ANTICANCER

DRUGS

SUBMITTED BY: Resident Pharmacist Ahsan

Shehzad

SUBMITTED TO: Principal Pharmacist Bushra Anjum

 1. FOLATE ANTAGONISTS: METHOTREXATE, PEMETREXED,
ANTIMETABOLITES PRALATREXATE
2. PURINE ANTAGONISTS: 6-MERCAPTOPURINE, 6-THIOGUANINE,
AZATHIOPRINE, FLUDRABNE
3. PYRAMIDINE ANTAGONISTS: 5-FLOURUURACIL, CYTARABINE,
CELL-CYCLE CAPECITABINE, GEMICITABINE
SPECIFIC
DRUGS (CCNS)
ANTICANCER DRUGS

ANTIBIOTICS ANTITUMOR: BLEOMYCIN, PLICAMYCIN, VALRUBICIN

MICROTUBULE (MITOTIC)
DOCETAXEL, PACLITAXEL, VINCRISTINE, VINBLASTINE, VINORELBINE
INHIBITORS

TOPOISOMERASE ETOPOSIDE, IRINOTECAN, TENIPOSIDE, TOPOTECAN

IHIBITORS

1. NITROGEN MUSTARDS: MECHLORETHAMINE, CYCLOPHOSPHAMIDE,

IFOSFAMIDE, CHLORAMBUCIL, MEPHALAN
2. ETHLENIMINE: TIO-TEPA
ALKYLATING AGENTS 3. ALKYLSULPHONATE: BUSULFAN
4. NITROSUREAS: CARMUSTINE, LOMUSTINE
5. TRIAZINE: DARABAZINE, TREMOZOLOMIDE
6. METHYLHADRAZINE: PROCARBAZINE
CELL-CYCLE
7. PLATINUM: CARBOPLATIN, CISPLATIN, OXALIPLATIN
NON-SPECIFIC
DRUGS (CCNS)
1. ANTHRACYCLES: DAUNORUBICIN, DOXORUBICIN, EPIRUBICIN,
ANTIBIOTICS IDARUBICIN, MITOXANTRONE
2. ANTITUMOR: DACTINOMYCIN, MITOMYCIN
 ANTIANDROGENS FLUTAMIDE, BICALUTAMIDE

AROMATASE INHIBITORS LETROZOLE, ANASTROZOLE, EXEMESTANE

GLUCOCORTICOIDS PREDNISOLONE AND OTHERS

SERMS TAMOXIFEN, TOREMIFENE

ESTROGEN ETHINYL ESTRADIOL, FOSFESTROL

ANTICANCER DRUGS

HORMONAL
THERAPY
SER-DOWN REGULATOR FLUVESTRANT

5-ALFA REDUCTASE
FINASTERIDE, DUTASTERIDE
INHIBITORS

GnRH ANALOGUES NAFARELIN, LEUPRORELIN, TRIPTORELIN

PROGESTINS HYDROXY-PROGESTERONE ACETATE AND OTHERS

MISCELLANEOUS ASPARAGINASE, BEXAROTENE, ERIBULIN, EVEROLIMUS, HYDROXYUREA, IXABEPILONE, LENALIDOMIDE, METOTANE,

OMACETAXINE, POMALIDOMIDE, TAGRAXOFUSP, TELOTRISTAT, TEMSIROLIMUS, THALIDOMIDE, VENETOCLAX
 ANTICANCER DRUGS

TYROSINE KINASE INHIBITORS

GEFITINIB
5

SORAFENIB
ERLOTINIB
SUNITINIB

10
PAZOPANIB
ICOTINIB 8
9
2 3 VANDETANIB IMATINIB
4 6 7
TRAMETINIB
CRIZOTINIB AXITINIB
LAPATINIB
AFATINIB ERDAFITINIB
LARTOTRECTINIB PRALSET TEPOTINIB
CABOZANTINIB INIB
ALECTINIB
COBEMETINIB
OSIMERTINI NERATINIB REGORAFENIB
RIPRETINIB
B
CERTINIB APATINIB
BINIMETINIB
DACOMITINI PYROTINIB
B
LENVATINIB
BRIGATINIB
ENTRECTINIB ANLOTINIB SELPERCA CAPMATINIB PEMIGATINIB
TINIB AVAPRITINIB
ALMONERTI
TUCATINIB SELUMETINIB
NIB LORLATINIB FRUQUINTINIB
 EGFR INHIBITORS CETUXIMAB, PANITUMUMAB, NECITUMUMAB

HER2/Neu INHIBITORS TRASTAZUMAN, PERTUZUMAB

PDGF RECEPTOR OLARATUMAB

INHIBITORS

VEGF INHIBITORS BAVACIZUMAB

MONOCLONAL VEGF RECEPTOR RAMUCIRCUMAB

ANTICANCER DRUGS

ANTIBODIES INHIBITORS

PD-1 INHIBITORS
NIVOLUMAB, PEMBROLIZUMAB

PD-1 LIGAND
ATEZOLIMUMAB, DURVALUMAB, AVELUMAB
ANTAGONISTS

CTLA4 INHIBITORS IPILIMUMAB, TREMELIMUMAB

CD20 INHIBITORS RITUXIMAB, OFATUMUMAB, OBINITUZUMAB

OTHERS ALEMTUZUMAB, DINUTUXIMAB

DIFFERENTIATING
1. RETINOIDS: TRETIOIN
AGENTS
2. HISTONE DEACETYLASE INHIBITORS: BELINOSTAT, PANOBINOSTAT, ROMIDEPSIN, VORINOSTAT