimizing the emergency n Emergency physicians face
errors. Consequently, it is important to department environment. Physicians can numerous interruptions that
be cognizant of these interruptions and prioritize tasks according to acuity, and necessitate frequent task
the physician’s response to them. establish methods to redirect or prevent switching. These distractions can
increase the risk of errors, decrease
Memory consists of both working/ interruptions during high-risk situations.
the likelihood of task completion,
short-term and long-term memory. Cognitive load can be mitigated through
and compromise the quality of
While long-term memory is focused on continued education and deliberate
work.
unlimited, stored information, working practice. By increasing proficiency in n Task switching is the shifting
memory is capable of processing only procedural skills and clinical knowledge, between two discrete tasks. This
a finite amount of new information tasks ultimately will be stored in long-term skill is in contrast to multitasking,
(depending upon the cognitive load memory, allowing physicians to multitask which is the simultaneous
inherent in completing a particular in situations where they otherwise would performance of two separate tasks.
action). In particular, short-term memory have had to task switch. n To reduce the risks of task
is strained under the cognitive load of Environmental interventions should switching, a clinician can improve
frequent or competing interruptions. focus on minimizing distractions in the his or her skills through deliberate
Multitasking requires the two workspace and improving situational practice, which can decrease the
tasks to be automated and solidified awareness. Interprofessional teams can cognitive load of certain tasks
in our long-term memory (eg, walking work to create a consensus about the and move them into long-term
and talking), where each is performed circumstances in which interruptions memory.
n To minimize interruptions and
almost subconsciously. However, many are acceptable, and provide feedback
the need to task switch, changes
activities performed in the emergency when unnecessary intrusions occur.
should be made to optimize the
department, especially by more novice Hospital policies or systems can further
work environment and electronic
physicians, require deliberate attention offload responsibilities to decrease medical records.
— and therefore use working memory. interruptions. Electronic medical record

Critical Decisions in Emergency Medicine’s series of LLSA reviews features articles articles from ABEM’s 2018 Lifelong Learning and
Self-Assessment Reading List. Available online at acep.org/llsa and on the ABEM website.

12 Critical Decisions in Emergency Medicine


Well Maintained
ABEM’s Maintenance
of Certification

LESSON 2

By Catherine Marco, MD and Mary Nan S. Mallory, MD, MBA


Dr. Marco is a professor of emergency medicine at Wright State University in
Dayton, Ohio. Dr. Mallory is a professor of emergency medicine at the University
of Louisville in Louisville, Kentucky. Both serve as directors on the ABEM Board
of Directors.
Reviewed by Michael S. Beeson, MD, MBA, FACEP

OBJECTIVES
On completion of this lesson, you should be able to: CRITICAL DECISIONS
1. Identify the components of the ABEM MOC program. n What are the four components of Maintenance
2. Understand the evolution of ABEM’s MOC process. of Certification, and what are the best ways to
3. Discuss methods to meet the Improvement in Medical satisfy the requirements?
Practice requirements. n What are the benefits and risk of taking the
4. Discuss ways to meet the Lifelong Learning and Self- ConCert Examination early?
Assessment requirements.
n Why is it important to maintain certification?
5. Discuss timing strategies for taking the ConCert
n What is the best way to satisfy ABEM’s
Examination.
Improvement in Medical Practice requirements?
FROM THE EM MODEL n Are there “fun” or “easy” ways to meet
20.0 Other Core Competencies of the Practice the Lifelong Learning and Self-Assessment
of Emergency Medicine
requirements?
20.2 Practice-Based Learning and Improvement

In response to public patient safety concerns, the American Board of Emergency Medicine (ABEM) developed
an external assessment of cognitive skills to ensure that emergency care is meeting the highest standard.
Since 2000, ABEM-certified physicians have been required to meet rigorous, specialty-specific standards predicated
on Maintenance of Certification (MOC), episodic assessments of performance that extend beyond licensure and
traditional continuing medical education.

January 2018 n Volume 32 Number 1 13


CASE PRESENTATIONS
■ CASE ONE ■ CASE TWO ■ CASE THREE
K.G. is a 42-year-old ABEM J.K. is a 38-year-old ABEM J.M. is a 40-year-old ABEM
diplomate with 15 years of diplomate who is required to take the diplomate who passed the ConCert
experience and ABEM certification. ConCert Examination for recertification
Examination three years ago. He
She has read about problems posed in two years. He wonders whether there
is looking for ways to satisfy the
by other specialties’ MOC programs are benefits to taking the test early,
and wonders whether they are rather than waiting until the 10th year Improvement in Medical Practice
similar to ABEM’s. (the recertification deadline). (IMP) requirements.

The American Board of Medical known as Maintenance of Certification. 2014. Summit participants included
Specialties (ABMS) requires all 24 Subsequently, certification and MOC representatives from the American
medical specialty member boards to activities have been shown to enhance Academy of Emergency Medicine
provide an MOC program to promote patient safety, improve the quality (AAEM) and its Resident and
continuous learning, and supply a of clinical care, and reduce health Student Association, the Association
periodic external assessment of each care costs.3-7 Nonetheless, detractors of Academic Chairs of Emergency
board-certified physician’s cognitive (mainly in other specialties) suggest Medicine, the American Board of
expertise. While differences in the that continuous board certification is Medical Specialties, the American
specifics of each program vary, a too time-consuming, too expensive, and College of Emergency Physicians,
consistent goal among all organizations irrelevant to their practices. the Council of Emergency Medicine
is to ensure that clinicians are Residency Directors, the Emergency
continually working to improve patient
Other Approaches
Medicine Residents Association,
care. ABEM makes changes to its MOC
the Residency Review Committee–
program based on participation, passing
Emergency Medicine, and the Society
History of MOC rates, and physician feedback. Annual
for Academic Emergency Medicine.
When the ABMS was first formed, diplomate surveys are conducted to
Participants critically reviewed
physicians who achieved board evaluate the physician experience with
ABEM’s MOC program as well as
certification were issued lifetime each component of the program, and
ABMS’s MOC 2015 Standards.
certificates. In light of patient safety the ABEM MOC Committee regularly
Roundtable discussions included
concerns described in the 1999 Quality reviews the survey data and diplomate
recognizing strengths of the program
of Health Care in American Committee correspondence to determine what
and opportunities for improvement,
of the Institute of Medicine (IOM) improvements should be made.
assessing professionalism, identifying
report, lifetime certification was felt Unlike diplomates of many other
and filling competency gaps, enhancing
to be insufficient for ensuring the boards, physicians certified by ABEM
relevancy, and adding value to the
highest standards of care.1 Due to have always been required to pass
requirements.
rapid advances in medicine, career-long a secure examination to renew their
performance standards were no longer certification every 10 years. ABEM
guaranteed by initial certification and also provides MOC credit for activities
TABLE 1. Areas of ABEM
annual continuing medical education that emergency physicians are already
Subspecialty Certification
(CME) activities, which typically are doing during each shift. For example,
guided by the physician and may not many quality measures that The Joint Anesthesiology Critical Care
address gaps in competency.2 Commission requires hospitals to Emergency Medical Services
Other than a state medical monitor, including door-to-balloon Hospice and Palliative Medicine
licensing board intervention, there time for the treatment of an acute Internal Medicine-Critical Care Medicine
was no mechanism for evaluating myocardial infarction, can count toward
Medical Toxicology, Pain Medicine
physician engagement in a career-long the Improvement in Practice (IMP)
Pediatric Emergency Medicine
program of continuous professional requirement for MOC.
development built on a set of national Sports Medicine
standards. Certification and periodic, Keeping ABEM’s MOC Undersea and Hyperbaric Medicine
external physician assessment became a Program Relevant Note: ABEM diplomates who pass one
fundamental concern to the public. As ABEM convened an MOC of the subspecialty examinations receive
a result, the ABMS outlined a program Summit of stakeholder organizations a certificate that is valid for 10 years.
of continuous professional development in emergency medicine in October

14 Critical Decisions in Emergency Medicine


Some of the dissatisfaction related Cost of MOC CRITICAL DECISION
to MOC in other specialties has The ABEM Board of Directors What are the four components
stemmed from the assertion that the
is cognizant of the costs associated of Maintenance of Certification,
requirements are unrelated to daily
with MOC, including the ConCert and what are the best ways to
practice or are too resource intense.
To the contrary, ABEM is developing Examination. There has been no fee satisfy the requirements?
ways to meet reporting requirements increase for Lifelong Learning and There are four parts to Maintenance
as seamlessly as possible. For example, Self-Assessment (LLS) activities since of Certification (Figure 1):
the organization is working with ACEP 2011, and no increase in the cost of • Professionalism and Professional
to provide automatic IMP requirement the ConCert Examination or any other Standing
credit for physicians who participate in service since 2012. The current fee for • Lifelong Learning and Self-
the Clinical Emergency Data Registry Assessment
the ConCert Examination is $1,850.
(CEDR). CEDR houses data used to • Assessment of Knowledge,
The annualized cost of ABEM MOC is
comply with federal quality measure Judgement, and Skills
comparable to the cost of other ABMS • Improvement in Medical Practice
reporting, enabling participating
programs ($265 per diplomate, or about
emergency physicians to monitor and Professionalism and
assess their adherence to nationally $5 per week).
established quality measures. ABEM certification is associated Professional Standing
with higher professional reimbursement. The Professionalism and
ABEM diplomates want to have a
Professional Standing component
clear description of their pending MOC More than 11,600 ABEM diplomates
serves as a screening mechanism to
requirements. As a result, the board chose to participate in the Centers for
ensure that board-certified physicians
has created an online MOC personal Medicare & Medicaid (CMS) PQRS maintain professional behavior and
page for each diplomate, which can be MOC bonus program from 2012-2014, have no sanctions against their medical
accessed from www.abem.org. From
resulting in a total of $3.8 million in license(s) by a state medical licensing
the personal access page, diplomates board. Participants in the MOC process
added reimbursement, or an average
can view their emergency medicine must hold a current, active, valid, full,
of $7,000 for each ABEM-certified
certification, MOC requirements, unrestricted, and unqualified license
and status at any time. Physicians are physician who participated. On average,
to practice medicine in at least one
encouraged to contact ABEM directly ABEM certification is associated
jurisdiction in the United States, its
should any questions arise about their with an additional $7,000 in annual territories, or Canada, and in each
MOC requirements. compensation per physician. jurisdiction in which they practice.
Participants also must report to the
board all licenses they currently
hold and/or previously held.8 This
requirement is especially important for
physicians working in multiple states,
(eg, an emergency physician with a
locum tenens practice).
n Ideas for fulfilling the IMP component of MOC may be found in a dropdown
Any license that is conditional,
menu on the ABEM website. Most clinically active emergency physicians likely will
under probation, or limits the physician
be able to select one of the available options based on performance measures
already being tracked by their hospitals. to a specific practice setting does not
meet this MOC requirement. If even one
n Although each diplomate must complete four out of five available LLS activities
during each five-year certification period, these activities may be performed in a of these licenses fails to comply with
group setting to allow discussion and enhance the educational value of this MOC these standards, ABEM will revoke the
activity. diplomate’s certificate. Due to reporting
n Diplomates may take the ConCert Examination during the fall administration in among state medical boards through the
years six through 10 of their certification period in an effort to lessen the stress Federation of State Medical Boards, a
associated with taking a high-stakes test. sanction against a physician in one state
n CME credit may be earned for every LLS activity (from AAEM or ACEP), as well as can result in another state also revoking
both the Oral Certification Examination and the ConCert Examination (from the the physician’s medical license, even
American Medical Association). Diplomates are encouraged to take advantage of though there is no action in the second
this relatively low-cost CME option. state. Physicians also should be mindful
n There are specific pathways to regain certification. Anyone who is in this that states may choose to suspend
circumstance is encouraged to contact ABEM directly for assistance. medical licenses due to civil or criminal
matters unrelated to the clinical practice

January 2018 n Volume 32 Number 1 15


of medicine, including being charged for emergency medical services, of the diplomate’s cognitive skills. It is
with driving under the influence, pediatric emergency medicine, and a carefully designed examination with
domestic violence, or failure to pay medical toxicology if the physician has a approximately 205 multiple-choice
child support. particular interest in one of these areas. questions written by clinically active
These subspecialty activities also count emergency physicians. Focusing on
Lifelong Learning toward meeting MOC requirements areas of everyday emergency medicine
and Self-Assessment (Table 1). practice, more than 60% of the test’s
ABEM’s requirement for meeting Ninety-eight percent of emergency questions require diagnostic processing,
the Lifelong Learning and Self- physicians report that the LLS readings not simply fact recall.
Assessment component is twofold. are relevant to emergency care, and Content for the examination is
The first element is completion of four 92% maintain that the information derived from The Model of the Clinical
LLS activities within each five-year they learned changed their practices.9 Practice of Emergency Medicine, the
period of certification; the second is to Additionally, in response to diplomate outline of the knowledge, skills, and
obtain at least 25 American Medical feedback about how to improve abilities required of an ABEM-certified
Association (AMA) PRA Category 1 the MOC experience, ABEM now emergency physician. The model,
Continuing Medical Education (CME) provides the answer rationale for the which is reflective of clinical care,
credits per year. Of note, ABEM has LLS questions after the physician has is developed and routinely updated
removed the requirement for each completed and passed a given test. through a collaboration between the
physician to report an average of at key stakeholder emergency medicine
least eight hours of annual of self- Assessment of Knowledge, organizations.
assessment activities. Judgement, and Skills The test questions are written by a
To enhance the value of this Physicians must pass the ConCert team of trained volunteer question (or
MOC requirement, ABEM provides Examination during any one of years “item”) writers, all of whom are board-
a seamless option for obtaining CME six to 10 of their certification. Taken certified emergency physicians. Items
credit for completed LLS activities at a proctored computer-testing center, are then reviewed and edited by ABEM
from an external provider. The the test is ABEM’s external assessment directors, who are clinically active
physician can obtain an average of 7 to
15 AMA PRA Category 1 Credits for
each LLS activity, and may choose to FIGURE 1. Four Components of the ABEM MOC Program
receive these credits from the American
Academy of Emergency Medicine or
the American College of Emergency
Physicians (ACEP). Sixty percent of
diplomates take advantage of this CME Professionalism
opportunity. and Professional
The Lifelong Learning and Self-
Standing
Assessment component is specifically
designed to promote continuous
learning for the practicing emergency
physician. A list of 10 to 15 emergency
medicine–relevant articles is released Assessment
Lifelong Learning
annually. The activity is designed to of Knowledge,
be self-study; however, many find that and
Judgment,
discussing the LLS readings in a group Self-Assessment
and Skills
setting enhances the learning and
retention of topics highlighted by the
questions; this approach is encouraged
by ABEM.
Each diplomate then takes an Improvement
open-book test based on the readings, in
which consists of 20 to 30 questions. A Medical Practice
physician has up to three opportunities
per registration to pass each LLS test;
a score of 85% or higher is considered
passing. ABEM diplomates also may
take the subspecialty LLS examinations

16 Critical Decisions in Emergency Medicine


TABLE 2. Acceptable Types of Patient Care Practice Improvement (PI) Activities
Diplomates may complete PI efforts related to any of the measures or activities below. Others that are not listed may be acceptable,
provided they follow the four steps ABEM requires.

Time-Related (throughput time, length of stay, and other Communication — Patient Care
process time measures)
• Patient call-back system
• Door-to-doctor times (door-to-provider, door-to-evaluation)  • Improving patient understanding of discharge instructions
• Emergency department length of stay for discharged • Improvements in response to Patient Experience of Care
psychiatric and transferred patients Survey results
• Throughput time improvement • Safe sign-out between emergency physicians
• Time to disposition decision (admit, discharge, etc.) • Transfer of care to other care provider (consultant,
admitting physician, etc.)
Infectious Disease-Related
Pain Management and Sedation
• Goal-directed sepsis pathway, use of the Sepsis DART toolkit,
other sepsis guidelines • Time to pain management for all pain, including long-
• Appropriate testing for children with pharyngitis bone fractures
• Appropriate treatment for children with upper respiratory • Reassessment of pain after administration of analgesia
infection • Procedural sedation safety (includes appropriate
• Antibiotic treatment for adults with acute bronchitis: medication selection, checklists, etc.)
avoidance of inappropriate use • Adherence to opioid prescribing recommendations for
• Antibiotic stewardship (includes selection, administration chronic pain
time, local resistance pattern identification, etc.)  • Completion of “Prescribing Opioids in the Emergency
• Blood culture before antibiotics Department” from EMPainline.org
• Use of statewide electronic pain medication prescribing
Stroke-Related system
• Evaluation for risk of opiate misuse
• Head CT within 45 minutes of arrival of stroke patient
• Thrombolytic consideration or use in eligible patients Patient Safety, Error Reduction, and Complication
• Door to puncture time for endovascular stroke treatment Avoidance
• Stroke activations and care pathways
• Adherence to indications for central line insertion
• Prevention of central venous catheter-related blood
Cardiac-Related
stream infections
• Door-to-balloon times for acute myocardial infarction (AMI) • Ultrasound use for central line insertion
• Fibrinolysis for AMI (median time and within 30 minutes) • Appropriate Foley catheter use in the emergency
• Transfer time to another facility for AMI intervention department
• Aspirin at arrival for AMI or chest pain • Medication error reduction, including ACEP module,
“Preventing Medication Errors”
• Median time to electrocardiogram (ECG) for AMI or chest
pain • Appropriate use of restraints and seclusion
• Assessment for chest pain (including risk stratification, • Reassessment of vital signs at discharge
non-invasive testing and stress testing, diagnostic protocols • Planning safer and more effective aftercare, including
for early rule-out, TIMI risk assessment) ACEP module
• Improving care for patients with chest pain • Reducing discrepancies between emergency physician
• Cardiac resuscitation and post-resuscitation care and radiologist x-ray interpretation
• Screening for high blood pressure and documented • Notification of regional poison control center for
follow up poisoned patient
• Coagulation studies in patients presenting with chest pain
Additional Common Measures and Activities
with no coagulopathy or bleeding

Appropriate Imaging • Left without being seen


• Unscheduled return visits to emergency department
• Appropriate CT use in minor blunt head trauma (including 72-hour returns)
• Appropriate CT use for abdominal pain in adults • Ongoing Professional Practice Evaluation (OPPE) and
• Appropriate imaging for renal and ureteral colic Focused Professional Practice Evaluation (FPPE) processes
• Appropriate imaging for trauma patients (includes NEXUS • Improvement of difficult airway management
Criteria and Ottawa Rules) • Management of the intoxicated or alcohol withdrawal
• Use of imaging for low back pain patient
• Use of ultrasound for diagnosis for abdominal pain, pediatric • Tobacco use screening and cessation
• Ultrasound determination of pregnancy location for pregnant • Asthma pathways
patients with abdominal pain • Emergency Medical Associates (EMA) Clinical
• Appropriate use of neuroimaging for patients with primary Performance Improvement Program
headache, a normal neurological examination, and no trauma • Unhealthy alcohol use: screening and brief counseling

January 2018 n Volume 32 Number 1 17


in their field. Along with previously reassess performance in achieving the CRITICAL DECISION
validated questions, new questions practice performance metric.
Why is it important to maintain
are field tested and undergo statistical A prior IMP activity was
analyses to measure the level of difficulty certification?
communication/professionalism
and discrimination. Comments from test (C/P). However, in June 2016, ABEM Although ABEM board
takers also are factored into the review implemented a pilot that no longer certification is voluntary, the reality
process, and are evaluated before any required completion of a C/P activity is that many hospitals, medical
new question is included in the ConCert for the MOC program. This pilot will staffs, and third-party payors
Examination. require it. Generally speaking, the
conclude December 31, 2018, at which
The test is criterion referenced, patient does not choose his or her
time it will be evaluated by ABEM
meaning there is no curve. However, emergency physician. In light of this,
and ABMS to determine whether
more than 90% of emergency physicians maintenance of ABEM certification
this requirement will be permanently
who took the ConCert Examination publicly demonstrates a career-
report that preparing for and taking the removed from the MOC program.
long commitment to continuous
test added to and/or reinforced medical professional development.
knowledge.10 CRITICAL DECISION
Certification also is an important
What are the benefits and risk of element of professional self-regulation.
Improvement in
taking the ConCert Examination Historically, physicians did not
Medical Practice adequately address health care costs or
early?
Improvement in Medical Practice quality; as a result, federal statutes and
emphasizes advancements that There are significant advantages
regulations were imposed. To maintain
diplomates make in their work settings and no downside to taking the
the privilege of professional self-
by focusing on areas of practice-based ConCert Examination early. Moreover, regulation, medicine must demonstrate
learning related to patient care and diplomates who pass the test in the that specialty certification boards
professionalism. ABEM offers IMP sixth year of their certification will such as ABEM perform a summative
credit for practice improvement, or remain certified until the end of their assessment of physician cognitive
Practice Improvement (PI) projects that current certification period. That is, the skills and knowledge. The ConCert
emergency medicine groups are already
certificate renews for another 10 years Examination does this effectively.
doing (Table 2).
after the end of the physician’s current In addition, there is a learning
First, the PI activity is required
10-year cycle, regardless of when benefit to the ConCert Examination.
to be completed once during the first
the ConCert Examination is passed, Physicians who took the 2015
five years and once during the second
provided that the other components of test completed a voluntary, post-
five years of each 10-year certification
MOC continue to be fulfilled. Taking examination survey (96.5% response
period. The four required steps include
the test early also can reduce anxiety rate). Of the 2,511 respondents,
1) measure 10 or more patients with a
and may lead to more security in 92.0% reported a benefit to
specific condition or clinical situation;
2) compare this metric to a national length of board certification. In fact, preparing for and taking the ConCert
standard of care; 3) implement an a physician may make five attempts Examination. Among all respondents,
improvement in medical practice; and 4) before losing certification. 90.4% reported that their medical
knowledge was reinforced and/or
improved.
There are pathways to regaining
ABEM certification for physicians
who allow it to lapse.11 If less than
five years have passed since the date
a certificate has expired and four or
n Failing to avoid negative actions against your medical license, including those fewer LLS test requirements were
unrelated to the practice of medicine, which may result in the loss of ABEM missed while certified, certification
board certification. may be regained by making up missed
n Waiting until your final year of certification to take the ConCert Examination, requirements. If it has been longer
turning the test into a high-stakes situation that could have been avoided by than five years since a certificate
taking it earlier.
expired, or if more than four LLS
n Forgetting to register in advance—before taking the LLS test—for the relatively
test requirements were missed while
inexpensive CME activities offered by AAEM and ACEP.
n Falling behind on annual LLS tests. Procrastination makes it difficult and time certified, a physician must pass the
consuming to catch up in year five; keep up annually! ConCert Examination and then the
Oral Certification Examination to

18 Critical Decisions in Emergency Medicine


regain certification. Physicians in these screening for hypertension at the time CRITICAL DECISION
situations are encouraged to contact of discharge. For physicians working Are there “fun” and “easy”
ABEM directly for assistance. in lower-acuity settings such as urgent ways to satisfy the Lifelong
CRITICAL DECISION care centers, meeting IMP requirements Learning and Self-Assessment
may be more challenging. requirements?
What is the best way to satisfy
You can meet the PI requirement
ABEM’s Improvement in The Lifelong Learning and Self-
using your practice group data, Assessment component of MOC
Medical Practice requirements?
provided that physician-specific data, affords diplomates the option to
Many consider Improvement in
including your own, is among the enhance knowledge retention while
Medical Practice to be the easiest
information tracked for improvement networking with other emergency
component of MOC to satisfy. Every
physicians. ABEM diplomates are
emergency department, regardless through your emergency department.
encouraged to complete the LLS
of size or location, is beholden to ABEM has provided a dropdown
activities as a group, using the
performance metrics that monitor menu of options from which you may questions to help facilitate discussions
and guide practice changes designed
attest your participation. of the reading content.
to improve patient care. Sometimes,
Should you choose to do so, ABEM Many emergency medicine faculty
however, emergency physicians are
allows you to submit individualized and emergency department groups set
unaware of the metrics that are being
aside time annually to complete the
monitored by their particular hospital practice improvement attestations,
LLS requirement — tackling it over
or department. which must include pre- and post-
pizza, or converting the activity into a
Examples of emergency intervention data. Externally journal club for advanced physicians.
department measures that meet this
developed practice improvement The articles, which are relevant
MOC requirement cover the entire
activities also are available if you are to the daily practice of emergency
spectrum of care, from tracking door-
not able to identify an appropriate medicine, also provide an opportunity
to-balloon times for the treatment
for earning CME credit — an added
of acute myocardial infarction, to option from ABEM’s list.
bonus.

CASE RESOLUTIONS
■ CASE ONE specialty-specific gaps in competency. example, you remain certified, and
The only time a physician’s practice your certification will renew at the
The ABEM MOC program
was assessed was in the event of a end of your current 10-year period.
meets the requirements set forth
negative action taken by a state medical In essence, you are creating your own
by the ABMS. In an effort to make
board. The selected LLS readings, with timeframe in which to pass the test.
the requirements relevant and less
their associated optional CME, aim to
burdensome, ABEM incorporates
ensure that physicians are up to date ■ CASE THREE
the work that emergency physicians
in their respective specialties and are
already are performing into MOC. Satisfying the PI activity of the
maintaining the highest standards of
LLS articles may be submitted Improvement in Medical Practice
care.
to ABEM by any diplomate for component of MOC should be
consideration. Multiple ABEM ■ CASE TWO relatively easy for most emergency
LLS test editors and physician Physicians may take the ConCert physicians. Whether you are
representatives from AAEM Examination as early as year six of their working in an urgent care or in
and ACEP review each article to certification period. Taking the test a busy trauma center, tracking
determine the relevance, likelihood early, rather than waiting until the final physician performance is a common
to change practice, and suitability (or 10th) year of certification, offers
denominator. Measurements
for CME. The list of potential several potential advantages and no
can include, for example, a Joint
articles is then narrowed to the downside. If you fail the examination
best 10 to 15 articles relevant to prior to your certification end date, Commission’s Core Measure, an
emergency medicine practice. your board certification status is improvement in documentation,
CME activities historically were maintained—you are not decertified. a doctor-patient communication
selected by the physician, with no If you pass the ConCert Examination measurement, or patient safety event
assurance of addressing individual or in year six of your certification, for reporting.

January 2018 n Volume 32 Number 1 19


Summary 2. Davis D, O’Brien MA, Freemantle N, et al. Impact
of formal continuing medical education: do
Maintenance of Certification for conferences, workshops, rounds, and other
traditional continuing education activities change
ABEM-certified physicians aims to physician behavior or health care outcomes? JAMA.
1999;282(9):867-874.
ensure the highest standards for the 3. Holmboe ES, Wang Y, Meehan TP, et al. Association
specialty of emergency medicine. ABEM between maintenance of certification examination
scores and quality of care for Medicare beneficiaries.
continues to incorporate diplomate Arch Intern Med. 2008;168(13):1396-1403.
feedback into improvements in the 4. Galliher JM, Manning BK, Petterson SM, et al.
Do professional development programs for
MOC process in an effort to make the maintenance of certification (MOC) affect quality of
patient care? J Am Board Fam Med. 2014;27(1):19-25.
requirements more relevant and less 5. Gray BM, Vandergrift JL, Johnston MM, et al.
burdensome. Association between imposition of a maintenance
of certification requirement and ambulatory care-
Developed as a response to public sensitive hospitalizations and health care costs.
JAMA. 2014;312(22):2348-2357.
patient safety concerns, the various
6. Brennan TA, Horwitz RI, Duffy FD, et al. The role of
components of MOC assess varied physician specialty board certification status in the
quality movement. JAMA. 2004;292(9):1038-1043.
aspects of physician performance 7. Marco CA, Counselman FL, Korte RC, et al.
beyond licensure and traditional CME. Emergency physicians maintain performance on the
American Board of Emergency Medicine Continuous
Unrestricted state licensure remains the Certification (ConCert™) examination. Acad Emerg
Med. 2014;21(5):532-537.
foundation of professionalism. The LLS
8. American Board of Emergency Medicine. Policy on
activity features articles relevant to the Medical Licensure. Available at: https://www.abem.
org/public/docs/default-source/policies/policy-
day-to-day clinical practice of emergency on-medical-licensure.pdf?sfvrsn=20. Accessed
medicine, and now allows ABEM December 5, 2016.
9. Jones JH, Smith-Coggins R, Meredith JM, et al.
diplomates to concentrate on particular Lifelong learning and self-assessment is relevant to
emergency physicians. J Emerg Med. 2013;45(6):935-
subspecialties interest. 941.
Taking the ConCert Examination 10. Marco CA, Wahl RP, Counselman FL, et al. The
American Board of Emergency Medicine ConCert™
early will not reduce your certification examination: emergency physicians’ perceptions
period, and could lessen the anxiety of learning and career benefits. Acad Emerg Med.
2016;23(9):1082-1085.
commonly associated with high-stakes 11. American Board of Emergency Medicine. Policy on
Regaining Certification. Available at: https://www.
examinations. The IMP component abem.org/public/docs/default-source/policies/
allows diplomates to select from a policy-on-regaining-certification.pdf?sfvrsn=16.
Accessed December 5, 2016.
variety of options to document the 12. Davis D, O’Brien MA, Freemantle N, et al. Impact
numerous quality improvement activities of formal continuing medical education: do
conferences, workshops, rounds, and other
many emergency physicians are doing traditional continuing education activities change
physician behavior or health care outcomes? JAMA.
already. ABEM will continue to monitor 1999;282(9):867-874.
its MOC program, and welcomes any
suggestions about how to improve the
process.

Editor’s Note:
After this article was written,
ABEM convened a retreat of its
Board of Directors, followed by
an MOC Summit that specifically
addressed the Part III requirements
of Assessment of Knowledge,
Judgment, and Skills. This compo­
nent is satisfied by passage of the
ConCert Examination. Although
no changes have been formalized
as of the time of this printing, the
next 18 months are likely to bring
further adjustments or additions to
the Part III requirements.

REFERENCES
1. Committee on Quality Healthcare in America,
Institute of Medicine. Crossing the Quality
Chasm: A New Health System for the 21st Century.
Washington, D.C.: National Academy Press; 2001.

20 Critical Decisions in Emergency Medicine


A 61-year-old woman with dyspnea and hypoxia.

The Critical ECG


Multifocal atrial tachycardia (MAT), rate 115, left ventricular By Amal Mattu, MD, FACEP
Dr. Mattu is a professor, vice chair, and
hypertrophy (LVH), diffuse ischemia. When the rhythm is an irregularly director of the Emergency Cardiology
Fellowship in the Department of
irregular tachycardia, the main diagnostic considerations are atrial
Emergency Medicine at the University
fibrillation, atrial flutter with variable atrioventricular conduction, and of Maryland School of Medicine in
Baltimore.
MAT. The presence of distinct P waves excludes the diagnosis of atrial
fibrillation. On the contrary, P waves are present with at least three
different morphologies and they occur at irregular intervals, confirming the diagnosis of MAT and excluding the
diagnosis of atrial flutter. MAT is often associated with pulmonary disease — this patient was suffering from an acute
exacerbation of emphysema. Slight ST-segment depression is noted in multiple leads and resolved with treatment of
the patient’s hypoxia.

From Mattu A, Brady W, ECGs for the Emergency Physician 2. London: BMJ Publishing; 2008:11,23. Reprinted with permission.

January 2018 n Volume 32 Number 1 21


CME
Reviewed by Lynn Roppolo, MD, FACEP

Qualified, paid subscribers to Critical Decisions in Emergency Medicine may receive


CME certificates for up to 5 ACEP Category I credits, 5 AMA PRA Category 1
Credits™, and 5 AOA Category 2-B credits for completing this activity in its entirety.

QUESTIONS Submit your answers online at acep.org/newcriticaldecisionstesting; a score of 75%


or better is required. You may receive credit for completing the CME activity any time
within three years of its publication date. Answers to this month’s questions will be
published in next month’s issue.

1 What is the appropriate concentration and dose


of intramuscular epinephrine for managing
anaphylaxis?
6 What is the minimum length of time recommended for
observing a patient with anaphylaxis?
A. 0 to 2 hours
A. .3 mL of 1:1,000 solution B. 4 to 6 hours
B. .3 mL of 1:10,000 solution C. 12 hours
C. 1 mL of 1:1,000 solution D. 24 hours
D. 1 mL of 1:10,000 solution

2 What is the appropriate dosage of intravenous (IV)


methylprednisolone for treating anaphylaxis or
7 Which of the following reflects the target SpO2 when
providing supplementary oxygen to a patient with a
COPD exacerbation?
asthma in an adult patient? A. 90%
A. 1 mg B. 92%
B. 10 mg C. 95%
C. 125 mg D. 99% to 100%
D. 1,000 mg

3 Which of the following criteria can help confirm the


diagnosis of anaphylaxis?
8 You are treating a woman in the emergency department
with a likely COPD exacerbation. You have attempted
oxygen by nasal cannula and facemask, but the patient
A. Centor criteria continues to have respiratory difficulty, including visible
B. Duke criteria retractions; her oxygen saturation is 86% on 15 liters
C. Light criteria oxygen via facemask. There is no evidence of stridor and
D. NIAID/FAAN criteria she is alert and oriented. What would be an appropriate

4 A 25-year-old woman presents with an apparent


anaphylactic reaction after accidentally eating a
dessert that contained peanuts. She initially
next step to improve her respiratory status?
A. Attempt oral and/or nasal airway
B. Initiate immediate endotracheal intubation
reports having some difficulty swallowing. After C. Initiate continuous/bilevel positive airway pressure
being treated with intramuscular (IM) epinephrine D. Perform a jaw thrust
and IV steroids, she is transferred to the observation
unit. Three hours later, her symptoms recur,
requiring multiple doses of IM epinephrine and
9 Which of the following characteristics helps differentiate
asthma from COPD?
an epinephrine drip. What is the appropriate A. Asthma often is accompanied by emphysema
disposition for this patient? B. Asthma is caused by a narrow inflammatory mediator
A. Continue observation, and check vital sign every response
2 hours C. COPD is marked by more intermittent airflow
B. Discontinue drip after 90 minutes, and discharge obstruction
with a prescription for an IM epinephrine injector D. COPD may be evidenced by cellular inflammation (eg,
C. Initiate immediate allergen testing neutrophils, macrophases, eosinophils, and mast cells)

10

D. Transfer to inpatient (potentially ICU) bed A 25-year-old man presents with an acute asthma

5
How long should you generally wait prior to attack. Which of the following should exclude him from
administering a second dose of intramuscular admission to the emergency department observation
epinephrine to a patient with asthma or unit?
anaphylaxis? A. Continued wheezing, despite bronchodilator treatments
A. 3 minutes B. New sinus tachycardia noted on ECG
B. 5 minutes C. New ST-segment elevations noted on ECG
C. 10 to 15 minutes D. Requires three nebulizer treatments before
D. 30 minutes improvement is seen

22 Critical Decisions in Emergency Medicine


11
In outlining an MOC program for its member boards to
tailor and implement, the ABMS was responding not only
to the rapid advances in medicine, but also to patient
16
How much does it cost to take the ConCert
Examination (once every 10 years)?
A. $1,850
safety concerns raised by which organization in 1999? B. $2,250
A. American Medical Association C. $2,850
B. Centers for Medicare & Medicaid Services D. $3,250
C. Institute of Medicine
D. The Joint Commission

17 The IMP component emphasizes practice-based
learning activities related to patient care and


12
In 2014, nine emergency medicine stakeholder
organizations participated in a critical review of the
specialty’s continuous certification program. This MOC
professionalism. Which of the following best
represents ABEM’s current requirements for these
activities?
Summit was convened by which organization? A. Five continuous years of data are required
A. American Academy of Emergency Physicians (AAEM) B. Improvement projects are verified by ABEM every
B. American Board of Emergency Medicine (ABEM) year
C. American College of Emergency Physicians (ACEP) C. Patient satisfaction survey data must be uploaded
D. American Medical Association (AMA) to ABEM website


13 What is the best way for an ABEM diplomate to locate D. Quality improvement projects that emergency
a clear, up-to-date description of his completed and department groups are already doing

18

pending MOC requirements? A physician wishes to take the ConCert Examination
A. Ask a colleague who has recently completed early, in her sixth year of certification. Which of the
requirements following statements best represents her options?
B. Call member services at AAEM or ACEP A. If she takes the examination and does not pass,
C. Consult your ABEM MOC personal page at she will lose ABEM certification
www.abem.org B. She can take the examination early; if she passes,
D. Refer to the ABEM annual report she will remain certified for 10 years beyond her

14
At least one active, valid, and unrestricted license is current certification date
required for MOC. When holding multiple state licenses, C. She can take the examination early; if she passes,
which of the following statements does not reflect the she will be certified for the ensuing 10 years
Professionalism and Professional Standing requirement? D. She cannot take the examination until her final
year of certification
A. All active medical licenses must meet ABEM’s policy on
licensure
B. All surrendered licenses must have meet ABEM’s policy
on licensure
19
According to 2016 data published in Academic
Emergency Medicine, what percentage of
emergency physicians who took the ConCert
C. Licenses limiting a physician to a practice setting do not Examination found that it added to and/or
meet MOC reinforced medical knowledge?
D. Sanctions in one state do not affect a diplomate’s license A. 20%
in another state B. 50%

15
The prior Improvement in Medical Practice (IMP) C. 78%
communication/professionalism (C/P) requirement D. 90%
typically was measured by patient satisfaction surveys.
What piloted changes did ABEM make regarding this
component in 2016?
20
Once a physician allows his ABEM certification
to lapse, what activities are required to become
recertified?
A. Indefinitely deleted the C/P component of MOC A. Register for and pass the ConCert and Oral
B. Piloted a process for direct third-party C/P reporting to Examinations
ABEM B. Register for and pass the Qualifying and Oral
C. Substituted approved C/P didactic module for the Examinations
patient survey data C. Requirements vary; the physician should contact
D. Until pilot reassessment in 2018, no C/P attestation is ABEM staff directly
required D. There is no pathway for recertification after a lapse

ANSWER KEY FOR DECEMBER 2017, VOLUME 31, NUMBER 12


1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
D C C D B B C A B D C B D C B D A B C B

January 2018 n Volume 32 Number 1 23


Drug Box Tox Box
DEXMEDETOMIDINE SCOMBROID POISONING
By Ryan Fisher, MD, and Katie Fisher, PA, Maricopa Medical By Richard A. Koch, MD, FACEP, and Christian A. Tomaszewski, MD,
Center, Phoenix, Arizona MS, MBA, FACEP, University of California, San Diego
Reviewed by Frank Lovecchio, DO, MPH, FACEP Scombroid (ie, histame fish) poisoning is the most common seafood-
Indicated for the short-term sedation (<24 hours) of ICU patients borne illness in the US, and often is confused with allergic reactions.
on mechanical ventilation, and the sedation of non-intubated Toxicity most commonly is due to ingestion of inadequately frozen fish
patients prior to and/or during surgery or other procedures. from the Scombridae family, or another dark-fleshed fish.

Mechanism of Action Etiology


Histamine is produced by the decarboxylation of histidine, which is
The agent, which has a high affinity for alpha-2 receptors, is
naturally present in fish muscle. The responsible enzyme, histidine
a relatively selective central alpha 2-adrenergic agonist with
decarboxylase, is released by enteric bacteria (Escherichia, Klebsiella,
sedative properties. This effect appears to be due to G-protein
Proteus, Vibrio, Pseudomonas, etc.) in poorly refrigerated fish.
activation in the brainstem, which inhibits norepinephrine
Mechanism
release, and decreases sympathetic tone and peripheral vascular
Histamine activates H1, H2, H3, or H4 histamine receptors.
resistance. Alpha-1 and alpha-2 activity, which results in transient
• H1 activation produces allergic symptoms.
vasoconstriction, can be observed with high doses or with rapid
• H3 activation leads to neurotransmitter release with nausea,
intravenous administration.
vomiting, and headaches.
Dosing
Presentation
Adult
Symptom onset occurs 10–60 minutes after ingestion. Some patients
Initial loading infusion (optional) of 1 mcg/kg over 10 minutes,
report noticing a metallic, bitter, or peppery taste. Symptoms
followed by a maintenance infusion of 0.2-0.7 mcg/kg/hr; titrate
generally resolve in <24 hours (usually 6-8 hours), rarely lasting days.
no more frequently than every 30 minutes. Maintenance doses
• Hives, urticarial, erythematous rash, facial flushing and swelling
between 0.2 and 1.5 mcg/kg/hr have been used. Consider dose
• Abdominal cramps, nausea, vomiting, diarrhea
reduction for geriatric patients and those with hepatic impairment.
• Headache, dizziness, dry mouth, palpitations
Pediatric
• Orthostatic hypotension, wheezing, respiratory distress
Neonatal (limited data): loading dose (optional) 0.1-0.5 mcg/kg
Evaluation
over 10-20 minutes, followed by a maintenance dose of
0.1-0.3 mcg/kg/hr • Evaluate orthostatic vital signs due to possible fluid losses.
Infants, children, adolescents (limited data): loading dose • Consider electrolytes to treat losses to due to vomiting and
(optional) 0.5-1 mcg/kg over 10 minutes, followed by a mainten­ diarrhea.
ance infusion of 0.2-0.5 mcg/kg/hr • Histamine levels are not rapidly available and do not guide
treatment.
Side Effects
• Tryptase level may help distinguish allergic reactions.
Most common: hypotension, bradycardia and sinus arrest,
transient hypertension with loading dose administration Management
Less common: agitation, constipation, nausea, anxiety, • Decontamination generally is not required, and is contraindicated
xerostomia, anemia, withdrawal syndrome (use >6 hours), in vomiting patients.
tolerance, and tachyphylaxis (use >24 hours) • Mainly with antihistaminic medications (IV or IM):
­ — H1 blockers: diphenhydramine, cetirizine, etc.
Precautions
­ — H2 blockers: famotidine, ranitidine, etc.
Contraindicated in patients with hypersensitivity to the drug or a
• Provide antiemetics for persistent vomiting (eg, promethazine,
component of its formulation.
chlorpromazine, odansetron).

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