Hypertension Drugs

Sympathoplegics, Sympathetic Nerve α blockers β blockers

Diuretics Centrally Acting Terminal Blockers

Prazosin, Terazosin, Metoprolol,

Reserpine Doxazosin Carvedilol, Nebivolol
Clonidine & Blocks vesicular amine Selectively block α1 Block β1 receptors;
THIAZIDES: Block Na/Cl
transporter in renal distal Methyldopa transporter in adrenoceptors carvedilol also blocks
convoluted tubule Activates Alpha-2 noradrenergic nerves α receptors; nebivolol
-Hydrochlorothiazide also releases nitric
-Metolazone (Popular for use with adrenoceptors and depletes
loop agents for synergistic effects) transmitter stores oxide
-Chlorothiazide (Only parenteral
thiazide available (IV))
-Chlorthalidone (Long half-life
(50–60 h) due to binding to red
blood cells)

LOOP DIURETICS: Block Propanolol

Na/K/2Cl transporter in Guanethidine Nonselective
renal loop of Henle prototype β blocker
-Furosemide Interferes with amine
-Bumetanide and Torsemide
(sulphonamide loop agent similar
release and replaces
to Furosemide) norepinephrine in
-Ethacrynic acid (Not a vesicles
sulfonamide but has typical loop
activity and some uricosuric
action)

Metoprolol, Atenolol
SPIRONOLACTONE: Block Very widely used as
aldosterone receptor in
renal collecting tubule β1-selective blockers
-Eplerenone (Like spironolactone,
more selective for aldosterone
receptor)