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Original Article
a r t i c l e i n f o a b s t r a c t
Article history: Background: A successful antibiotic stewardship program depends not only the knowledge and percep-
Received 10 January 2019 tions of healthcare providers but also patients and caregivers. Accordingly, the caregiver will decide to
Received in revised form 9 April 2019 give the medication for their children. This survey was conducted to observe the caregivers’ knowledge
Accepted 9 May 2019
and perceptions of antibiotic use and antibiotic resistance; and their relationship.
Methods: We developed 14 item questions in a knowledge questionnaire and 30 item questions in a
Keywords:
perception questionnaire. The knowledge questionnaire was measured by a Guttman scale, with ‘Yes’ or
Caregiver
‘No’ answers, while the perception questionnaire used a five-point Likert scale.
Knowledge
Perception
Results: The knowledge about antibiotic resistance is low, while the knowledge about antibiotic admin-
Belief istration was the highest score. Caregivers’ perceptions and beliefs about antibiotic use and antibiotic
Antibiotic resistance were mostly in the neutral category. The association between knowledge and perceptions
about antibiotic use and antibiotic resistance in this study was weak.
Conclusions: The caregivers’ knowledge about antibiotic use was identified to be sufficient, particu-
larly, the antibiotic definition (highest score). The caregivers’ belief about antibiotic use and microbial
resistance was neutral (3.5–3.7).
© 2019 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University
for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
https://doi.org/10.1016/j.jiph.2019.05.006
1876-0341/© 2019 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the
CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
2088 F. Herawati et al. / Journal of Infection and Public Health 13 (2020) 2087–2091
Table 1
Hospital demography.
Characteristics A B C D E
Hospital classificationa A B C B B
Levels of care A tertiary hospital A tertiary hospital A secondary hospital A tertiary hospital A tertiary hospital
Number of beds 467 328 109 235 117
Area geographical Sidoarjo regency Gresik regency Bangil district Surabaya municipality Surabaya municipality
Ownership Government Government Government Private Private
a
In conformity with the Ministry of Health Republic of Indonesia (MoH-RI) regulation. Peraturan Menteri Kesehatan No. 56 tahun 2014: Klasifikasi dan perizinan rumah
sakit: MoH-RI; 2014 [17].
Table 2
Respondents’ demography.
Age (years)
≤20 0 (0) 0 (0) 5 (5.2) 0 (0) 0 (0)
>20–25 0 (0) 6 (6.3) 8 (8.3) 4 (4.2) 5 (5.2)
>25–30 19 (19.8) 21 (21.9) 17 (17.7) 25 (26) 29 (30.2)
>30–35 16 (16.7) 28 (29.2) 18 (18.8) 34 (35.4) 31 (32.3)
>35–40 28 (29.2) 14 (14.6) 10 (10.4) 26 (27.1) 26 (27.1)
>40–45 22 (22.9) 16 (16.7) 20 (20.8) 3 (3.1) 5 (5.2)
>45–50 3 (3.1) 9 (9.4) 8 (8.3) 2 (2.1) 0 (0)
>50–55 0 (0) 0 (0) 6 (6.3) 0 (0) 0 (0)
>55–60 0 (0) 2 (2.1) 2 (2.1) 1 (1) 0 (0)
>60 0 (0) 0 (0) 2 (2.1) 0 (0) 0 (0)
Not available 8 (8.3) 0 (0) 0 (0) 1 (1) 0 (0)
Sex
Male 12 (12.5) 21 (21.9) 37 (38.5) 19 (19.8) 31 (32.3)
Female 84 (87.5) 75 (78.1) 59 (61.5) 77 (80.2) 65 (67.7)
Education
Primary school 8 (8.3) 6 (6.3) 33 (34.4) 0 (0) 0 (0)
Middle school 13 (13.5) 24 (25) 25 (26) 1 (1) 0 (0)
High school 45 (46.9) 42 (43.8) 28 (29.2) 26 (27.1) 36 (37.5)
University 30 (31.3) 22 (22.9) 10 (10.4) 68 (70.8) 60 (62.5)
Not available 0 (0) 2 (2.1) 0 (0) 1 (1) 0 (0)
Monthly income
Less than IDR1,000,000 44 (45.8) 5 (5.2) 57 (59.4) 1 (1) 0 (0)
IDR1,000,000– 3,000,000 13 (13.5) 28 (29.2) 29 (30.2) 11 (11.5) 1 (1)
IDR3,000,001– 5,000,000 31 (32.3) 9 (9.4) 10 (10.4) 36 (37.5) 34 (35.4)
IDR5,000,001– 10,000,000 8 (8.3) 1 (1) 0 (0) 27 (28.1) 42 (43.8)
More than IDR10,000,000 0 (0) 0 (0) 0 (0) 17 (17.7) 19 (19.79)
Not available 0 (0) 53 (55.2) 0 (0) 4 (4.2) 0 (0)
people were unsure whether antibiotics were indicated for bacte- in medical treatment can be influenced more by nurses and other
rial and/or viral infection [12]. care providers [16].
Based on research done with Americans about perceptions and
knowledge, from 215 respondents, most of them agreed that the Methods
improper use of antibiotics could cause antibiotic resistance (92%).
However, more than 70% responded neutrally or did not agree with All procedures performed in studies involving human par-
the statement that antibiotic resistance was a problem. The conclu- ticipants were in accordance with the ethical standards of the
sion of the research indicated that the participants are aware that institutional and/or national research committee and with the
antibiotic abuse could cause antibiotic resistance. Nevertheless, 1964 Helsinki Declaration and its later amendments or compara-
most people had the correct perception but incorrectly assumed ble ethical standards. The study was approved by the respective
that this issue was not an important matter [13]. hospital managements and was conducted in accordance with the
This research was aimed to measure the parent’s knowledge and Indonesian Law for the Protection of Personal Data. The study
beliefs about antibiotic use; and therefore, to what extent parents was ethically cleared by the Health Research Ethics Committee
need to know about the wise use of antibiotics in their children. of Politeknik Kesehatan Kemenkes Surabaya, Kementerian Kese-
The use of antibiotics in children depends upon their parents, who hatan No. 025/S/KEPK/V/2017. This research was conducted at five
become the decision makers in the medical treatment of their chil- hospitals in East Java, i.e. one public hospital in Sidoarjo regency,
dren. Based on the Narrative Review of Pediatric Decision Making, one public hospital in Gresik regency, and one public hospital in
out of 55 articles, 52 different descriptive qualitative studies indi- Bangil district, and two private hospitals in Surabaya city (Table 1).
cated that the decision making in children’s medical treatment, These hospitals are representative of the various types of hospitals
namely by parents were also influenced by factors such as the in Indonesia [17].
health condition of their children, the knowledge of the parents,
and personal reasons like emotions and beliefs [14,15]. In children, Measurements
the knowledge and perceptions of the parents were measured as
the indicators of the achievement of the proper use of antibiotics. This cross-sectional study used questionnaires with a Guttman
This study was implemented with hospital outpatients and not scale (Yes or No) to measure caregiver knowledge (14 questions)
inpatients, because in hospital settings the parents’ participation and a 5-point Likert scale to measure perceptions (30 questions)
F. Herawati et al. / Journal of Infection and Public Health 13 (2020) 2087–2091 2089
Table 3
The percentage of the respondents’ correct answer on knowledge questionnaire.
about antibiotic use and antibiotic resistance (1 for strongly dis- were questions related with income (salary). From 329 partici-
agree and 5 for strongly agree). There were four domains in the pants who completed the questionnaire, 69.0% of participants were
knowledge questionnaire, i.e.: knowledge about antibiotic defini- female. The age of the respondents ranged 25–45 years old in Hospi-
tion (1 question), antibiotic resistance (2 questions), healthcare role tal A, B, and C; whereas it was between 25–40 years old in Hospital
(1 question); and antibiotic administration (10 questions) (Table D and E. More than 70% reached primary – high school and more
3). The percentage of correct answers for every item was depicted than 50% of respondents have monthly income < IDR 3.000.000 in
descriptively. There were thirty questions in the patient belief ques- the government hospitals (Hospital A, B, C); while almost all fin-
tionnaire, i.e. 8 questions on perceived benefits, 6 questions on ished high school and university and more than 50% of respondents
perceived barriers, 8 questions on perceived threats, and 8 ques- have monthly income > IDR 3.000.000 in private hospitals (Hospital
tions on self-efficacy (Appendix 1). D, E). More than 50% of respondents in one hospital did not answer
the question about monthly income (Table 2).
Participants The participants had strong knowledge scores on antibiotic
administration and antibiotic definition (high: 87.5% and 94.8%,
The participants of this study were the parents of the outpa- respectively), average on healthcare role (high: 68.4%), and weak
tient children who were prescribed and administered antibiotics conceptions of knowledge about antibiotic resistance (high: 25.2%)
(Table 2). The inclusion criteria for sample selection were: the par- (Table 2). Questions with correct answers less than 60% were (i)
ents of the outpatient children who got antibiotics prescriptions ‘The selection of antibiotics is not always performed by doctors
from the physician, the age of the children was 1 month to 15 years or pharmacists’ in Hospital C (Bangil district), (ii) ‘The dosage of
old, and the participants could communicate and had good read- antibiotics can be reduced by him/her self if the body condition
ing and writing ability. The exclusion criteria were: the parents of feels better’ in Hospital C, (iii) ‘Buying or discontinuing the use of
children treated as inpatients <1 month or >15 years old, and who antibiotics without any notification from doctors/pharmacists does
could not complete the surveys. not result in bacterial resistance to antibiotics’ in Hospital B (Gresik
regency), (iv) ‘Antibiotics can be stopped immediately if symptoms
Results
have improved, even though the antibiotics are not yet finished’ in
Hospital B and C, (v) ‘Antimicrobial resistance to antibiotics can
There were 480 questionnaires distributed but only 329 par-
be prevented by stop antibiotics as soon as possible if you feel
ticipants completed the surveys. One hundred and fifty-one
healed’ in Hospital A-B-C, and (vi) ‘Antibiotic resistance is a con-
questionnaire demographic data were incomplete, and mostly
2090 F. Herawati et al. / Journal of Infection and Public Health 13 (2020) 2087–2091
Table 4 (in case the symptom were getting worse) [10]. Some respondents
The respondents’ perceived score.
believed that antibiotics are a medicine to prevent diseases and not
Domain A B C D E a medicine to cure diseases; [21,25] or antibiotics cure common
Perceived benefit 3.34 3.51 3.15 3.58 3.38 colds more quickly [26].
Perceived barrier 3.60 3.57 3.43 3.31 3.30 In this study, more than 50% of parents of the children patients
Perceived threat 3.59 3.95 3.59 3.77 3.59 in the hospitals feel a barrier to follow the antibiotic administra-
Perceived self-efficacy 3.81 3.85 3.75 3.81 3.64 tion instruction, i.e. ‘difficult to take antibiotics every 8 h a day’.
Belief 3.58 3.73 3.48 3.64 3.49
This result was similar to studies by Ingerski [27] and Modi [28]
that found the barriers to treatment adherence involved difficulties
dition in which antibiotics are successful in combating bacteria’ in with time management. This situation would threaten antibiotic
all hospitals (Table 3). effectiveness, particularly for a time-dependent antibiotic.
Individual beliefs consist of four domains, i.e. threats felt or per-
ceived threats, benefits felt or perceived benefits, barriers felt or Conclusion
perceived barriers and beliefs towards what they can do or per-
ceived self-efficacy. The perceived self-efficacy had the highest Knowledge of the caregivers of children patients in the hospitals
score; the perceived benefits and barriers had the lowest score. The in the antibiotic administration and definition was identified to be
overall respondents’ belief score was 3.5–3.6 (Table 4, Appendix 1). sufficient for getting benefits from antibiotics and having to admin-
ister them regularly. The belief of the caregivers in the hospitals in
Discussion antibiotic use was neutral. The knowledge about antibiotic resis-
tance and their perceived barrier score were low. Considering their
This study shows that the caregivers’ knowledge about antibi- essential role, caregivers are one of the important targets of the
otic was sufficient. Ninety-six percent and ninety-two percent educational strategy in successful antibiotic stewardship programs
of participants respectively answered the questions about antibi- [26]. Continued public awareness campaigns and education are
otic definition and administration correctly. This information was necessary to increase their knowledge, to strengthen their beliefs
usually given by pharmacists whenever the patient took their med- and to improve their health behavior.
ication at a pharmacy [18]. The results of the knowledge of the
participants were also related to previous personal experience and Funding
the quality of the information provided [19]. Patients with good
knowledge were more likely to have good antibiotic practices [20]. This study was supported with a research grant No. 29/SP-
The lowest score for correct answers was the question about Lit/LPPM-01/Dikti/FF/V/2017 from Ministry of Research, Technol-
antibiotic resistance. Only thirty-three percent of respondents ogy and Higher Education of the Republic of Indonesia (Menteri
answered it correctly. The lack of respondents’ knowledge about Riset, Teknologi dan Pendidikan Tinggi, Menristekdikti).
antibiotic resistance in this study was similar with research by
Andre et al. in the US, which indicated that people, in general, were Conflict of interest
still confused about antibiotic resistance and believed that people,
not bacteria, would become resistant to antibiotics [21]. This study The authors declare that they have no conflict of interest.
showed that respondents from the private hospitals more likely
answered correctly the question, ‘antibiotic resistance is a condi- Key points
tion in which antibiotics are successful in combating bacteria’ than
respondents from the public hospitals. The number of respondents The appropriateness of children medications depends on the
with a university degree at private hospitals was almost three times caregivers’ knowledge and perceptions. This study shows that
higher than the number of respondents with a university degree the caregivers’ knowledge and perceptions are low, therefore
at public hospitals. This finding supported the findings from the continued public awareness campaigns and education are neces-
Davis study, where ninety-three percent of patients with college sary to increase their knowledge, to strengthen their beliefs and to
level education correctly believed that antibiotics work for treating improve their health behavior.
infections from bacteria whereas only eighthy percent of patients
without college level education believed it [22].
In this study, the knowledge result agrees with the perceived Acknowledgements
benefit score (3.4), indicating the respondents believe antibiotics
are effective and prevent any disease from getting worse. The We are grateful to the management and staff of hospitals for
results concurred with Hamm et al.’s study, sixty-five percent of allowing us to collect the data and to use them for the evaluation.
patients expected antibiotics to treat their sinusitis or bronchitis We would like to thank the staff at Klinik Bahasa, Faculty Kedok-
and even when diagnosed with viral infections [23]. Hansen et al.’s teran, Universitas Gadjah Mada (Yogyakarta) for helping to edit the
study in 2015 showed that parents in Brisbane, Australia assumed manuscript.
that antibiotics were the best treatment for acute otitis media in
children [24]. In 2017, a systematic review summary stated that
parents are not disappointed for not prescribing antibiotics if the
APPENDIX 1 Questionnaire on patient’s belief
physician provided a proper explanation and an alternative plan
No Statements Strongly disagree→
strongly agree
Perceived benefit
1 Despite the bitter taste of antibiotics, my child has to take them because I know my child can recover 1–2–3–4–5
2 If my child’ bacteria is susceptible to antibiotics, I can use cheaper drugs for my child 1–2–3–4–5
3 If my child completes the course of antibiotic, I can reduce the risk of antibiotic resistance 1–2–3–4–5
F. Herawati et al. / Journal of Infection and Public Health 13 (2020) 2087–2091 2091
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