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Knee Surg Sports Traumatol Arthrosc

DOI 10.1007/s00167-014-3261-5

Knee

Predictive parameters for return to pre‑injury level of sport


6 months following anterior cruciate ligament reconstruction
surgery
Ulrike Müller · Michael Krüger‑Franke ·
Michael Schmidt · Bernd Rosemeyer 

Received: 24 October 2013 / Accepted: 21 August 2014


© European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2014

Abstract  distance (p = 0.005), crossover hop (p = 0.008) and triple


Purpose  The aim of the study was to find predictive hop (p = 0.001) were significantly lower, in addition to the
parameters for a successful resumption of pre-injury level ACL–RSI (p  = 0.013) and IKDC 2000 (p  = 0.037). The
of sport 6 months post anterior cruciate ligament (ACL) cut-off points for LSI single hop for distance were 75.4 %
reconstruction. (sensitivity 0.74; specificity 0.88), and for ACL–RSI 51.3
Methods  In a prospective study, 40 patients with a rup- points (sensitivity 0.97; specificity 0.63). Logistic regres-
tured ACL were surgically treated with semitendinosus sion distinguished between RS and nRS subjects (sensitiv-
tendon autograft. Six months after surgery, strength of ity 0.97; specificity 0.63).
knee extensors and flexors, four single-leg hop tests, Ante- Conclusions  The single hop for distance and ACL–RSI
rior Cruciate Ligament–Return to Sport after Injury Scale were found to be the strongest predictive parameters, assess-
(ACL–RSI), subjective International Knee Documentation ing both the objective functional and the subjective psycho-
Committee (IKDC) 2000 and the Tampa Scale of Kinesio- logical aspects of returning to sport. Both tests may help to
phobia-11 (TSK-11) were assessed. Seven months post- identify patients at risk of not returning to pre-injury sport.
operatively, a standardized interview was conducted to Level of evidence  II.
identify “return to sport” (RS) and “non-return to sport”
(nRS) patients. Logistic regression and “Receiver Operat- Keywords  Anterior cruciate ligament rupture · Operative
ing Characteristic” (ROC) analyses were used to determine reconstruction · Return to sport · Predictors
predictive parameters.
Results No significant differences could be detected
between RS and nRS patients concerning socio-demo- Introduction
graphic data, muscle tests, square hop and TSK-11. In nRS
patients, the Limb Symmetry Index (LSI) of single hop for The most common ligament injury of the knee joint is the
tearing of the anterior cruciate ligament (ACL) [9, 43]. In
Germany, approximately 35,000 ACL ruptures are reported
U. Müller (*) 
annually (raw incidence 45:100,000), with women being
Department of Orthopaedics, Physical Medicine
and Rehabilitation, University of Munich, Marchioninistrasse 15, more often affected than men [6, 22]. Most patients harm
81377 Munich, Germany themselves without direct physical contact, particularly in
e-mail: Ulrike.Mueller@med.uni‑muenchen.de sports involving pivoting, cutting and jumping [43]. About
28,000 ACL operations are performed in Germany per year
M. Krüger‑Franke · B. Rosemeyer 
MVZ Nordbad, Schleißheimerstrasse 130, 80797 Munich, [22]. Giving-way episodes, as well as the hope to regain
Germany full sport activities, are reasons to consider surgical therapy
[2, 6].
M. Schmidt 
With regard to the knee joint, sport activities can be
Department of Medical Informatics, Biometry and Epidemiology
of the Faculty of Medicine, University of Munich, classified into four levels [17]. Level I is comprised of
Marchioninistrasse 15, 81377 Munich, Germany sports that involve jumping, pivoting and hard cutting

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Knee Surg Sports Traumatol Arthrosc

movements, such as football or soccer [17]. Level II Materials and methods


describes activities such as tennis or skiing, level III
activities such as jogging, cycling or swimming and The study was designed as a prospective controlled trial
level IV activities of daily life. If patients want to return with a cohort of 40 patients after ACL reconstruction sur-
to their pre-injury sport level after surgery, the appro- gery. Patients underwent surgical treatment from July
priate time point for restarting is essential. Currently, 2011 to March 2012 at Medizinisches Versorgungszentrum
no scientifically established time point exists. Based (MVZ) Nordbad-Munich. All of the patients received the
on empirical data, a number of authors suggest return- same treatment and rehabilitation, according to a standard
ing to level I and level II sports approximately 6 months scheme [32]. The surgical treatment consisted of an arthro-
post-surgery [2, 13, 15, 29]. According to a review by scopic evaluation of the injured joint and the management
Barber-Westin et al. [5], one-third of the 264 analysed of the ruptured ACL in an anatomic single-bundle technique
studies considered the time factor as the only criterion, with a fourfold semitendinosus tendon and bioabsorbable
while only 13 % utilized individual-based objective cri- interference screw fixation (Matryx, Linvatec–Conmed).
teria. This is in line with a recently published review by Inclusion criteria were an isolated rupture of ACL, age
Petersen and Zantop [39]. between 18 and 65 years and the intension to return to
Objective criteria, for instance, include muscle strength their pre-injury level I or level II recreational sports [17].
and single-leg hop tests [5, 13, 16, 24, 33, 47]. Single-leg At the 6-month surgeon’s examination, the operated knee
hop tests allow for a more comprehensive assessment of joint had to be free of pain, without irritation, and had pas-
the functional capacity of the knee joint [29]. The single sively full range of motion. The Lachman and Pivot Shift
hop for distance, crossover hop for distance, triple hop for Test had to be positive. The patients had to be able to stand
distance and 6-m timed hop test are most often applied [5, and hop on the operated leg and did not report a subjective
13, 16, 24, 33, 47]. Assessed is the Limb Symmetry Index feeling of instability. They had to be able to perform level
(LSI), the ratio of the operated leg to the non-operated leg. III activities without symptoms. Permission for returning to
As a criterion for returning to sport, LSI values of muscle pre-injury sport level was given by the surgeon if the above
strength and/or single-leg hop tests above 85 % [5, 13, 24, clinical criteria were fulfilled.
33] or 90 % [5, 16, 24, 35, 47], respectively, are recom- Exclusion criteria were concomitant injuries, such as
mended. For participation in sport activities with frequent injuries involving lateral ligaments or menisci, adjacent
pivoting movements, a value of 100 % is suggested [47]. joints (hip or foot) or the contralateral leg. Patients with
Several authors have proposed decision criteria for return- other orthopaedic, internal, neurological or psychiatric dis-
ing to sport using special equipment [5, 13, 16, 24, 33, 47]. eases, as well as pregnant women, were excluded.
However, their implementation into daily clinical routine From a cohort of 186 operated ACL patients, 112 were
is not possible. Myer et al. [35] took this into account by excluded due to concomitant or prior injuries or because
defining three single-leg hop tests as part of a test battery to of age [23]. Fifty-nine of the remaining 74 patients could
evaluate the operated knee. be contacted for the 6-month examination. Eleven of these
There is strong evidence that psychological factors, patients had not performed any level I and level II sports
such as fear of pain, fear of re-injury and deficient confi- before surgery. The remaining 48 patients were informed
dence, have a great influence on returning to sport [2, 4, about the study and asked whether they would be willing
46]. A considerable number of patients do not return to to participate. At the 6-month examination by the surgeon,
their pre-injury level of sport despite successful rehabilita- 40 of the 48 patients fulfilled the inclusion criteria (Fig. 1).
tion and satisfactory physical recovery [2, 24, 25, 27]. To The study was designed according to the guidelines
investigate such psychological factors, various self-report of the Helsinki International Conference on Harmoniza-
questionnaires are in use, such as the Tampa Scale of Kine- tion—Good Clinical Practice. The ethics committee of the
siophobia, the Emotional Response of Athletes to Injury Bavarian State Chamber of Physicians (Landesaerztekam-
Questionnaire or the Anterior Cruciate Ligament–Return to mer) stated that no approval for the study was required.
Sport after Injury Scale [7, 8, 25, 27, 30, 49]. All patients in the study signed informed consent prior to
The aim of the study was to define parameters—func- inclusion.
tional tests and/or self-report questionnaires—that can
be used to predict the successful resumption of pre-injury Assessment instruments and procedure
level I and level II sports 6 months after ACL reconstruc-
tion. These parameters may be helpful in the clinical deci- The assessment by the same physical therapist was per-
sion of clearing a patient to return to sport. The 6-month formed the same day, but subsequent to the surgeon’s
time point was chosen as many surgeons decide about examination. The assessment instruments included 4
clearance for returning to sport at this time. questionnaires, followed by six functional tests. The first

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Knee Surg Sports Traumatol Arthrosc

ACL-reconstruction questionnaire assessing the psychological impact (emo-


01.07.2011-31.03.2012 tions, confidence in performance and risk appraisal) of
n=186 Concomitant injuries,
re-rupture, age returning to sport after ACL reconstruction surgery [49].
n=112 The questionnaire has high reliability, validity and test–
Isolated ACL rupture
n=74
retest reliability [26, 49], and was recently translated into
German language [31].
No contact For the functional testing, the patient warmed up using
n=15
Contacted for study stationary cycling at 50 W over 5 min. All functional clini-
n=59 cal tests were performed with the non-operated leg first.
The tests started with an isometric muscle strength meas-
Level III and IV
n=11 urement instead of an isokinetic strength measurement
[13, 16]. The Pearson correlation coefficient for the rela-
Level I and II,
Consent to participate tionship between isometric and isokinetic muscle strength
n=48 measurements in healthy subjects for knee extensors and
knee flexors is 0.74 (p < 0.0001) and 0.77 (p < 0.0001),
respectively [40]. The maximal isometric strength of the
Medical examination functional muscle groups is measured in a defined position
n=48 with a hand-held isometric strength device (Wagner Force
Inclusion criteria Dial TM model FDL) with good reliability and validity [19,
not met
Assessment n=8 44, 45]. The test was performed analogous to the method
n=40 described by Huber et al. [19]. Each patient underwent two
tests with a 20-s rest between the measurements. The bet-
ter result was recorded. The Limb Symmetry Index (LSI),
Telephone interview as well as the ratio of flexors to extensors, were calcu-
n=40
lated. Afterwards, the single-leg hop tests were performed
Scalet fever in the following order: single hop for distance, crossover
n=1
hop for distance and triple hop for distance, analogous to
Return to sport Non return the description by Myer et al. [35]. In patients with ACL
n=31 to sport reconstruction surgery, the tests show high reliability and
n=8
validity [41]. Each hop test was performed 3 times on the
respective leg with a 60-s rest in between. The longest dis-
Fig. 1  Flow chart for participants’ enrolment tance was used for calculating the LSI. The square hop test
has high reliability [14, 38] and was performed according
to the description by Gustavsson et al. [14]. It was executed
questionnaire inquired about socio-demographic data, twice on each leg with a rest of 2 min in between each. The
cause of injury and sports activities (current and before highest number of valid hops was used for evaluation.
surgery). The second questionnaire was the latest edition One month after assessment (i.e. 7 months after sur-
[1] of the International Knee Documentation Committee gery), the patient was called and in a standardized man-
(IKDC) subjective knee evaluation form, a knee-specific ner, the patient was asked about the level of sport he or she
10-item questionnaire measuring symptoms, function and had returned to, the average time spent per week and the
sport activities [20]. The IKDC subjective knee evaluation type/intensity of symptoms that might have occurred. The
form is valid and reliable for ACL injuries with a signifi- discrimination between return and non-return to sport was
cant test–retest reliability [20] and is used as criterion for made at this point. Patients who had not returned to their
returning to sport after ACL reconstruction [13, 33]. The pre-injury level of sport were asked for their reasons. In the
Tampa Scale for Kinesiophobia (TSK) is a questionnaire current study, “return to sport” is defined as the resumption
assessing pain-related fear of movement [21]. It is appro- of pre-injury level of sport, but does not imply immediate
priate for patients after ACL reconstruction [7, 8, 12]. The return to unrestricted activity.
TSK-11 was shortened from the original version by remov-
ing 6 psychometrically weak items, with a total of 11 items Statistical methods
remaining on the questionnaire [52]. The validity, reli-
ability and test–retest reliability of both questionnaires are The mean and standard deviation were calculated by using
comparable [52]. The Anterior Cruciate Ligament–Return conventional methods. The combined group of level I and
to Sport after Injury Scale (ACL–RSI) is a specific 12-item level II (return to sport) patients was compared with level

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Knee Surg Sports Traumatol Arthrosc

III (non-return to sport) patients. To analyse confounding patients (n.s.). The time between assessment and the tel-
factors in the socio-demographic data, the Mann–Whitney ephone interview was 30.9 ± 1.2 in the RS patients and
U or Fisher’s exact test was applied. The assessed param- 30.0 ± 1.9 days in the nRS patients (n.s.). Due to a diag-
eters of the functional tests and the scores of the question- nosis of scarlet fever in one patient, the final study group
naires were tested for normal distribution using the Kol- consisted of 39 patients.
mogorov–Smirnov test. Group differences were examined
with the Mann–Whitney U test or Student’s t test, where Return to level I and II sport activities
applicable.
The correlations were calculated using Pearson’s cor- Prior to injury, 23 patients had been active in level I sports
relation coefficient and illustrated with the respective r, R2 and 17 in level II sports. Of the 23 patients, 18 (78.3 %)
und p value. The cut-off points of the functional tests and had returned to a level I sport, 4 patients had remained in
the questionnaires were determined using a ROC analysis a level III sport, and one patient dropped out. Of the 17
and area under the curve (AUC) statistics. Using the step- patients in a level II sport, 13 (76.5 %) had returned to
wise forward method, the variables of the functional tests the pre-injury level of sport and 4 remained in a level III
and the questionnaires were simultaneously analysed in a sport.
binary logistic regression model. The significance level was
defined as p < 0.05. The presented evaluations were carried Functional tests
out using an explorative approach. The statistics were cal-
culated with Gnu R software (version 2.15.2). The mean LSI values of knee flexors and extensors are
shown in Table 2. The mean values of the knee flexors were
distinctly lower than those of knee extensors. The means
Results of the nRS patients for knee flexors and extensors were
slightly, but not significantly, lower than those of the RS
Socio‑demographic data patients. Likewise, the quotient between knee flexors and
extensors did not differ significantly.
Table 1 shows the socio-demographic data of the RS group When comparing single-leg hop tests of the RS patients
(level I and level II) in comparison with the nRS group (range 86 to 92 %) with the nRS patients (range 62 to
(level III). There were no significant differences between 84 %), significant differences were observed for the single
the two groups. hop for distance (p = 0.005), the crossover hop (p = 0.008)
The time between operation and assessment was and the triple hop (p = 0.001) (t test), but not for the square
6.2  ± 0.3 months in both the RS patients and the nRS hop.
With regard to age, no significant difference between
the two age groups (<30 years vs. ≥30 years) was seen for
Table 1  Sociodemographic data of level I + II and level III patients
muscle strength and hop tests. A gender-specific significant
Level I + II Level III p value

Number of patients 31 8
Table 2  Six-month LSI values and questionnaire scores
Sex male/female (%) 61.0/39.0 25.0/75.0 n.s. (2)
Age at surgery (years) 31.4 ± 10.3 33.0 ± 10.5 n.s. (1) Parameter Level I + II Level III p value
Body weight (kg) 74.3 ± 14.2 69.0 ± 14.2 n.s. (1)
LSI knee flexors (%) 76.3 ± 13.1 69.1 ± 20.3 n.s. (3)
Height (cm) 176.0 ± 9.8 173.8 ± 9.5 n.s. (1)
LSI knee extensors (%) 88.6 ± 7.9 79.7 ± 22.0 n.s. (1)
Operated leg left/right 18/13 4/4 n.s. (2)
LSI flexors/extensors (%) 86.5 ± 15.2 91.1 ± 32.6 n.s. (1)
Sport before injury (h per week) 8.6 ± 3.7 9.4 ± 4.1 n.s. (1)
LSI single hop (%) 85.6 ± 20.0 61.7 ± 20.5 0.005 (3)
Injury during sport yes/no 27/4 8/0 n.s. (2)
LSI crossover hop (%) 91.9 ± 14.3 75.1 ± 18.5 0.008 (3)
Time between injury–surgery 13.3 ± 19.2 30.6 ± 39.3 n.s. (1)
LSI triple hop (%) 88.3 ± 10.1 72.1 ± 13.1 0.001 (3)
(weeks)
LSI square hop (%) 87.5 ± 20.4 83.8 ± 44.6 n.s. (1)
Time between surgery–level III 9.2 ± 3.1 10.8 ± 4.1 n.s. (1)
sport (weeks) TSK-11 19.0 ± 4.7 21.6 ± 5.0 n.s. (3)
Sport duration level III (h per 4.4 ± 3.0 3.8 ± 1.7 n.s. (1) ACL–RSI scale 76.8 ± 15.0 48.7 ± 27.2 0.013 (1)
week) IKDC 2000 81.7 ± 9.5 74.0 ± 6.5 0.037 (3)

Mean, standard deviation, (1) Mann–Whitney U test, (2) Fisher’s Mean, standard deviation, (1) Mann–Whitney U test, (3) Student’s t
exact t test test
Level I and II return to sport patients, level III non-return to sport Level I and II return to sport patients, level III non-return to sport
patients patients

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Knee Surg Sports Traumatol Arthrosc

difference was found only in the LSI score of the single hop Correlation between functional parameters
for distance (men 88.3 ± 17.3 %/women 72.3 ± 23.6 %; and questionnaires
p = 0.022; Mann–Whitney U test).
No significant correlation was found between muscle
Questionnaires strength and the scores of the 3 questionnaires (Table 3).
A minor correlation existed between the ACL–RSI and
The mean values of the ACL–RSI, the TSK-11 and the the IKDC 2000 with regard to the single hop for distance
IKDC 2000 are shown in Table 2. The RS patients scored (r = 0.36, p = 0.023; r = 0.35, p = 0.028) and the triple
significantly higher on the ACL–RSI scale (p  = 0.013; hop (r = 0.41, p = 0.009; r = 0.47, p = 0.002). Also, there
Mann–Whitney U test) and the IKDC 2000 (p  = 0.037; t was a small correlation between the IKDC 2000 and square
test). The values of the TSK-11 showed a slightly higher hop by r = 0.32, p = 0.046.
score in the nRS patients (n.s.). No significant gender or
age-specific differences were observed. Cut‑off points as predictive parameters

Complaints and return to pre‑injury level of sport The AUC and the cut-off points, indicating the threshold
for inclusion into either the RS or the nRS patient group,
In the telephone interviews, 18 of the 39 patients com- together with sensitivity, specificity and accuracy, are pre-
plained of symptoms on the operated knee that were related sented in Table 4. Only parameters with significant p values
to their sport activities during the previous 4 weeks (pain, are listed. The AUC revealed moderate-to-good discrimina-
swelling, feeling of instability); 21 patients had no symp- tive accuracy for the single hop for distance, crossover hop,
toms. The symptoms occurred mostly during or shortly triple hop as well as the ACL–RSI and IKDC 2000 ques-
after sport activity. Symptoms were found to be nearly tionnaires (Table 4).
equal between the RS and nRS patients, and further analy- The single hop for distance had a high specificity (0.88)
sis of the subgroups with and without symptoms showed no and high sensitivity (0.74), while the ACL–RSI had a very
relationship between the symptoms and the results of mus- high sensitivity (0.97) and moderate specificity (0.63).
cle strength and single-leg hop tests, except for the crosso- When both cut-off points were applied together, all eight
ver hop (symptoms yes/no p  = 0.044; Mann–Whitney U nRS patients could be assigned correctly, and of the 31 RS
test). patients, 23 were assigned correctly.

Table 3  Correlations between Parameter ACL–RSI TSK-11 IKDC 2000


LSI values and scores of
questionnaires r p value r p value r p value

LSI knee flexors 0.24 n.s. −0.20 n.s. 0.21 n.s.


LSI knee extensors −0.02 n.s. 0.02 n.s. 0.12 n.s.
LSI flexors/extensors 0.25 n.s. −0.26 n.s. 0.11 n.s.
LSI single hop 0.36 0.023 −0.05 n.s. 0.35 0.028
LSI crossover hop 0.19 n.s. −0.10 n.s. 0.25 n.s.
LSI triple hop 0.41 0.009 −0.08 n.s. 0.47 0.002
Presented are Pearson’s r with LSI square hop −0.03 n.s. 0.07 n.s. 0.32 n.s.
corresponding p values

Table 4  AUC values and cut-off points


Parameter p (I + II/III) AUC Cut-off Sensitivity Specificity Accuracy

LSI single hop 0.005 (3) 0.823 75.4 % 0.74 0.88 0.77
LSI crossover hop 0.008 (3) 0.762 77.2 % 0.87 0.75 0.85
LSI triple hop 0.001 (3) 0.839 90.2 % 0.55 1.00 0.64
ACL–RSI scale 0.013 (1) 0.790 51.3 0.97 0.63 0.90
IKDC 2000 0.037 (3) 0.712 78.7 0.58 0.88 0.64

(1) Mann–Whitney U test, (3) Student’s t test


Level I and II return to sport patients, level III non-return to sport patients

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Knee Surg Sports Traumatol Arthrosc

Logistic regression analysis Similar to muscle strength, hop tests improve continu-
ously at 3, 6 and 12 months post-surgery [16, 48, 51]. In
A logistic regression analysis with binary outcome “return the nRS patients, LSI values of the single-leg hops for
to pre-injury sport level YES/NO” was applied to the distance were significantly lower (62–75 %) than those of
parameters. Age and gender were not introduced into the the RS patients. The LSI means for the single-leg hops for
model since they were not significant (age p = 0.477; gen- distance of the RS patients ranged between 86 and 92 %,
der p = 0.872). The final model consisted of the parameters which corresponds to ranges reported by other authors [42,
ACL–RSI (OR for an increase of 10 units 1.83; p = 0.018) 48, 51]. The LSI mean of the square hop of the RS patients
and LSI single hop for distance (OR for an increase of 10 was 87.5 ± 20.4 % and thus was higher than the value
units 1.78; p = 0.042), which leaded to an AUC of 0.91 and reported by Thomeé et al. [48]. In contrast, the square hop
an accuracy of 0.90. did not differ significantly. Although the patients performed
Using the logistic model, 35 out of the 39 patients could the square hop as the last test, the aspect of endurance and
be assigned correctly. Of the 31 RS patients, 30 could be fatigue in the present collective did not seem to be an issue.
identified as such, which corresponded to a sensitivity of Several authors recommended LSI values of muscle
0.97. Of the eight nRS patients, five could be identified, strength and/or single-leg hops above 85 % [5, 13, 24, 33]
which corresponded to a specificity of 0.63. or 90 % [5, 16, 24, 35, 47], respectively, as criterion for
returning to sport. According to Thomeé et al. however,
at 6 months post-surgery, only 70 % of the patients had
Discussion reached an individual LSI value of ≥85 % of the knee flex-
ors and only 25 % of the knee extensors [48]. Even after
The important findings of the present study are that RS and 12 months, a large number of patients would not have met
nRS patients differ significantly regarding single-leg hop the recommended criterion of 85 % [48]. The same applies
tests and the ACL–RSI score. The single hop for distance to the single-leg hop tests [48]. Wells et al. described a sim-
and ACL–RSI scale were the strongest predictive param- ilar finding regarding the muscle strength of knee extensors
eters for assessing return to sport. in an investigation with juvenile athletes [50]. The crite-
Out of the 39 patients, 31 (79.5 %) successfully resumed rion of ≥85 % for returning to sport was met, irrespective
their pre-injury level of sport, while 8 patients remained of gender, after 6 months by 59 % and after 10 months by
in a level III sport. A number of authors consider the time 78 % of the participants. However, 18 % of the participants
point of 6 months to be appropriate for a return to level I had not achieved the required criterion, even after 1 year
and II sports [2, 5, 13, 14, 29], while others permit return- [50].
ing after 4 months [10, 18]. It appears that women take The criteria quoted in the literature are purely empirical
longer to return, but finally reach the same rate as men [3]. values [24]. In a study on healthy athletes, the strength of
In our cohort, 6 women and 2 men did not return to their the strongest and the weakest leg was compared and a max-
sport. Age seems to play a role, and patients older than imum difference of 4–16 % was found [24, 44]. Therefore,
32 years of age returned to sport significantly less often it was proposed to accept about 15 % as greatest deficiency
than did patients younger than 32 years [3]. in muscle strength before allowing the patient to return to
sport [24]. For the single-leg hop tests, by contrast, no dif-
Differences between RS and nRS patients ference could be established [38].
The most common reasons for not returning to sport
In the nRS patients, LSI values of knee extensors and knee according to Kvist et al. [25] were “problems with knee
flexors were slightly, but not significantly, lower than in function”, as well as “fear of re-injury”. This is consistent
the RS patients. The LSI mean values of knee extensors in with the findings of Ardern et al. [2], Flanigan et al. [11]
RS patients were in the range of 88.6 ± 7.9 %, which is and Lee et al. [28]. In the present study, all 8 nRS patients
consistent with the results of most other authors [37, 48, indicated fear of re-injury and 3 patients indicated feel-
51]. The LSI mean values of knee flexors reported by other ing of joint unsteadiness as reasons for not returning to
investigators are often higher than the values in this study sport. Correspondingly, the ACL–RSI scores of the 8 nRS
(76.3  ± 13.1 %) [16, 37, 48, 51]. It is documented, how- patients were significantly lower (48.7 ± 27.2) than the
ever, that LSI for knee flexors in patients with a semiten- scores of the RS patients (76.8 ± 15.0; p  = 0.013), sug-
dinosus tendon graft, as used in this study, was distinctly gesting that in the nRS group, psychological aspects have
lower than in patients with patellar tendon graft, 6 months an important impact on athletes’ return to sport, which is
after surgery [29, 48]. It is known that the LSI values of consistent with the previous studies [4, 27, 49]. In a follow-
knee flexors and extensors improve continuously from 3 to up of 3, 6 and 12 months following ACL reconstruction,
6 and 12 months post-surgery [16, 48, 51]. the ACL–RSI score improved continuously in both the RS

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Knee Surg Sports Traumatol Arthrosc

and the nRS group (p < 0.001) [27], which suggests that The cut-off model described offers a promising and prac-
patients developed an increasingly positive attitude towards ticable instrument to predict the return to sport 6 months
returning to sport during rehabilitation. However, an impor- after reconstruction of the ACL. Both tests—the single hop
tant fact was that the ACL–RSI scores of nRS patients after for distance and ACL–RSI scale—are easy to apply and
6 and 12 months remained significantly lower (p = 0.005) may help to identify (a) patients at risk of not returning to
than did those of the RS subjects [27]. When comparing pre-injury sport and (b) the underlying reason—functional,
various psychological variables, Ardern et al. [4] demon- psychological, or both. However, the instrument needs to
strated that the ACL–RSI is the variable with the best dis- be validated in a larger number of patients before it can be
criminative capabilities for returning to sport. In summary, implemented into routine clinical practice. A larger patient
results in the literature and also in this study suggest that sample would allow for more precise calculation of the cut-
the ACL–RSI scale can be applied during an early stage of off points for both variables, as well as their combination.
rehabilitation to identify patients that are psychologically The results are valid only for patients with isolated ACL
insufficiently prepared to return to their sport. In those ruptures and cannot be generalized to patients with con-
patients, an appropriate treatment may be considered in comitant injuries.
order to develop more confidence in the performance of the
operated knee [4, 25, 27].
Conclusions
Predictive parameters for return to sport
In this study, the single hop for distance and the ACL–RSI
Two approaches were used in the attempt to develop a pre- scale were found to be the strongest parameters in predict-
diction model for returning to pre-injury sport. In the logis- ing the return to pre-injury sport 6 months after ACL recon-
tic regression analysis, the two strongest parameters were struction. The two parameters consider both the objective
the single hop test for distance and the ACL–RSI scale. functional and the subjective psychological aspects of
The two tests consider both the objective functional and returning to sport. The results of our study encourage an
the subjective psychological aspects of returning to sport. intensified use of the single hop for distance and the ACL–
The model allowed to identify 30 of the 31 RS patients cor- RSI scale in decision-making.
rectly, but only 5 of the 8 nRS patients, corresponding to a
specificity of 0.63, which is not convincing. Conflict of interest  Authors declare that there is no conflict of
interest with any organization.
The second model provided a higher specificity. In this
approach, the cut-off points of the two strongest param-
eters were used to predict the likelihood of returning to
sport. If the two threshold values were applied to the indi- References
vidual data of the patients, all 8 nRS patients were clas-
sified correctly, corresponding to a specificity of 1. Five 1. AOSSM, The American Orthopaedic Society for Sports Medicine
(2011) International Knee Documentation Committee 2000 sub-
of these patients had an ACL–RSI score below the cut-off jective knee evaluation form. http://www.sportsmed.org. http://
point. On the other hand, the model only recognized 23 www.sportsmed.org/uploadedFiles/Content/Medical_Profession-
of 31 patients who in fact returned to sport. Eight patients als/Research/Grants/IKDC_Forms/Deutsch_2000.pdf. Accessed
returned, although their LSI values of the single hop test 29 Sep 2011
2. Ardern CL, Webster KE, Taylor NF, Feller JA (2011) Return to
for distance were below the cut-off point. This observa- sport following anterior cruciate ligament reconstruction surgery:
tion is in line with the several reports stating that patients a systematic review and meta-analysis of the state of play. Br J
had successfully returned to sport although the subsequent Sports Med 45:596–606
assessment revealed individual values below the recom- 3. Ardern CL, Taylor NF, Feller JA, Webster KE (2012) Return-to-
sport outcomes at 2 to 7 years after ACL reconstruction surgery.
mended criteria of single-leg hop tests and/or quadriceps Am J Sports Med 40:41–48
strength [27, 35, 36, 51]. Thus, at the time of clinical 4. Ardern CL, Taylor NF, Feller JA, Whitehead ST, Webster KE
assessment, the model recognized all patients (100 %) who (2013) Psychological responses matter in returning to preinjury
did not resume their sport and about 74 % of the patients level of sport after anterior cruciate ligament reconstruction sur-
gery. Am J Sports Med 41:1549–1558
that resumed their pre-injury sport. There was, however, 5. Barber-Westin SD, Noyes FR (2011) Factors used to determine
a remaining group of patients who successfully returned, return to unrestricted sports activities after anterior cruciate liga-
but on the basis of their LSI levels, and according to the ment reconstruction. Arthroscopy 27:1697–1705
model, would not have been recommended to return at that 6. Beynnon BD, Johnson RJ, Abate JA, Fleming BC, Nichols CE
(2005) Treatment of anterior cruciate ligament injuries, part 1.
point of time. This interesting group needs to be observed Am J Sports Med 33:1579–1602
carefully with a longer follow-up to register any adverse 7. Chmielewski TL, Jones D, Day T, Tillman SM, Lentz TA, George
events. SZ (2008) The association of pain and fear of movement/reinjury

13
Knee Surg Sports Traumatol Arthrosc

with function during anterior cruciate ligament reconstruction 26. Kvist J, Österberg A, Gauffin H, Tagesson S, Webster K, Ardern
rehabilitation. J Orthop Sports Phys Ther 38:746–753 C (2012) Translation and measurement properties in the Swed-
8. Chmielewski TL, Zeppieri G Jr, Lentz TA, Tillman SM, Moser ish version of ACL-Return to Sports after Injury questionnaire.
MW, Indelicato PA, George SZ (2011) Longitudinal changes in Scand J Med Sci Sports 23:568–575
psychosocial factors and their association with knee pain and 27. Langford JL, Webster KE, Feller JA (2009) A prospective lon-
function after anterior cruciate ligament reconstruction. Phys gitudinal study to assess psychological changes following ante-
Ther 91:1355–1366 rior cruciate ligament reconstruction surgery. Brit J Sports Med
9. Clayton RAE, Court-Brown CM (2008) The epidemiology of 43:377–381
musculoskeletal tendinous and ligamentous injuries. Injury 28. Lee DYH, Karim SA, Chang HC (2008) Return to sport after
39:1338–1344 anterior cruciate ligament reconstruction—a review of patients
10. De Carlo M, Shelbourne KD, Oneacre K (1999) Rehabilita-
with minimum 5-year follow-up. Ann Acad Med Singapore
tion program for both knees when the contralateral autogenous 37:273–278
patellar tendon graft is used for primary anterior cruciate liga- 29. Logerstedt DS, Snyder-Mackler L, Ritter RC, Axe MJ, Godges JJ
ment reconstruction: a case study. J Orthop Sports Phys Ther (2010) Knee stability and movement coordination impairments:
29:144–153 knee ligament sprain. J Orthop Sports Phys Ther 40:A1–A37
11. Flanigan DC, Everhart JS, Pedroza A, Smith T, Kaeding CC 30. Morrey MA (1999) A longitudinal examination of athletes emo-
(2013) Fear of reinjury (kinesiophobia) and persistent knee symp- tional and cognitive responses to ACL injury. Clin J Sport Med
toms are common factors for lack of return to sport after anterior 9:63–69
cruciate ligament reconstruction. Arthroscopy 29:1322–1329 31. Müller U, Schmidt M, Krüger-Franke M, Rosemeyer B (2014)
12. George SZ, Lentz TA, Zeppieri G, Lee D, Chmielewski TL
Die ACL–Return to Sport after Injury Skala als wichtiger Param-
(2012) Analysis of shortened version of the Tampa scale for kine- eter bei der Beurteilung Rückkehr zum Sport Level I und II nach
siophobia and pain catastrophizing scale for patients after ante- Rekonstruktion des vorderen Kreuzbands (deutsche Version).
rior cruciate ligament reconstruction. Clin J Pain 28:73–80 Sport Orthop Traumatol 30:135–144
13. van Grinsven S, van Cingel RE, Holla CJ, van Loon CJ (2010) 32. MVZ (2011) Einheitliches Nachbehandlungsschema für vordere
Evidence-based rehabilitation following anterior cruciate liga- Kreuzbandplastik ohne Begleitverletzungen
ment reconstruction. Knee Surg Sports Traumatol Arthrosc 33. Myer GD, Paterno MV, Ford KR, Quatman CE, Hewett TE

18:1128–1144 (2006) Rehabilitation after anterior cruciate ligament reconstruc-
14. Gustavsson A, Neeter C, Thomeé P, Silbernagel KG, Augusts- tion: criteria-based progression through the return-to-sport phase.
son J, Thomeé R, Karlsson J (2006) A test battery for evaluating J Orthop Sports Phys Ther 36:385–402
hop performance in patients with an ACL injury and patients who 34. Myer GD, Paterno MV, Ford KR, Hewett TE (2008) Neuromus-
have undergone ACL reconstruction. Knee Surg Sports Traumatol cular training techniques to target deficits before return to sport
Arthrosc 14:778–788 after anterior cruciate ligament reconstruction. J Strength Cond
15. Harris JD, Abrams GD, Bach BR, Williams D, Heidloff D, Bush- Res 22:987–1014
Joseph CA, Verma NN, Forsythe B, Cole BJ (2014) Return to 35. Myer GD, Schmitt LC, Brent JL, Ford KR, Foss KDB, Scherer
sport after ACL reconstruction. Orthopedics 37:e103–e108 BJ, Heidt RS Jr, Divine JG, Hewett TE (2011) Utilization of
16. Hartigan EH, Axe MJ, Synder-Mackler L (2010) Time line for modified NLF combine testing to identify functional deficits in
noncopers to pass return-to-sports criteria after anterior ligament athletes following ACL reconstruction. J Orthop Sports Phys
reconstruction. J Orthop Sports Phys Ther 40:141–154 Ther 41:377–388
17. Hefti F, Müller W, Jakob RP, Stäubli HU (1993) Evaluation of 36. Myer GD, Martin L, Ford KR, Paterno MV, Schmitt LC, Heidt
knee ligament injuries with the IKDC form. Knee Surg Sports RS, Colosimo A, Hewett TE (2012) No association of time from
Traumatol Arthrosc 1:226–234 surgery with functional deficits in athletes after ACL-reconstruc-
18. Howell S, Taylor M (1996) Brace-free rehabilitation, with
tion: evidence for objective return-to-sport criteria. Am J Sports
early return to activity, for knees reconstructed with a double- Med 40:2256–2263
looped semitendinosus and gracilis graft. J Bone Joint Surg Am 37. Neeter C, Gustavsson A, Thomeé P, Augustsson J, Thomeé R,
78:814–825 Karlsson J (2006) Development of a strength test battery for
19. Huber E, Stoll T, Ehrat B, Wäckerlin B, Hofer HO, Seifert B, evaluating leg muscle power after ACL injury and reconstruction.
Stucki G (1997) Zuverlässigkeit und Normperzentilen einer Knee Surg Sports Traumatol Arthrosc 14:571–580
neuen isometrischen Muskelkraftmessmethode. Schweizer Ztschr 38. Östenberg A, Roos E, Ekdahl C, Roos H (1998) Isokinetic knee
Physiotherap 5:29–39 extensor strength and functional performance in healthy female
20. Irrgang JJ, Anderson AF, Boland AL, Harner CD, Kurosaka M, soccer players. Scand J Med Sci Sports 8:257–264
Neyret P, Richmond JC, Shelborne KD (2001) Development and 39. Petersen W, Zantop T (2013) Return to play following ACL

validation of the International Knee Documentation Committee reconstruction: survey among experienced arthroscopic surgeons
subjective knee form. Am J Sports Med 29:600–613 (AGA instructors). Arch Orthop Trauma Surg 133:969–977
21. Kori SH, Miller RP, Todd DD (1990) Kinesiophobia: a new view 40. Reed RL, Den Hartog R, Yochum K, Pearlmutter L, Ruttinger
of chronic pain behaviour. Pain Manag 3:35–43 AC, Mooradian AD (1993) A comparison of hand-held isometric
22. Krudwig WK (2000) Situation der Arthroskopie in Deutschland. strength measurement with isokinetic strength measurement in
Arthroskopie 13:191–193 the elderly. J Am Geriatr Soc 41:53–56
23. Krüger-Franke M, Reinmuth S, Kugler A, Rosemeyer B (1995) 41. Reid A, Birmingham TB, Stratford PW, Alcock GK, Giffin JR
Concomitant injuries with anterior cruciate ligament rupture. A (2007) Hop testing provides a reliable and valid outcome meas-
retrospective study. Unfallchirurg 98:328–332 ure during rehabilitation after anterior cruciate ligament recon-
24. Kvist J (2004) Rehabilitation following anterior cruciate ligament struction. Phys Ther 87:337–349
injury: current recommendations for sports participation. Sports 42. Shaw T, Williams MT, Chipchase LS (2005) Do early quadri-
Med 34:269–280 ceps exercises affect the outcome of ACL reconstruction? A ran-
25. Kvist J, Ek A, Sporrstedt K, Good L (2005) Fear of re-injury: a domised controlled trial. Aust J Physiother 51:9–17
hindrance for returning to sports after ACL reconstruction. Knee 43. Spindler KP, Wright RW (2008) Anterior cruciate ligament tear.
Surg Sports Traumatol Arthrosc 13:393–397 N Engl J Med 359:2135–2142

13
Knee Surg Sports Traumatol Arthrosc

44. Stoll T, Huber E, Seifert B, Michel A, Stucki G (2000) Maximal performance after ACL-reconstruction. Knee Surg Sports Trau-
isometric muscle strength: normative values and gender-specific matol Arthrosc 20:1143–1151
relation to age. Clin Rheumatol 19:105–113 49. Webster KE, Feller JA, Lambros C (2008) Development and

45. Stoll T, Huber E, Seifert B, Stucki G, Michel BA (2002) Isomet- preliminary validation of a scale to measure the psychological
ric muscle strength measurement. Thieme, Stuttgart impact of returning to sport following anterior cruciate ligament
46. te Wierike SCM, van der Sluis A, van den Akker-Scheck I,
reconstruction surgery. Phys Ther Sport 9:9–15
Elferink-Gemser MT, Visscher C (2013) Psychosocial fac- 50. Wells L, Dyke JA, Albaugh J, Ganley T (2009) Adolescent ante-
tors influencing the recovery of athletes with anterior cruciate rior cruciate ligament reconstruction: a retrospective analysis of
ligament injury: a systematic review. Scand J Med Sci Sports quadriceps strength recovery and return to full activity after sur-
23:527–540 gery. J Pediatr Orthop 29:486–489
47. Thomeé R, Kaplan Y, Kvist J, Myklebust G, Risberg MA, The- 51. Wilk KE, Romaniello WT, Soscia SM, Arrigo CA, Andrews JR
isen D, Tsepis E, Werner S, Wondrasch B, Witvrouw E (2011) (1994) The relationship between subjective knee scores, isoki-
Muscle strength and hop performance criteria prior to return to netic testing, and functional testing in the ACL-reconstructed
sports after ACL reconstruction. Knee Surg Sports Traumatol knee. J Orthop Sports Phys Ther 20:60–73
Arthrosc 19:1798–1805 52. Woby SR, Roach NK, Urmston M, Watson PJ (2005) Psychomet-
48. Thomeé R, Neeter C, Gustavsson A, Thomeé P, Augustsson J, ric properties of the TSK-11: a shortened version of the Tampa
Eriksson B, Karlsson J (2012) Variability in leg power and hop Scale for Kinesiophobia. Pain 117:137–144

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