Immunization - Vaccine Efficacy; Studies from

University of Cape Town Have Provided New

Data on Vaccine Efficacy (Mycobacterium
tuberculosis-specific CD4 T cells expressing
CD153 inversely associate with bacterial load and
disease severity in human tuberculosis)
Publication info: AIDS Vaccine Week ; Atlanta [Atlanta]27 July 2020: 60.

ProQuest document link

FULL TEXT
2020 JUL 27 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Vaccine Week -- Research findings on
Immunization - Vaccine Efficacy are discussed in a new report. According to news originating from Cape Town,
South Africa, by NewsRx correspondents, research stated, "Recent data from mice and non-human primate models
of tuberculosis suggested that CD153, a TNF super family member, plays an important role in Mycobacterium
tuberculosis (Mtb) control. However, this molecule has not been comprehensively evaluated in humans."
Our news journalists obtained a quote from the research from the University of Cape Town, "Here, we show that the
proportion of Mtb-specific CD4 T cells expressing CD153 was significantly reduced in active TB patients compared
to latently infected persons. Importantly, the CD153+ Mtb-specific CD4 response inversely correlated with lung
bacterial load, inferred by Xpert cycle threshold, irrespective of HIV status. Antitubercular treatment partially
restored CD153 expression on Mtb-specific CD4 T cells. This is the first report of a subset of Mtb-specific CD4 T
cells showing strong negative correlation with bacterial burden."
According to the news editors, the research concluded: "Building on substantial evidence from animal models
implicating CD153 as a mediator of host protection, our findings suggest it may play a similar role in humans and
its measurement may be useful to evaluate TB vaccine efficacy."
For more information on this research see: Mycobacterium tuberculosis-specific CD4 T cells expressing CD153
inversely associate with bacterial load and disease severity in human tuberculosis. Mucosal Immunology, 2020;():.
Mucosal Immunology can be contacted at: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-
1707, USA. (Nature Publishing Group - www.nature.com/; Mucosal Immunology - www.nature.com/mi/)
The news correspondents report that additional information may be obtained from Sheena Ruzive, Wellcome
Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University
of Cape Town, Observatory, Cape Town, 7925, South Africa. Additional authors for this research include Elsa Du
Bruyn, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Alan Sher, Daniel L. Barber, Robert J. Wilkinson and
Catherine Riou. and can be your direct source for a journal article and its citation.
The publisher's contact information for the journal Mucosal Immunology is: Nature Publishing Group, 345 Park
Avenue South, New York, NY 10010-1707, USA.
Keywords for this news article include: Cape Town, South Africa, Immunization, Actinobacteria, Mycobacteriaceae,
Vaccine Efficacy, Gram-Positive Rods, Infectious Disease, Biological Products, Drugs and Therapies, Health and
Medicine, Gram-Positive Bacteria, Mycobacterium Infections, Actinomycetales Infections, Mycobacterium
Tuberculosis.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2020, NewsRx

PDF GENERATED BY PROQUEST.COM Page 1 of 3

LLC
The citation for this news report is: NewsRx. Studies from University of Cape Town Have Provided New Data on
Vaccine Efficacy (Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with
bacterial load and disease severity in human tuberculosis). AIDS Vaccine Week. July 27, 2020; p 60.

DETAILS

Subject: Lymphocytes; Infectious diseases; Gram-positive bacteria; Vaccines; Immunization;

Tuberculosis; Publishing; Immunology

Location: United States--US South Africa New York

Company / organization: Name: Nature Publishing Group; NAICS: 511120; Name: University of Cape Town;
NAICS: 611310

Identifier / keyword:
Cape Town South Africa Africa Actinobacteria Actinomycetales Actinomycetales
Infections Biological Products Drugs and Therapies Gram-Positive Asporogenous
Rods Gram-Positive Bacteria Gram-Positive Rods Health and Medicine Immunization
Infectious Disease Mycobacteria Mycobacteriaceae Mycobacterium Mycobacterium
Infections Mycobacterium Tuberculosis Tuberculosis Vaccine Efficacy Vaccines

Publication title: AIDS Vaccine Week; Atlanta

First page: 60

Publication year: 2020

Publication date: Jul 27, 2020

Publisher: NewsRx

Place of publication: Atlanta

Country of publication: United States, Atlanta

Publication subject: Medical Sciences

ISSN: 15436918

e-ISSN: 1543690X

Source type: Wire Feeds

Language of publication: English

Document type: News

ProQuest document ID: 2428266794

PDF GENERATED BY PROQUEST.COM Page 2 of 3

 Document URL: https://search.proquest.com/wire-feeds/immunization-vaccine-efficacy-studies-
university/docview/2428266794/se-2?accountid=25704

Copyright: Copyright 2020, NewsRx LLC

Last updated: 2020-07-30

Database: Consumer Health Database

Database copyright  2021 ProQuest LLC. All rights reserved.

Terms and Conditions Contact ProQuest

PDF GENERATED BY PROQUEST.COM Page 3 of 3