~ &~~ P"°'c.:\-ic.e..

Ex~m =t:\=i

(i) q>
~®--- --
!i1J. 0

Circ~ QI\ sp3 ~\o""idize.d ~~W\5.

5foQf'2. ~\\ sp:l ~b,.-idiz~cl "'krs.

Tri~n:1k_ ~\\ 'Sp h~k>ridiz.ed °'+ams.
§' t>JV\\ t-V\ J .\k. t\\Clll:ilV\9
r VV\C)~¼.

@
 i
is mo~-\- ocic\ic_ ~

~01-\

M.os.f- Addi c ··
F r

® L0V\o.-\- I':> ~ di-/+uimce b/w

0c_rd/bo..~ V<;. _
Lfwls
°' &l'W)'$~ - Lo~ o.c_id//oosQ___ Cwt exa.W\plks ct
~ -\-o sholD w,d.m~e. crf- vnckr:s¼Vldit\9 · ·
LW-)·1~ cldt.rMi..U..~ . A/r's b3 elt.c.1vt!Y'\ dtm~ c~~) ~ W..t.:h~'\ c,c.c~ I

l,rev,s.\trul- ~ chl«"Mi'lt-",l.o ~ H J.c,.,.CII'" ( Ad cl) ,1- 4- 1-t <>C£.epir,r(.,{;,,_~~)

@ Dei;YUL AufOOu Pr,t1cipk I PQu\i Exclus,on Principlt,
I \.\uV\d's ~\lUL , t- 1-\ci~ bvr-9 01'lce.rh:,.it'\4:Y Pri V\C ifle .
~ Mt l'J'\~h_ YooM , bu+ look @ l'lok'.:> tl- re.view p~'>e._ 1~
1
~ be__ o.bk to o~ \"1tt2.- o.v-elll -tefMo\o..-\-ioY\, dOf:iWLcs,
tJJectrc:i . + o.c,c1; m~<:i ! 4
I
 ~Com~\Dk ll.¾.w"'icfc.h\\D-s,<Ll
winq
~
add / loo.se_ f-eAC.t,c,Y) s '.
~va-r-e.ol i"' ~ equililo..-i~.
cf ~b ~v\
' ®
~ }-
••
~ R\-\ + "\- '-, \ . ~ ?1-1 ...
tt ~ ~

·· 0
+ : C. \ :

.. .·o·. ©
•
NH 3 + NH
11

~ dw{-1-- ...,,,.,.':1 "'oo~ )as:!-- va:tMfU, '.)•V W<M '+ :sei_ ~

l,·~ 4\.tt~ OA.. °'-\.'\.. exct\vL '· +

I '
I
 ,·

I I

® I-low IVIM ~ ~ of ~-1-um-ho-n o.A>.. i~-\k mol2.cul.e.. ab?IR ?:@J _

® OJ.,',c,h J- -¾w._ fo llow1n3 ~ftoffi110Y)<:> woo Id ~<A rTO fJ~ ?

(_F) /vortQ, J .-lk Above.

I

© Are ~~ ef ~ J k to llow1Y19 compounds ~ .~ o ?

 '
® ()ro_\U ~ I\Jeu)Mo.r\ ptt>~t,on -hr("~ tr,I\~ ~txlVt l~S.
I

l I . I.' .

0~10
0 0 Pi JG)

tt OH

z_ f_
 • I

KO\:Bo

® Ar~ cis f fml'\S a\~s ~ s\·°'bli.? w~ ? ,

Tro.ns ( SJ 0i)knt.5 o.Y£, WI~ ski\ok. 1oc/ ~ pv+ !Qss stra1t1 en .Jk_
~ Mtl.ec.v{.Q_ . »\~, tro.Y·6 c:ont&r~~o>1 ·spolES ou+Ifunc-hOYJCi\l 9!1Sllfls1-1,
@ ~t- o.~ -\luz.. pn,duc.+(s) 1

• . I

,I'
I ,
\ ' I

® L,s-\- fbla'f _~protit. on~ ·' ~\at p11>-hc. ~\venh. · 1

Polo.f Ap<t,\ic.. - ' > D~fi) I A ~ I THF, DMFJ Ac.dmrtrile' + HmPA

Po\o.r P<btiC. ~ EH-,qno}, M.dhW10( H2 0, ~ -

@ Who.t b ~ ~°'c_~n-\- tc,y- 1k_ tnJlow,n~ reru:_Bcrn?

SNd-.
1
Q) T ~ -\hQ... ~\ \ow ·,~ ~~olJY1ci3 CAS o.romMc_, c:w,-t1-C\romc
xliL,
I
crr nOY\ - °'romo..-\ic.. .
@ ~

( j , ·o C) d
.

0
V'IOY'I o-.mYvt°'--h c.., ncm Ct<V""'1o.tic. ~@ ,
• I-
I
• i.. • o..ro Y\'lO..i, c.
I ' \ ' I
I~ -1¼_ ,Mo~-\- bo.s·,c. nH·myn ?
I
© i) '
e,) 2.

C.) ~ ~ LeC\."S.+

@N
H
I 6)
®
. ,
;Y\o-s+
NH
z.
. I

® N()'L I

Bra ~~.
I I 1

➔ ?
A\e r • £,("
3

£~

® Dro.lD -Jk F AS MQCh CAY-ii 5M CY'-"> c;su--: &,se,::;, (lY E

® O~ln.9 ~ c.o\or wh.eQJ, if o.. subs-\-v.Y\e,e_ h°'~ mo.x.

01'o'::>QfroV\c~ a--\- 100 nM I LVho.+ ·,s --rh2__ c<i\or Jr- ihcx\--
~u'o":)1CA\l'\c.eZ G r~
 NH'2-

D 0
--~

' I
l. ,·

® ·/\h. 2 Crz. 0'7 I ' 0

"
\~

H+
J

~ 7 esr-OH
•

',

@ t0h1c.V\ ~dYox\ck Is maf-e_ . CA c,d ,t-? 1

? i i ' .
~\
l I .

I
' .,
 0~ .,_. '
o/0~
50 H

?• ,,,
'.
,-JO'Z-

ot-\

J
I
, sof/
NOz.
'
Mi no r

I
I
I
I
l
.. $ :H
NO,;.. J
- - - -- -- -- -- - -- - -
- - - - ~ 1 --
A\C\?)
..... - -- - - - - - - -- - - ,-- - - -

- - -- - - - - - -- -
-- - -- - -- - - - - - --

7
. '

"10 ~ r~c.f t~
~ (\o-k: I • 11. ~ 5 wi \\ V\ot r~ac+ err °'\\
 <~ '
l
X
0

A
Ol-\
/. A I
l I I

I I
I ' I
I '

H,
. I

,,
I

I f I , j

,,
 I
---- ------ ----- ------ 3
§) Dr(Aw or-"10 - <l1lcr(b +oluenJL.

?•
@C\
-- ----- - ---- - --- -
@) HSr -
/;1/
-8Doc ~
?
•
~
l HBr
~
)
'10oc ?

- -- - - - -- - -- - - - -- - - ----
e,r

A\CJ 3
7• fV&r
C\
C\

.,

l ?
 J I

I©
7•
[ ? J
[ ? J7
' I

(xs) ) - 01-\ I ,

_.:,_..---~
•

I I

I ,,
 •I
(?)
~CN DI.<5AL- r\ .
-----~
H+

~
® 0
)-fY19 ,Br
~
~CN
---- ~~ 7•
H+

~2C.\
.7 - . ~

OH
C.\
0

~
0
,,
 0

~OH

?
. ~OH

'(

®
~ N 02 .. PJ/c. rlz. I

- ---~c~~')

PJ. /e, H2.

0
/j
--~-~
c~sJ
I
7 GY
j

l I
@ ulio.t o.Q ~ ru~s tor l'IO.l'l'l\n~ o.ldtl,i~ + k.e:hJYlit:, { '-
® OH
0 Ct-\

-
Ofi
n OH

Or'
01-f C)
 0
'0~ ___ ~Cl
o _ _~ 7

® 0

-""- o~O II
'"'z.
~tw~C \

Mo+
1
7• To~ N~

@
!N~
0 0
l..,.N ~ o:cP.,AL-H
l ~ 7• (

~ f1
0

?•
LAH

b 0

76
•
---
2.
--- ~

I •
 fo.w example. of + t.x.p\o.iv-i tl:\ui"DnuriuHOV1
e.rio\
/VllChCAY1iSW1 ~ Th ~ e>1ol~.
OH cH

CY \
if
© b.p\o.\"' o.C\di~ im'ld'5 in re90.rd'!, TI> ot-f, kUo/q~-
~-\tx- {l~\r-&. .

u. Which H ·,s M~T ~icAit ~

· o ~ ,J:..,,
·- 0>1

© 0

Y' 7

® 0
~0----l__

0
 0 0 <
o~oA -
L.IJI\ ~ I 11
b
11
0
r
~
I 0 ~D
0 /'-....

~
~

t•

0 ~ NoDr\
® [ l. I a.,
0
.,,,.

~
o/
~o
/ . 7 ) 1-\~0+
o OH
(
@ (dCuLi
~Cl
0
~z.O
1- ~ 7•
I
~
0

® &r.,. C,

Hz.O
7
• Gfo