Scribd Logo
Upload

Welcome to Scribd!

  • CLO3 WW2 - Critical Thinking Exercise Start - Mariel Maristela

    Uploaded by

    AngelaM
    44 views2 pages
    Mr. Apidra, a 40-year-old male with advanced AIDS, has a CD4 count of 145 and has been prescribed AZT and zalcitabine to treat his HIV infection. It is important to monitor his CD4 count and neurologic status, as well as perform bloodwork, as the medications can cause side effects like peripheral neuropathy and blood disorders. The nurse should also monitor for potential drug interactions and bone marrow suppression from medications like AZT. Zalcitabine is a reverse transcriptase inhibitor used to treat HIV in combination with other antiretrovirals by blocking the growth of the virus.

    Original Description:

    Drugs acting on the immune system

    Original Title

    CLO3 WW2- Critical Thinking Exercise Start- Mariel Maristela

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Mr. Apidra, a 40-year-old male with advanced AIDS, has a CD4 count of 145 and has been prescribed AZT and zalcitabine to treat his HIV infection. It is important to monitor his CD4 count and neurologic status, as well as perform bloodwork, as the medications can cause side effects like peripheral neuropathy and blood disorders. The nurse should also monitor for potential drug interactions and bone marrow suppression from medications like AZT. Zalcitabine is a reverse transcriptase inhibitor used to treat HIV in combination with other antiretrovirals by blocking the growth of the virus.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    44 views2 pages

    CLO3 WW2 - Critical Thinking Exercise Start - Mariel Maristela

    Uploaded by

    AngelaM
    Mr. Apidra, a 40-year-old male with advanced AIDS, has a CD4 count of 145 and has been prescribed AZT and zalcitabine to treat his HIV infection. It is important to monitor his CD4 count and neurologic status, as well as perform bloodwork, as the medications can cause side effects like peripheral neuropathy and blood disorders. The nurse should also monitor for potential drug interactions and bone marrow suppression from medications like AZT. Zalcitabine is a reverse transcriptase inhibitor used to treat HIV in combination with other antiretrovirals by blocking the growth of the virus.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    Mariel Cristin Joyce C.

    Maristela
    BSN-202N

    Dugs that Affect Immune System

    Case Scenario: Critical Thinking

    Situation

    Mr. Apidra is a 40-year-old male client who has been diagnosed with advanced acquired
    immune deficiency syndrome (AIDS). His CD4 cell count is 145. His primary care provider
    has Rx azidothymidine (AZT also called zidovudine) (Retrovir) 200 mg t.i.d. to be
    administered concomitantly with zalcitabine (Hivid) 200 mg p.o.. Before starting the client on
    combination therapy, the nurse continued to closely monitor his neurologic status and check
    his complete blood count (CBC) and CD4 count

    1. What is the normal range value of CD4 cell count and why is it important to monitor
    CD4 cell count in client who are being treated for HIV infection?.

    A. Normal cell value of CD4 cell count: 500-1,200 cells/mm3

    B. Why:

    B.1: If too many CD4 cells are lost, your immune system will have trouble fighting off
    infections.

    B.2: 250–500 cells per cubic millimeter. It means you have a weakened immune
    system and may be infected with HIV.

    B.3:The test can also check to see how well HIV medicines are working.

    2. What is the significance of burning and tingling in the fingers and toes for clients
    taking nucleoside reverse transcriptase inhibitors?

    A. Burning and tingling in the fingers and toes are the potential side effect of certain
    medications used to treat HIV/AIDS.

    B. Nucleoside reverse transcriptase inhibitors (NRTIs), or “d-drugs”, are most frequently


    associated with peripheral neuropathy.

    C. This symptoms caused by these medications that can often be treated by reducing the
    dosage or withdrawing the drug.

    D. Side effects from taking NRTIs vary, depending on the individual.


    3. Why is it important to closely monitor the complete blood count of clients taking
    zidovudine (AZT)?

    A. Because Zidovudine may decrease the number of certain cells in your blood, including
    red and white blood cells

    B. And this may result blood disorders such as anemia (a lower than normal number of red
    blood cells)

    C. Including bone marrow problems.

    4. What drugs should the client avoid while taking zidovudine (AZT) because they can
    cause bone marrow suppression?

    A. dapsone (Avlosulfon)

    B. ganciclovir (Cytovene)
    C. ribavirin (used as treatment for hepatitis C)
    D. valganciclovir (Valcyte)
    E. valproic acid (Depakene, Divalproex, other brand names)

    5. Drug classification of zalcitabine and its usual indication.

    Drug Classification Usual Indication

    It is in a class of drugs called reverse Zalcitabine is an oral medication that is


    transcriptase inhibitors which also includes used for the treatment of infections with the
    lamivudine (Epivir), zidovudine (Retrovir), human immunodeficiency virus (HIV).It is
    didanosine (Videx), and stavudine (Zerit). used in combination with other medicines.
    Zalcitabine in a nucleoside reverse
    transcriptase inhibitor. It works by blocking
    the growth of HIV.

    REFERENCES:

    https://medlineplus.gov/lab-tests/cd4-lymphocyte-count/

    https://www.foundationforpn.org/what-is-peripheral-neuropathy/causes/inflammatory-
    neuropathy/hiv-aids/

    https://www.catie.ca/fact-sheets/nukes/azt-zidovudine-retrovir

    You might also like