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SYNDROME
Dr RAHUL VARSHNEY
Deaths from ACS
others
23%
ACS
Hypertension
48%
5%
CHF
5%
Atherosclerosis
2% Stroke
Cong. 17%
0.5% RHD
0.5%
Hospitalizations in the U.S. Due to Acute
Coronary Syndromes (ACS)
Acute Coronary
Syndromes*
UA/NSTEMI† STEMI
Heart Disease and Stroke Statistics – 2007 Update. Circulation 2007; 115:69-171.
*Primary and secondary diagnoses. †About 0.57 million NSTEMI and 0.67 million UA.
Acute Coronary Syndrome
Definition:
The spectrum of acute ischemia related syndromes ranging from UA to MI
with or without ST elevation that are secondary to acute plaque rupture or plaque
erosion.
[----UA---------NSTEMI----------STEMI----]
The pain may spread to other parts of the upper body, including:
• Recent research shows that women, the elderly and people with diabetes are
less likely to experience chest pain as a symptom.
Anginal equivalent syndrome
• Patients who are experiencing ACS, yet do not complain of typical chest
pain; rather, these patients note atypical pain, dyspnea, weakness,
diaphoresis, or emesis—these complaints, in fact, are the manifestation of
the ACS event.
• Patients with altered cardiac pain perception e.g., the elderly or patients
with longstanding diabetes mellitus, are potentially at risk to present with
anginal equivalent syndromes.
• The most frequently encountered anginal equivalent chief complaint is
dyspnea, which is found in 10% to 30% of patients with AMI, often due to
pulmonary edema.
CHARACTERISTICS OF
TYPICAL ANGINAL CHEST PAIN
CHARACTERISTIC SUGGESTIVE OF ANGINA LESS SUGGESTIVE OF
ANGINA
Pathophysiology ACS
Decreased O2 Supply
•Flow- limiting stenosis
Asymptomatic
•Anemia
•Plaque rupture/clot
Increased O2 Demand
Angina
O2 supply/demand mismatch → Ischemia
ECG (new ST-T wave changes, new left bundle branch block or evolving
pathological Q waves)
IDEAL MARKER:
• High concentration in
myocardium
• Myocardium specific
• Released early in injury
• Proportionate to injury
• Non expensive testing
Advantages
2. Ability to detect early 2. Useful in early detection of MI 2. Greater sensitivity and specificity
reinfarction than CK-MB
5. Detection of reperfusion
Diadvantages
2. Low sensitivity during early MI 2. Rapid return to normal 2. Limited ability to detect late minor
(<6 h) or late (>36 h) after re-infarction
symptom onset and for minor
myocardial damage
• Cardiac Imaging
1–2 hours
Minor heart muscle damage only
2–4 hours
Some heart muscle damage with moderate heart muscle salvage
4–6 hours
Significant heart muscle damage with only minor heart muscle salvage
6–12 hours
No heart muscle salvage (permanent loss) with potential infarct
healing benefit
> 12 hours
Reperfusion is not routinely recommended if the patient is
asymptomatic and haemodynamically stable
Therapy STEMI
• Sublingual Nitroglycerin (unless systolic pressure is <90 mm Hg), and Aspirin, 160
to 325 mg orally.
• Opiates relieve pain and also reduce anxiety, the salutary effects of which have
been known for decades and should not be underestimated.
Fibrinolytic therapy
• Early reperfusion of an occluded coronary artery is indicated for all
eligible candidates.
• Fibrinolytic agents administered early in the course of an acute MI
reduce infarct size, preserve LV function, and reduce short-term and
long-term mortality.
• Multiple studies conclude that greatest mortality benefit is seen if
fibrinolytics are administered within the first 12 hours of symptom
onset, but it is reasonable to administer fibrinolytics to patients
whose onset of symptoms exceeds 12 hours but who have continued
clinical or ECG evidence of ischemia.
INDICATIONS FOR AND
CONTRAINDICATIONS TO
FIBRINOLYTIC THERAPY IN
ACUTE MYOCARDIAL INFARCTION
• After administration of fibrinolytics for
STEMI, the patient should be monitored
High-risk features include
for signs and symptoms of adequate
reperfusion within 90 minutes, as • Extensive ST-segment elevation (>2 mm
indicated by relief of symptoms and/or ST elevation in two anterior leads),
hemodynamic/ electrical instability
• New-onset LBBB,
coupled with at least a 50% resolution of
the highest initial ST elevation. • Previous MI,
Alteplase (tPA) a 15-mg bolus, then 0.75 mg/kg (up to 50 mg) IV over the initial 30
minutes, and 0.5 mg/kg (up to 35 mg) over the next 60 minutes
Unstable Angina:
• May present with nonspecific or transient ST segment depressions
or elevations
Diagnosis
Evolving Risk Stratification
• Provides prognostic information
• Determines treatment and level of
intervention
Low risk patients ---> early discharge,
High risk ---> admission to high care
• Helps decongest the casualty and make
available medical resources to more
needy patients.
• Risk stratification should be ongoing – at
admission, 6-8 hrs, 24hrs, discharge
Evolving risk stratification…
Intermediate-risk NSTEACS
YES NO
• admit to CCU or high dependency unit: • undertake stress test (e.g. exercise ECG):
Appropriate period of
observation. Consider if
stress test (e.g. exercise
ECG) needed?
YES NO
Stress test (e.g. exercise ECG) Proceed to discharge patient with urgent
using treadmill. cardiac follow-up (on upgraded medical
therapy) according to long-term
management after control of myocardial
ischemia.
Variables Used in the TIMI Risk Score
Recommendation
Low risk : Aspirin + Anticoagulant + either a glycoprotein IIb/IIIa inhibitor or a
thienopyridine
High Risk: Aspirin + Anticoagulant + a glycoprotein IIb/IIIa inhibitor + a
thienopyridine
Interventional Management
In patients with High Risk, following treatment with anti-ischemic and
antithrombotic agents, coronary arteriography is carried out within ~ 48 h of
admission, followed by coronary revascularization (PCI or coronary artery
bypass grafting), depending on the coronary anatomy.
In low-risk patients, the outcomes from an
invasive strategy are similar to those
obtained from a conservative strategy,
which consists of anti-ischemic and
antithrombotic therapy followed by
“watchful waiting,” and in which coronary
arteriography is carried out only if rest pain
or ST-segment changes recur or there is
evidence of ischemia on a stress test.
UA/NSTEMI
treatment Algorithm
Complications
• Ventricular dysfunction
• Cardiogenic shock
• Right Ventricular Infarction
• Pericarditis
• Thromboembolism
• Left ventricular aneurysm
• Sinus bradycardia
• AV Block
• Ventricular tachycardia and fibrillation
THANK
Take all these pills daily until a new clinical trial is
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