Professional Documents
Culture Documents
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{Sci – Space – 20/05} Luhman 16: Binary Brown Dwarf System .................................................................................. 40
{Sci – Space – 20/06} Potentially Hazardous Asteroid (PHA) ...................................................................................... 41
{S&T – Biotech – 19/11/03} IndiGen: India’s are responsible for making amino acids, pro-
Genome Sequencing Project teins and, thereby, everything that is necessary
for the body to function.
TH | 03-11-2019 | GS3 > Awareness in the field of
Biotechnology | Basics: NCERT: Nucleic acids – DNA
& RNA
• The Council of Scientific and Industrial Research
(CSIR) concluded the six-month long exercise of
conducting a “whole-genome sequence” of a
1,008 Indians that beloged to diverse ethnicities.
• The project is part of a programme called “Indi-
Gen” and is a precursor to a much larger exercise
funded by the Department of Biotechnology to
sequence at least 10,000 Indian genomes.
• The project involved the Hyderabad-based
Centre for Cellular and Molecular Biology
(CCMB) and the CSIR-Institute of Genomics
and Integrative Biology (IGIB).
• Globally, many countries have undertaken ge-
nome sequencing of a sample of their citizens to
determine unique genetic traits, susceptibility
(and resilience) to disease.
Genome
2
• This “deciphering” or reading of the genome is • Genome Sequencing will help us understand ge-
what sequencing is all about. netic variations & uique traits of different ethnic
populations.
• In this particular piece of DNA, an adenine (A) is • It will widen public understanding about the in-
followed by a guanine (G), which is followed by a formation that genes hide about one’s suscepti-
thymine (T), which in turn is followed by a cyto- bility to disease.
sine (C), another cytosine (C), and so on. • It will help identify gene variants that make a per-
son less responsive to certain classes of drugs.
Whole genome sequencing For example, having a certain gene makes some
people less responsive to clopidogrel, a drug
• Exome, the portion of the genes responsible for
that prevents heart attack.
making proteins occupies just about 1% of the
• Whole genome sequencing data of a person can
actual gene.
be analyzed to determine if they carry genes for
• Rather than sequence the whole gene, many ge-
particular single genetic disorders. This will help
neticists rely on “exome maps”.
usher in a new era of personalized medicine.
• However, the non-exome portions also affect the
• WGS findings are starting to guide treatments
functioning of the genes.
for common cancers and are also being used to
• Hence to know which genes of a person’s DNA
determine which medications are safe (and
are “mutated” the whole genome sequencing is
which are not) on a person-by-person basis.
required.
• Whole genome sequencing is the process of de-
{S&T – Biotech – 20/01/12} Genome Se-
termining the complete DNA sequence of an quencing Applications
organism's genome at a single time.
• This entails sequencing all of an organism's chro- TH | 12-01-2020 | Awareness in the field of Biotech-
mosomal DNA as well as DNA contained in the nology | Basics: NCERT: Nucleic acids – DNA & RNA
mitochondria and, for plants, in the chloro- • A consortium of scientists has mapped the ge-
plast. nome (genome sequencing) of the Indian cobra.
• In practice, genome sequences that are nearly • The Indian cobra is part of the so called ‘Big 4’:
complete are also called whole genome se- the Indian cobra (common cobra), the com-
quences. mon krait, Russell’s viper, and the saw-scaled
• The whole genome sequencing relies on new viper.
technologies that allow rapid sequencing of the
entire genome in a matter of a few days.
• While India, led by the CSIR, first sequenced an
Indian genome in 2009, it is only now that the
organisation’s laboratories have been able to
scale up whole-genome sequencing and offer
them to the public.
3
• The quartet has long been considered responsi- • In the Indian cobra, the authors identified 19
ble for most snake bites on the Indian subconti- toxin genes, the only ones that should matter in
nent. treatment.
• The foray into the Indian cobra genome involved • Using recombinant technology, the genetic se-
making a map of its 38 chromosomes & over quence for each toxin can be pasted into a yeast
12,000 genes. or E. coli to produce a new antivenom that would
• The human genome, in comparison, has 23 chro- target only the specific toxins.
mosomes and the estimated 20,000-25,000
genes. {S&T – Biotech – 20/01/21} Xenobot
• Knowing the sequence of genes could aid in un-
IE | 21-01-2020 | GS3 > Awareness in the filed of bi-
derstanding the chemical constituents of the
otechnology
venom and contribute to development of new
• Scientists in the US have created the world’s first
effective antivenom therapies without side ef-
“living (biological) machines” — tiny robots
fects.
built from the cells of the African clawed frog,
The issues with the present ativenoms that can move around on their own.
• They have named the millimetre-wide robots
• In the case of the polyvalent antivenom available
“xenobots”.
in India, it is made by injecting it into horses.
• The xenobots “can move toward a target, per-
• The antibodies that form are then collected from
haps pick up a payload (like a medicine that
the domestic animal’s blood, purified and iso-
needs to be carried to a specific place inside a
lated.
patient) — and heal themselves after being cut.
• Antivenom is currently produced by a very-old
• Xenobots can used for searching out nasty com-
process which is considered expensive and time
pounds or radioactive contamination, gathering
consuming.
microplastic in the oceans, travelling in arteries
• Their efficacy varies, besides producing side ef-
to scrape out plaque, etc.
fects.
TH | 31-01-2020
• The blood collected from the umbilical cord
of the new-born is a rich source of stem cells.
• The stem cells are unspecialised cells (they
• Venom is a complex mixture of an estimated don’t have a specific predefined function).
140-odd protein or peptides. • The stem cells are separated, processed, and pre-
• Only some of these constituents are toxins that served in liquid nitrogen in cord blood banks.
cause the physiological symptoms seen after • Technically, there is no expiry date and these
snakebite. stem cells can be preserved for a lifetime.
• But antivenom available today does not target • Scientifically, evidence exists that they can be
these toxins specifically. stored for about 20 years.
4
• Stem cells taken from umbilical cord blood • The blood collected from the umbilical cord
are like those taken from bone marrow, capa- of the new-born is a rich source of stem cells.
ble of producing all blood cells: red cells, • The stem cells are unspecialised cells (they do
platelets and immune system cells. not have a specific predefined function).
• That is, they are capable of renewing themselves
Stem cell banking or Cord blood (umbilical cord
through cell division to give rise to new stem
blood) Banking
cells or specialized cell types (bone cells, mus-
cle cells, etc.). • Cord blood is the blood that remains in the um-
• When used, stem cells are first concentrated, bilical cord and placenta post-delivery.
then injected into the patient. • Cord blood at the time of delivery a rich source
• Once transfused, they produce new cells of every of stem cells and other cells of the immune sys-
kind. tem.
• They can be induced to become tissue- or organ- • Cord blood banking is the process of collecting
specific cells with special functions. the cord blood and extracting and cryogenically
• In some organs, such as the bone marrow, stem freezing its stem cells and other cells of the im-
cells regularly divide to repair and replace dam- mune system for potential future medical use.
aged tissues. • In some parts of the world, cord blood banking
• The stem cells can treat around 70 blood related is more often referred to as stem cell banking.
disorders and genetic disorders including thalas- • Cord blood banking is designed to collect the
semia, sickle cell anaemia, leukaemia, and im- stem cells and not the actual blood cells them-
mune related disorders. selves.
• But given the present state of medicine, they are
effective only for around a dozen of them. How long can the stem cells be preserved?
• Stem cells offer the possibility of a renewable
• The stem cells are preserved in liquid nitrogen in
source of replacement cells and tissues to
cord blood banks.
treat diseases including macular degeneration,
• Technically, there is no expiry date and these
spinal cord injury, stroke, burns, heart disease, di-
stem cells can be preserved for a lifetime.
abetes, etc.
• Scientifically, evidence exists that they can be
{S&T – Biotech – 20/03} Stem Cell or Cord stored for about 20 years.
Blood Banking
Why are stem cells special?
TH | TH | GS3 > S&T: Developments and their Appli-
• In some organs, such as the bone marrow, stem
cations in Everyday Life | Awareness in the field of
cells regularly divide to repair and replace dam-
Bio-tech.
aged tissues.
• Poona Citizen Doctor Forum, a body that pro-
• Stem cells taken from umbilical cord blood
motes ethical medical practice, is making efforts
are like those taken from bone marrow, capa-
to bust the aggressively promoted concept of
ble of producing all blood cells: red cells,
cord blood banking (Stem cell banking).
platelets, and immune system cells.
• That is, they are capable of renewing themselves
Stem Cells
through cell division to give rise to new stem
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cells or specialized cell types (bone cells, mus- • According to ICMR, cord blood banking is advis-
cle cells, etc.). able when there is an elder child in the family
with a condition treatable with stem cells and the
What are the uses of stem cells? mother is expecting the next baby.
Are stem cells useful for family members? Pune, has developed a microwave steriliser
named as ‘Atulya’.
• Body’s immune system does not accept outside • Defence Institute of Advanced Technology is a
stem cells and other cells of the immune system. deemed university supported by DRDO.
• Cord blood taken from a baby's umbilical cord is • The Covid-19 virus gets disintegrated by differ-
always a perfect match for the baby. ential heating of Atulya in the range of 56° to 60°
• In addition, immediate family members are more C.
likely to also be a match for the banked stem • However, it can be used for sterilising non-me-
cells. tallic objects only.
• Hence, it may sometimes be possible to use the • Sterilisation refers to any process that eliminates,
stem cells of the immediate family member to removes, kills, or deactivates microorganisms
treat certain diseases. such as fungi, bacteria, viruses, spores, etc. and
other biological agents.
What does Indian Council of Medical Research
(ICMR) say about cord blood banking? {S&T – In News – 20/05} NSafe Mask
• Companies convince parents (emotional market-
TH | In News Topic for Prelims
ing) to bank the cells promising future therapeu-
• Recently, an IIT-Delhi start-up has launched an
tic use.
antimicrobial and washable face mask
• However, the ICMR does not recommend com-
called ‘NSafe’.
mercial stem cell banking.
• NSafe mask is reusable up to 50 wash, thus
• According to ICMR, there is no scientific basis for
greatly cutting down the cost of use.
preservation of cord blood for future self use.
6
• It will also provide a solution to disposal issues PIB | GS3 > Indigenization of Technology and Devel-
of single use masks. oping New Technology
• It is a triple-layered product consisting of inner • NSM was set up to provide the country with su-
hydrophilic layer for comfort, middle layer hav- percomputing infrastructure to meet the increas-
ing antimicrobial activity and outer most layer ing computational demands by manufacturing
having water and oil repellent behaviour. supercomputers indigenously in India.
• The mask has 99.2% bacterial filtration effi- • The National Super Computing Mission is
ciency along with breathability and splash re- steered jointly by the Ministry of Electronics
sistance. and IT (MeitY) and Department of Science and
Technology (DST).
{S&T – In News – 20/05} UV Blaster • It is implemented by the Centre for Develop-
ment of Advanced Computing (C-DAC), Pune
PIB | “In News” topics for prelims
and the Indian Institute of Science (IISc), Ben-
• DRDO has developed an Ultra Violet (UV) Disin-
galuru.
fection Tower for rapid and chemical free disin-
• The target of the mission was set to establish a
fection of high infection prone areas.
network of supercomputers ranging from a few
• The equipment named “UV blaster” is designed
Tera Flops to greater than or equal to 3 Peta
and developed by Laser Science & Technology
Flops (PF) in institutions of National importance
Centre (LASTEC ― Delhi based premier labora-
across the country by 2022.
tory of DRDO) with the help of a private com-
• This network of Supercomputers envisaging a
pany.
total of 15-20 PF was approved in 2015 and was
later revised to a total of 45 PF (45000 TFs).
• Supercomputer PARAM 8000 (made by C-
DAC) launched on July 1, 1991 is considered In-
dia's first supercomputer. It was indige-
nously built in 1991 by C-DAC.
• National Supercomputing Mission's first indige-
nously build supercomputer is called ‘Param
• The UV blaster is a UV based area sanitiser useful
for high tech surfaces like electronic equipment, Shivay’
computers and other gadgets in laboratories and • Param Shivay was followed by Param Shakti and
Param Brahma supercomputers.
offices that are not suitable for disinfection with
chemical methods. Focus of the mission
• The product is also effective for areas with large
• The Mission envisages empowering national ac-
flow of people such as airports, shopping malls,
ademic and R&D institutions spread over the
metros, hotels, factories, offices, etc.
country by installing a vast supercomputing grid
• The UV based area sanitiser may be used by re-
comprising of more than 70 high-performance
mote operation through laptop/mobile phone
computing facilities.
using wifi link.
• These supercomputers will also be networked on
{S&T – Indigenization – 20/03} National Su- the National Supercomputing grid over the Na-
percomputing Mission (NSM) tional Knowledge Network (NKN).
7
• The NKN is another programme of the govern- sectors and issues arising out of their design and im-
ment which connects academic institutions and plementation.
R&D labs over a high speed network. • Context: Centre announced an interim ban on
59 apps with Chinese links, citing “Emergent
Significance of supercomputers
Threats” to the country’s sovereignty & national
• Most to the supercomputers across the world are security.
dedicated for weather and climate research.
• Weather prediction has reached accuracy of What is Data Localization?
forecast as well as real time tracking of natural
• Data localisation is the act of storing data on
phenomenon.
any device physically present within the borders
• Timely warning of cyclones in the recent past
of a country.
have saved many lives and property.
• Localisation mandates that companies collect-
The speed of a supercomputer ing critical data about consumers must store &
process them within the borders of the coun-
• The average computer’s processor performance try.
is measured by megahertz (MHz) units to calcu-
late its clock speed. Why is it important?
• Since supercomputers are far more capable, the
• The main intent behind data localisation is to
performance is calculated in Floating-point op-
protect the personal & financial information
erations per second, or FLOPS which is of a
of the country’s citizens from foreign surveil-
considerably larger scale.
lance.
1 billion flops = 1 giga flops (109)
• Storing of data locally is expected to help law–
1000 giga flop = 1 tera flop (1012)
enforcement agencies to access information
1000 tera flop = 1 peta flop (1015)
that is needed for the detection of a crime or to
• Param 8000 supercomputer had a maximum
gather evidence.
speed of one giga flop.
• On–shoring global data could also create do-
• PARAM SHIVAY (February 2019) ➔ 833 TFLOPS
mestic jobs & skills in data storage & analytics
• PARAM Brahma (September 2019) ➔ 0.85
too.
PFLOPS
• Where data is not localised, the agencies need
• Pratyush and Mihir (fastest supercomputers in
to rely on mutual legal assistance treaties
India) ➔ 6.8 PetaFlops
(MLATs) to obtain access, delaying investiga-
• The most advanced supercomputer Summit
tions.
(U.S.) ➔ ~150 PFLOPS
• Technologies like machine learning, Artificial In-
telligence (AI) & Internet of Things (IoT) can
{S&T – Internal Security – 20/07/02} Data
Localization and Data Protection produce tremendous value out of various data.
It can be disastrous if data is not contained
TH | GS3 > Challenges to internal security through within boundaries.
communication networks | GS2 > Government poli- • To curtail the threatening of unregulated & ar-
cies and interventions for development in various bitrary use of personal data, data localization is
necessary.
8
B.N Shrikrishna report on Data Protection or organization that acts on behalf of another
person, including the State).
• The SC in 2017 declared “privacy” a funda- • It will make the data fiduciary liable for harms
mental right. caused to the data principal.
• A committee headed by retired SC Judge BN • It also calls for privacy by design on part of data
Srikrishna was constituted by GOI in 2017, to processors, & defines terms like consent, data
deliberate on a "Data Protection Framework". breach, etc.
• The report has emphasized that interests of the
Right to be forgotten
citizens & the responsibilities of the state have
to be protected, but not at the cost of trade & • It refers to the ability of individuals to limit, de-
industry. link, delete, or correct the disclosure of per-
• The committee proposed a draft Personal Data sonal information on the internet that is mis-
Protection Bill. leading, embarrassing, irrelevant, etc.
Highlights of the report and the proposed Per- Data Protection Authority
sonal Data Protection Bill
• The law will set up a Data Protection Authority
(DPA), which will be an independent regulatory
body responsible for the enforcement & effec-
tive implementation of the law.
Personal Data
9
• DPA will be given the residuary power to notify disclosure of information from public authori-
further categories in accordance with the crite- ties may lead to private harm being caused.
ria set by law.
Exceptions
Data Storage
• The state can process data without consent
• The Bill makes it mandatory for a copy of per- of the user on ground of public welfare, law &
sonal data to be stored in India. order and emergency situations.
• Processing of data for certain interests such as
Appellate Tribunal
security of the State, legal proceedings, re-
• The Central Government shall establish an ap- search & journalistic purpose, may be exempt
pellate tribunal or grant powers to an existing from certain obligations of the proposed data
appellate tribunal to hear & dispose of any ap- protection law.
peal against an order of the DPA.
Cross border data transfers
Penalties
• Cross border data transfers of personal data will
• Penalties may be imposed for violations of the be through model contract clauses.
data protection law. • Personal data determined to be critical will be
• The penalties paid by violating entities will be subject to the requirement to process only in
deposited to a Data Protection Fund, which India (there will be a prohibition against cross
will, among other purposes, finance the func- border transfer for such data).
tioning of the Data Protection Authority.
Data of Children
Obligations on Fiduciaries
• Committee has made specific mention of the
• Obligations would include “purpose limita- need for separate & more stringent norms for
tion” where data will be used only for clear, protecting the data of children.
specific & lawful purposes & “collection limi-
tation” where only data necessary for the pur- Limitations
10
• GDPR stands for General Data Protection • The data fiduciary does not need to share the
Regulation that is in effect in EU since 2018. source of the personal data to the data princi-
• It is a new set of rules designed to give EU citi- pal in case the data has not been collected
zens more control over their personal data. from him/her which is an explicit requirement
• GDPR framework applies to organisations in all in GDPR
EU member-states. • Unlike GDPR, there is no requirement that the
• GDPR has almost become a common noun for data fiduciary share with the data principal the
personal data protection regulation. existence of automated decision making, in-
• Justice BN Srikrishna committee has referred to cluding profiling.
GDPR repeatedly. • In India, a citizen has not been given the right
to demand his/her data to be erased. Data
The key differences between GDPR and Data erasure, which is an article in itself in GDPR
Protection Bill
does not even find a mention in the Indian draft
• GDPR is not an Act; individual member nations bill.
have enacted their own legislations based on • In case of a breach, there’s no requirement
GDPR. by Indian draft bill to share it with the data
• Unlike in GDPR, Indian draft legislation does principal. This is also in contrast to GDPR pro-
not require the data fiduciary to share the visions.
names and categories of other recipients of the • In India, every data fiduciary should ensure the
personal data with the data principal. storage of personal data locally. GDPR leaves
• There is no obligation on data fiduciary to share this to specific countries most of which have
with the data principal for how long the data chosen to allow free flow of data.
will be stored while collecting or at any time, as
{S&T – ISRO – 20/01/13} GSAT-30
GDPR mandates.
11
TH | 13-01-2020 | GS3 > Sci & Tech – developments • GSATs (Geo synchronous Satellites)
and their applications, indigenization of technology.
Indian National Satellite System (INSAT)
Basics: Kepler's laws, Satellite Orbits, Launch Vehicles
PSLV & GSLV • INSAT, is a series of multipurpose geostationary
• Isro's GSAT-30 satellite was placed in geostation- satellites launched by ISRO.
ary orbit by Ariane-5 launch vehicle. • Established in 1983 with commissioning of IN-
• Ariane-5 was launched from Ariane Launch Com- SAT-1B, the INSAT system with more than 200
plex at Kourou, French Guiana (overseas terri- transponders in the C, Extended C and Ku-bands
tory of France). provides services to telecommunications, televi-
• The 3,357-kg GSAT-30 will serve as a replace- sion broadcasting, satellite newsgathering,
ment to INSAT-4A services. weather forecasting, disaster warning and Search
• The satellite provides Indian mainland and is- and Rescue operations.
lands coverage in Ku-band and extended cover-
age in C-band covering Gulf countries, a large GSATs (Geo synchronous Satellites)
number of Asian countries and Australia.
• The new generation INSATs are now named as
• With a mission life of 15 years, GSAT-30 provides
GSATs (Geo synchronous Satellites).
DTH, television uplink, digital satellite news
• The GSAT satellites are used for digital audio,
gathering (DSNG) and VSAT services.
data and video broadcasting.
Why didn’t ISRO use GSLV Mk III to place
Transponder
GSAT-30 in orbit?
• In a communications satellite, a satellite tran-
• GSLV Payload Capacity to LEO: 5,000 kg
sponder receives signals over a range of uplink
• GSLV Payload Capacity to GTO: 2,500 kg
frequencies, usually from a satellite ground sta-
• GSLV-III Payload Capacity to LEO: 8,000 kg
tion.
• GSLV-III Payload Capacity to GTO : 4000 kg
• The transponder amplifies them and re-transmits
• ISRO’s GSLV Mk III has the capability to place sub
them on a different set of downlink frequencies
4 ton satellites in GTO.
to receivers on Earth, often without changing the
• Though GSAT-30 is not a heavier satellite
content of the received signal or signals.
(3,500+ kg), ISRO had to use the services of Ari-
anespace.
• This is because of budget and time constraints.
• MK III rockets were already used for Chan-
drayaan-2 and other missions.
• ISRO didn’t have a spare GSLV vehicle for Gsat-
30 and there was an urget need to replace the
dying Insat-4A to ensure continuity of several
services.
12
Source and Credits: ESA
L-band (1–2 GHz) • Primarily used by the military.
• Sub-bands are used in civil, military and govern-
• Used by Global Positioning System (GPS) carriers
ment institutions for weather monitoring, air
and satellite mobile phone communication de-
traffic control, maritime vessel traffic control, de-
vices.
fence tracking and vehicle speed detection for
S-band (2–4 GHz) law enforcement.
• Used by weather radar, surface ship radar, and Ku-band (12–18 GHz)
some communications satellites.
• Used for satellite communications, most notably
C band (4–8 GHz) the downlink used by DTH television.
• Because of the higher frequencies, Ku band
• Used for satellite communications, for full-time
waves have shorter wavelengths.
satellite TV networks.
• Shorter wavelengths mean that you need a
• Ssed in areas that are subject to tropical rainfall
smaller dish to receive these frequencies.
(less susceptible to signal degradation than Ku
band). K-band (18–26 GHz)
• Because of the low frequencies, C band waves
• Due to the 22 GHz water vapor absorption line
have longer wavelengths.
this band has high atmospheric attenuation and
• Because of bigger wavelengths, a bigger dish is
is only useful for short range applications.
required to receive such frequencies.
Ka-band (26–40 GHz)
Why are the Geostationary satellites launched from east coast in eastward direction and from
locations that are close to the equator?
13
• If you observe the location of all the launch cen- • Earth’s rotational velocity is maximum at the
ters like Sriharikota, Kennedy Launch Center equator (on earth, centrifugal force is maximum
(USA: Florida), Guiana Space Centre etc., all are at the equator).
located on the East coast of the continent and • Hence for maximum initial boost, the launch site
are close to the equator. needs to be closer to the equator.
• The location of Kennedy Space Center and Satish • Anything on the surface of the Earth at the equa-
Dawan Space Center makes them particularly tor is already moving at 1670 kilometers per hour
vulnerable to tropical cyclones and other (rotational velocity of earth).
weather “events”. • But this benefit can be taken only for such satel-
• However, they are good locations for rocket lites which are placed in geo-stationary orbit or
launches as thay are on the east coast and close which circle the Earth parallel to the equator.
to the equator.
Reason 2:
• Also, the islands are less densely populated,
making them safer to carry out launches. • Communication satellites are put into geosta-
tionary orbit above the equator with zero incli-
Why in eastward direction? nation to the equatorial plane.
• The ideal place to launch to geostationary orbit
• As the earth rotates from west to east, a satellite
is, obviously, on the equator.
launched in the east direction will get an initial
• Equatorial launches only require the vehicle to
boost equal to the velocity of Earth surface.
bring the payload to orbital speed and do not
Why at equator? require inclination changes.
• For launches that are not on the equator, the ve-
Reason 1: hicle must perform a complex adjustment burn
in the GTO (geostationary transfer orbit) phase
14
of the mission to bring the vehicle an inclination • Such satellites are generally launched in south
of 0º. ward or north ward direction and therefore can-
not take advantage of the Earth’s rotation.
why equatorial launches (or as close as possible) the orbital plane of the Earth-Sun system.
15
• These can be used by spacecraft to reduce fuel • GISAT-2 (similar to GISAT-2) is shcheduled to be
consumption needed to remain in position. launched in August 2020
• The L1 point is home to the Solar and Helio- • The two identical satellites will provide resolution
spheric Observatory Satellite (SOHO), an inter- in the range of 42 to 318 m.
national collaboration project of NASA and the
Objectives of GISAT-1
European Space Agency (ESA).
• Quick monitoring of natural disasters.
What is the importance of understanding • Keep a constant watch on borders.
Sun’s atmosphere? • Monitor any changes in the geographical condi-
tion of the country.
• Sun's corona gives rise to solar wind which are
• Helps to obtain spectral signatures of agricul-
hot, energised and charged particles that stream
ture, forestry, mineralogy, disaster warning,
outward from the Sun and fill the solar system.
cloud properties, snow, glaciers and oceanogra-
• These charged particles (solar wind) beaming
phy.
outwards affects space weather and violent solar
wind can hamper satellites and electronics on
{S&T – ISRO – 20/03} Oceansat
Earth.
Suggested Reading: Sun’s Internal Structure and At- PIB | GS3 > Indigenization of technology and devel-
mosphere, Solar Wind oping new technology.
• The Indian National Centre for Ocean Infor-
{S&T – ISRO – 20/03} GISAT-1 or Geo Imag- mation Services (INCOIS) has reported that
ing Satellite-1
Oceansat Satellite data are used to prepare the
• The launch of GISAT-1 from Sriharikota, planned concentration obtained from ISRO's Oceansat-
for March 05, 2020, is postponed due to tech- 2 satellite and the sea surface temperature
16
• Microwave Radiometer offers information re- {S&T – NanoTech – 20/05} Nanomaterials
garding sea surface temperature, cloud water Based Supercapacitors
content, etc.
• Oceansat-1 completed its mission in 2010. PIB | Source | GS3 > Awareness in the fields of nano-
17
• Supercapacitors deliver quick bursts of energy
during peak power demands and then quickly
store energy and capture excess power that is
otherwise lost.
• In the example of an electric car, a supercapaci-
tor can provide needed power for acceleration,
while a battery provides range and recharges the
supercapacitor between surges.
18
• A Nanoparticle is a small particle that ranges be- • Gold nanoparticles are used to detect breast
tween 1 to 100 nanometres (nm) in size. cancer.
• Undetectable by the human eye, nanoparticles • Photodynamic therapy: when light is applied to
can exhibit significantly different physical & a tumour containing gold nanoparticles, the par-
chemical properties to their larger material ticles rapidly heat up, killing tumour cells.
counterparts. • It was also discovered that the nanoparticles
• Nanoparticles (NPs) have wide variety of poten- could detect toxins & pathogens.
tial applications in the fields of biomedical, opti- • The scattered colours of gold nanoparticles are
cal & electronics research. currently used for biological imaging applica-
tions.
What is Nanotechnology? • The optical–electronics properties of gold na-
• Nanotechnology is science, engineering, & tech- noparticles are being explored widely for use in
nometres).
{S&T – New Tech – 20/07/06} Winter Diesel
• Nanoscience & nanotechnology can be used
across all the other science fields. IE | GS3 > Developments & Their Applications & Ef-
fects in Everyday Life.
Gold Nano Particles (GNP)
• Context: India’s armed forces may soon be using
• Gold Nano Particles (GNP) are a small gold par- winter diesel for operations in high altitude ar-
dispersed in water, are also known as colloidal • Winter diesel is a specialised fuel that was intro-
• The versatile surface chemistry of gold nano- tude regions & low–temperature regions such as
particles allows them to be coated with small Ladakh, where ordinary diesel can become unus-
molecules, thereby extending their range of ap- • IOC may begin supplying winter diesel to the
• The morphology of gold nanoparticles is spher- torate General for Quality Assurance of the
• GNPs can be used as a composite therapeutic • The flow characteristics of diesel change at low
agent clinical trials, especially in Anti–cancer, temperatures & using it may be detrimental to
Anti–Viral, anti–diabetic, & cholesterol–lowering vehicles.
drugs. • Winter diesel which contains additives to main-
• Researchers have coated gold particles with tain lower viscosity can be used in tempera-
DNA & injected them into plant embryos or tures as low as minus 30°C & that besides a low
plant cells. This will ensure that some genetic pour point, it had higher cetane rating.
material will enter the cells & enhances plant • Cetane Rating is an indicator is the combustion
plastids. speed of diesel & compression needed for
19
ignition — & lower sulphur content, which rate of neutrons & therefore the neutron popu-
would lead to lower deposits in engines & better lation decreases as time goes on.
performance. • “Supercritical” refers to a system where the
production rate of neutrons is greater than the
{S&T – Nuclear Energy – 20/07/23} Kakrapar loss rate of neutrons & therefore the neutron
Atomic Power Plant
population increases.
• When the neutron population remains constant,
IE | GS3 > Energy | Nuclear fission
this means there is a perfect balance between
• Context: Third unit at Kakrapar Atomic Power
production rate & loss rate, & the nuclear sys-
Plant (Gujarat) achieves criticality.
tem is said to be “critical.”
• KAPP–3 is the country’s first 700 mwe (mega-
• When a reactor is starting up, the neutron pop-
watt electric) unit, & the biggest indigenously
ulation is increased slowly in a controlled man-
developed variant of the Pressurised Heavy
ner, so that more neutrons are produced than
Water Reactor (PHWR).
are lost, & the nuclear reactor becomes super-
critical.
• When the desired power level is achieved, the
nuclear reactor is placed into a critical config-
uration to keep the neutron population & power
constant.
• Finally, during shutdown, the reactor is placed
in a subcritical configuration so that the neu-
tron population & power decreases.
• Therefore, when a reactor is said to have “gone
critical,” it actually means it is in a stable con-
figuration producing a constant power!
✓ Supercritical == Car [nuclear reactor] is
accelerating.
✓ Critical == Car is going at a constant
speed.
✓ Sub critical == Car is slowing down.
Criticality
Must Read: Types of Nuclear Reactors
Must Read: Nuclear Fission:
https://www.pmfias.com/nuclear-fission-nu- Nuclear Power Corporation of India Limited
(NPCIL)
clear-reactor-types/
• Criticality is a nuclear term that refers to • The Nuclear Power Corporation of India Limited
the balance of neutrons in the system. (NPCIL) is an Indian PSU, Headquartered at
• Balance of neutrons can be achieved using mod- Mumbai.
erators & control rods. • It is wholly owned by GOI & is responsible for the
• “Subcritical” refers to a system where the loss generation of nuclear power for electricity.
rate of neutrons is greater than the production
20
• NPCIL is administered by the Department of domestic agencies to deliver their commitments
Atomic Energy (DAE). to ITER.
• ITER–India is the Indian domestic agency, a spe-
{S&T – Nuclear Energy – 20/07/29} Interna- cially empowered project of the Institute for
tional Thermonuclear Experimental Reactor Plasma Research (IPR), an aided organization
(ITER)
under Dept. of Atomic Energy.
PIB | GS3 > Science and Technology – developments • ITER–India is responsible for delivery of the
• Context: The ITER Organization celebrated the ITER India has shipped the base, upper cylinder
Start of Assembly of the ITER Tokamak (device & lower cylinder for the cryostat.
which uses a powerful magnetic field to con- • Cryostat is a cylindrical vessel which will act has
fine a hot plasma). a huge refrigerator & provide cooling to the fu-
sion reactor that will attempt to harness the en-
What is International Thermonuclear Experi- ergy produced by fusion of atoms
mental Reactor (ITER)
Funding of Project
• ITER is an international nuclear fusion research
& engineering megaproject. • The project is funded & run by seven member
Objectives
21
• There are two methods which can be used to re- • He also set up India's first rocket launch site in
lease energy from radioactive minerals: Thumba, a small village near Thiruvananthapu-
1. Nuclear fission: In this process, the nucleus ram.
of heavy atom namely of uranium (U 235) • Vikram Sarabhai was also responsible for bring-
or plutonium (P239) breaks apart into ing cable television to India.
smaller fragments, releasing an enormous • His constant contact with NASA paved a way for
amount of energy. the establishment of Satellite Instructional Tele-
2. Nuclear fusion: In this process, small nucleus vision Experiment (SITE) in 1975.
like those of isotopes of hydrogen, namely • Sarabhai was the mastermind behind building
deuterium & tritium fuse or join together India's first satellite, Aryabhata.
to form heavier nuclei, releasing vast • He was one of the founding members of the In-
amounts of energy. dian Institute of Management, Ahmedabad
(IIMA).
{S&T – Persons of Interest – 20/02} Dr. • Vikram Sarabhai received the Padma Bhushanin
Vikram Sarabhai 1966.
• He was also awarded the Padma Vibhushan in
TOI | Source | Achievements of Indians in Science &
1972, posthumously.
Technology
• ISRO and Department of Atomic Energy (DAE)
{S&T – Space – 20/05} Long March 5B
are conducting various year long events at na-
tional level to commemorate the 100th birth an- TH | Basics: Kepler's laws, Satellite Orbits, Launch Ve-
niversary of Dr. Vikram Sarabhai. hicles PSLV & GSLV
About Vikram Sarabhai • China has successfully launched the Long March
5B’ rocket and prototype spacecraft.
• Vikram Sarabhai was born in 1919. • It is expected to transport astronauts to a space
• Sarabhai was instrumental in forming India's fu- station that China plans to complete by 2022.
ture in astronomy. • Long March 5B is a step in the direction of
• Sarabhai founded the Physical Research Labora- China’s ambition to operate a permanent space
tory in Ahmedabad in the year 1947. station and send astronauts to the Moon.
• Its first topic of research was cosmic rays. • The United States is so far the only country to
• The most significant contribution of Sarabhai have successfully sent humans to the Moon.
was his role in setting up the country's space re-
search facilities. International Space Station (ISS)
• He persuaded GOI to set up the Indian National
• A space station is a spacecraft capable of sup-
Committee for Space Research (INCOSPAR) in
porting crew members, designed to remain in
1962.
space for an extended period of time and for
• Sarabhai was the first chairman of the commit-
other spacecraft to dock.
tee.
• One fully functional space station in the Earth's
• The INCOSPAR was restructured and renamed as
lower orbit is the International Space Station and
ISRO in 1969.
astronauts conduct different experiments in it.
22
• ISS is a habitable artificial satellite – the single • The Perseverance rover will seek signs of ancient
largest man-made structure in low earth orbit. life & collect rock & soil samples for possible re-
• Its first component was launched into orbit in turn to Earth.
1998. • The rover blasted off from Cape Canaveral in
• It circles the Earth in roughly 92 minutes and Florida atop an Atlas V rocket, beginning its 6 ½
completes 15.5 orbits per day. month trip (July 30 2020 to February 18, 2021) to
• The ISS programme is a joint project be- the red planet.
tween five participating space agencies: • The rover is accompanied by the helicopter In-
1. NASA (United States), genuity, which will help scout locations to study.
2. Roscosmos (Russia), • Most dramatic goal of the mission will be the
3. JAXA (Japan), rover’s attempt to demonstrate a technology
4. ESA (Europe), and that converts carbon dioxide in the Martian at-
5. CSA (Canada) mosphere into oxygen.
• Its ownership and use have been established by
intergovernmental treaties and agreements. {S&T – Technologies – 20/02} Quantum
computing gets funds
• It serves as a microgravity and space environ-
ment research laboratory in which crew mem-
D2E | Science and Technology: Developments and
bers conduct experiments in biology, human bi-
their Applications, Awareness in the fields of Com-
ology, physics, astronomy, meteorology, and
puters
other fields.
• Union Budget for 2020-21 proposed Rs 8,000
crore over five years for National Mission on
{S&T – Space – 20/07/30} Perseverance-
NASA’s mission to Mars Quantum Technologies and Applications.
• Quantum technologies comprise quantum com-
TH | GS3 > Awareness in The Fields of Space puting, quantum communication, quantum op-
• Context: NASA has launched its Mars 2020 Per- tics, quantum information processing, quantum
severance rover. internet and quantum artificial intelligence.
• Perseverance is the fifth rover sent to Mars by
Need for special attention
NASA.
• The first four are Sojourner (1996), Spirit (2004) • The excitement about quantum computer is be-
and Opportunity (2004), and Curiosity (2011). cause of its power to dabble with complex calcu-
lations involved in fields like cyber-security which
What is Perseverance Mars Mission? digital computers now deal with.
• Quantum communications can enhance (cyber)
security, provide unique fingerprints and also in-
crease available bandwidth for internet net-
works.
Suggested Reading: {S&T – 19/09/29} Quantum
supremacy
23
TH | TH | TH | GS3 > Science and Technology: Devel- • Diffusion through a permeable membrane
opments and their Applications and Effects in Every- moves a substance (solute) from a region of high
day Life. solute concentration (hypertonic solution) to
• NGT has recently passed an order prohibiting the a region where its concentration is low (hypo-
use of reverse osmosis (RO) purifiers where total tonic solution).
dissolved solids (TDS) in the supplied water are
below 500 mg per litre.
• The NGT had ordered the ban on the grounds
that RO filters often deprived drinking water of
essential salts (affecting the nutritional security)
and were also wasting a lot of water and power.
• Current BIS regulations consider 500 mg/litre to
1,200 mg/litre of total dissolved solids, which
consist of salts and some organic matter, as ac- • In living organisms, diffusion plays an important
• MoEF has recently issued a draft notification that well as the cell and its external environment.
seeks to regulate membrane-based RO water fil- • Exchange of O2 & CO2 in alveoli (millions of tiny,
balloon-shaped air sacs in lungs) is an example
tration systems in areas where the source of wa-
of diffusion.
ter meets drinking water norms of the Bureau of
Indian Standards.
Basics
Solution
24
• Reverse osmosis (RO) is a water purification
technology that uses a semipermeable mem-
brane to remove larger particles from drinking
water.
• In reverse osmosis, an applied pressure is used
to overcome osmotic pressure so that pure
water flows from a region of high solute con-
centration (hypertonic) through a semi-per-
meable membrane to a region of low solute
concentration (hypotonic).
Note: In NCERT Biology Compilation, I have
given a wrong explanation for both Osmosis
and Reverse Osmosis. What I have given here is
the correct explanation.
• Thus, osmosis is a special case of diffu-
sion through a selectively permeable mem- Application of Reverse Osmosis (RO)
brane.
• RO was originally a technology devised in the
• Unicellular freshwater organisms and most plant
late 1950s to desalinate sea water.
cells tend to gain water through osmosis.
• At present, it is possible to deploy a wide array
• Absorption of water by plant roots is also an
of membranes and multiple stages of filters to
example of osmosis.
filter a wide variety of solutes — arsenic, fluo-
Reverse Osmosis (RO) ride, hexavalent chromium, nitrates, bacteria.
• This has led to an industry of home-RO systems
for drinking water.
• To create external pressure, RO relies on a pump
and electric motors.
• It uses “activated carbon” components, such as
charcoal and carbon black that can filter out
contaminants as well as organic substances
such as bacteria (UV light is also used to kill bac-
teria).
• It all depends on the filtering material and the
number of filters that incoming tap water must
pass through.
25
Problem with RO water purifiers What is the quality of water globally?
• In making tap water pass through multiple • Countries with a high development index tend to
stages of cleaning, RO systems end up wasting a have good quality tap water.
lot of water. • Finland, Denmark, Germany, UK have access to
• Anywhere between three-five times more water freshwater lakes or glacier melt (clean and min-
is wasted by them (high carbon footprint). eral rich).
• RO system filters out essential micronutrients • Singapore and Israel rely on extensive recycling
such as calcium, zinc, magnesium. Drinking and even making sewage water fit for drinking.
such water over time could be harmful. • But for much of the world, access to clean piped
• However, many manufacturers claim to over- water from the public supply remains a chal-
come this challenge by “post-treatment” (added lenge.
minerals).
• RO system only reduces Total Dissolved Solids, {S&T – Technologies – 20/03} Cyber Physical
Systems (CPS)
ensure water is odourless and has a pH from 6.5-
8.5.
IT | PIB | GS3 > Technologies and their applications
• The National Institute of Virology (NIV) claimed
in daily life
that most RO methods did not eliminate Hepati-
• Department of Science & Technology has sanc-
tis E virus.
tioned funds to IIT Mandi to start a Technology
• However, a combination of filtration systems can
Innovation Hub (TIH) in its campus.
eliminate most contaminants (more power con-
• DST has sanctioned the funds under its National
sumption).
Mission on Interdisciplinary Cyber-Physical Sys-
• RO systems reduce the incentive for public-
tems.
funded water distribution systems and vast ma-
jority of the country can ill-afford such systems. Cyber Physical Systems (CPS)
• In case of sea water desalinization, deposition of
brine (highly concentrated salt water) along the • CPS integrates digital elements with physical
shores affects plankton, which is the main food objects (e.g. machines, autonomous vehicles)
for small fish species. and data.
• CPS have the capabilities of communication, data
How is the quality of piped water in the coun- collection & processing, decision making and ac-
try? tion.
• In CPS, a complex mechanism is controlled or
• Under the Jal Jeevan Mission, GOI has committed
monitored by computer algorithms.
to provide tap water to the entire country by
• CPS is closely associated with technologies like
2024.
Al, Internet of Things (loT), Machine Learning
• However, studies show that the existing quality
(ML), Deep Learning (DP), Big Data Analytics, Ro-
of piped water is deficient in much of India.
botics, Cybernetics, Mechatronics, Quantum
• In Delhi, all tap water samples drawn from vari-
Computing, etc.
ous places did not comply with the BIS’s require-
• Examples of CPS include smart grid, autono-
ments.
mous automobile systems, medical
• The case is the same with a lot of other cities.
26
monitoring, industrial control systems, robotics • Give impetus to advanced research in CPS, Tech-
systems, etc. nology development and higher education in
Science, Technology and Engineering disciplines.
National Mission on Interdisciplinary Cyber • Place India at par with other advanced countries
Physical Systems (NM-ICPS) and derive several direct and indirect benefits.
27
(PHEIC) because it feared the announcement • Coronaviruses are a specific family of viruses,
would anger the countries in the region. with some of them causing less-severe damage,
• Till date, WHO has declared a global health such as the common cold, and others causing
emergency six times. respiratory and intestinal diseases.
1. April 2009 for the spreading of H1N1 pan- • A coronavirus has many regularly arranged pro-
demic. trusions on its surface, because of which the en-
2. May 2014 for the spreading of polio. tire virus particle looks like an emperor’s crown,
3. August 2014 for Ebola outbreaks in west- hence the name “coronavirus”.
ern Africa. • Apart from human beings, coronaviruses can af-
4. February 2016 for Zika outbreaks in the fect pigs, cattle, cats, camels, some birds, etc.
Americas.
5. July 2019 Ebola outbreak in Congo. 2019-nCoV
6. January 2020 2019-nCoV outbreak in • China shared the whole genome sequence data
China. with WHO and global researchers.
• However, much still remains to be understood
International Health Regulations (2005)
about the present novel coronavirus (2019-
• WHO has been working on strengthening health nCoV).
security through the implementation of the In- • Experts have confirmed animal-to-human and
ternational Health Regulations (2005) adopted human-to-human transmission of the new
by 194 countries. strain.
• The IHR are an international legal instrument • Symptoms include dry cough, fever, fatigue,
that aim to help the international community muscle aches and acute breathing difficulty.
prevent and respond to acute public health risks • The incubation period for the virus can last from
that have the potential to cross borders and 10 to 14 days.
threaten people worldwide. • The infection can cause pneumonia, respiratory
• Countries are legally required to share infor- distress, kidney failure and in some cases, in
mation with WHO under the IHR. which immunity is weak, even death.
• As of now, there is no vaccine against corona-
Coronaviruses virus infection. There is also no cure for the
2019-nCoV.
• According to a new study, 2019-nCoV likely re-
sided in snakes before being transmitted to hu-
mans.
• Comparing the genome of 2019-nCoV with
those of different coronaviruses, the study found
that the new virus formed from a combination of
CoV found in bats, and another of unknown
origin.
28
• It is critical to determine the animal reservoir of • The reason could lie in the busy food markets
the 2019-nCoV in order to understand the mo- dotting cities across the country — where fruits,
lecular mechanism of its cross-species spread. vegetables, hairy crabs and butchered meat are
often sold next to bamboo rats, snakes, turtles,
Previous Coronavirus outbreaks and palm civets.
• So far, there are four known disease-causing • Closely packed stalls in busy marketplaces, the
coronaviruses, among which the best known are Chinese taste for exotic meats, and the high pop-
the SARS corona virus and the Middle East ulation density of cities create the conditions for
• Severe Acute Respiratory Syndrome (SARS) out- Ban on trade in exotic species is essential
break in China in 2002-03 killed nearly 800 peo-
• The outbreak of a new virus in China is prompt-
ple.
ing renewed calls for enforcement of laws
• The SARS coronavirus is thought to be an animal
against the trade in and consumption of exotic
virus from an yet-uncertain animal reservoir, per-
species.
haps bats, that spread to other animals and first
• Not all of Zoonotic diseases come from wildlife
infected humans in the Guangdong province of
trade — rabies is endemic across many species
China in 2002.
and one of the biggest causes of death in the de-
• The MERS coronavirus was passed on from cam-
veloping world.
els to humans in Saudi Arabia in 2012.
• But mixing species of wild animals increases the
Zoonotic infections risk of diseases mutating and growing more vir-
ulent as they spread in unregulated markets, ex-
• Zoonotic diseases, or those contracted by hu- perts say.
mans that originated in other species, account
for a large share of human infectious illnesses. Lessons from Kerala (Importance of Decen-
• The relationship between zoonotic pathogens — tralization in public health)
those of animal origin — and global pandemics
Suggested reading: {Bio – Diseases – 19/06/04}
is not new.
Nipah virus
• The modern pandemics such as HIV/AIDS,
• The Kerala government dealt effectively with the
SARS, and H1N1 influenza have one thing in
Nipah virus outbreak in May 2018.
common: the causal organisms came to humans
• Nipah is also zoonotic and made the jump from
from animals.
fruit bats to humans.
Why China has emerged as the epicentre of • Though there were 17 deaths in India, effective
global zoonotic disease outbreaks? quarantine measures by local authorities pre-
vented the spread. It helped that health is a
• Several deadly new viruses in recent years have
state subject.
emerged in China — Severe Acute Respiratory
• The State health machinery responded with alac-
Syndrome (SARS), bird flu, and now the novel
rity with many put under observation.
coronavirus (nCOV).
• Kerala was declared Nipah-free after a few
• The SARS epidemic began in November 2002 in
months.
China and spread across the world.
29
• Had the district and State authorities not taken • Truenat takes about 25 minutes to extract the
the initiative and only reported matters to Delhi DNA and another 35 minutes for TB diagnosis.
and awaited instructions while Delhi sent teams • Testing for rifampicin resistance takes an hour
to prepare plans, the outbreak would have taken and is done only if the sample tests positive for
a higher toll. TB.
• The overall sensitivity of the Truenat MTB assay
India needs a better infrastructure and re- is 83% and specificity is 99%.
sponse mechanism • In comparison, Xpert, which is also a molecular
diagnostic test, the sensitivity is 85% and speci-
• Infectious diseases including those of the zoon-
ficity is 98%.
otic variety are on the rise in India.
• Truenat MTB-RIF test for knowing rifampicin re-
• In addition, regions in India suffer from seasonal
sistance has 93% sensitivity and 95% specificity.
outbreaks of dengue, malaria and influenza
• Truenat MTB will be used as an initial test to di-
strains.
agnose TB thus replacing sputum smear mi-
• The nation-wide disease surveillance pro-
croscopy.
gramme needs to be strengthened.
• Sputum smear microscopy (testing mucus for TB
• There is an acute shortage of epidemiologists,
bacteria) has only 50% sensitivity and fails to de-
microbiologists and entomologists which trans-
tect TB when the bacterial load is low.
lates into wasteful delays in diagnostics.
• It is time to put in place a robust public-private
Advantages of Truenat MTB over other di-
partnership model that can transform the health
agnostic tests
sector in the country, covering disease surveil-
lance, diagnostic kit availability and accelerated • Compared with smear microscopy, Truenat had
vaccine development. better ability to diagnose more TB positive cases.
• Instead of smear microscopy, Truenat can be
{Sci – Diseases – 20/01/18} TB diagnostic used as an initial and point-of-care tool for diag-
test Truenat MTB
nosing TB.
• Not much expertise is needed to carry out the
TH | TH | National Health Programme | 18-01-2020 |
test using Truenat.
GS3 > Applications of S&T in everyday life | GS2 >
• While Xpert needs electricity supply and air-con-
Issues related to health sector | Basics: {Bio – Dis-
ditioning, Truenat is battery operated and porta-
eases – 19/08/16} New Tuberculosis Drug Preto-
ble.
manid
• Tuenat takes an hour to diagnose rifampicin re-
• Truenat is a molecular diagnostic test (MTB – ala-
sistance while Xpert takes two hours to complete
lysing individual's genetic code) to diagnose pul-
the TB diagnosis and test for rifampicin re-
monary and extrapulmonary TB (TB in organs
sistance.
other than lungs).
• Truenat is cost effective as it will test for rifam-
• It can also be used to diagnose rifampicin-re-
picin resistance only after detecting TB. This is
sistant TB.
unlike Xpert where both TB diagnosis and rifam-
• WHO had mentioned that the India-made
picin resistance test are done at one go.
Truenat MTB has high diagnostic accuracy.
30
The goal to end TB by 2025 with the goal of ‘universal access to quality TB
diagnosis and treatment’.
• Revised National TB Control Programme was re- • Significant interventions were taken during NSP
named as the National TB Elimination Pro- 2012-2017 in terms of mandatory notification
gramme (NTEP). of all TB cases, integration of the programme
• The change in name is in line with the larger goal with the National Health Mission, etc.
of eliminating the disease by 2025, five years • To eliminate TB in India by 2025, National
ahead of the Sustainable Development Goals tar- Strategic Plan for Tuberculosis Elimination
get. 2017-2025 involving all the stakeholders was
• NTEP got a much needed boost with the WHO formulated by RNTCP.
stating that TrueNat MTB has high diagnostic ac- • On 01-01-2020, RNTCP was renamed as Na-
curacy. tional TB Elimination Programme (NTEP).
• As a first step, TrueNat MTB will be available at
community health centres and would slowly be National strategic plan for tuberculosis elimina-
extended to primary health centres across the tion (NSP) 2017-2025 (NSP)
country.
• TB elimination has been integrated into the four
• There are 5,500-6,000 community health centres
strategic pillars of “Detect – Treat – Prevent –
and about 25,000 PHCs.
Build” (DTPB).
• The states will be procuring the diagnostic ma-
chine directly from the Goa-based manufacturer. Detect
32
• Patients develop sudden onset of fever, head- Zoonotic Disease
ache, chills, & weakness & one or more swollen
• Zoonotic diseases (also known as zoonoses)
lymph nodes.
are caused by germs that spread between ani-
• This form is usually the result of an infected flea
mals & people.
bite.
• A zoonosis is any disease or infection that is nat-
• The bacteria multiply in the lymph node clos-
urally transmissible from vertebrate animals to
est to where the bacteria entered the human
humans.
body.
• Animals thus play an essential role in maintain-
• If the patient is not treated with appropriate an-
ing zoonotic infections in nature.
tibiotics, the bacteria can spread to other parts
• Zoonoses may be bacterial, viral, or parasitic,
of the body.
or may involve unconventional agents.
Septicemic plague
• Skin & other tissues may turn black & die, espe-
cially on fingers, toes, & the nose.
• Septicemic plague can occur as the first symp-
toms of plague, or may develop from untreated
bubonic plague.
• This form results from bites of infected fleas or
from handling an infected animal.
Source & Credits
Pneumonic plague
{Sci – In News – 20/01/25} Archaea
• Patients develop fever & a rapidly developing
pneumonia with shortness of breath, chest pain,
IE | 25-01-2020 | In News Topic for Prelims
cough, & sometimes bloody or watery mucous.
• Scientists from Pune have reported a new ar-
• Pneumonic plague may develop from inhaling
chaeon (a kind of microorganism), which they
infectious droplets or from untreated bubonic or
discovered in Sambhar Salt Lake in Rajasthan.
septicemic plague that spreads to the lungs.
• Archaea (singular archaeon) are a primitive
• Pneumonic plague is the most serious form of
group of microorganisms that thrive in extreme
the disease & is the only form of plague that can
habitats such as hot springs, cold deserts and
be spread from person to person (by infectious
hypersaline lakes.
droplets).
• These slow-growing organisms are also present
in the human gut and have a potential relation-
ship with human health.
• They are known for producing antimicrobial mol-
ecules, and for anti-oxidant activity with applica-
tions in eco-friendly waste-water treatment.
33
Source | In News Topic for Prelims | Agri > Animal • Kerala will impose a ban on the sale of CFL and
Rearing > Pork Industry incandescent bulbs starting from November
• The Indian Institute of Veterinary Research (IVRI) 2020.
of ICAR has developed a new vaccine to control
swine fever. Tungsten Lamp or incandescent light bulb
• India currently requires 22 million doses of the
• In an incandescent light bulb, a wire filament
CSF (Classical Swine Fever) vaccine every year.
(tungsten) is heated to a high temperature by
• However, currently, only 1.2 million doses are be-
passing an electric current through it until it
ing produced.
glows with visible light.
• The reason behind its less production is that only
• The hot filament is protected from oxidation with
50 doses can be prepared from the spleen of a
a glass or quartz bulb that is filled with inert gas.
rabbit.
• The vaccine is a live attenuated CSF cell culture • Pure tungsten has very high melting point
vaccine. (3400 °C) (An electric current can heat the fila-
• The indigenously developed vaccine will help in ment around 2000-3000 °C, which stays below
saving rabbits as the currently used vaccine the melting point of tungsten).
(lapinized CSF vaccine) is produced by sacrificing • It has very low vapor pressure, and greatest ten-
large numbers of rabbits. sile strength out of all the metals.
• Besides, the new vaccine gives immunity for two
CFL
years as compared to 3 to 6 months protection
under the currently used vaccines. • Compact fluorescent lamp is a fluorescent lamp
• The new vaccine will be a part of the govern- designed to replace tungsten lamp.
ment's One Health Initiative. • Compared to incandescent lamps, CFLs are
What is Classical Swine Fever (CSF)? highly energy efficient.
• Like all fluorescent lamps, CFLs contain toxic
• Classical swine fever (CSF) is a contagious viral mercury.
disease in domestic (pig) and wild swine (Wild
boar). Fluorescent lighting
• Although there is no health risk to humans, it is
• A fluorescent lamp is a low pressure mercury-va-
highly transmissible among swine (pigs).
por gas-discharge lamp.
• As per 2019 census, the country's pig population
• Electrons that are bound to mercury atoms are
declined to 9.06 million from 11.13 million in
excited to states where they will radiate ultravio-
2007.
let light as they return to a lower energy level.
{Sci – In News – 20/02} Kerala bans CFL and • This emitted ultraviolet light is converted into
filament bulbs from Nov 2020 visible light as it strikes the fluorescent coating
on the bulb (phosphor coating).
IE | General Science for Prelims
LED lamp
34
• An LED lamp is a light-emitting diode (LED) • It is a p–n junction diode, which emits light
product which is assembled into a lamp. when activated.
• LED lamps have a lifespan and electrical effi- • When a suitable voltage is applied to the leads,
ciency which are several times longer than incan- electrons are able to recombine with electron
descent lamps, and significantly more efficient holes within the device, releasing energy in the
than most fluorescent lamps. form of photons.
• This effect is called electroluminescence, and
Light-emitting diode (LED) the color of the light corresponds to the energy
Type
35
radiation) discovered by Sir Chandrasekhara • These Centres are expected to house instru-
Venkata Raman in 1928. ments to provide common services of high-end
• Raman Effect is a change in the wavelength of analytical testing, thus avoiding duplication and
light that occurs when a light beam is deflected reduced dependency on foreign sources.
by molecules.
Objectives of SATHI
• When a beam of light traverses a dust-free, • To address the issues of accessibility, mainte-
transparent sample of a chemical compound, a nance, redundancy and duplication of expensive
small fraction of the light emerges in directions equipment in the institutions.
other than that of the incident beam. • This will also foster a strong culture of collabora-
• Most of this scattered light is of unchanged tion between institutions and across disciplines
wavelength (color) (Rayleigh scattered light). to take advantage of developments, innovations
• A small part, however, has wavelengths (color) and expertise in diverse areas.
different from that of the incident light.
• In this case, energy from the light particle is
{Sci – In News – 20/03} COVID-19 National
Teleconsultation Centre (CoNTeC)
transferred to the molecules in the material
and the remaining energy is emitted as scattered PIB | In news topic for prelims
light. This interaction process is known as the Ra- • CoNTeC: COVID-19 National Teleconsultation
man effect. Centre.
• Raman spectroscopy can be used in applications • CoNTeC, conceptualised by the Ministry of
requiring microscopic chemical analysis & imag- Health, is being implemented by the AIIMS, New
ing. Delhi.
• One simple example is that the Raman spectros- • The CoNTeC is a Telemedicine Hub wherein ex-
copy can be used for measuring fat content in pert doctors from various clinical domains will be
milk. available 24x7 to answer the multifaceted ques-
tions from specialists from all over the country.
{Sci – In News – 20/02} Sophisticated Ana-
• It is a multi-modal telecommunications hub
lytical & Technical Help Institutes
through which 2-way audio-video and text com-
TOI | In News topics for Prelims munications can be undertaken from any part of
• The Department of Science & Technology the country as well as the world at large.
(DST) has launched a scheme called "Sophisti-
cated Analytical & Technical Help Institutes
{Sci – In News – 20/03} RaIDer-X
(SATHI)".
PIB | In news topics for prelims
• SATHI offers shared, professionally managed and
• DRDO & the Indian Institute of Science, Banga-
strong S&T infrastructure which is readily acces-
lore have developed a bomb detection device
sible to academia, start-ups, manufacturing, in-
called Raider-X.
dustry and R&D labs.
• RaIDer-X can detect up to 20 explosives from a
• DST has set up three such centres in the country,
stand-off distance of two meters.
one each at IIT Kharagpur, IIT Delhi and BHU.
• It can also discern bulk explosives even if they
have been concealed.
36
• RaIDer-X can also thwart the threat from home- • It cannot be said if this new strain, if transmitted
made explosives made from ingredients like pet- from pigs to humans, can transmit among hu-
rol. mans.
• The device has various applications including • An epidemic is defined as “an outbreak of dis-
narcotics, for local police, for customs and other ease that spreads quickly and affects many in-
detection agencies who need to detect various dividuals at the same time."
elements which may be explosive or non-explo- • A pandemic is a type of epidemic, an outbreak
sive in nature. that occurs over a wide geographic area and af-
fects a high proportion of the population.
{Sci – In News – 20/07/04} G4 Flu Virus • However, there is no clear line distinguishing an
epidemic from a pandemic.
IE | In News Topic for Prelims
• Context: The G4 flu virus with ‘Pandemic Po- The 2009 Swine Flu Pandemic
tential’, found by researchers in China.
• The US Centres for Disease Control & Prevention
About G4 Flu Virus (CDC) defines swine flu as, “a respiratory dis-
ease of pigs caused by type A influenza vi-
• Scientists report that the new strain (G4) has
ruses” that regularly cause outbreaks of influ-
descended from the H1N1 strain of influenza
enza in pigs.
that was responsible for the 2009 swine flu
• Influenza viruses that commonly circulate in
pandemic.
swine are called “swine influenza viruses” or
• It is infecting Chinese pigs & has the potential of
“swine flu viruses”.
triggering a pandemic.
• Like human influenza viruses, there are different
• G4 swine flu strain has genes similar to those in
sub–types & strains of swine influenza viruses.
the virus that caused the 2009 swine flu pan-
• While humans typically do not get infected by
demic.
such a virus that circulates among pigs, when
• It can grow & multiply in the cells that line the
they do, it is called “variant influenza virus”.
human airways.
• Human–to–human transmission among vari-
• The G4 strain has the capability of binding to hu-
ant influenza viruses is limited.
man–type receptors (like, the SARS–CoV–2 vi-
• Most commonly, humans may get infected by
rus binds to ACE2 receptors in humans)
such viruses due to exposure from infected
• It is able to copy itself in human airway epithelial
pigs.
cells, & it showed effective infectivity & aerosol
• The 2009 pandemic was caused by a strain of the
transmission.
Swine Flu called the H1N1 virus, which was
• Pigs are intermediate hosts for the generation of
transmitted from human to human.
pandemic influenza virus.
• The symptoms of swine flu include fever, cough,
What is the difference between Pandemic & sore throat, body aches, headaches, chills & fa-
Epidemic? tigue.
37
• Produced synthetically, HGH is the active ingre-
dient in a number of prescription drugs.
• Some people turn to a substance called human
growth hormone (HGH) in hopes that it will keep
them feeling & looking youthful.
About WADA
About NADA
38
is because the detector has a lower sensitivity • In 1905, Albert Einstein determined that the
than the LIGO detectors. laws of physics are the same for all non-ac-
celerating observers and that the speed of
Gravitational waves light in a vacuum was independent of the
motion of all observers.
• Gravitational waves are 'ripples' in the fabric
• As a result, he found that space and time
of space-time caused by some of the most vio-
were interwoven into a single continuum
lent and energetic processes in the Universe.
known as space-time.
(Spacetime:
• Events that occur at the same time for one
https://www.youtube.com/watch?v=sryrZwYguR
observer could occur at different times for
Q)
another. This was the theory of special rela-
• These ripples travel at the speed of light
tivity.
through the Universe, carrying with them infor-
• In 1915, Einstein published his theory of gen-
mation about their origins.
eral relativity. In it, he determined that mas-
• Albert Einstein predicted the existence of grav-
sive objects distort space-time, which is felt
itational waves in 1916 in his general theory of
as gravity.
relativity.
• Gravitational lensing and gravitational
• He observed that massive accelerating objects
waves are strong evidence for Einstein’s the-
(such as neutron stars or black holes orbiting
ory of general relativity.
each other) would disrupt space-time in such a
way that 'waves' of distorted space would radiate Gravitational lensing
from the source (like the movement of waves
away from a stone thrown into a pond). • Light around a massive object, such as a
• In 2015, LIGO (The Laser Interferometer Gravita- black hole, is bent, causing it to act as a
tional-Wave Observatory, USA) physically sensed lens for the things that lie behind it.
the distortions in spacetime caused by passing Source: space.com
gravitational waves generated by two colliding
Importance of gravitational waves
black holes nearly 1.3 billion light-years away!
39
too hot and not too cold for liquid water to exist • Luhman 16A is part of a binary system (Luhman
on the surface of surrounding planets. 16) containing a second brown dwarf, Luhman
• The planet was discovered using NASA’s Trans- 16B.
iting Exoplanet Survey Satellite (TESS), the • This pair of brown dwarfs Luhman 16A and Luh-
first Earth-sized planet that has been discovered man 16B orbit each other.
since the satellite was launched in April 2018. • It is situated at a distance of about 6.5 light
years from the Sun and the third closest system
{Sci – Space – 20/05} Luhman 16: Binary to the Sun after Alpha Centauri and Barnard’s
Brown Dwarf System star.
40
component stars to be directly deter- 1. Sun
mined, which in turn allows other stellar param- 2. Sirius
eters to be indirectly estimated. 3. Alpha Centauri
What are the closest stars to the Sun? {Sci – Space – 20/06} Potentially Hazardous
Asteroid (PHA)
• Alpha Centauri is the third brightest star in the
sky (4.37 light-years away). IE | GS3 > Awareness in the fields of Space | Down-
• Alpha Centauri is not one star, it is a system of load “Solar System PDF” | Read Online on
three stars ― Alpha Centauri A & B and Proxima Pmfias.com
Centauri. Context
• Alpha Centauri A and Alpha Centauri B are a bi-
nary pair, orbiting a common centre of gravity. • NASA has announced that an asteroid named
• Alpha Centauri A is a little more massive than the 2002 NN4 is expected to pass Earth on 6th June
Sun, & Alpha Centauri B is slightly less massive. 2020.
• Proxima Centauri is the faint red dwarf • The asteroid is a Near-Earth Object and classi-
star, and it is the closest star to our Sun (4.24 fied as a Potentially Hazardous Asteroid
light-years away). (PHA).
• Proxima Centauri has been the nearest star for • The asteroid is estimated to be between 250-570
about 32,000 years. meters in diameter.
• After 33,000 years from now, the nearest star will
Near-Earth Objects (NEOs)
be Ross 248.
• Alpha Centauri is only visible in the Southern • NEOs are comets and asteroids whose orbits
Hemisphere. are brought close to the earth’s neighbourhood
• In the Northern Hemisphere, the closest visible by the gravitational influence of the nearby plan-
star is Barnard’s Star, another red dwarf which ets.
is too dim just like Proxima Centauri to see with
the unaided eye. Asteroids
• The closest star that you can see with the naked
• Asteroids are remnants of planetary formation
eye in the Northern Hemisphere is Sirius (Dog
that circle the Sun in a zone lying between Mars
Star).
& Jupiter.
• Sirius is the second brightest star when viewed
• The circular chain of asteroids between Mars and
from the earth, the brightest being the sun.
Jupiter is called the asteroid belt.
Closest Stars
41
• Asteroids (planetoids) are composed mainly of Kuiper belt
refractory rocky and metallic minerals, with some
• The Kuiper belt is a great ring of debris similar to
ice.
the asteroid belt but consisting mainly of objects
• Asteroids range in size from hundreds of kilome-
composed primarily of ice.
tres across to microscopic.
• It extends between 30 and 50 AU from the Sun.
• Ceres (2.77 AU) is the largest asteroid (946 km
in diameter), a protoplanet, and a dwarf planet. Oort Cloud
42
• A meteoroid is any solid debris originating from • This impact made a huge explosion and a crater
asteroids, comets or other celestial object and about 180 km across (E = mc2 ➔ more speed =
floats through interplanetary space. more energy).
• A meteor is the streak of light that appears in the • Debris layer in the atmosphere blocked sunlight
sky when a meteoroid enters the atmosphere for months and led to impact winters that lasted
(mesosphere) at about 200 km at high speed for years, leading to the extinction of roughly 3/4
and burns up because of the friction. of species that existed at that time, including the
dinosaurs.
• Tiny mammals that lived in burrows survived.
Hence mammals replaced giant reptiles after the
impact.
• Many asteroids of this type cross Earth's orbit
every now and then.
• In some cases, the meteoroid does not burn up • Some of these could potentially hit Earth in the
completely and makes its way to the Earth’s future.
surface. Related: {Sci – Space – 19/12/03} Asteroid Impact
• The surviving chunk is called a meteorite. Deflection Assessment (AIDA)
• The depression created on the earth’s surface af-
ter the meteorite’s impact is called as a meteor-
ite crater. ✓ If you purchased these notes from
Chicxulub crater Pmfias.com, you have recognized and val-
• Chicxulub crater (Mexico's Yucatan Peninsula) ued our work and have done us a lot of
was caused by a meteorite impact that is be- help. We really appreciate that :)
th
lieved to have wiped out the dinosaurs (5
✓ If you got these notes from elsewhere,
mass extinction at the end of the Cretaceous 65
then you can do your bit by making a vol-
million years ago).
untary contribution from here
https://imjo.in/5Gp8f5. Thank you in ad-
vance :)
43