1.

The Evaluation of Ovarian reserve should be conducted in :

 Women ageless than 30 years old
 Women with adenomyosis
 Severe Oligoas the noteratozoospermia
 Female leukemia survivor after chemotheraphy
 Women with history of ovarian hyperstimulation syndrome

2. In the two cell gonadotropin theory, the main product of theca cell is :
 Estrogen
 Progesterone
 Insulin like growth factors
 Prostagiandins
 Androgen

3. The decrease of progesterone in the end of menstrual cycle will lead to :

 The decrease of plasminogen activator inhibitor activity
 The activation of metallic proteinases
 The blocking of metallic proteinases
 The decrease of prostaglandin activity
 The decrease of inflammation activity

4. For clinical purpose, the assessment of hyperandrogenism may be done by

 Measurement of free androgen index
 Measurement of free testosterone
 Assessing clinical evidence of hirsutism
 Assessing clinical evidence of polycystic ovaries
 Assessing clinical evidence of acanthosis nigricans

5. Compared to normally cycling women, those with PCOS generally exhibit.

 Increased serum LH and low to normal FSH level
 Decreased serum LH and decreased LH/FSH ratio
 Decreased LH/FSH ratio and increased estrogen
 Decreased IGF-I and high FSH
 Increased LH/FSH ratio and decreased androgen.

6. The example of WHO group I anovulation is :

 In female cancer survivor after cyclophosphamide chemotherapy
 Excessive weight loss due to strenuous exercise
 Congenital adrenal hyperplasia which lead to hyperandrogenism
 Tumor of the hypophysis
 Turner’s syndrome

7. The LH surge will lead to

 Ovulation at the same time with LH surge
 Arrest of melosis I
 Condensation of cumulus cells to oocyte
 Disconnection of granulosa cell
 Inhibition of oocyte maturation inhibitor (OMI)
8. The polypeptide hormones regulate their activity using :
 The conformational change inside cytoplasm
 The internalization process
 The binding affinity with specific protein
 The coupling with cyclic AMP
 The content of kinase enzyme

9. The proper definition of amenorrhea is :

 In women who have menstruated previously, no menses for an interval of time
equivalent to a total of at least three previous cycles or no menses over a 3 month
period.
 No menses by age 16 regardless of the presence of normal growth and development
of secondary sexual characteristics
 No menses by age 16 in the absence of growth or development of secondary sexual
characteristics
 In women who have menstruated previously, no menses by age 16 in the absence of
growth or development of secondary sexual characteristic
 All no menses in non-pregnant women

10. The example of short loop feedback in the endocrinologic regulatory mechanism is :
 From androgen to hypothalamus
 From hypophysis to hypothalamus
 From hypothalamus to hypothalamus it self
 From one cell to adjacent cells
 From TRH to TSH

11. The hormone may act on the neighboring target cells without entering circulation, and it is
called :
 Endocrine communication
 Autocrine communication
 Interactive communication
 Exorcise communication
 Paracrine communication

12. According to the 2018 FIGO system for abnormal bleeding, the normal duration of menstrual
flow is :
 Less than or equal to 8 days
 5-7 days
 Less than 10 days
 1-7 days
 2-10 days

13. The disordered follicular development in PCOS was strongly suggested to be caused by :
 Excessive LH secretion
 Excessive estrogen secretion, leading to chronic anovulation
 Disorders of insulin metabolism which lead to increased SHBG production
 High AMH metabolism which lead to decrase its activity
 Short feedback disorder between LH and GnRH
14. Polypeptide hormone which helps gonadotrophin actions in theca and granulosa cells is :
 Insulin-like growth factors
 Leptin
 Anti mullerian hormone
 Epinephrine
 Glucagon

15. The characteristics of adaptive immunity are as follows, except :

 Specificity
 Memory
 Diversity
 Tolerance
 Inflammation

16. According to the 2018 FIGO system for abnormal uterine bleeding, the menstrual cycle is
said to be frequent if :
 Occur in less than 21 days
 Occur in more than 38 days
 Occur in more than 35 days
 Occur in more than 9 days
 Occur in less than 24 days

17. The LH surge will lead to :

 Ovulation at the same time with LH surge
 Arrest of meiosis I
 Condensation of cumulus cell to oocyte
 Disconnection of granulosa cell
 Inhibition of oocyte maturation inhibitor (OMI)

18. In the implantation, on order to facilitate apposition, the embryo should :

 Loss contact with zona pellucida and hatch
 Develop two mass of cells i.e inner and outer cell mass
 Express progesterone receptors
 Develop pinopodes
 Express a full set of human leukocyte antigen (HLA)

19. Most aromatase activity for estrogen production occurred in :

 Luteal cells
 Cumulus cells
 Granulosa cells
 Theca cells
 Lactotroph cells

20. The main strategy in prevention of osteoporosis daring menopause at period is :

 High calcium intake during perimenopausal period
 Attain highest peak bone mass during perimenopausal period
 Attain highest peak bone mass during premenopausal period
 High parathyroid hormone intake during premenopause
  High vitamin D intake during premenopausal period.

21. The sign of estrogen exposure in puberty is :

 Breast development
 Fat deposit in Iep
 Public Hair development
 Menarche
 Linear long bone development

22. The hypothalamic hormone which control the lphysiological effect of prolactin is :
 Gonadotrophin teleasing hormone
 Somatostatin
 Kisspeptin
 Leptin
 Dopamin

23. The measurement of ovarian reserve is conducted in :

 Women aged >30 years old
 Woman with history of poor response in previous ovarian stimulation
 Women aged 20-35 years old
 Woman with history of deep infiltrating endometriosis
 Woman with history of adenomyosis

24. Blastocyst has capability of

 Secreting hCG
 Secreting prostaglandin
 Secreting progesterone
 Secreting chemokines
 Secreting IGF-H

25. The enzyme that take an important role in endometrial shedding

 Metalloproteinase
 Aromatase
 5 alpha reductase
 17 hydroxysteroid dehydrogenase
 Tyrosin kinase