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  • 2016 - Prediction of Kinase-Specific Phosphorylation Sites Through An Integrative Model of Protein Context and Sequence

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    morteza hosseini
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    The document contains mathematical equations and graphs but provides no context or explanation. It is not possible to determine what the equations, graphs, or document are about based on the information given.

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    2016 _ Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence

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    The document contains mathematical equations and graphs but provides no context or explanation. It is not possible to determine what the equations, graphs, or document are about based on the information given.

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    5 views10 pages

    2016 - Prediction of Kinase-Specific Phosphorylation Sites Through An Integrative Model of Protein Context and Sequence

    Uploaded by

    morteza hosseini
    The document contains mathematical equations and graphs but provides no context or explanation. It is not possible to determine what the equations, graphs, or document are about based on the information given.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 10

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    −

    − −
    Sensitivity difference f rylation sites
    99.9% specificity 99% specificity
    1.0

    Sensitivity difference
    0.5

    0.0

    C
    K1
    K

    TK
    er
    E

    E
    C

    C
    al

    TK

    al

    K1
    er
    M

    ST
    G

    ST

    AM
    AG

    AG

    th
    ic

    ic
    th
    C

    C
    M

    M
    A
    yp

    yp

    O
    O
    C

    C
    At
    At

    Family
    Method

    − −

    − − − −

    −
    −
    − −
    − −
    − −
    Predicted kinase binding sites around NLSs
    Kinase Akt1 AMPKA1 AurB CDK2 p70S6K p90RSK PAK1 PKA

    Akt1 AMPKA1
    60

    40

    20

    0 * ** * * * **
    AurB CDK2
    60

    40

    20
    Count

    0 ** ** * * * ** **
    p70S6K p90RSK
    60

    40

    20

    0 * ** * * * ** *
    PAK1 PKA
    60

    40

    20

    0 ** * * ** ** ** *
    0 10 0 10
    Position

    −
    b b
    − −

    β
    α

    α β

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