2-Ethylhexanol

Material Safety Data Sheet

SECTION 1: IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY

1.1. Product identifier
EC name 2-ethylhexan-1-ol
Alternative name 2-EH, 2EH, 2-ethylhexanol;
EC number 203-234-3
CAS number: 104-76-7
Registration number 01-2119487289-20-0002
Chemical formula

H3C OH

H3C

1.2. Relevant identified uses of substance and uses advised against

1.2.1. Relevant identified uses
− Use as intermediate
− Distribution of substance
− Formulation of substance
− Use in coatings (industrial)
− Use in coatings (professional)
− Dilution of a concentrate to prepare end use mixture (professional)
− Dilution of a concentrate to prepare end use mixture (consumers)
− Use in laboratories (industrial)
− Use in functional fluids (industrial)
− Use in functional fluids (professional)
− Use in cleaning products (professional)
− Use in oil and gas field drilling (industrial)
− Manufacture
1.2.2. Uses advised against
None
1.3. Details of the supplier of the safety data sheet
Name Grupa Azoty Zakłady Azotowe Kędzierzyn Spółka Akcyjna
Address PO Box 163, ul. Mostowa 30A, 47-220 Kędzierzyn-Koźle, Poland
Telephone № /+48 77/ 481 20 00 (operator)
Person responsible for safety data sheet (e-mail) karta_oxoplast@grupaazoty.com
1.4. Emergency telephone number
In Poland:
Police 997
Fire 998
Medical 999
Emergency system 112

PM-006.02-01 Page 01/13

Revision date 2014.08.01
Issue No 1
Revision No 6
 2-Ethylhexanol

SECTION 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance
2.1.1. Classification according to CLP / GHS
Acute toxicity (inhal.), Hazard Category 4: Acute Tox. 4
H332: Harmful if inhaled.
Skin corrosion/irritation, Hazard Category 2: Skin Irrit. 2
H315: Causes skin irritation.
Serious eye damage/eye irritation, Hazard Category 2: Eye Irrit 2
H319: Causes serious eye irritation.
Specific target organ toxicity — Single exposure,
Hazard Category 3, Respiratory tract irritation: STOT Single Exp. 3
H335: May cause respiratory irritation.
2.1.2. Classification according Annex I of Directive 67/548/EEC
Xn; R20 Harmful; Harmful by inhalation
Xi; R36/37/38 Irritant; Irritating to eyes, respiratory system and skin
2.1.3. Important adverse human heath effects
Harmful if inhaled. Causes skin irritation and serious eye irritation. May cause: respiratory irritation, cough, headache,
weakness, dizziness, gastrointestinal discomfort, nausea, unconsciousness, shortness of breath.
2.1.4. Important adverse environmental effects
Substance is readily biodegradable in water. Potential for bioaccumulation is expected to be low (BCF of 25.3).
Do not allow to reach sewage or effluent systems. Do not discharge product into the aquatic environment without
pretreatment (biological treatment plant). Hazardous waste according to European Waste Catalogue (EWC).
2.1.5. Important adverse physicochemical effects
Vapours are heavier than air and may spread along floors. Vapour/air-mixtures are explosive at intense warming
2.2. Label elements
Identification data: name, address and telephone number of the supplier(s)
Product identifier:
Substance name: “2-Ethylhexan-1-ol”
EC number: “EC number 203-234-3”
CAS number “CAS number 104-76-7”
Hazard Pictogram:

GHS07: exclamation mark

Signal Word: “Warning”

Hazard statements:
H332: “Harmful if inhaled.”
H315: “Causes skin irritation.”
H319: “Causes serious eye irritation.”
H335: “May cause respiratory irritation.”
Precautionary statements:
P233: “Keep container tightly closed.”
P261: “Avoid breathing mist/vapours/spray.”
P280: “Wear protective gloves/protective clothing/eye protection/face protection.”
P302+P352: “IF ON SKIN: Wash with plenty of soap and water.”
P305+P351+P338: “IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.”
P304+P340: “IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.”
P312: “Call a POISON CENTER or doctor/physician if you feel unwell.”

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2.3. Other hazards

Based on the available data it is concluded that 2-ethylhexanol
− is readily biodegradable and does not fulfill the P or vP criterion
− is not bioaccumulative and does not fulfill the B or vB criterion
− does not fulfill the T criterion
and therefore is evaluated to be not a PBT or vPvB substance.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1. Substances
Substance name EC number CAS number Concentration [%]
2-Ethylhexan-1-ol 203-234-3 104-76-7 >99.7

SECTION 4: FIRST AID MEASURES

4.1. Description of first aid measures
4.1.1. General informations
Remove contaminated, soaked clothing immediately and dispose of safely. First aider needs to protect himself.
4.1.2. Inhalation
Keep at rest. Aerate with fresh air. When symptoms persist or in all cases of doubt seek medical advice.
4.1.3. Skin
Wash off immediately with soap and plenty of water. When symptoms persist or in all cases of doubt seek medical advice.
4.1.4. Eyes
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses. Immediate
medical attention is required.
4.1.5. Ingestion
Call a physician immediately. Do not induce vomiting without medical advice.
4.2. Most important symptoms and effects, both acute and delayed
4.2.1. Main symptoms
Cough, headache, weakness, dizziness, gastrointestinal discomfort, nausea, unconsciousness, shortness of breath.
4.2.2. Special hazard
Lung irritation.
4.3. Indication of any immediate medical attention and special treatment needed
Treat symptomatically. If ingested, irrigate the stomach using activated charcoal.

SECTION 5: FIREFIGHTING MEASURES

5.1. Extinguishing media
5.1.1. Suitable extinguishing media
Foam, dry chemical, carbon dioxide (CO2), water spray
5.1.2. Unsuitable extinguishing media
Do not use a solid water stream as it may scatter and spread fire.
5.2. Special hazards arising from the substance
Special exposure hazards arising from the substance or preparation itself, its combustion products, or released gases. Under
conditions giving incomplete combustion, hazardous gases produced may consist of: carbon monoxide (CO), carbon dioxide
(CO2). Combustion gases of organic materials must in principle be graded as inhalation poisons. Vapours are heavier than air
and may spread along floors. Vapour/air-mixtures are explosive at intense warming
5.3. Advice for firefighters
5.3.1. Special protective equipment
Fire fighter protection should include a self-contained breathing apparatus (NIOSH-approved or EN 133) and full fire-fighting
turn out gear.

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5.3.2. Recommended precautions

Cool containers / tanks with water spray. Dike and collect water used to fight fire. Keep people away from and upwind of
fire.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures
6.1.1. For non-emergency personnel
Avoid contact with skin and eyes. Avoid breathing vapours or mists. Keep people away from and upwind of spill/leak. Ensure
adequate ventilation, especially in confined areas. Keep away from heat and sources of ignition.
6.1.2. For emergency responders:
Personal protection: see section 8.
6.2. Environmental precautions
Prevent further leakage or spillage. Do not discharge product into the aquatic environment without pretreatment (biological
treatment plant).
6.3. Methods and material for containment and cleaning up
6.3.1. Methods for containment
Stop the flow of material, if possible without risk. Dike spilled material, where this is possible.
6.3.2. Methods for cleaning up.
Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. If liquid has been spilt in large
quantities clean up promptly by scoop or vacuum. Dispose of in accordance with local regulations. Take necessary action to
avoid static electricity discharge (which might cause ignition of organic vapours).
6.3.3. Other information
Do not discharge product into the aquatic environment without pretreatment (biological treatment plant).
6.4. Reference to other sections
See Section 8 and 13

SECTION 7: HANDLING AND STORAGE

7.1. Precautions for safe handling
7.1.1. Recommendations on safe handling
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Provide
sufficient air exchange and/or exhaust in work rooms.
7.1.2. Recommendations for fire/explosion protection
Keep away from sources of ignition - No smoking. Take necessary action to avoid static electricity discharge (which might
cause ignition of organic vapours). In case of fire, emergency cooling with water spray should be available. Ground and bond
containers, when transferring material. Vapour/air-mixtures are explosive at intense warming.
7.1.3. Recommendations for protection of the environment
See Section 8: Environmental exposure controls.
7.2. Conditions for safe storage, including any incompatibilities
7.2.1. Technical measures/Storage conditions
Keep containers tightly closed in a cool, well-ventilated place. Handle and open container with care. Keep at temperatures
between 0 and 49 °C (32 and 120 °F).
7.2.2. Recommendations for common storage
Incompatible products: strong oxidizing agents
Temperature class T3
7.3. Specific end use(s)
Use as intermediate See: Exposure Scenario ES 1
Distribution of substance See: Exposure Scenario ES 2
Formulation of substance See: Exposure Scenario ES 3
Use in coatings (industrial) See: Exposure Scenario ES 4
Use in coatings (professional) See: Exposure Scenario ES 5
Dilution of a concentrate to prepare end use mixture (professional) See: Exposure Scenario ES 6

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Dilution of a concentrate to prepare end use mixture (consumer) See: Exposure Scenario ES 7
Use in laboratories (industrial) See: Exposure Scenario ES 8
Use in functional fluids (industrial) See: Exposure Scenario ES 9
Use in functional fluids (professional) See: Exposure Scenario ES 10
Use in cleaning products (professional) See: Exposure Scenario ES 11
Use in oil and gas field drilling (industrial) See: Exposure Scenario ES 12
Manufacture See: Exposure Scenario ES 13

SECTION 8: EXPOSURE CONTROLS / PERSONAL PROTECTION

8.1. Control parameters
8.1.1. OELs (Poland)
OEL (long-term) 160 mg/m3
OEL (short-term) 320 mg/m3
8.1.2. Derived No Effect Levels (DNELs) - Workers
8.1.2.1. ACUTE / SHORT TERM EXPOSURE (SYSTEMIC EFFECT)
DNEL Dermal 2-Ethylhexanol is of very low acute toxicity (LD50 oral and dermal
> 2000mg/kg) and no classification for acute toxicity is warranted.
Therefore, in agreement with ECHA Guidance on Information Requirements
and CSA, R.8, no DNELs for acute toxicity are derived.
DNEL Inhalation Toxicity after acute inhalation exposure was observed at high aerosol
exposure concentrations only. Possible respective hazards are covered by
the acute inhalation DNEL derived for local respiratory irritation effects.
8.1.2.2. ACUTE / SHORT TERM EXPOSURE (LOCAL EFFECT)
DNEL Dermal No-threshold effect and/or no dose-response information available
DNEL Inhalation 106.4 mg/m3 (DNEL is set equal to a recent German short-term occupational exposure
limit set by the German MAK Kommission at 20 ppm)
8.1.2.3. LONG-TERM EXPOSURE (SYSTEMIC EFFECTS)
DNEL Dermal 23 mg/kg bw/day (Assessment factor = 87.5) AF = 7 (allometric scaling) * 2.5 (interspecies dif-
ferences) * 5 (intraspecies differences), factor 0.1 for oral to dermal
(absorption correction factor)
DNEL Inhalation 53.2 mg/m3 DNEL is set equal to a very recent European occupational exposure limit set
by the European Scientific Committee for Occupational Exposure Limits
(SCOEL) at 10 ppm
8.1.2.4. LONG-TERM EXPOSURE (LOCAL EFFECTS)
DNEL Dermal No-threshold effect and/or no dose-response information available
DNEL Inhalation Covered by systemic DNEL inhalation
8.1.3. Derived No Effect Levels (DNELs) - General population
8.1.3.1. ACUTE / SHORT TERM EXPOSURE (SYSTEMIC EFFECT)
DNEL Dermal 2-Ethylhexanol is of very low acute toxicity (LD50 oral and dermal
> 2000mg/kg) and no classification for acute toxicity is warranted.
Therefore, in agreement with ECHA Guidance on Information Requirements
and CSA, R.8, no DNELs for acute toxicity are derived.
DNEL Inhalation Toxicity after acute inhalation exposure was observed at high aerosol
exposure concentrations only. Possible respective hazards are covered by
the acute inhalation DNEL derived for local respiratory irritation effects.

DNEL Oral 2-Ethylhexanol is of very low acute toxicity (LD50 oral and dermal
> 2000mg/kg) and no classification for acute toxicity is warranted.
Therefore, in agreement with ECHA Guidance on Information Requirements
and CSA, R.8, no DNELs for acute toxicity are derived.
8.1.3.2. ACUTE / SHORT TERM EXPOSURE (LOCAL EFFECT)
DNEL Dermal No-threshold effect and/or no dose-response information available
DNEL Inhalation 53.2 mg/m3 Derived from the short-term inhalation DNEL for workers by an additional
factor of 2 for increased intra individually susceptibility.

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8.1.3.3. LONG-TERM EXPOSURE (SYSTEMIC EFFECTS)

DNEL Dermal 11.4 mg/kg bw/day (Assessment factor = 175) AF = 7 (allometric scaling) * 2.5 (interspecies
differences) * 10 (intraspecies differences), factor 0.1 for oral to dermal
(absorption correction factor)
DNEL Inhalation 2.3 mg/m3 (Assessment factor = 50) corrected NOAEL (inhalative) = NOAEL * (6 [h/d] /
24 [h/d]) * (5/7 days) =114 mg/m3. AF = 2.5 (interspecies differences) * 10
(intraspecies factor) * 2 (subchronic to chronic extrapolation)

DNEL Oral 1.1 mg/ kg bw/day (Assessment factor = 175) AF = 7 (allometric scaling) * 2.5 (interspecies
differences) * 10 (intraspecies differences)
8.1.3.4. LONG-TERM EXPOSURE (LOCAL EFFECTS)
DNEL Dermal No-threshold effect and/or no dose-response information available
DNEL Inhalation covered by systemic DNEL inhalation
8.1.4. Predicted No Effect Concentration (PNEC)
PNEC aqua (freshwater) 0.017 mg/l (extrapolation method: assessment factor 1000)
PNEC aqua (marine water) 0.0017 mg/l (extrapolation method: assessment factor 10000)
PNEC aqua (intermittent releases) 0.17 mg/l (extrapolation method: assessment factor 100)
PNEC STP 10 mg/l (extrapolation method: assessment factor 10)
PNEC sediment (freshwater) 0.28 mg/kg sediment dw (extrapolation method: partition coefficient)
PNEC sediment (marine water) 0.028 mg/kg sediment dw (extrapolation method: partition coefficient)
PNEC soil 0.047 mg/kg soil dw
PNEC oral 55 mg/kg food
8.2. Exposure controls
See Section 7.3 “Specific end use(s)”

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties
Appearance: at. 20°C Clear and colourless organic liquid
Odour: slight
Odour treshold: no data
pH no data
Melting point/freezing point -89°C (at 101 325 Pa)
Initial boiling point: 184°C (at 101 325 Pa)
Boiling range no data
Flash point: 77°C at 1013hPa, (closed cup)
Evaporation rate no data
Flammability (solid, gas): In accordance with chapter R.7.1.10 of the REACH Guidance on
Information Requirements and CSA, the flammability of a liquid is
described by flash point and boiling point. In accordance with chapter
R.7.1.10.4 of the absence of structural alerts will mean that testing is
not necessary for pyrophoric properties and flammability of contact with
water. This is the case for this substance
Explosive limits: lower no data
upper no data
Vapour pressure: at 20°C <1hPa
Vapour density no data
Relative density: at 20°C 0.8325
Solubility(ies): in water 0.9 g/l at 20°C and pH = 5.8
Partition coefficient: n-octanol/water (log):at 25°C 2.9
Auto-ignition temperature: 280°C at 1017hPa
Decomposition temperature: no data
Viscosity: at 20°C 9.845 mPas

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Explosive properties: The substance does not contain any groups associated with explosivity
(REACH Guidance on Information Requirements and CSA; version May
2008; R.7.1.11)
Oxidising properties: Based on the molecular composition of the evaluated molecules
and in accordance with the REACH Guidance on Information
Requirements and CSA (chapter R7.1.13.3), the substances do not
contain structural elements indicating oxidising properties. This is
in agreement with text-book chemical knowledge and practical
handling experience.
9.2. Other information
Density: at 20°C 832.5 kg/m3
Surface tension: at 20°C 47 mN/m at 20°C, (concentration 0.81 g/l)
Granulometry REACH Guidance on Information Requirements and CSA; version May
2008; R.7.1.14.1 Information requirements on granulometry. The study
does not need to be conducted if the substance is marketed or used in a
non solid or non granular form.
Dissociation constant In accordance with chapter R.7.1.17 of the REACH Guidance on
Information Requirements and CSA, a study does not need to be
conducted if it is scientifically not possible to perform the test
(e. g. because the analytical method is not sensitive enough).

SECTION 10: STABILITY AND REACTIVITY

10.1. Reactivity
No data.
10.2. Chemical stability
Based on text-book chemical knowledge and practical handling experience the product is stable in organic common solvents
under ambient conditions. Stable under recommended storage conditions.
10.3. Possibility of hazardous reaction
No data.
10.4. Conditions to avoid
Avoid contact with heat, sparks, open flame, and static discharge. Avoid any source of ignition.
10.5. Incompatible materials
Strong oxidizing agents
10.6. Hazardous decomposition products
No decomposition if stored and applied as directed.

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects
11.1.1. Toxicokinetics
Overall, 2-EH was rapidly absorbed, metabolised, and excreted mainly via urine within 28 hours following the oral
administration to rats. Accumulation of 2-EH or its metabolites is unlikely to occur
Rapid absorption, metabolism and excretion of 2-EH as polar glucuronides predominantly in urine following oral ingestion.
Bioaccumulation is unlikely due to virtually complete excretion (>95% within 96 hrs).
Dermal absorption of 2-EH by rat skin is slow and bioavailability is low. Metabolism and excretion show no differences
compared to the oral route. The absorption rate was 5.78 times higher with rat skin compared to human stratum corneum.
Absorption rate is 6.6%
11.1.2. Acute toxicity
LD50 (oral): 2047 mg/kg bw
LD50 (dermal): >3000 mg/kg bw
LC50 (inhalation): ≥1400 mg/m³ air

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11.1.3. Skin corrosion/irriation

Highly irritating but not corrosive. Risk of severe skin irritation. Changes are not reversible.
Rabbit
Erythema score: 3.33
Edema score 4.00
Overall irritation score: 6.75
11.1.4. Serious eye damage/irritation
Risk of damage to the eyes. Irritating, full reversible
Rabbit (two data set)
Cornea score: 1.44; 1.75
Iris score: 0.89; 0.67
Conjunctivae score: 2.56; 2.08
Chemosis score: 0.78; 1.92
11.1.5. Respiratory tract irritation
2 -EH may cause respiratory irritation at concentrations of 50 ppm or higher. Signs of respiratory irritation of unclear
adversity were observed in human experimental studies at 20 ppm
11.1.6. Respiratory or skin sensitisation
Skin: not sensitizing
Respiratory tract no data
11.1.7. Germ cell mutagenicity
Genetic toxicity: negative
2-EH was not mutagenic in bacteria (Salmonella typhimurium strains TA100, TA1535, TA1537, and TA98, with or without
metabolic activation) or in mammalian cells in vitro (HGPRT in CHO cells and TK in mouse lymphoma cells), and it did not
induce chromosome aberration or sister chromatid exchange in mammalian cells.
11.1.8. Carcinogenicity
2 -EH was not carcinogenic in two valid long term rodent studies using F344 Fischer rats and B6C3F1 mice of either sex.
Oral:
NOAEL: 750 mg/kg bw/day
Target organs for carcinogenicity: liver
Dermal: no data.
Inhalation: no data.
11.1.9. Reproductive toxicity
11.1.9.1. FERTILITY
There is no valid fertility study available or known to exist to date.
11.1.9.2. DEVELOPMENTAL TOXICITY – ORAL
Maternal toxicity was most severe at the high dose level and marginal at the intermediate dose level. At the low dose no
maternal toxicity was noted.
NOAEL : 130 mg/kg/day (used for classification)
Toxicity to reproduction: signs of embryo-/fetotoxicity were dose-dependently noted in dams showing signs of maternal
toxicity at 650 and 1300 mg/kg/d.
NOAEL: 130 mg/kg/day
Teratogenicity was noted in fetuses from the high dose dams only.
NOAEL: 650 mg/kg/day
11.1.9.3. DEVELOPMENTAL TOXICITY – DERMAL
The maternal toxicity was mild.
NOAEL: 840 mg/kg bw/day
Developmental toxicity
NOAEL: 2520 mg/kg bw/day (used for classification)
Teratogenicity toxicity
NOAEL: 2520 mg/kg bw/day

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11.1.9.4. DEVELOPMENTAL TOXICITY – INHALATION

No maternal toxicity or developmental toxicity was noted in a rat inhalation study that was conducted similar to OECD TG
414.
NOAEC: 850 mg/m³ (used for classification)
11.1.10. STOT – single exposure
Inhalation
DNEL: 106.4 mg/m³
Target organs: respiratory tract
11.1.11. STOT – repeated exposure
No data
11.1.12. Repeated dose toxicity
Oral
NOAEL: 200 mg/kg bw/day (chronic; mouse)
Target organs: digestive: stomach; digestive: liver
The NOEL was 250 mg/kg bw/day in the oral subchronic rat and mouse studies, which is far beyond the threshold of
the EC Directive 67/548 peraining to severe health hazards resulting from repeated exposure
Inhalation
NOAEC: 638.4 mg/m³
Target organs: no target organs
Dermal
Presently no valid studies available

SECTION 12: ECOLOGICAL INFORMATION

12.1. Toxicity
12.1.1. Aquatic toxicity
12.1.1.1. ACUTE TOXICITY
LC50/96h Fish: Leuciscus idus melanotus; 17.1 mg/l
LC50/96h Fish: Pimephales promelas; 28.2 mg/l
EC50/48h Crustacea: Daphnia magna 39 mg/l
EC50 /72h A Algae: Scenedesmus subspicatus. 11.5 mg/l; biomass
16.6 mg/l; freshwater
EC120/LC10 or NOEC (freshwater) 5.3 mg/l
12.1.1.2. LONG-TERM TOXICITY
According to REACH Annex IX, 9.1, Column 2, the test is not required (CSR does not indicate the need for further
investigations)
12.1.2. Sediment toxicity
The substance is readily biodegradable, the adsorption potential is low (Log Koc = 1.42), as is the bioconcentration factor
(the estimated Log BCF was 1.4). Direct and indirect exposure to soil is not likely, since the substance is not intentionally
applied to soil. Therefore, no testing is required in accordance with REACH; ANNEX X; No. 9.5.1, column 2.
12.1.3. Terrestrial toxicity
12.1.3.1. TOXICITY TO SOIL MICRO-ORGANISMS.
The substance is readily biodegradable, and the adsorption potential is low (low Pow and Koc). Direct and indirect exposure
to soil is not likely, since the substance is not intentionally applied to soil. Therefore, no testing is required in accordance
with REACH; ANNEX X; No. 9.4, column 2.
12.1.3.2. TOXICITY TO SOIL MACRO-ORGANISMS
Arthropods The substance is readily biodegradable, and the adsorption potential is low (low Pow and Koc). Direct and
indirect exposure to soil is not likely, since the substance is not intentionally applied to soil. Therefore, no
testing is required in accordance with REACH; ANNEX VIII; No. 9.4, column 2.
Other The substance is readily biodegradable, and the adsorption potential is low (low Pow and Koc).
Direct and indirect exposure to soil is not likely, since the substance is not intentionally applied to
soil. Therefore, no testing is required in accordance with REACH; ANNEX X; No. 9.4, column 2.

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12.1.3.3. TOXICITY TO TERRESTRIAL PLANTS

The substance is readily biodegradable, and the adsorption potential is low (low Pow and Koc). Direct and indirect exposure
to soil is not likely, since the substance is not intentionally applied to soil. Therefore, no testing is required in accordance
with REACH; ANNEX VIII; No. 9.4, column 2.
12.1.3.4. TOXICITY TO TERRESTRIAL ANIMALS
Birds: The substance is readily biodegradable, the adsorption potential is low (low Pow and Koc), as is the
bioconcentration factor (the estimated Log BCF was 1.4). Direct and indirect exposure to soil is not likely,
since the substance is not intentionally applied to soil. Therefore, no testing is required in accordance with
REACH; ANNEX X; No. 9.6.1, column 2.
Mammals: Toxicity in repeated dose toxicity studies with rodents was moderate. The NOAEL observed in a chronic study
was 200 mg/kg bw/d.
12.1.4. Microbiological activity in sewage treatment systems
The substance is readily biodegradable. Therefore, no testing is required in accordance with REACH; ANNEX VIII; No. 9.1.4,
column 2.
NOEC/24h (activated sludge, domestic) >300 mg/l
12.2. Persistence and degradability
12.2.1. Stability
In accordance with Annex VIII, No. 9.2.2.1, column 2, no testing is required because the substance is readily biodegradable
12.2.1.1. HYDROLYSIS:
2-EH is not expected to hydrolyze in water due to the absence of hydrolysable groups. Since alcohols are generally resistant
to hydrolysis and the substance structure does not contain other hydrolyzable elements, 2 -ethylhexanol will not hydrolyze in
water under environmental conditions (GUBDH, 2008).
12.2.2. Biodegradation
12.2.2.1. BIODEGRADATION IN WATER
Biodegradation in water: readily biodegradable
2-ethylhexanol was readily biodegradable in a MITI-I Test, (equivalent to OECD TG 301-C). This is in line with the observation
that the chemical oxygen demand (COD) was reduced by >95% in the Zahn-Wellens test (OECD 302B guideline; reliability 2)
within 5 days demonstrating rapid biodegradation. Kinetic of test substance (in %; Hoechst, 1979):
Day 1 2 5 7 9
% degraded 23 36 96 97 96

According to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.16.4.4. the
degradation rate constant is approx. k = 4.7 x 10-2 (d-1), with a half-life of 15 days .
12.2.2.2. BIODEGRADATION IN SOIL
The substance is readily biodegradable. Therefore, no testing is required in accordance with REACH; ANNEX IX; No. 9.2.1.3,
column 2.
12.3. Bioaccumulative potential
Log Kow 2.9
BCF 25.33
Using an accepted calculation method (BCF program, version 2.17) the estimated Log BCF was 1.404 (BCF = 25.33) (GUBDH,
2008).
In accordance with column 2 of Annex IX, due to the low log Pow of 2.9 for 2-Ethylhexanol (Perstorp, 2010) no
bioaccumulation study is required. Potential for bioaccumulation is expected to be low. A BCF of 25.3 calculated by QSAR
also points towards low bioaccumulation potential. In addition the substance is readily biodegradable (NITE, 2002). Therefore
and for reasons of animal welfare a fish study is not performed.
12.4. Mobility in soil
12.4.1. Adsorption/desorption
Using an accepted calculation program (PCKOC version 1.66, connectivity index method) the estimated Koc was 26, i.e. Log
Koc=1.42 (GUBDH, 2008).
In accordance with column 2 of Annex IX, the study does not need to be conducted if the substance has a low potential for
bioaccumulation. The log Pow of 2.9 for 2-Ethylhexanol (Perstorp, 2010) indicates a low potential for bioaccumulation. Low
values for Koc calculated with a QSAR tool also point to low absorption to soil. In addition the substance is readily
biodegradable (NITE, 2002).

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12.4.2. Volatilisation
No information available
12.4.3. Distribution modelling
No information available
12.5. Results of PBT and vPvB assessment
Based on the available data it is concluded that 2-ethylhexanol
− is readily biodegradable and does not fulfill the P or vP criterion
− is not bioaccumulative and does not fulfill the B or vB criterion
− does not fulfill the T criterion
and therefore is evaluated to be not a PBT or vPvB substance.
12.6. Other adverse effects
No data.

SECTION 13: DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods
13.1.1. Product Information
Disposal required in compliance with all waste management related state and local regulations. The choice of the
appropriate method of disposal depends on the product composition by the time of disposal as well as the local statutes and
possibilities for disposal. Hazardous waste according to European Waste Catalogue (EWC).
13.1.2. Uncleaned empty packaging
Contaminated packaging should be emptied as far as possible and after appropriate cleansing may be taken for reuse.
13.1.3. Physical and chemical properties
Flash point 77°C
Density 832.5 kg/m3
13.1.4. Special precautions
Do not discharge product into the aquatic environment without pretreatment (biological treatment plant). Vapours are
heavier than air and may spread along floors. Vapour/air-mixtures are explosive at intense warming.
13.1.5. Regulations
1. Directive 2008/98/EC of the European Parliament and of the Council of 19 November 2008 on waste and repealing
certain Directives (Official Journal of the UE of 2008 r. Vol 51, L312 with further amendments).
2. Local statements.

SECTION 14: TRANSPORT INFORMATION

14.1. UN number
RID/ADR not restricted
IMDG -
ADN ID 9006
ICAO/IATA UN 3334
14.2. UN proper shipping name
RID/ADR not restricted
IMDG -
ADN ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
ICAO/IATA Aviation regulated liquid, n.o.s.
14.3. Transport hazard class
RID/ADR not restricted
IMDG -
ADN 9
ICAO/IATA 9

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 2-Ethylhexanol

14.4. Packing group

RID/ADR not restricted
IMDG -
ADN -
ICAO/IATA -
14.5. Environmental hazards
No data
14.6. Special precautions for user
No data
14.7. Transport in bulk according to Annex II of MARPOL73/78 and IBC Code
No data

SECTION 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
1. Regulation (EC) № 1907/2006, of the European Parliament and of the Council, of 18 December 2006, concerning the
Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals
Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) № 793/93 and Commission Regulation
(EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC,
93/105/EC and 2000/21/EC, with further amendments;
2. Regulation (EC) № 1272/2008, of the European Parliament and of the Council, of 16 December 2008, on classification,
labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC,
and amending Regulation (EC) № 1907/2006, with further amendments;
3. Local regulations
15.2. Chemical safety assessment
Chemical safety assessment has been carried out

SECTION 16: OTHER INFORMATION

16.1. Changes
Change graphics.
16.2. A key or legend to abbreviations and acronyms used
REACH Registration, Evaluation, Authorisation and restriction of CHemicals
CSR Chemical Safety Report
OEL Occupational Exposure Limit
DNEL Derived No Effect Level
PNEC Predicted No Effect Concentration
LD50 Lethal Dose 50%
LC50 Lethal Concentration 50%
EC50 Effective Concentration 50%
NOEL No Observable Effect Level
NOEC No Observable Effect Concentration
NOAEC No Observable Adverse Effect Concentration
NOAEL No Observable Adverse Effect Level
STP Sewage Treatment Plant
PBT Persistent, Bioaccumulative, and Toxic
vPvB Very persistent and very bioaccumulative
16.3. Key literature references and sources for data
2-Ethylhexan-1-ol registration dossier

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 2-Ethylhexanol

16.4. List of relevant R phrases, hazard statements, and precautionary statements.

16.4.1. Danger symbols
Xn; Harmful;
Xi; Irritant;
16.4.2. R phases
R20 Harmful by inhalation
R36/37/38 Irritating to eyes, respiratory system and skin
16.4.3. Hazard statement
H335: May cause respiratory irritation.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
16.4.4. Precautionary statements
P233: Keep container tightly closed.
P261: Avoid breathing mist/vapours/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
16.5. Advice on any training
1. Every employer is obliged to instruct his employees who work in contact with 2-ethylhexanol on the hazards and
personal protection means which have been specified in this Data Sheet.
2. Every distributor is obliged to provide the information specified in this Data Sheet to his clients who buy 2-ethylhexanol.
16.6. In place of
PM-006.02 (issue No 1, revision No 5)

This Material Safety Data Sheet is NOT any product quality specification, and it may NOT be understood as any
guarantee for the product quality or for the product compliance with the client’s requirements for individual
applications. The purpose of this MSDS is to provide the guidelines for safe handling of the product (occupational
safety and environmental protection), its transport and storage. The figures and data specified herein are based on
our current knowledge and on current legislation. The clients should verify that information against the provisions of
the laws and/or regulations which are valid in their countries and/or companies.

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