Group 1 (10-Rose)

Rachel Ann Guinto

Alondra Jane Aguilan
Alyana Margarette cayabyab
Jiedy Hannah Ramos
Alesandra Alexie Tamondong
Jhoner Austria

HYPOGLYCEMIC ACTIVITY OF JAVA PLUM (Syzygium cumini) FRUIT EXTRACT

IN ALBINO WINSTER RAT
Objectives:
1. The researcher conducted the study to determine the hypoglycemic activity of
java plum (Syzygium cumini) fruit extract in albino winster rat.
2. The researcher wanted to identify the active constituents present in Java plum
extract to treat hypoglycemia.
3. The researcher also objectifies to determine the level of effectiveness of
hypoglycemic activity of java plum (Syzygium cumini) fruit extract in albino
winster rat.
4. The researcher aims to determine if there is a significant difference between the
hypoglycemic activity of java plum (Syzygium cumini) fruit extract in albino
winster rat and the commercially prepared product.
Related Literature:
Jambolan is rich in compounds containing anthocyanins, glucoside, ellagic acid,
isoquercetin, kaemferol and myrecetin. The seeds are claimed to contain alkaloid, jambosine, and
glycoside jambolin or antimellin, which halts the diastatic conversion of starch into sugar and
seed extract has lowered blood pressure by 34.6% and this action is attributed to the ellagic acid
content. (Morton J. Fruits of warm climates. Miami: Julia Morton Winterville North Carolina; p.
1987)
The fruit is acrid, sweet, cooling and astringent to the bowels and removes bad smell
form mouth, biliousness, stomachic, astringent, diuretic and antidiabetic. (Nadkarni KM. Indian
materia medica. Bombay: Popular Prakashan Ltd; 1976.)
The plant has been viewed as an antidiabetic plant since it became commercially
available several decades ago. In the early 1960s to 1970s, some preliminary reports on the
antidiabetic activity of different parts of jambolan in diabetic animals were reported. Most of
these studies have been conducted using crude preparation of the plant without pointing out their
chemical profile and antidiabetic action in animals is not fully understood. A number of herbal
formulations were also prepared in combination with this plant available in market which
showed potential antidiabetic activity and are used regularly by diabetic patients on the advice of
the physicians. Different parts of the jambolan were also reported for its antioxidant, anti-
inflammatory, neuropsycho-pharmacological, anti-microbial, anti-bacterial, anti-HIV,
antileishmanial and antifungal, nitric oxide scavenging, free radical scavenging, anti-diarrheal,
antifertility, anorexigenic, gastroprotective and anti-ulcerogenic and radioprotective activities.
(Sagrawat H, Mann AS, Kharya MD. Pharmacological potential of Eugenia jambolana: a
review. Pharmacogn Mag. 2006;2:96–104.)
Different parts of the jambolan especially fruits, seeds and stem bark possess promising
activity against diabetes mellitus and it has been confirmed by several experimental and clinical
studies. In the early 1960s to 1970s, Chirvan-Nia and Ratsimamanga (C R Acad Sci Hebd
Seances Acad Sci D. 1972)., Sigogneau-Jagodzinski et al (C R Acad Sci Hebd Seances Acad Sci
D. 1967) , Lal and Choudhuri (Lal BN, Choudhuri KD, Indian J Med Res. 1968), Shrotri et al
( Shrotri DS, Kelkar M, Deshmukh VK, Indian J Med Res. 1963) , Bose and Sepha (Bose Sn,
Sepaha Gc, J Indian Med Assoc. 1956)  and Vaish (Vaish SK.  1954. p. 230) reported the
antidiabetic activity of various parts of jambolan in diabetic animals. Tea prepared from leaves
of jambolan was reported to have antihyperglycemic effect (Teixeira CC, Knijnik J, Pereira MV,
Fuchs FD, 1989. p. 191). The stem bark of the plant could induce the appearance of positive
insulin staining cells in the epithelia of the pancreatic duct of treated animals (Schossler DRC,
Mazzanti CM, Almeida da Luzi SC, Filappi A, Prestes D, Ferreria da Silveira A, et al. Syzygium
cumini and the regeneration of insulin positive cells from the pancreatic duct. Braz J Vet Res
Anim Sci. 2004) and a significant decrease in blood glucose levels was also observed in mice
treated with the stem bark by oral glucose tolerance test (Villaseñor IM, Lamadrid MR J
Ethnopharmacol. 2006). Many clinical and experimental studies suggest that, different parts of
the jambolan especially fruits and seeds possess promising activity against diabetes mellitus.
(Ravi K, Ramachandran B, Subramanian S, Biol Pharm Bull. 2004)
Traditional medical healers in Madagascar have been using the seeds of jambolan for
generations as the centerpiece of an effective therapy for counteracting the slow debilitating
impacts of diabetes. (Ratsimamanga U. Native plants for our global village. (TWAS
Newslett. 1998)
References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609276/
https://www.academia.edu/1140031/Phytochemistry_traditional_uses_and_pharmacology_of_Eu
genia_jambolana_LAM._black_plum_A_review
https://www.academia.edu/11002413/Nutritive_therapeutic_and_processing_aspect_of_jamun_S
yzygium_cumini_L_Skeel_an_overview
https://www.academia.edu/11625767/Antidiabetic_and_Hypoglycemic_Effects_of_Syzygium_c
umini_Black_Plum