General Inhibitors of CYP450 3A4

GENERAL INHIBITORS OF 3A4:

• Acute alcohol
• Antiulcer meds (cimetidine, omeprazole)
• Antimicrobials (the macrolide erythromycin, ketoconazole,
chloramphenicol, protease inhibitor: ritonavir)
HINT: Drugs that Inhibit Expression CYP450s (esp. 3A4)
A CCOKE and Grapefruit juice with PIe
ASSUMPTION: Drug metabolism turns drug off
TAKEAWAY: Inhibitors will increase activity of other drugs
COMMON 3A4 SUBSTRATES : Warfarin, theophylline, statins
(metabolize slowly  substrate builds up  drug toxicity)

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