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2004-10-28

Järnbristanemi Sekundär anemi Megaloblastanemi Hemolytisk anemi


(hemolytiskt inslag finns)
Perifera blodet

Retikulocyter N ( - ↓) N N ↑
MCV ↓ N(-↓) ↑ Varierar
Erytrocyter Hypokroma, anisocytos, Oftast ua Ofta varierad bild, många Ofta varierad bild, många
poikilocytos olika förändringar olika förändringar
Serum/plasma

Fe ↓ ↓ ↑ ↑
TIBC/Transferrin ↑ ↓ N-↓ N(-↓)
Järnmättnad ↓ N N ↑
Ferritin ↓ N-↑ ↑ ↑
Haptoglobin ↓ ↓
LD ↑ ↑
Bilirubin ↑ ↑
Homocystein
↑ N
Metylmalonsyra
↑ N
B12
Folsyra ↓-N(-↑) N
↓-N N
Benmärg

Cellhalt Normal Normal ↑ ↑


Erytropoes Normoblastisk Normoblastisk Megaloblastisk Normoblastisk
Depåjärn ↓↓ ↑(-N) ↑ ↑
Sideroblaster ↓↓ ↓↓ ↑ ↑
Myelopoes N Vänsterförskjuten N – ibland jätteformer N

Johan Hultdin, Medicinsk biovetenskap, klinisk kemi


2004-10-28

Iron deficiency anemia Secondary anemia Megaloblastic anemia Hemolytic anemia


(hemolytic signs)
Peripheral blood

Reticulocytes N ( - ↓) N N ↑
MCV ↓ N(-↓) ↑
Erythrocytes Hypochromic, anisocytosis, Often normal Often varied picture, many Often varied picture, many
poikilocytos different changes different changes
Serum/plasma

Fe ↓ ↓ ↑ ↑
TIBC/Transferrin ↑ ↓ N-↓ N(-↓)
Iron saturation ↓ N N ↑
Ferritin ↓ N-↑ ↑ ↑
Haptoglobin ↓ ↓
LD ↑ ↑
Bilirubin ↑ ↑
Homocysteine
↑ N
Methylmalonic acid
↑ N
B12
Folate ↓-N(-↑) N
↓-N N
Bone marrow

Cellularity Normal Normal ↑ ↑


Erythropoesis Normoblastic Normoblastic Megaloblastic Normoblastic
Storage iron ↓↓ ↑(-N) ↑ ↑
Sideroblasts ↓↓ ↓↓ ↑ ↑
Myelopoesis N Left shift N – sometimes giant forms N

Johan Hultdin, Medicinsk biovetenskap, klinisk kemi

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