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Hypothyroid Testing
Hypothyroidism is an under-diagnosed condition. Find out how you can
identity symptoms and make changes to get well!
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10 Things You Need to Know About Your Thyroid
Most of us are no stranger to a little bit of fatigue now and then, a few
pounds we wouldn’t mind losing, the occasional irregular period, or blue mood.
But if you are struggling with any of these on a regular basis, with some
severity, or a cluster of these symptoms, your thyroid function may be the
culprit.
Your thyroid gland is the thermostat regulating energy for your entire body. It
controls everything from your mood to your menstrual cycles to your
metabolism – and about a thousand other biological functions – including how
efficiently you burn calories and how easily you lose weight.
Through a series of chemical reactions, the thyroid gland takes iodine and
repurposes it into fuel for numerous important functions throughout your
entire body. This fuel starts out mostly in the form of the inactive hormone
Free T4 which is then supposed to be converted as needed into the active
form of the hormone called Free T3 – which does the heavy lifting!
Fast Fact
With an underactive thyroid, you might experience fatigue, constipation, dry
skin, brain fog or trouble concentrating, depression, anxiety, hair loss,
depression, joint and muscle aches (even carpal tunnel syndrome and
tendonitis!), generalized swelling, cold intolerance (or you always feel a little
cold) dry skin, even an excessively low heart rate.
If you feel unusually blue in the year after the birth of your baby, or at any
time, and especially if you have any of the above symptoms, get tested for
thyroid problems!
underactive thyroid.
Say what? Yes, it’s true. Hypothyroidism can lead to high cholesterol because
slower metabolism isn’t burning up your fat. So before you go on special diet
or a statin drug to control your cholesterol – get your thyroid levels checked.
The answer might be in finding the root cause – a thyroid problem!
Thyroid problems may affect as many as 10% of women – but for many of
these women, the labs tests that doctors currently use, and the way those
tests are interpreted, leads many women to be told that they don’t have a
thyroid problem, and in fact, they are just fine.
THIS TRANSLATES AS: “This is all in your head because I, with my medical
degree, cannot find a darned thing wrong with you, Lady.” And this often
results in an antidepressant prescription. I check the following labs on my
patients in whom I, or they, suspect thyroid problems:
TSH
Free T3
Free T4
Thyroid Peroxidase Antibodies
(TPOAb)
Thyroglobulin Antibodies (TgAb)
Reverse T3
Tuning up your thyroid gland will rev up your metabolism and burn calories
without you having to do anything extra. If you’ve tried diet after diet, exercise
program after exercise program without success, it might be time to tap into
the root causes – and hypothyroidism might just be one of them.
Make sure your diet and your daily supplements provide you with iodine,
selenium, and zinc which are three key nutrients needed by the thyroid gland
for basic functioning. Sea vegetables such as 1 tablespoon of dulse flakes daily
provides you with a nice dose of iodine, just 1-2 Brazil nuts each day provide
you with ample selenium, and zinc is found in beef, oysters, dark meat chicken,
cashews, pumpkin seeds, almonds, yogurt, and many other sources.
If you are having a hard time regulating your thyroid function, even with
medications and a supportive doc, look for sources of these in your life and
try to reduce/eliminate exposure.
Thyroid problems can be fixed! I help women to achieve healthy thyroid function in my
practice every day. In most conventional medical practices, you may have to advocate
for yourself in the doctor’s office to get the testing you need.
Just recently a patient came into my practice feeling fatigued, moody, was having
heavy periods, no libido, and was bothered by constipation. She also wasn’t sleeping
well – waking up too early in the morning and unable to fall back to sleep, and she’d
gained 7 pounds in just a couple of months even though she hadn’t changed her eating
habits.
We talked. She really didn’t feel that stress was causing her symptoms – nothing in her
life was really that troublesome. She had no outlier symptoms that suggested another
diagnosis. She was pretty sure something was wrong with her thyroid so she’d asked
her primary doctor to check her thyroid labs before scheduling to come see me for an
more integrative medicine consult. He’d checked her thyroid stimulating hormone (TSH)
test only, and told her that since it was still in the normal range, even though it was at
the upper end of normal, she did not have a thyroid problem. He sent her on her way
suggesting that maybe an antidepressant would be good to consider.
But her labs weren’t normal. One step over a very thin line and she’d have had a slam
dunk diagnosis of the most common thyroid problem: hypothyroidism. And in fact, this is
what I diagnosed. She started appropriate treatment and her energy and symptoms
quickly began to improve!
While not all hypothyroid-like symptoms turn out to be a problem with the thyroid or
thyroid hormones, we do know that statistically, hypothyroidism is an under-diagnosed
condition. In fact, only about half of Americans with a thyroid problem know they have
one, and it is estimated that this can be as many as 4-10% of Americans
When your thyroid is not functioning optimally, you can feel dull, tired, constipated, gain
weight, your skin gets dry, your hair can become dry and even fall out, muscles and
joints might ache, your periods become irregular, you might have fertility problems,
brain fog, sugar and carb cravings (because your body is desperate for energy!), high
cholesterol even if your diet is amazing, and other large to small symptoms.
What is Hypothyroidism?
• Fatigue
• Increased sensitivity to cold
• Constipation
• Dry skin
• Unexplained weight gain
• Cravings for sugar and carbohydrates
• Puffy face
• Muscle weakness
• Elevated blood cholesterol level
• Muscle aches, tenderness and stiffness
• Pain, stiffness or swelling in your joints
• Heavier than normal or irregular menstrual periods
• Thinning hair
• Slowed heart rate
• Depression
• Impaired memory (“Brain fog”)
There are 6 key tests that can unlock the mystery of your thyroid function and are what
your doctor should be looking at. Thyroid testing should be simple to obtain from your
primary doctor or local lab.
However, the nuances may take some skill to interpret, depending on the results, and
your doctor might be resistant to ordering more than the TSH test. That’s where an
open-minded endocrinologist or a skilled Functional Medicine doctor can be of help!
In my practice, if my patient’s
symptoms are highly suggestive
of hypothyroidism, I will run the
entire thyroid panel described
below right up front. If there are
other diagnoses that are equally
likely, I will run just the first 3
tests (Panel 1), and if these
come back borderline or positive
for thyroid or thyroid hormone
problems, I will then add in the
remainder of the test panel
(Panel 2). I will also sometimes
recheck test results for TSH,
FT3, and FT4, if normal in a
newly symptomatic patient, in
6-12 weeks, because I’ve occasionally seen initial testing be normal then a short time
later, voila – the tests come back confirming the problem.
Thyroid Stimulating Hormone (TSH) is produced in a part of your brain called the
pituitary gland. The job of TSH is to tell the thyroid gland that it’s time to get busy
producing more thyroid hormone. When the healthy thyroid gets this chemical message,
it produces two hormones: triiodothyronine (T3) and thyroxine (T4),
The normal range for TSH is somewhat controversial. Most labs consider the upper
range to be between 4 and 5 mU/L. However, many experts – even in conventional
endocrinology – believe that the upper end of normal is actually more like 2.5-3 mU/L.
This is based on the fact that when Americans without any hypothyroid symptoms have
this test done, that is the most usual upper range.
Many integrative and functional medicine doctors find that their patients feel their best
at an upper limit of 1.5-2 mU/L.
My patient was one of these people. At a TSH of 4 she was really at the upper limit of
normal, over the preferred upper limit according to some docs, and well over the 1-2
mU/L upper range! This controversy and discrepancy of opinion over the normal upper
range for TSH is one of the most common reasons that women get under-diagnosed
for hypothyroidism and suffer with unnecessary symptoms that can seriously interfere
with health and quality of life.
In most cases hypothyroidism occurs because the thyroid gland is sluggish – that is, it is
having trouble producing T3 and T4. This can be due to a variety of reasons ranging
from nutritional deficiencies to autoimmunity. So TSH gets pumped out in a higher
amount to try harder to stimulate the thyroid gland into action. Think of it like this: You
are TSH. Your best friend’s house is the thyroid gland. When you go to visit your friend
you knock on her front door. If she doesn’t answer, what do you do? You knock louder to
get a response. In just the same way, the TSH amps up to knock louder, hoping to get
When stress is suppressing the pituitary gland enough to interfere with producing TSH,
you might see low or normal TSH levels in the presence of low thyroid hormone
production (T3 or T4), and hypothyroid symptoms.
Triiodothyronine (T3) and thyroxine (T4) are the hormones produced by your thyroid
gland. T4 is produced in a much larger amount and is then converted to T3, the active
form of the hormone, as needed to up-regulate metabolic functions. T3 and T4 are
sent out into your bloodstream where they are responsible for the thyroid’s actual work
of controlling your metabolism. Free T3 (FT3) and Free T4 (FT4) are called this
because they are not bound to proteins in your blood, making them free to perform
their work in your cells – keeping your metabolism appropriately revved up for your
optimal health.
Measuring FT3 and FT4 is important because they are the indicators of thyroxine and
triiodothyronine activities in the body. A high TSH and low FT4 and FT3 indicate
hypothyroidism. A normal TSH, normal FT4, and low FT3 can indicate T4 to T3
conversion problems, and a normal or high TSH, normal FT4 and high FT3 can indicate
cellular resistance to FT3 which can still lead to hypothyroid symptoms because the
active hormone can’t get to the cell to do its job.
The two thyroid antibody tests that I order are Thyroid peroxidase antibody (TPOAb)
and Thyroglobulin antibody (TgAb). Some people do have an autoimmune thyroid
condition but don’t initially test positive.
If positive, antibody testing can be repeated every six months to trend improvement
while you are working with an integrative physician to address possible underlying
causes.
Reverse T3 is the third most abundant form of thyroid hormone. When your body
wants to conserve – rather than “burn” – energy, it will divert the active T3 into an
inactive “reserve” form. This might happen when you are sick, under stress, or
undernourished. If TSH and FT4 look ok, but FT3 is low this can be because it is being
diverted into rT3 – which will be elevated. It is worth checking rT3 if there are obvious
symptoms suggesting hypothyroidism, but the typical tests aren’t demonstrating low
TSH or low FT4.
There is some controversy amongst conventional doctors about the utility of this test –
I personally find it very useful.
If labs return showing that there is hypothyroidism, then I also test for deficiencies of
selenium, iron, and zinc and make sure there is adequate dietary intake or
supplementation if needed, and look for environmental factors that can interfere with
iodine utilization, for example, fluoride and bromide exposures from water and flame-
retardant products, respectively. I will then also start to look more closely for other
underlying causes, for example, gluten intolerance, heavy metal exposure, and other
environmental triggers.
As a doctor, I can tell you that in medical school we are taught that doctors know best.
But this is often not the case. You are your body’s best expert. After all, you live with
you all the time! And you have a right to ask for basic testing and receive it. We’re not
talking about tens of thousands of dollars in MRI’s and CT scans here – we’re talking
about modest amounts of blood work.
That said, do discuss your symptoms with your doctor because there’s a lot of hype in
the natural medicine and natural products world, and your doctor is possibly just trying
to protect your from the opposite problem – getting OVER-diagnosed or misdiagnosed
with a thyroid problem – and believe me, I’ve also had many patients who were put on
thyroid medications by integrative practitioners when these meds were not needed.
If you can’t, then figure out whether the obstacle is in your being unable to speak up
because of a perceived power differential (many of us become weak in the knees when
we face our doctors, especially if we feel vulnerable about our health) or whether your
doctor is just not communicating respectfully. And make the change!
It’s dark and it’s late. You’re coming out of a club in the city heading back to your car,
which is parked on a poorly lit side street. About 50 yards from your car door, you
notice a man crossing the street toward you. Nobody is on the street.
Your heart is racing, and your muscles tighten. You are on red alert. Should you run?
Prepare to fight? Your keys are already in your hand – you could use them to defend
yourself. Your fingers clench so tightly around the keys that you feel them digging
into your palm. You recognize this feeling. It’s terror.
Now closer to you, you hear the man’s footsteps stop and from the corner of your
eye you catch light coming from an open apartment building door. You hear laughter.
You turn your head slightly and see a woman step out of the building. She embraces
that man. More laughter…
Your shoulders drop, your breathing relaxes after a huge exhale accompanied by a
nervous and relieved chuckle. You release the grip on those keys clenched in your
hand. You’re safe.
When the danger is done, your body is designed to quickly recover without any lasting
damage. The extra blood sugar gets swept up into your cells by the insulin, your blood
vessels relax, and blood flow returns to your gut and reproductive hormones once again
get released in normal amounts. All of the numerous changes caused by the activation
of the HPA axis return to normal.
Thankfully, most of us do not find ourselves on dark roads thinking we’re being followed
too often. However, most of us do experience more minor levels of stress on a day-to-
day basis that keep us in survival mode. And if we’ve had past trauma of any
magnitude, even relatively small, we are more primed to perceive situations as
threatening.
Here are just a handful of situations that keep us in chronic survival mode. I’m
sure you can probably relate to one or more:
These are all real stressors that activate the HPA axis – and are even more activating if
you’ve been fired from a job, experienced a relationship trauma as a child or adult,
been exposed to vulnerability due to severe financial stress, or any other stressful past
trauma, or perceived potential disaster.
When chronically activated, the HPA axis puts us in a state of on-going survival mode,
and this can have a huge impact on numerous aspects of our health, leading to:
I want to emphasize the connection between being stuck in survival mode, and its effect
on thyroid function, and offer you tools to heal both.
Your thyroid gland, the butterfly shaped small organ at the front of your neck, performs
literally hundreds, if not thousands, of essential functions related to growth, metabolism,
hormonal control, and utilizing and conserving energy depending on what your body
needs moment to moment. Your adrenal glands, two tiny triangular glands (I mean you
blinked you missed them small!) sitting atop your kidneys, control the hormones and
nervous system chemicals that regulate your stress response, immunity, blood
pressure, your reproductive hormones, and much more.
When you are under prolonged chronic stress your adrenal system tells your body to
conserve, rather than spend too much energy. Your thyroid slows down, too. It’s like a
warning system that protects you from over-drafting on your energy bank account.
Further, chronic adrenal stress has a major impact on your immunity – over time
increasing your risk of developing chronic inflammation and autoimmunity.
When you are under stress, immune system chemicals called inflammatory cytokines
(which have names like IL-1 beta, IL-6 and TNF-alpha) are released. These “down
regulate” (medical speak for decrease) the production of the key thyroid related
hormones TSH, T3, and T4, make the thyroid less sensitive to TSH which stimulates the
function of thyroid hormone production, and decreases the conversion of the inactive
form of the thyroid hormone T4 to the active form, Free T 3. Acute stress can do this
for days; chronic stress can make this a more regular state and in time, lead to thyroid
suppression – or hypothyroidism. Chronic inflammation also makes the thyroid hormone
receptors on your cells less sensitive to the active form of thyroid hormone, such that
thyroid hormone can’t do its job. This is called thyroid hormone resistance.
Remember how I also said that chronic stress diverts energy away from important
functions like your gut and your reproductive hormones? These can also have an
impact on your thyroid function.
Both of these gut changes can lead to a condition called leaky gut which makes you
more susceptible to all manner of food triggers and harmful gut bug triggers from
gluten to dairy to numerous other foods, and to developing a condition called
“endotoxemia,” all of which in turn can lead to inflammation in your body significant
Hashimoto’s thyroiditis is the most common autoimmune disease in the US, affecting far
more women than men, and rates are on the increase along with our stress levels! It’s
also a vicious cycle, because the more our body perceives stress due to inflammation,
the more the stress response system gets triggered. We pump out more cortisol, one
of our key stress and inflammation protection hormones, which in turn causes us to gain
more weight, break down muscle for fuel, and store extra fuel as harmful forms of
cholesterol.
Cortisol reduces our ability to clear estrogen from our system through our liver.
Increased estrogen up regulates (medical speak for increases) the production of a
carrier protein called thyroid binding globulin (TBG) which does exactly what it sounds
like – binds onto thyroid hormone. Bound forms of thyroid hormone are not very active
– so your thyroid function goes down even when your thyroid is pumping out the stuff
like it’s supposed to. The active free form just doesn’t get to your cells where it’s
supposed to do its good work.
The problem gets even more complex, because it’s part of the role of the thyroid to
metabolize cholesterol – so not only is your overworked or now exhausted adrenal
stress system causing you to produce more cholesterol, inefficient thyroid functioning is
preventing you from using it up. BOING: you end up with high cholesterol even if your
diet seems pristine!
Not to mention, you’ve either got the symptoms of hypothyroidism: fatigue, weight gain,
dry skin, constipation, thinning hair, irregular hormone function and menstrual or
gynecologic problems, and more, or you’ve actually developed Hashimoto’s!
Once you learn to recognize them, you can learn to respond quickly with a relaxation
response, rather than react with a prolonged stress response. See # 3 below for
relaxation response techniques.
that you can get out of survival mode and into a life that
This might mean saying no to some things you’ve taken on, rethinking how you approach
your work:life ratio, take more time for self care so you can have the resilience to cope
with what’s on your plate, rethink your economics to want less of what you don’t really
need and earn more so you can have what you do need, reaching out to friends
(oxytocin, the love hormone gets released when we connect with peeps we love, and
this is a counterbalancing hormone to the stress system).
We all need tools for on the spot stress reduction, and also regular self-care habits that
keep our nervous system well fueled for meeting life’s inevitable stresses. My favorite
exercise for traffic jams, the sudden urge to quit your job or throw something at your
boss is called “the quickie.” Here’s how to do it: Center yourself wherever you are, sitting
or standing or lying down, feeling the parts of your body touching the ground…just feel
that grounding with the earth. Breathe naturally at first, then after a few breaths, inhale
for 4 counts while saying I am in your mind. Then exhale for 4 counts while saying at
peace to yourself. Repeat this I am…at peace cycle at least 4 times.
So you’ve got to’ feed your head. Regularly. With protein, good quality fats, and carbs
from whole grains and veggies. My top tips for keeping your blood sugar steady are: eat
protein at breakfast, don’t skip meals, graze on high protein snacks if your blood sugar
tends to tank, and keep a healthy emergency food stash within reach.
reactions.
Adaptogens help your body to cope more effectively with the demands of everyday
life. They provide a sustained sense of calm, and while they increase energy, with the
Also, one of the definitions of adaptogens is that they are non-toxic, even with long-
term use. You can rely on these herbs to be safe and gentle.
Tupac, Nas, Lauren Hill…I mean, Holy Basil, Ashwagandha, Rhodiola, American Ginseng,
and Reishi.
Taking care of your stress system will help quiet down your inflammatory responses,
allowing your thyroid to more effectively produce thyroid hormones and revert
Hashimoto’s antibodies (I’ve seen this happen many times!), and allow your cells to
convert and use those thyroid hormones.
In the process, you’ll find yourself more energetic, resting better, losing those love
handles you just don’t love and couldn’t get a handle on, your cravings will fade, and life
will seem so much easier!
Dr. Romm's focus is on women’s and children’s health, with an emphasis on the impact
of stress on health, energy, food cravings, weight, chronic disease, and hormone
imbalance. She is also an avid environmental health advocate, focusing on the impact of
toxins on fertility, pregnancy, women’s hormones, chronic illness and children’s health.
Dr. Romm is one nation’s leaders in the field of botanical medicine and is the author of 7
books on natural medicine for women and children, including the textbook Botanical
Medicine for Women’s Health. She is also the integrative medicine curriculum author for
the Yale Internal Medicine and Pediatric Residencies.
Recently named by Mind Body Green as one of the 100 Women to Watch in Wellness,
Dr. Romm lives and practices medicine in Massachusetts and is a nationally sought
speaker, author, and consultant.