A scheme for Hyaluronan catabolism

Vinh Mai
School of Mathematics, Statistics and Applied Mathematics

17-11-2017

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 Hyaluronan

Hyaluronan: a high-molecular-weight, highly anionic

glycosaminoglycan.

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 Hyaluronan

Hyaluronan: a high-molecular-weight, highly anionic

glycosaminoglycan.
D-Glucuronic acid,
N-Acetylglucosamine.

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 Hyaluronan

Hyaluronan: a high-molecular-weight, highly anionic

glycosaminoglycan.
D-Glucuronic acid,
N-Acetylglucosamine.

2
 Hyaluronan

Hyaluronan: a high-molecular-weight, highly anionic

glycosaminoglycan.
D-Glucuronic acid,
N-Acetylglucosamine.

Polymer degree: very high.

Can exist in numerous form of sizes.

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 Hyaluronan

HA participates in many biological processes such as

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 Hyaluronan

HA participates in many biological processes such as

wound healing,
inflammation, etc.

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 Hyaluronan

HA participates in many biological processes such as

wound healing,
inflammation, etc.
And it functions as
a lubricant,
a shock absorber, etc.

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 Hyaluronan

HA participates in many biological processes such as

wound healing,
inflammation, etc.
And it functions as
a lubricant,
a shock absorber, etc.
HA functions are dependent on its size. For instance, HA fragments
of 104 kDa are anti-angiogenic, whereas ones of 20 kDa are highly
angiogenic.

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 Hyaluronidases

Bacterial hyaluronidases (HA lyases)

Picture from DOI: 10.5772/57227

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 Hyaluronidases

Bacterial hyaluronidases (HA lyases)

Invertebrate (leech) hyaluronidases

Picture from DOI: 10.5772/57227

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 Hyaluronidases

Bacterial hyaluronidases (HA lyases)

Invertebrate (leech) hyaluronidases
Mammalian hyaluronidases

Picture from DOI: 10.5772/57227

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 HA Catabolism

http://www.glycoforum.gr.jp/science/hyaluronan/HA15a/HA15aE.html

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 References

[1] J. Necas, L. Bartosikova, P. Brauner, J. Kolar: Hyaluronic acid

(Hyaluronan): a review. Veterinarni Medicina, 53, 2008 (8):397-411.
[2] Robert Stern, Akira A. Asari, Kazuki N. Sugahara: Hyaluronan
fragments: An information-rich system. European Journal of Cell
Biology 85 (2006) 699-715.
[3] Nermeen S. El-Safory, Ahmed E. Fazary, Chang-Kang Lee:
Hyaluronidase, a group of glycosidases: Current and foture
perspectives. Carbohydrate Polymers 81 (2010) 165-181.
[4] Robert Stern: Hyaluronan catabolism: a new metabolic pathway.
Eur. J. Cell Biol. 83 (2004); 317-325.