Liver Investigation: Testing Marker Utility

in Steatohepatitis
Fact Sheet

Project Information

LITMUS Funded under

H2020-EU.3.1.
Grant agreement ID: 777377 H2020-EU.3.1.7.


Overall budget
€ 47 281 406,63
Start date End date
1 November 2017 31 October 2022 EU contribution
€ 15 797 881

Coordinated by
UNIVERSITY OF NEWCASTLE
UPON TYNE
  United Kingdom

Objective
Strongly associated with the epidemics of obesity and type 2 diabetes that are
testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is
an increasingly common cause of advanced liver disease that is characterized by
substantial inter-patient variability in severity and rate of progression. It is currently
assessed by liver biopsy, an invasive, costly and risky procedure. The lack of
noninvasive biomarkers has hampered patient care and impeded drug development
by complicating conduct of clinical trials.The overarching aim of LITMUS is to
develop, robustly validate and advance towards regulatory qualification biomarkers
that diagnose, risk stratify and/or monitor NAFLD/NASH progression and fibrosis
stage. This will be achieved through a goal-oriented, tri-partite collaboration
delivering a definitive and impartial evaluation platform for biomarkers, bringing
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together: (i) End-users of biomarker technologies (clinicians with expertise in NAFLD
and the pharmaceutical industry)? (ii) Independent academics with expertise in the
evaluation of medical test/biomarker performance? and (iii) Biomarker researchers
and developers (academic or commercial).

LITMUS has the demonstrable capability to fulfil the IMI call remit. Built upon
foundations laid by the EU-funded FLIP/EPoS projects and long-established,
successful scientific collaborations amongst many of Europe’s leading clinical-
academic centres, LITMUS is at a unique advantage due to its existing large-scale
patient cohorts, bioresources and multi-omics datasets. Consortium members are
internationally recognised experts with substantial relevant expertise supporting the
program’s clear focus on biomarker identification, validation and accelerating
EMA/FDA qualification. Thus, LITMUS is powered to provide clarity on biomarker
validity for NAFLD at scale and pace: supporting drug development and the targeting
of medical care and limited healthcare resources to those at greatest need.

Programme(s)

Topic(s)

Call for proposal

H2020-JTI-IMI2-2016-09-two-stage

Funding Scheme

Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE


Address Activity type EU contribution
Kings Gate Higher or Secondary € 2 938 036,25
NE1 7RU Newcastle Upon Education Establishments
Tyne
  United Kingdom

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Participants (55)

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 ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
  Netherlands

EU contribution
€ 1 180 910

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Meibergdreef 15 Higher or Secondary
1105AZ Amsterdam Education Establishments

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 INST CARDIOMETABOLISME NUTRITION ICAN

  France

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€ 684 250

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Boulevard De L'hopital 47-83 Research Organisations
75013 Paris

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 ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

  France

EU contribution
€ 260 500

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3 Avenue Victoria Research Organisations
75000 Paris

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 UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET

MAINZ
  Germany

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€ 1 073 015

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Langenbeckstrasse 1 Higher or Secondary
55131 Mainz Education Establishments

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 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF
CAMBRIDGE
  United Kingdom

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€ 598 005

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Trinity Lane The Old Schools Higher or Secondary
CB2 1TN Cambridge Education Establishments

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 OREBRO UNIVERSITY
  Sweden

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€ 312 500

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Fakultetsgatan 1 Higher or Secondary
70182 Orebro Education Establishments

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 ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS

  Spain

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€ 403 017,50

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Parque Tecnologico Edificio Research Organisations
801 A
48160 Derio Vizcaya

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 UNIVERSITAET BERN
  Switzerland

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€ 435 000

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Hochschulstrasse 6 Higher or Secondary
3012 Bern Education Establishments

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 THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF

OXFORD
  United Kingdom

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€ 1 818 750

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Wellington Square University Higher or Secondary
Offices Education Establishments
OX1 2JD Oxford

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 PERSPECTUM LTD
  United Kingdom

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€ 250 000

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Gemini One, 5520 John Smith Private for-profit entities
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 SERVICIO ANDALUZ DE SALUD

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18 Research Organisations and
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 NORDIC BIOSCIENCE A/S

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 EU contribution
€ 1 427 093

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Herlev Hovedgade 205-207 Private for-profit entities
2730 Herlev (excluding Higher or
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 LUXEMBOURG INSTITUTE OF HEALTH

  Luxembourg

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€ 540 033,75

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Val Fleuri 84 Research Organisations
1526 Luxembourg

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 UNIVERSITA DEGLI STUDI DI TORINO

  Italy

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€ 365 160,75

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Via Giuseppe Verdi 8 Higher or Secondary
10124 Torino Education Establishments

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 UNIVERSITE D'ANGERS
  France

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€ 122 500

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Rue De Rennes 40 Higher or Secondary
49035 Angers Cedex 01 Education Establishments

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   Belgium

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€ 167 100

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Drie Eikenstraat 655 Research Organisations
2650 Edegem

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 LINKOPINGS UNIVERSITET
  Sweden

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€ 99 600

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Campus Valla Higher or Secondary
581 83 Linkoping Education Establishments

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 HELSINGIN YLIOPISTO
  Finland

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 UNIVERSITAIR MEDISCH CENTRUM UTRECHT

  Netherlands

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   Greece

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 FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA

  Portugal

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 UNIVERSITA DEGLI STUDI DI MILANO

  Italy

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 UNIVERSITA CATTOLICA DEL SACRO CUORE
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 UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN

JULIUS-MAXIMILIANS-UNIVERSITAT
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 UNIVERSITAETSKLINIKUM AACHEN
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 THE UNIVERSITY OF NOTTINGHAM

  United Kingdom

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 MEDIZINISCHE UNIVERSITAET WIEN
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 ANTAROS MEDICAL AB
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€ 231 275

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 THE UNIVERSITY OF BIRMINGHAM

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 IXSCIENT LIMITED
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€ 344 375

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 Faculdade de Farmácia da Universidade de Lisboa

  Portugal

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Av. Prof. Gama Pinto Higher or Secondary
1649-003 Lisboa Education Establishments

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 EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER

  Switzerland

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€ 61 680

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1203 Geneve

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 GENFIT
  France

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€0

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885 Avenue Eugene Avinee Private for-profit entities
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 INTERCEPT PHARMA EUROPE LTD

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 ONE WAY LIVER SL

  Spain

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Bizkaia Edif 502 (excluding Higher or
48160 Derio Bizkaia Secondary Education
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 EXALENZ BIOSCIENCE LTD 

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 ELI LILLY AND COMPANY LTD

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 PFIZER LIMITED
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 BOEHRINGER INGELHEIM INTERNATIONALGMBH

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 SOMALOGIC INC
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 NOVO NORDISK A/S

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 ELLEGAARD GOTTINGEN MINIPIGS AS

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   United States

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 HISTOINDEX PTE LTD

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 ALLERGAN LIMITED
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 RESEARCH TRIANGLE INSTITUTE

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 TAKEDA PHARMACEUTICALS INTERNATIONAL AG

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Last update: 20 September 2021
Record number: 212225

Permalink: https://cordis.europa.eu/project/id/777377

© European Union, 2021

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