Fat

In nutrition, biology, and chemistry, fat usually means any ester of fatty acids, or a mixture of such compounds, most
commonly those that occur in living beings or in food.[1]

The term often refers specifically to triglycerides (triple esters of glycerol), that are the main components of vegetable oils and
of fatty tissue in animals;[2] or, even more narrowly, to triglycerides that are solid or semisolid at room temperature, thus
excluding oils. The term may also be used more broadly as a synonym of lipid—any substance of biological relevance,
composed of carbon, hydrogen, or oxygen, that is insoluble in water but soluble in non-polar solvents.[1] In this sense,
besides the triglycerides, the term would include several other types of compounds like mono- and diglycerides,
phospholipids (such as lecithin), sterols (such as cholesterol), waxes (such as beeswax),[1] and free fatty acids, which are
usually present in human diet in smaller amounts.[2]
Idealized representation of a
Fats are one of the three main macronutrient groups in human diet, along with carbohydrates and proteins,[1][3] and the main molecule of a typical triglyceride, the
components of common food products like milk, butter, tallow, lard, salt pork, and cooking oils. They are a major and dense main type of fat. Note the three fatty
source of food energy for many animals and play important structural and metabolic functions, in most living beings, acid chains attached to the central
including energy storage, waterproofing, and thermal insulation.[4] The human body can produce the fat that it needs from glycerol portion of the molecule.
other food ingredients, except for a few essential fatty acids that must be included in the diet. Dietary fats are also the carriers
of some flavor and aroma ingredients and vitamins that are not water-soluble.[2]

Contents
Chemical structure
Conformation
Examples
Nomenclature
Common fat names
Chemical fatty acid names
IUPAC
Fatty acid code
Classification
By chain length
Saturated and unsaturated fats
Cis and trans fats
Omega number
Examples of saturated fatty acids
Examples of unsaturated fatty acids
Biological importance
Adipose tissue
Production and processing
Nutritional and health aspects
Essential fatty acids
Saturated vs. unsaturated fats
Cardiovascular disease
Cancer
Bones
Disposition and overall health
Monounsaturated vs. polyunsaturated fat
Cardiovascular disease
Insulin resistance and sensitivity
Cancer
Pregnancy disorders
"Cis fat" vs. "trans fat"
Cardiovascular disease
Breast feeding
Other health risks
Biochemical mechanisms
Natural "trans fats" in dairy products
Official recommendations
Regulatory action
Alternatives to hydrogenation
Omega-three and omega-six fatty acids
Interesterification
Fat digestion and metabolism
See also
Further reading
References

Chemical structure
The most important elements in the chemical makeup of fats are the fatty acids. The molecule of a fatty acid consists of a
carboxyl group HO(O=)C− connected to an unbranched alkyl group –(CHx)n H: namely, a chain of carbon atoms, joined by
single, double, or (more rarely) triple bonds, with all remaining free bonds filled by hydrogen atoms[5]

The most common type of fat, in human diet and most living beings, is a triglyceride, an ester of the triple alcohol glycerol
H(–CHOH–)3 H and three fatty acids. The molecule of a triglyceride can be described as resulting from a condensation
reaction (specifically, esterification) between each of glycerol's –OH groups and the HO– part of the carboxyl group
HO(O=)C− of each fatty acid, forming an ester bridge −O−(O=)C− with elimination of a water molecule H2 O.

Other less common types of fats include diglycerides and monoglycerides, where the esterification is limited to two or just
one of glycerol's –OH groups. Other alcohols, such as cetyl alcohol (predominant in spermaceti), may replace glycerol. In the
phospholipids, one of the fatty acids is replaced by phosphoric acid or a monoester thereof.

Conformation

The shape of fat and fatty acid molecules is usually not well-defined. Any two parts of a molecule that are connected by just
one single bond are free to rotate about that bond. Thus a fatty acid molecule with n simple bonds can be deformed in n-1
independent ways (counting also rotation of the terminal methyl group).

Such rotation cannot happen across a double bond, except by breaking and then reforming it with one of the halves of the
molecule rotated by 180 degrees, which requires crossing a significant energy barrier. Thus a fat or fatty acid molecule with
double bonds (excluding at the very end of the chain) can have multiple cis–trans isomers with significantly different
chemical and biological properties. Each double bond reduces the number of conformational degrees of freedom by one.
Each triple bond forces the four nearest carbons to lie in a straight line, removing two degrees of freedom.

It follows that depictions of "saturated" fatty acids with no double bonds (like stearic) having a "straight zig-zag" shape, and
those with one cis bond (like oleic) being bent in an "elbow" shape are somewhat misleading. While the latter are a little less
flexible, both can be twisted to assume similar straight or elbow shapes. In fact, outside of some specific contexts like crystals
or bilayer membranes, both are more likely to be found in randomly contorted configurations than in either of those two
shapes.

Examples
Examples of 18-carbon fatty acids.

Stearic acid
saturated

Oleic acid
unsaturated
cis-8

Elaidic acid
unsaturated
trans-8
Vaccenic acid
unsaturated
trans-11

Stearic acid is a saturated fatty acid (with only single bonds) found in animal fats, and is the intended product in full
hydrogenation.

Oleic acid has a double bond (thus being "unsaturated") with cis geometry about midway in the chain; it makes up 55–80%
of olive oil.

Elaidic acid is its trans isomer; it may be present in partially hydrogenated vegetable oils, and also occurs in the fat of the
durian fruit (about 2%) and in milk fat (less than 0.1%).

Vaccenic acid is another trans acid that differs from elaidic only in the position of the double bond; it also occurs in milk fat
(about 1-2%).

Nomenclature

Common fat names

Fats are usually named after their source (like olive oil, cod liver oil, shea butter, tail fat) or have traditional names of their
own (like butter, lard, ghee, and margarine). Some of these names refer to products that contain substantial amounts of other
components besides fats proper.

Composition of fats from various

Chemical fatty acid names foods, as percentage of their total fat
In chemistry and biochemistry, dozens of saturated fatty acids and of hundreds of unsaturated ones have traditional
scientific/technical names usually inspired by their source fats (butyric, caprylic, stearic, oleic, palmitic, and nervonic), but
sometimes their discoverer (mead, osbond).

A triglyceride would then be named as an ester of those acids, such as "glyceryl 1,2-dioleate 3-palmitate".[6]

IUPAC

In the general chemical nomenclature developed by the International Union of Pure and Applied Chemistry (IUPAC), the Example of a natural triglyceride with
recommended name of a fatty acid, derived from the name of the corresponding hydrocarbon, completely describes its three different fatty acids. One fatty
structure, by specifying the number of carbons and the number and position of the double bonds. Thus, for example, oleic acid is saturated (blue highlighted),
acid would be called "(9Z)-octadec-9-enoic acid", meaning that it has an 18 carbon chain ("octadec") with a carboxyl at one another contains one double bond
end ("oic") and a double bound at carbon 9 counting from the carboxyl ("9-en"), and that the configuration of the single within the carbon chain (green
bonds adjacent to that double bond is cis ("(9Z)") The IUPAC nomenclature can also handle branched chains and derivatives highlighted). The third fatty acid (a
where hydrogen atoms are replaced by other chemical groups. polyunsaturated fatty acid,
highlighted in red) contains three
A triglyceride would then be named according to general ester rules as, for example, "propane-1,2,3-tryl 1,2-bis((9Z)- double bonds within the carbon
octadec-9-enoate) 3-(hexadecanoate)". chain. All carbon-carbon double
bonds shown are cis isomers.

Fatty acid code

A notation specific for fatty acids with unbranched chain, that is as precise as the IUPAC one but easier to parse, is a code of the form "{N}:{D} cis-{CCC} trans-
{TTT}", where {N} is the number of carbons (including the carboxyl one), {D} is the number of double bonds, {CCC} is a list of the positions of the cis double
bonds, and {TTT} is a list of the positions of the trans bounds. Either list and the label is omitted if there are no bounds of that type.

Thus, for example, the codes for stearic, oleic, elaidic, and vaccenic acids would be "18:0", "18:1 cis-9", "18:1 trans-9", and "18:1 trans-11", respectively. The code
for α-oleostearic acid, which is "(9E,11E,13Z)-octadeca-9,11,13-trienoic acid" in the IUPAC nomenclature, has the code "18:3 trans-9,11 cis-13"

Classification

By chain length

Fats can be classified according to the lengths of the carbon chains of their constituent fatty acids. Most chemical properties, such as melting point and acidity, vary
gradually with this parameter, so there is no sharp division. Chemically, formic acid (1 carbon) and acetic acid (2 carbons) could be viewed as the shortest fatty acids;
then triformin would be the simplest triglyceride. However, the terms "fatty acid" and "fat" are usually reserved for compounds with substantially longer chains.

A division commonly made in biochemistry and nutrition is:

Short-chain fatty acid (SCFA) with less than six carbons (e. g. butyric acid).
Medium-chain fatty acid (MCFA) with 6 to 12 carbons (e.g. capric acid).
Long-chain fatty acids (LCFA) with 13 to 21 carbons (e.g. petroselinic acid).
Very long chain fatty acids (VLCFA) with 22 or more carbons (e. g. cerotic acid with 26)

A triglyceride molecule may have fatty acid elements of different lengths, and a fat product will often be a mix of various triglycerides. Most fats found in food,
whether vegetable or animal, are made up of medium to long-chain fatty acids, usually of equal or nearly equal length.

Saturated and unsaturated fats

For human nutrition, an important classification of fats is based on the number and position of double bonds in the constituent fatty acids. Saturated fat has a
predominance of saturated fatty acids, without any double bonds, while unsaturated fat has predominantly unsaturated acids with double bonds. (The names refer to
the fact that each double bond means two fewer hydrogen atoms in the chemical formula. Thus, a saturated fatty acid, having no double bonds, has the maximum
number of hydrogen atoms for a given number of carbon atoms — that is, it is "saturated" with hydrogen atoms.)[7][8]

Unsaturated fatty acids are further classified into monounsaturated (MUFAs), with a single double bond, and polyunsaturated (PUFAs), with two or more.[7][8]
Natural fats usually contain several different saturated and unsaturated acids, even on the same molecule. For example, in most vegetable oils, the saturated palmitic
(C16:0) and stearic (C18:0) acid residues are usually attached to positions 1 and 3 (sn1 and sn3) of the glycerol hub, whereas the middle position (sn2) is usually
occupied by an unsaturated one, such as oleic (C18:1, ω–9) or linoleic (C18:2, ω–6).[9])

Stearic acid (saturated, C18:0)

Palmitoleic acid (mono-unsaturated, C16:1 cis-9, omega-7)

Oleic acid (mono-unsaturated, C18:1 cis-9, omega-9)

α-Linolenic acid (polyunsaturated, C18:3 cis-9,12,15, omega-3)

γ-Linolenic acid (polyunsaturated, C18:3 cis-6,9,12, omega-6)

While it is the nutritional aspects of polyunsaturated fatty acids that are generally of greatest interest, these materials also have non-food applications. They include the
drying oils, such as linseed (flax seed), tung, poppy seed, perilla, and walnut oil, which polymerize on exposure to oxygen to form solid films, and are used to make
paints and varnishes.

Saturated fats generally have a higher melting point than unsaturated ones with the same molecular weight, and thus are more likely to be solid at room temperature.
For example, the animal fats tallow and lard are high in saturated fatty acid content and are solids. Olive and linseed oils on the other hand are unsaturated and liquid.
Unsaturated fats are prone to oxidation by air, which causes them to become rancid and inedible.

The double bonds in unsaturated fats can be converted into single bonds by reaction with hydrogen effected by a catalyst. This process, called hydrogenation, is used
to turn vegetable oils into solid or semisolid vegetable fats like margarine, which can substitute for tallow and butter and (unlike unsaturated fats) can be stored
indefinitely without becoming rancid. However, partial hydrogenation also creates some unwanted trans acids from cis acids.

In cellular metabolism, unsaturated fat molecules yield slightly less energy (i.e., fewer calories) than an equivalent amount of saturated fat. The heats of combustion of
saturated, mono-, di-, and tri-unsaturated 18-carbon fatty acid esters have been measured as 2859, 2828, 2794, and 2750 kcal/mol, respectively; or, on a weight basis,
10.75, 10.71, 10.66, and 10.58 kcal/g — a decrease of about 0.6% for each additional double bond.[10]

The greater the degree of unsaturation in a fatty acid (i.e., the more double bonds in the fatty acid) the more vulnerable it is to lipid peroxidation (rancidity).
Antioxidants can protect unsaturated fat from lipid peroxidation.

Cis and trans fats

Another important classification of unsaturated fatty acids considers the cis–trans isomerism, the spatial arrangement of the C–C single bonds adjacent to the double
bonds. Most unsaturated fatty acids that occur in nature have those bonds in the cis ("same side") configuration. Partial hydrogenation of cis fats can turn some of their
fatty acids into trans ("opposite sides") variety.

Elaidic acid is the trans isomer of oleic acid, one of the most common fatty acids in human diet. The single change of configuration in one double bond causes them
to have different chemical and physical properties. Elaidic acid has a much higher melting point than oleic acid, 45 °C instead of 13.4 °C. This difference is
commonly attributed to the supposed ability of the trans molecules to pack more tightly, forming a solid that is more difficult to break apart.[11]

Omega number

Another classification considers the position of the double bonds relative to the end of the chain (opposite to the carboxyl group). The position is denoted by "ω−k" or
"n−k", meaning that there is a double bond between carbons k and k+1 counted from 1 at that end. For example, alpha-Linolenic acid is a "ω−3" or "n−3" acid,
meaning that there is a double bond between the third and fourth carbons, counted from that end; that is, its structural formula ends with –CH=CH–CH2 –CH3 .[12]

Examples of saturated fatty acids

Some common examples of fatty acids:

Butyric acid with 4 carbon atoms (contained in butter)

Lauric acid with 12 carbon atoms (contained in coconut oil, palm kernel oil, and breast milk)
Myristic acid with 14 carbon atoms (contained in cow's milk and dairy products)
Palmitic acid with 16 carbon atoms (contained in palm oil and meat)
Stearic acid with 18 carbon atoms (also contained in meat and cocoa butter)

Examples of unsaturated fatty acids

Myristoleic acid C14:1, ω−5, cis-9-tetradecenoic acid
Sapienic acid C16:1 ω−10, cis-6-Hexadecenoic acid
Palmitoleic acid C16:1, ω−7 , cis-9-hexadecenoic acid
Oleic acid C18:1 ω−9, cis-9-octadecenoic acid
Petroselinic acid C18:1 ω−12, cis-Octadec-6-enoic acid
cis-Vaccenic acid, C18:1 ω−7), cis-11-octadecenoic acid
Vaccenic acid C18:1 ω−7, trans-11-octadecenoic acid
Elaidic acid 18:1 ω−9, trans-9-octadecenoic acid (trans-oleic acid)
Linoleic acid
Linolenic acid
Paullinic acid C20:1 ω−7, cis-13-eicosenoic acid
Gadoleic acid C20:1 ω−11, cis-9-icosenoic acid
Gondoic acid 20:1 ω−9, cis-11-eicosenoic acid
Erucic acid C22:1 ω−9, cis-15-tetracosenoic acid
Brassidic acid C22:1 ω−9, trans-15-tetracosenoic acid
Nervonic acid C24:1 ω−9, | cis-15-tetracosenoic acid
Arachidonic acid

Biological importance
In humans and many animals, fats serve both as energy sources and as stores for energy in excess of what the body needs immediately. Each gram of fat when burned
or metabolized releases about 9 food calories (37 kJ = 8.8 kcal).[13]

Fats are also sources of essential fatty acids, an important dietary requirement. Vitamins A, D, E, and K are fat-soluble, meaning they can only be digested, absorbed,
and transported in conjunction with fats.
Fats play a vital role in maintaining healthy skin and hair, insulating body organs against shock, maintaining body temperature, and promoting healthy cell function.
Fat also serves as a useful buffer against a host of diseases. When a particular substance, whether chemical or biotic, reaches unsafe levels in the bloodstream, the
body can effectively dilute—or at least maintain equilibrium of—the offending substances by storing it in new fat tissue. This helps to protect vital organs, until such
time as the offending substances can be metabolized or removed from the body by such means as excretion, urination, accidental or intentional bloodletting, sebum
excretion, and hair growth.

Adipose tissue

In animals, adipose tissue, or fatty tissue is the body's means of storing metabolic energy over extended periods of time.
Adipocytes (fat cells) store fat derived from the diet and from liver metabolism. Under energy stress these cells may degrade
their stored fat to supply fatty acids and also glycerol to the circulation. These metabolic activities are regulated by several
hormones (e.g., insulin, glucagon and epinephrine). Adipose tissue also secretes the hormone leptin.[14]

The location of the tissue determines its metabolic profile: visceral fat is located within the abdominal wall (i.e., beneath the
wall of abdominal muscle) whereas subcutaneous fat is located beneath the skin (and includes fat that is located in the
abdominal area beneath the skin but above the abdominal muscle wall). Visceral fat was recently discovered to be a
significant producer of signaling chemicals (i.e., hormones), among which several are involved in inflammatory tissue The obese mouse on the left has
responses. One of these is resistin which has been linked to obesity, insulin resistance, and Type 2 diabetes. This latter result large stores of adipose tissue. For
is currently controversial, and there have been reputable studies supporting all sides on the issue. comparison, a mouse with a normal
amount of adipose tissue is shown
on the right.
Production and processing
A variety of chemical and physical techniques are used for the production and processing of fats, both industrially and in cottage or home settings. They include:

Pressing to extract liquid fats from fruits, seeds, or algae, e.g. olive oil from olives;
Solvent extraction using solvents like hexane or supercritical carbon dioxide.
Rendering, the melting of fat in adipose tissue, e.g. to produce tallow, lard, fish oil, and whale oil.
Churning of milk to produce butter.
Hydrogenation to reduce the degree of unsaturation of the fatty acids.
Interesterification, the rearrangement of fatty acids across different triglycerides.
Winterization to remove oil components with higher melting points.
Clarification of butter.

Nutritional and health aspects

The benefits and risks of various amounts and types of dietary fats have been the object of much study, and are still highly controversial topics.[15][16][17][18]

Essential fatty acids

There are two essential fatty acids (EFAs) in human nutrition: alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an omega-6 fatty acid).[19][13] Other
lipids needed by the body can be synthesized from these and other fats.

Saturated vs. unsaturated fats

Different foods contain different amounts of fat with different proportions of saturated and unsaturated fatty acids. Some animal products, like beef and dairy products
made with whole or reduced fat milk like yogurt, ice cream, cheese and butter have mostly saturated fatty acids (and some have significant contents of dietary
cholesterol). Other animal products, like pork, poultry, eggs, and seafood have mostly unsaturated fats. Industrialized baked goods may use fats with high unsaturated
fat contents as well, especially those containing partially hydrogenated oils, and processed foods that are deep-fried in hydrogenated oil are high in saturated fat
content.[20][21][22]

Plants and fish oil generally contain a higher proportion of unsaturated acids, although there are exceptions such as coconut oil and palm kernel oil.[23][24] Foods
containing unsaturated fats include avocado, nuts, olive oils, and vegetable oils such as canola.

Saturated esterified fatty acids as percentage of total fat[25]

Myristic Palmitic Stearic
Food Lauric acid
acid acid acid
Coconut oil 47% 18% 9% 3%
Palm kernel oil 48% 1% 44% 5%
Butter 3% 11% 29% 13%
Ground beef 0% 4% 26% 15%
Salmon 0% 1% 29% 3%
Egg yolks 0% 0.3% 27% 10%
Cashews 2% 1% 10% 7%
Soybean oil 0% 0% 11% 4%

Many careful studies have found that replacing saturated fats with cis unsaturated fats in the diet reduces risk of risks of cardiovascular diseases,[26][27] diabetes, or
death.[28] These studies prompted many medical organizations and public health departments, including the World Health Organization,[29][30] to officially issue that
advice. Some countries with such recommendations include:

United Kingdom [31][32][33][34][35]

 United States [28][36][37][38][39]
India [40][41]
Canada [42]
Australia [43]
Singapore [44]
New Zealand [45]
Hong Kong [46]

A 2004 review concluded that "no lower safe limit of specific saturated fatty acid intakes has been identified" and recommended that the influence of varying
saturated fatty acid intakes against a background of different individual lifestyles and genetic backgrounds should be the focus in future studies.[47]

This advice is often oversimplified by labeling the two kinds of fats as bad fats and good fats, respectively. However, since the fats and oils in most natural and
traditionally processed foods contain both unsaturated and saturated fatty acids,[48] the complete exclusion of saturated fat is unrealistic and possibly unwise. For
instance, some foods rich in saturated fat, such as coconut and palm oil, are an important source of cheap dietary calories for a large fraction of the population in
developing countries.[49]

Concerns were also expressed at a 2010 conference of the American Dietetic Association that a blanket recommendation to avoid saturated fats could drive people to
also reduce the amount of polyunsaturated fats, which may have health benefits, and/or replace fats by refined carbohydrates — which carry a high risk of obesity and
heart disease.[50]

For these reasons, the United States Food and Drug Administration (FDA), for example, does not advise the complete elimination of saturated fat, but only
recommends that it does not exceed 30% of one's daily caloric intake. A 2003 report by the World Health Organization and the Food and Agriculture Organization
(FAO) recommends limiting the saturated fatty acids to less than 10% of daily energy intake and less than 7% for high-risk groups.[49] A general 7% limit was
recommended also by the American Heart Association in 2006.[51][52]

The WHO/FAO report also recommended replacing fats so as to reduce the content of myristic and palmitic acids, specifically.[49]

The so-called Mediterranean diet, prevalent in many countries in the Mediterranean Sea area, includes more total fat than the diet of Northern European countries, but
most of it is in the form of unsaturated fatty acids (specifically, monounsaturated and omega-3) from olive oil and fish, vegetables, and certain meats like lamb, while
consumption of saturated fat is minimal in comparison. A 2017 review found evidence that a Mediterranean-style diet could reduce the risk of cardiovascular diseases,
overall cancer incidence, neurodegenerative diseases, diabetes, and mortality rate.[53] A 2018 review showed that a Mediterranean-like diet may improve overall
health status, such as reduced risk of non-communicable diseases. It also may reduce the social and economic costs of diet-related illnesses.[54]

A small number of contemporary reviews have challenged this negative view of saturated fats. For example, an evaluation of evidence from 1966-1973 of the
observed health impact of replacing dietary saturated fat with linoleic acid found that it increased rates of death from all causes, coronary heart disease, and
cardiovascular disease.[55] These studies have been disputed by many scientists,[56] and the consensus in the medical community is that saturated fat and
cardiovascular disease are closely related.[57][58][59] Still, these discordant studies fueled debate over the merits of substituting polyunsaturated fats for saturated
fats.[60]

Cardiovascular disease

The effect of saturated fat on cardiovascular disease has been extensively studied.[61] The general consensus is that there is evidence of moderate-quality of a strong,
consistent, and graded relationship between saturated fat intake, blood cholesterol levels, and the incidence of cardiovascular disease.[28][61] The relationships are
accepted as causal,[62][63] including by many government and medical organizations.[49][64][65][28][66][67][68][69]

A 2017 review by the American Heart Association estimated that replacement of saturated fat with polyunsaturated fat in the American diet could reduce the risk of
cardiovascular diseases by 30%.[28]

The consumption of saturated fat is generally considered a risk factor for dyslipidemia — abnormal blood lipid levels, including high total cholesterol, high levels of
triglycerides, high levels of low-density lipoprotein (LDL, "bad" cholesterol) or low levels of high-density lipoprotein (HDL, "good" cholesterol). These parameters
in turn are believed to be risk indicators for some types of cardiovascular disease.[70][71][72][73][74][66][75][76][77] These effects were observed in children too.[78]

Several meta-analyses (reviews and consolidations of multiple previously published experimental studies) have confirmed a significant relationship between saturated
fat and high serum cholesterol levels,[28][79] which in turn have been claimed to have a causal relation with increased risk of cardiovascular disease (the so-called lipid
hypothesis).[80][81] However, high cholesterol may be caused by many factors. Other indicators, such as high LDL/HDL ratio, have proved to be more predictive.[81]
In a study of myocardial infarction in 52 countries, the ApoB/ApoA1 (related to LDL and HDL, respectively) ratio was the strongest predictor of CVD among all risk
factors.[82] There are other pathways involving obesity, triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity, among others, that play a
role in CVD, although it seems, in the absence of an adverse blood lipid profile, the other known risk factors have only a weak atherogenic effect.[83] Different
saturated fatty acids have differing effects on various lipid levels.[84]

Cancer

The evidence for a relation between saturated fat intake and cancer is significantly weaker, and there does not seem to be a clear medical consensus about it.

A meta-analysis published in 2003 found a epidemiology and etiology of breast cancer#Specific dietary fatty acidssignificant positive
relationship between saturated fat and breast cancer.[85] However two subsequent reviews have found weak or insignificant relation,[86][87] and
noted the prevalence of confounding factors.[86][88]
Another review found limited evidence for a positive relationship between consuming animal fat and incidence of colorectal cancer.[89]
Other meta-analyses found evidence for increased risk of ovarian cancer by high consumption of saturated fat.[90]
Some studies have indicated that serum myristic acid[91][92] and palmitic acid[92] and dietary myristic[93] and palmitic[93] saturated fatty acids and
serum palmitic combined with alpha-tocopherol supplementation[91] are associated with increased risk of prostate cancer in a dose-dependent
manner. These associations may, however, reflect differences in intake or metabolism of these fatty acids between the precancer cases and
controls, rather than being an actual cause.[92]
Bones

Various animal studies have indicated that the intake of saturated fat has a negative effect on effects on the mineral density of bones. One study suggested that men
may be particularly vulnerable.[94]

Disposition and overall health

Studies have shown that substituting monounsaturated fatty acids for saturated ones is associated with increased daily physical activity and resting energy expenditure.
More physical activity, less anger, and less irritability were associated with a higher-oleic acid diet than one of a palmitic acid diet.[95]

Monounsaturated vs. polyunsaturated fat

Assuming given that unsaturated fatty acids (UFAs) are generally healthier than saturated ones (SFAs), another question that
has gained attention in recent decades is the risks and benefits of monounsaturated fatty acids (MUFAs, with a single double
bond) versus polyunsaturated fatty acids (PUFAs, with two or more double bonds).

The most common fatty acids in human diet are unsaturated or mono-unsaturated. Monounsaturated fats are found in animal
flesh such as red meat, whole milk products, nuts, and high fat fruits such as olives and avocados. Algal oil is about 92%
monounsaturated fat.[96] Olive oil is about 75% monounsaturated fat.[97] The high oleic variety sunflower oil contains at least
70% monounsaturated fat.[98] Canola oil and cashews are both about 58% monounsaturated fat. Tallow (beef fat) is about
50% monounsaturated fat.[99] and lard is about 40% monounsaturated fat. Other sources include hazelnut, avocado oil, Amounts of fat types in selected
macadamia nut oil, grapeseed oil, groundnut oil (peanut oil), sesame oil, corn oil, popcorn, whole grain wheat, cereal, foods
oatmeal, almond oil, sunflower oil, hemp oil, and tea-oil Camellia.[100]

Polyunsaturated fatty acids can be found mostly in nuts, seeds, fish, seed oils, and oysters.[7]

Food sources of polyunsaturated fats include:[7][101]

Food source (100g) Polyunsaturated fat (g)

Walnuts 47
Canola Oil 34
Schematic diagram of a triglyceride with a
Sunflower seeds 33 saturated fatty acid (top), a monounsaturated one
Sesame Seeds 26 (middle) and a polyunsaturated one (bottom).

Chia Seeds 23.7

Unsalted Peanuts 16
Peanut Butter 14.2

Avocado Oil 13.5 [102]

Olive Oil 11

Safflower Oil 12.82[103]

Seaweed 11
Sardines 5
Soybeans 7
Tuna 14
Wild Salmon 17.3
Whole Grain Wheat 9.7

Cardiovascular disease

Studies have given conflicting indications about the effect of MUFA/PUFA intake and cardiovascular disease. Although PUFAs seem to protect against cardiac
arrhythmias, a study concluded that PUFA intake is positively associated with coronary atherosclerosis progression in a group of post-menopauseal women, whereas
MUFA intake is not.[104] This probably is an indication of the greater vulnerability of polyunsaturated fats to lipid peroxidation, against which vitamin E has been
shown to be protective.[105]

Insulin resistance and sensitivity

MUFAs (especially oleic acid) have been found to lower the incidence of insulin resistance PUFAs (especially large amounts of arachidonic acid) and SFAs (such as
arachidic acid) increased it. These ratios can be indexed in the phospholipids of human skeletal muscle and in other tissues as well. This relationship between dietary
fats and insulin resistance is presumed secondary to the relationship between insulin resistance and inflammation, which is partially modulated by dietary fat ratios
(Omega-3/6/9) with both omega 3 and 9 thought to be anti-inflammatory, and omega 6 pro-inflammatory (as well as by numerous other dietary components,
particularly polyphenols and exercise, with both of these anti-inflammatory). Although both pro- and anti-inflammatory types of fat are biologically necessary, fat
dietary ratios in most US diets are skewed towards Omega 6, with subsequent disinhibition of inflammation and potentiation of insulin resistance.[48] But this is
contrary to the suggestion of more recent studies, in which polyunsaturated fats are shown as protective against insulin resistance.

The large scale KANWU study found that increasing MUFA and decreasing SFA intake could improve insulin sensitivity, but only when the overall fat intake of the
diet was low.[106] However, some MUFAs may promote insulin resistance (like the SFAs), whereas PUFAs may protect against it.[107][108]

Cancer
Levels of oleic acid along with other MUFAs in red blood cell membranes were positively associated with breast cancer risk. The saturation index (SI) of the same
membranes was inversely associated with breast cancer risk. MUFAs and low SI in erythrocyte membranes are predictors of postmenopausal breast cancer. Both of
these variables depend on the activity of the enzyme delta-9 desaturase (Δ9-d).[109]

Results from observational clinical trials on PUFA intake and cancer have been inconsistent and vary by numerous factors of cancer incidence, including gender and
genetic risk.[110] Some studies have shown associations between higher intakes and/or blood levels of omega-3 PUFAs and a decreased risk of certain cancers,
including breast and colorectal cancer, while other studies found no associations with cancer risk.[110][111]

Pregnancy disorders

Polyunsaturated fat supplementation was found to have no effect on the incidence of pregnancy-related disorders, such as hypertension or preeclampsia, but may
increase the length of gestation slightly and decreased the incidence of early premature births.[7]

Expert panels in the United States and Europe recommend that pregnant and lactating women consume higher amounts of polyunsaturated fats than the general
population to enhance the DHA status of the fetus and newborn.[7]

"Cis fat" vs. "trans fat"

In nature, unsaturated fatty acids generally have double bonds in cis configuration (with the adjacent C–C bonds on the same side) as opposed to trans.[112]
Nevertheless, trans fatty acids (TFAs) occur in small amounts in meat and milk of ruminants (such as cattle and sheep),[113] typically 2–5% of total fat.[114] Natural
TFAs, which include conjugated linoleic acid (CLA) and vaccenic acid, originate in the rumen of these animals. CLA has two double bonds, one in the cis
configuration and one in trans, which makes it simultaneously a cis- and a trans-fatty acid.[115]

Trans fat contents in various

natural and traditionally
processed foods, in g per 100
g[116]
Food type Trans fat content
butter 2g to 7 g
whole milk 0.07g to 0.1 g

animal fat 0g to 5 g[114]

ground beef 1g

Concerns about trans fatty acids in human diet were raised when they were found to be an unintentional
byproduct of the partial hydrogenation of vegetable and fish oils. While these trans fatty acids (popularly called
"trans fats") are edible, they have been implicated in many health problems.[117]

The hydrogenation process, invented and patented by Wilhelm Normann in 1902, made it possible to turn
relatively cheap liquid fats such as whale or fish oil into more solid fats and to extend their shelf-life by preventing
rancidification. (The source fat and the process were initially kept secret to avoid consumer distaste.[118]) This
process was widely adopted by the food industry already in the early 1900s; first for the production of margarine,
a replacement for butter and shortening,[119] and eventually for various other fats used in snack food, packaged
baked goods, and deep fried products.[120][121]

Full hydrogenation of a fat or oil produces a fully saturated fat. However, hydrogenation generally was interrupted
before completion, to yield a fat product with specific melting point, hardness, and other properties. Unfortunately, Margarine, a common product that can contain
partial hydrogenation turns some of the cis double bonds into trans bonds by an isomerization trans fatty acids
reaction.[120][121][122] The trans configuration is favored because it is the lower energy form.

This side reaction accounts for most of the trans fatty acids consumed today, by far.[123][124] An analysis of some
industrialized foods in 2006 found up to 30% "trans fats" in artificial shortening, 10% in breads and cake products, 8% in
cookies and crackers, 4% in salty snacks, 7% in cake frostings and sweets, and 26% in margarine and other processed
spreads.[116] Another 2010 analysis however found only 0.2% of trans fats in margarine and other processed spreads.[125]
Up to 45% of the total fat in those foods containing man-made trans fats formed by partially hydrogenating plant fats may be
trans fat.[114] Baking shortenings, unless reformulated, contain around 30% trans fats compared to their total fats. High-fat
dairy products such as butter contain about 4%. Margarines not reformulated to reduce trans fats may contain up to 15%
trans fat by weight,[126] but some reformulated ones are less than 1% trans fat.

High levels of TFAs have been recorded in popular "fast food" meals.[124] An analysis of samples of McDonald's French
fries collected in 2004 and 2005 found that fries served in New York City contained twice as much trans fat as in Hungary,
and 28 times as much as in Denmark, where trans fats are restricted. For Kentucky Fried Chicken products, the pattern was
reversed: the Hungarian product containing twice the trans fat of the New York product. Even within the United States, there
was variation, with fries in New York containing 30% more trans fat than those from Atlanta.[127]

Cardiovascular disease

Numerous studies have found that consumption of TFAs increases risk of cardiovascular disease.[19][13] The Harvard School
of Public Health advises that replacing TFAs and saturated fats with cis monounsaturated and polyunsaturated fats is Cover of original Crisco cookbook,
beneficial for health.[128] 1912. Crisco was made by
hydrogenating cottonseed oil. The
Consuming trans fats has been shown to increase the risk of coronary artery disease in part by raising levels of low-density formula was revised in the 2000s and
lipoprotein (LDL, often termed "bad cholesterol"), lowering levels of high-density lipoprotein (HDL, often termed "good now has only a small amount of
cholesterol"), increasing triglycerides in the bloodstream and promoting systemic inflammation.[129][130][131] trans fat.
The primary health risk identified for trans fat consumption is an elevated risk of coronary artery disease (CAD).[132] A 1994 study estimated
that over 30,000 cardiac deaths per year in the United States are attributable to the consumption of trans fats.[133] By 2006 upper estimates of
100,000 deaths were suggested.[134] A comprehensive review of studies of trans fats published in 2006 in the New England Journal of
Medicine reports a strong and reliable connection between trans fat consumption and CAD, concluding that "On a per-calorie basis, trans fats
appear to increase the risk of CAD more than any other macronutrient, conferring a substantially increased risk at low levels of consumption (1
to 3% of total energy intake)".[135]

The major evidence for the effect of trans fat on CAD comes from the Nurses' Health Study – a cohort study that has been following 120,000
female nurses since its inception in 1976. In this study, Hu and colleagues analyzed data from 900 coronary events from the study's population Wilhelm
during 14 years of followup. He determined that a nurse's CAD risk roughly doubled (relative risk of 1.93, CI: 1.43 to 2.61) for each 2% Normann
increase in trans fat calories consumed (instead of carbohydrate calories). By contrast, for each 5% increase in saturated fat calories (instead of patented the
carbohydrate calories) there was a 17% increase in risk (relative risk of 1.17, CI: 0.97 to 1.41). "The replacement of saturated fat or trans hydrogenation of
unsaturated fat by cis (unhydrogenated) unsaturated fats was associated with larger reductions in risk than an isocaloric replacement by liquid oils in
carbohydrates."[136] Hu also reports on the benefits of reducing trans fat consumption. Replacing 2% of food energy from trans fat with non- 1902
trans unsaturated fats more than halves the risk of CAD (53%). By comparison, replacing a larger 5% of food energy from saturated fat with
non-trans unsaturated fats reduces the risk of CAD by 43%.[136]

Another study considered deaths due to CAD, with consumption of trans fats being linked to an increase in
mortality, and consumption of polyunsaturated fats being linked to a decrease in mortality.[132][137]

Trans fat has been found to act like saturated in raising the blood level of LDL ("bad cholesterol"); but,
unlike saturated fat, it also decreases levels of HDL ("good cholesterol"). The net increase in LDL/HDL
ratio with trans fat, a widely accepted indicator of risk for coronary artery, is approximately double that due
to saturated fat.[138][139][140] One randomized crossover study published in 2003 comparing the effect of
eating a meal on blood lipids of (relatively) cis and trans-fat-rich meals showed that cholesteryl ester transfer
(CET) was 28% higher after the trans meal than after the cis meal and that lipoprotein concentrations were
enriched in apolipoprotein(a) after the trans meals.[141]

The citokyne test is a potentially more reliable indicator of CAD risk, although is still being studied.[132] A
study of over 700 nurses showed that those in the highest quartile of trans fat consumption had blood levels
of C-reactive protein (CRP) that were 73% higher than those in the lowest quartile.[142]

Breast feeding

It has been established that trans fats in human breast milk fluctuate with maternal consumption of trans fat,
and that the amount of trans fats in the bloodstream of breastfed infants fluctuates with the amounts found in
their milk. In 1999, reported percentages of trans fats (compared to total fats) in human milk ranged from
1% in Spain, 2% in France, 4% in Germany, and 7% in Canada and the United States.[143]
Converson of cis to trans fatty acids in partial
hydrogenation
Other health risks

There are suggestions that the negative consequences of trans fat consumption go beyond the cardiovascular
risk. In general, there is much less scientific consensus asserting that eating trans fat specifically increases the risk of other chronic health problems:

Alzheimer's disease: A study published in Archives of Neurology in February 2003 suggested that the intake of both trans fats and saturated fats
promote the development of Alzheimer disease,[144] although not confirmed in an animal model.[145] It has been found that trans fats impaired
memory and learning in middle-age rats. The trans-fat eating rats' brains had fewer proteins critical to healthy neurological function. Inflammation
in and around the hippocampus, the part of the brain responsible for learning and memory. These are the exact types of changes normally seen
at the onset of Alzheimer's, but seen after six weeks, even though the rats were still young.[146]
Cancer: There is no scientific consensus that consuming trans fats significantly increases cancer risks across the board.[132] The American
Cancer Society states that a relationship between trans fats and cancer "has not been determined."[147] One study has found a positive
connection between trans fat and prostate cancer.[148] However, a larger study found a correlation between trans fats and a significant decrease
in high-grade prostate cancer.[149] An increased intake of trans fatty acids may raise the risk of breast cancer by 75%, suggest the results from the
French part of the European Prospective Investigation into Cancer and Nutrition.[150][151]
Diabetes: There is a growing concern that the risk of type 2 diabetes increases with trans fat consumption.[132][152] However, consensus has not
been reached.[135] For example, one study found that risk is higher for those in the highest quartile of trans fat consumption.[153] Another study
has found no diabetes risk once other factors such as total fat intake and BMI were accounted for.[154]
Obesity: Research indicates that trans fat may increase weight gain and abdominal fat, despite a similar caloric intake.[155] A 6-year experiment
revealed that monkeys fed a trans fat diet gained 7.2% of their body weight, as compared to 1.8% for monkeys on a mono-unsaturated fat
diet.[156][157] Although obesity is frequently linked to trans fat in the popular media,[158] this is generally in the context of eating too many calories;
there is not a strong scientific consensus connecting trans fat and obesity, although the 6-year experiment did find such a link, concluding that
"under controlled feeding conditions, long-term TFA consumption was an independent factor in weight gain. TFAs enhanced intra-abdominal
deposition of fat, even in the absence of caloric excess, and were associated with insulin resistance, with evidence that there is impaired post-
insulin receptor binding signal transduction."[157]
Infertility in women: One 2007 study found, "Each 2% increase in the intake of energy from trans unsaturated fats, as opposed to that from
carbohydrates, was associated with a 73% greater risk of ovulatory infertility...".[159]
Major depressive disorder: Spanish researchers analysed the diets of 12,059 people over six years and found that those who ate the most trans
fats had a 48 per cent higher risk of depression than those who did not eat trans fats.[160] One mechanism may be trans-fats' substitution for
docosahexaenoic acid (DHA) levels in the orbitofrontal cortex (OFC). Very high intake of trans-fatty acids (43% of total fat) in mice from 2 to 16
months of age was associated with lowered DHA levels in the brain (p=0.001).[145] When the brains of 15 major depressive subjects who had
committed suicide were examined post-mortem and compared against 27 age-matched controls, the suicidal brains were found to have 16% less
(male average) to 32% less (female average) DHA in the OFC. The OFC controls reward, reward expectation, and empathy (all of which are
reduced in depressive mood disorders) and regulates the limbic system.[161]
Behavioral irritability and aggression: a 2012 observational analysis of subjects of an earlier study found a strong relation between dietary trans
fat acids and self-reported behavioral aggression and irritability, suggesting but not establishing causality.[162]
 Diminished memory: In a 2015 article, researchers re-analyzing results from the 1999-2005 UCSD Statin Study argue that "greater dietary trans
fatty acid consumption is linked to worse word memory in adults during years of high productivity, adults age <45".[163]
Acne: According to a 2015 study, trans fats are one of several components of Western pattern diets which promote acne, along with
carbohydrates with high glycemic load such as refined sugars or refined starches, milk and dairy products, and saturated fats, while omega-3
fatty acids, which reduce acne, are deficient in Western pattern diets.[164]

Biochemical mechanisms

The exact biochemical process by which trans fats produce specific health problems are a topic of continuing research. Intake of dietary trans fat perturbs the body's
ability to metabolize essential fatty acids (EFAs, including Omega-3) leading to changes in the phospholipid fatty acid composition of the arterial walls, thereby
raising risk of coronary artery disease.[165]

Trans double bonds are claimed to induce a linear conformation to the molecule, favoring its rigid packing as in plaque formation. The geometry of the cis double
bond, in contrast, is claimed to create a bend in the molecule, thereby precluding rigid formations..

While the mechanisms through which trans fatty acids contribute to coronary artery disease are fairly well understood, the mechanism for their effects on diabetes is
still under investigation. They may impair the metabolism of long-chain polyunsaturated fatty acids (LCPUFAs).[166] However, maternal pregnancy trans fatty acid
intake has been inversely associated with LCPUFAs levels in infants at birth thought to underlie the positive association between breastfeeding and intelligence.[167]

Trans fats are processed by the liver differently than other fats. They may cause liver dysfunction by interfering with delta 6 desaturase, an enzyme involved in
converting essential fatty acids to arachidonic acid and prostaglandins, both of which are important to the functioning of cells.[168]

Natural "trans fats" in dairy products

Some trans fatty acids occur in natural fats and traditionally processed foods. Vaccenic acid occurs in breast milk, and some isomers of conjugated linoleic acid (CLA)
are found in meat and dairy products from ruminants. Butter, for example, contains about 3% trans fat.[169]

The US National Dairy Council has asserted that the trans fats present in animal foods are of a different type than those in partially hydrogenated oils, and do not
appear to exhibit the same negative effects.[170] While a recent scientific review agrees with the conclusion (stating that "the sum of the current evidence suggests that
the Public health implications of consuming trans fats from ruminant products are relatively limited"), it cautions that this may be due to the low consumption of trans
fats from animal sources compared to artificial ones.[135]

More recent inquiry (independent of the dairy industry) has found in a 2008 Dutch meta-analysis that all trans fats, regardless of natural or artificial origin equally raise
LDL and lower HDL levels.[171] Other studies though have shown different results when it comes to animal-based trans fats like conjugated linoleic acid (CLA).
Although CLA is known for its anticancer properties, researchers have also found that the cis-9, trans-11 form of CLA can reduce the risk for cardiovascular disease
and help fight inflammation.[172][173]

Two Canadian studies have shown that vaccenic acid, a TFA that naturally occurs in dairy products, could be beneficial compared to hydrogenated vegetable
shortening, or a mixture of pork lard and soy fat, by lowering total LDL and triglyceride levels.[174][175][176] A study by the US Department of Agriculture showed
that vaccenic acid raises both HDL and LDL cholesterol, whereas industrial trans fats only raise LDL with no beneficial effect on HDL.[177]

Official recommendations

In light of recognized evidence and scientific agreement, nutritional authorities consider all trans fats equally harmful for health and recommend that their consumption
be reduced to trace amounts.[178][179][180][181][182] The World Health Organization recommended that trans fats make up no more than 0.9% of a person's diet in
2003[114] and, in 2018, introduced a 6-step guide to eliminate industrially-produced trans-fatty acids from the global food supply.[183]

The National Academy of Sciences (NAS) advises the United States and Canadian governments on nutritional science for use in public policy and product labeling
programs. Their 2002 Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids[184] contains their findings
and recommendations regarding consumption of trans fat (summary (http://www.nap.edu/openbook/0309085373/html/423.html)).

Their recommendations are based on two key facts. First, "trans fatty acids are not essential and provide no known benefit to human health",[129] whether of animal
or plant origin.[185] Second, given their documented effects on the LDL/HDL ratio,[130] the NAS concluded "that dietary trans fatty acids are more deleterious with
respect to coronary artery disease than saturated fatty acids". A 2006 review published in the New England Journal of Medicine (NEJM) that states "from a nutritional
standpoint, the consumption of trans fatty acids results in considerable potential harm but no apparent benefit."[135]

Because of these facts and concerns, the NAS has concluded there is no safe level of trans fat consumption. There is no adequate level, recommended daily amount or
tolerable upper limit for trans fats. This is because any incremental increase in trans fat intake increases the risk of coronary artery disease.[130]

Despite this concern, the NAS dietary recommendations have not included eliminating trans fat from the diet. This is because trans fat is naturally present in many
animal foods in trace quantities, and thus its removal from ordinary diets might introduce undesirable side effects and nutritional imbalances. The NAS has, thus,
"recommended that trans fatty acid consumption be as low as possible while consuming a nutritionally adequate diet".[186] Like the NAS, the World Health
Organization has tried to balance public health goals with a practical level of trans fat consumption, recommending in 2003 that trans fats be limited to less than 1% of
overall energy intake.[114]

Regulatory action

In the last few decades, there has been substantial amount of regulation in many countries, limiting trans fat contents of industrialized and commercial food products.

Alternatives to hydrogenation

In recent years, the negative public image and strict regulations have driven many fat processing industries to replace partial hydrogenation by fat interesterification, a
process that chemically scrambles the fatty acids among a mix of triglycerides. When applied to a suitable bend of oils and saturated fats, possibly followed by
separation of unwanted solid or liquid triglycerides, this process can achieve results similar to those of partial hydrogenation without affecting the fatty acids
themselves; in particular, without creating any new "trans fat".
Researchers at the United States Department of Agriculture have investigated whether hydrogenation can be achieved without the side effect of trans fat production.
They varied the pressure under which the chemical reaction was conducted – applying 1400 kPa (200 psi) of pressure to soybean oil in a 2-liter vessel while heating it
to between 140 °C and 170 °C. The standard 140 kPa (20 psi) process of hydrogenation produces a product of about 40% trans fatty acid by weight, compared to
about 17% using the high-pressure method. Blended with unhydrogenated liquid soybean oil, the high-pressure-processed oil produced margarine containing 5 to 6%
trans fat. Based on current U.S. labeling requirements (see below), the manufacturer could claim the product was free of trans fat.[187] The level of trans fat may also
be altered by modification of the temperature and the length of time during hydrogenation.

A University of Guelph research group has found a way to mix oils (such as olive, soybean, and canola), water, monoglycerides, and fatty acids to form a "cooking
fat" that acts the same way as trans and saturated fats.[188][189]

Omega-three and omega-six fatty acids

The ω−3 fatty acids have received substantial atterntion in recent years.

In preliminary research, omega-3 fatty acids in algal oil, fish oil, fish and seafood have been shown to lower the risk of heart attacks.[110] Other preliminary research
indicates that omega-6 fatty acids in sunflower oil and safflower oil may also reduce the risk of cardiovascular disease.[190]

Among omega-3 fatty acids, neither long-chain nor short-chain forms were consistently associated with breast cancer risk. High levels of docosahexaenoic acid
(DHA), however, the most abundant omega-3 polyunsaturated fatty acid in erythrocyte (red blood cell) membranes, were associated with a reduced risk of breast
cancer.[109] The DHA obtained through the consumption of polyunsaturated fatty acids is positively associated with cognitive and behavioral performance.[191] In
addition DHA is vital for the grey matter structure of the human brain, as well as retinal stimulation and neurotransmission.[7]

Interesterification

Some studies have investigated the health effects of insteresterified (IE) fats, by comparing diets with IE and non-IE fats with the same overall fatty acid
composition.[192]

Several experimental studies in humans found no statistical difference on fasting blood lipids between a with large amounts of IE fat, having 25-40% C16:0 or C18:0
on the 2-position, and a similar diet with non-IE fat, having only 3-9% C16:0 or C18:0 on the 2-position.[193][194][195] A negative result was obtained also in a study
that compared the effects on blood cholesterol levels of an IE fat product mimicking cocoa butter and the real non-IE product.[196][197][198][199][200][201][202]

A 2007 study funded by the Malaysian Palm Oil Board[203] claimed that replacing natural palm oil by other interesterified or partial hydrogenated fats caused adverse
health effects, such as higher LDL/HDL ratio and plasma glucose levels. However, these effects could be attributed to the higher percentage of saturated acids in the
IE and partially hydrogenated fats, rather than to the IE process itself.[204][205]

Fat digestion and metabolism

Fats are broken down in the healthy body to release their constituents, glycerol and fatty acids. Glycerol itself can be converted to glucose by the liver and so become
a source of energy. Fats and other lipids are broken down in the body by enzymes called lipases produced in the pancreas.

Many cell types can use either glucose or fatty acids as a source of energy for metabolism. In particular, heart and skeletal muscle prefer fatty acids. Despite long-
standing assertions to the contrary, fatty acids can also be used as a source of fuel for brain cells through mitochondrial oxidation.[206]

See also
ANGPTL4 Diet and heart Food groups Junk foo
Advanced disease Food guide List of sa
glycation Dieting pyramid fatty acid
endproduct Fast food Framingham Heart List of u
Ancel Keys Fat content of milk Study fatty acid
Animal fat Fatty acid Healthy diet List of ve
D. Mark Hegsted synthesis High density oils
Food composition lipoprotein
data Iodine value

Further reading
Further information is available.[207][208][209][210][211][212][213][214][215][216][217][218][219]

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