CHE1009 BIOCHEMICAL L T P J C

ENGINEERING
3 0 0 0 3
Pre-requisite Nil Syllabus version
2.1
Course Objectives:

1. Impart the basic knowledge and overview of biotechnology covering the principles of cell and
kinetics, bioreactor design, sterilization agitation and aeration
2. Understand the physical processes involved in bio-systems
3. Apply the knowledge of chemical engineering principles to biological processes

Course Outcomes (CO):

1. Understand significance and scope of biochemical processes
2. Classify microorganisms and cell functions for industrial biochemical processes, enzyme and
kinetics for bioprocesses
3. Apply Chemical Engineering Principles to develop kinetic models for bioprocesses
4. Make use of theoretical basics of chemical engineering and unit operations in designing
bioprocess equipment
5. Analyze bioreactor performance
6. Distinguish downstream processing and biological Sewage treatment in solving open ended
chemical problems using biochemical route

Student Learning Outcomes (SLO): 1, 2, 9

1. Having an ability to apply mathematics and science in engineering applications
2. Having a clear understanding of the subject related concepts and of contemporary issues
9. Having problem solving ability- solving social issues and engineering problems

Module:1 Introduction to Biochemical Engineering 3 hours

An overview of industrial biochemical processes with typical examples comparing chemical and
biochemical processes – development and scope of biochemical engineering as a discipline.

Module:2 Basic microbiology and Biochemistry 5 hours

Industrially important microbial strains, their classification – structure – cellular genetics – typical
examples of microbial synthesis of biologicals

Module:3 Enzymes & Applications 8 hours

Enzymes - in industry, medicine and food – their classification with typical examples of
industrially important enzymes; Mechanism of enzymatic reactions – Michaelis Menten Kinetics –
enzymes inhibition factors affecting the reaction rates; Industrial production, purification and
immobilization – enzyme reactors with typical examples.

Module:4 Kinetics of Cell Growth 7 hours

Typical growth characteristics of microbial cells – factors affecting growth – Monod model;
Modelling of batch and continuous cell growth; Immobilized whole cells and their characteristics
– free cell and immobilized cell reactors; Typical industrial examples – transport in cells.

Module:5 Unit Operations in Biochemical engineering 6 hours

Newtonian and non-Newtonian behaviour of broth – agitation and mixing – power consumption;
Gas/liquid transport in cells – transfer resistances – mass transfer coefficients & their role in scale
up of equipment – O2 transfer; Heat transport in microbial systems – Heat transfer correlation’s;
Sterilization cycles; Heat addition & removal during biological production

Module:6 Bioreactors 8 hours

Bioreactors - Batch and continuous types, immobilized whole cell and enzyme reactors.
Highperformance bioreactors; Reactors in series with and without recycle. Design of reactors and
scale up with typical examples; Sterile and non-sterile operations.

Module:7 Downstream and effluent treatment processes 6 hours

Downstream processes and effluent treatment: Different Unit operations in down streaming with
special reference to membrane separations, extractive fermentation; Anaerobic and aerobic
treatment of effluents – typical industrial examples for downstream processing and effluent
disposal.

Module:8 Contemporary issues 2 hours

Total Lecture hours 45 hours

Text Books
1. Bailey J.B., Ollis D.F., Biochemical Engineering Fundamentals, 4th ed., McGraw Hill, USA,
1986.
Reference Books
1. Rao D.G., Introduction to Biochemical Engineering, 1st ed., Tata McGraw Hill, India, 2009.
2 Doran P.M., Bioprocess Engineering Principles, 3 rd ed., Academic Press, United Kingdom,
2013.
3 Aiba A, Humphrey A.E., Milli. N.R., Biochemical Engineering, 2nd ed., Academic Press,
USA, 2004.
Mode of evaluation: Continuous Assessment Test, Quizzes, Assignments, Final Assessment Test
Recommended by Board of Studies
Approved by Academic Council 47 Date 05.10.2017