STOPS THE GUMBORO

CYCLE

Drh Fauzi Iskandar

Veterinary Services Manager
Ceva Animal Health Indonesia
Infectious Bursal Disease
❑ Virus : Avi-birnavirus
❑ Target organ : bursa of Fabricius (B - Lympocytes)
❑ Clinical form : Immunosupressive, Clinical and Subclinical
❑ First Described in the 1960’s in Gumboro, Delaware, USA.

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Infectious Bursal Disease

❑Transmission
❑Clinical Sign
❑Pathology
❑Diagnosis
❑Prevention

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Infectious Bursal Disease
❑Kekebalan pasif dari induk (MAB = Maternal Antibody)
❑Asupan Nutrisi
❑Faktor stress external atau factor imunosupresi
❑Kondisi Patogen Lapangan
❑Teknologi sediaan dan aplikasi vaksin yang digunakan

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Prevention
• Improved Management
• Improved Nutrient Intake
• Improved Biosecurity
• Improve Immune Status

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BIOSECURITY

• Hierarchy Of Biosecurity
• Routine managemental procedures

OPERATIONAL
• Lay Out Farms
• Erection of Fences
STRUCTUAL
• Contruction of drainage

CONCEPTUAL • Selecting the location

• Reduce biodensity
• Avoid contact with free-living birds
• Public roads and service facilities :
hatcheries, feed mills, processing plants
CHICKEN BROIILERS
( n = ~8,000,000,000 )
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BIOSECURITY

Biosecurity
❑ Red Zone – Yellow Zone – Green Zone
❑ Control of Free Living Birds
❑ Control of Rodents & Insect
❑ Decontamination and disinfection

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 INFECTION
GROWING
WANING OF
MDA

SHEDDING

DELIVERY
THE
GUMBORO
The Gumboro

CYCLE
DEPLETION

DOWN TIME
CLEANING /
Cycle

DISINFECTION
Poultry vaccine technology

Key aspects of poultry vaccines and vaccination

• Safety
• Efficacy
- Onset and duration immunity
- Broad and complete protection
• Compatibility with others vaccines
• Easy to handle and application
• Mass with individual application system

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CEVA INNOVATION AREAS

1. C.H.I.C.K Program results

• 35 Doc producers
• 134 hatcheries
• > 800 dovac machine
• > 550 visits in 2020
• 99,8% injection quality

2. Global Protection Service (GPS)

IBD Monitoring 1.200 broiler
flock since 2014

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BROILERS &
BREEDER LAYERS & COLOR
W 2512 FEATHER BROILERS
SYZA 26

ADAPTED FOR EACH TYPE OF BIRD

 Controlling
the Gumboro disease
Protecting the bursa against the infection is the most important
characteristic that the vaccines should accomplish, but there are
remarkable differences in between them.

ONLY VACCINES THAT REPLICATE IN THE

BURSA CAN BLOCK THE
live Gumboro vaccine

INFECTION
Objectives of

STOP the PREVENT the

STOPS
shedding of the challenge risk
field virus cycle after cycle

REINFECTION
PROTECT against
infection from any
type of IBDV strains
VACCINE VIRUS STRAIN
(SYZA 26)
 • Transmune stops the Gumboro Cycle, due a better uniformity on application,
and adapts to MDA levels;

% of the VACCINE is
MDA Date of Vaccination
NEUTRALIZED – Broilers
Variation is Imprecise
not protected

Why it
happens?

PARTIAL A HIGH % of Opportunity to FIELD

Coverage of the broilers NOT STRAINS to INFECT and
flock VACCINATED COLONIZE the bursa
 • A well-balanced IBD Immune–Complex vaccine must be
able to induce immunity facing a very diverse levels of
maternally-derived antibodies

« All Immune-complex vaccines are different »

 • Transmune stops the Gumboro Cycle with uniformity, due a
faster complete flock coverage;
“Transmune provides more uniform results”
• Better protection against all IBD challenge strains.
SPAIN

PCR
Other IM-Cx ROMANIA
 • Safe vaccine in all MDA levels (low, medium or high),
due the immune-complex technology.
“Transmune provides a safe protection”

a naked IBD live

« Different vaccine technologies» virus
Transmune is an
Immune-complex
Depends on MDAs to be coated after the
injection and prevent too early replication in the
young chick´s bursa

BURSAL
REPLICATION
Transmune is SAFE VERY
OCCURS

EARLY
 • Safe vaccine in all MDA levels (low, medium or high), due
the immune-complex technology.

Why SAFETY PROTECTION is important:

« Consistency protection,
allows good results
Transmune Naked IBD Transmune Naked IBD Transmune Naked IBD »

Transmune Naked IBD Transmune Naked IBD Transmune Naked IBD

 Compatibility study Vectormune ND® & Transmune®

• The vaccines can be administered either to 18-day-old broiler chicken embryos by the in ovo route or to day old broiler
chickens by the subcutaneous (sc.) route at the hatchery. Challenge strain: Herts 33/56, dose: 5log10 ELD50/ bird
• Vaccine-take was confirmed following in ovo and subcutaneous (sc.) vaccinations both in the lab and field studies by
characteristic histological lesions for IBD virus replication found in the bursa samples

GYURO, Z., et al., 2018. Combining Vectormune® ND and Cevac® Transmune® IBD in one injection provides early protection in broilers against ND and
IBD. 12th International Symposium on Marek´s Disease and Avian Herpes viruses, July 29th, August 2nd, Yangzhou, China
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TRANSMUNE
LEADERSHIP
120 billion
WORLDWIDE BIRDS VACCINATED

Transmune is a reference IBD vaccine

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THANK YOU

Fauzi Iskandar
Veterinary Services Manager

IBD CONTROL FROM THE HATCHERY

ALLOWS YOU TO RE-THINK YOUR
VACCINATION PROGRAM