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  • Haplotype analysis of DNAJB2 locus markers

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    Le Doan
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    This document presents haplotype data for multiple families with markers on the DNAJB2 locus. It shows that affected individuals from different families share the same haplotype consisting of alleles at multiple markers including the c.352+1G>A mutation in DNAJB2, suggesting these families share a common ancestral mutation.

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    1-s2.0-S1525157815002615-mmc1

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    This document presents haplotype data for multiple families with markers on the DNAJB2 locus. It shows that affected individuals from different families share the same haplotype consisting of alleles at multiple markers including the c.352+1G>A mutation in DNAJB2, suggesting these families share a common ancestral mutation.

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    10 views1 page

    Haplotype analysis of DNAJB2 locus markers

    Uploaded by

    Le Doan
    This document presents haplotype data for multiple families with markers on the DNAJB2 locus. It shows that affected individuals from different families share the same haplotype consisting of alleles at multiple markers including the c.352+1G>A mutation in DNAJB2, suggesting these families share a common ancestral mutation.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 1

    Supplemental Table S1. Haplotype constructed with markers on the DNAJB2 locus.

        5' flanking markers DNAJB2 Chr2: 220143989-220151622 3' flanking markers


    21975699 22011338 22014528 22014640 22014660 22014665 22014773 22014776 22014784 220197,32 22019738
      Chr2:*   1 4 220136836 6 220145637 2 9 220146609 1 220146785 2 220147809 7 7 1 8 220234201
    rs20209056 rs14041973
    Family Subject D2S2250 rs8447 rs10166888 rs2276638 rs115665065 rs3731896 rs3832110 1 rs3731897 c.352+1G>A rs2276639 4 rs3821038 rs3821039 rs2385405 rs2385404 D2S2244

    SGT/271 176/182 G/G G/T C/T A/A C/T -/G C/G G/A G/A C/T -/- C/C A/A C/T C/A 231/236

    SGT/272 176/182 G/G G/T C/T A/A C/T -/G C/G G/A G/A C/T -/- C/C A/A C/T C/A 231/236

    fCMT- SGT/273 176/182 G/G T/T C/C A/A C/C -/- C/C G/G G/A C/C -/- C/C A/A C/C C/C 231/236
    391
    SGT/19 176/182 G/G T/T C/C A/A C/C -/- C/C G/G A/A C/C -/- C/C A/A C/C C/C 231/236

    SGT/20 NA G/G T/T C/C A/A C/C -/- C/C G/G A/A C/C -/- C/C A/A C/C C/C NA

    SGT/21 176/182 G/G T/T C/C A/A C/C -/- C/C G/G A/A C/C -/- C/C A/A C/C C/C 231/236

    SGT/149 176/182 G/G T/T C/C A/A C/C -/- C/C G/G G/A C/C -/- C/C A/A C/T C/A 231/236

    SGT/150 176/182 G/A T/T C/C A/A C/C -/- C/C G/G G/A C/C -/- C/C A/A C/C C/C 231/236
    fCMT-83
    SGT/151 176/182 G/G T/T C/C A/A C/C -/- C/C G/G G/A C/C -/- C/C A/A C/T C/A 231/236

    DNA_133 176/182 G/G T/T C/C A/A C/C -/- C/C G/G A/A C/C -/- C/C A/A C/C C/C 231/236
    fCMT-
    416 SGT/169 176/182 G/G T/T C/C A/A C/C -/- C/C G/G A/A C/C -/- C/C A/A C/C C/C 231/236
    fCMT-
    245 DNA_686 176/182 G/G T/T C/C A/A C/C -/- C/C G/G A/A C/C -/- C/C A/A C/C C/C 231/236
    fCMT- DNA_
    331 918 176/182 G/G T/T C/C A/A C/C -/- C/C G/G A/A C/C -/- C/C A/A C/C C/C 231/236
    *The positions of markers are according to the GRCh37/hg19 human assembly (UCSC Genome Bioinformatics Site, http://genome.cse.ucsc.edu).

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