Medizinische

EUROIMMUN Labordiagnostika
AG

Anti-Phospholipase A2 Receptor IIFT:

A milestone in the diagnosis of IMN
PLA2R isoform 1
Renal corpuscule Filtration barrier of the kidney
(recombinant protein)

Primary Blood
urine Extracellular
domain
Filtration
(conformation-
dependent
Anti-PLA2R epitopes)
Capillary
endothelium
Basement membrane Cell membrane
Capillary loops Podocyte foot processes Intracellular
with podocytes (with PLA2R on the surface) domain

Indication: idiopathic membranous nephropathy (IMN)

Gold standard for serological diagnosis: cells transfected with

phospholipase A2 receptor (PLA2R) as IF substrate

Rapid serological test – no kidney puncture required!

Specificity 100 %, sensitivity up to 70 %*

Quantitative detection of anti-PLA2R IgG for the determination

of the disease activity and for therapy monitoring

PLA2R-transfected cells Control transfection

* Depending on the patient panel/therapy status

EUROIMMUN AG · D-23560 Luebeck (Germany) · Seekamp 31 · Tel +49 451 58550 · Fax 5855591 · E-mail euroimmun@euroimmun.de
FA_1254_R_UK_A02, 07/2011