Drugs Mechanism of Indications and Contraindications Common Side Effects Nursing

Action Rationale Considerations

Generic Name: Accelerates increases the Contraindicated in  fever  Start at lower
Heparin formation of inhibitory action of patients  headache dosage
antithrombin III- antithrombin III (AT hypersensitive to  hyperkalemia  Monitor pt.
Brand Name: thrombin complex III) on clotting factors drug.  chills for
Hep-Pak (obsolete) and deactivates (XIIa, XIa, IXa, Xa),  nausea hyperkalemia
thrombin, and thrombin.  vomiting during
Classifications: preventing  epistaxis therapy
Therapeutic Class: conversion of Rationale: To treat  bruising  Check order
Anticoagulants fibrinogen to fibrin. and prevent blood  osteoporosis and vial
clots.  alopecia carefully.
Pharmacologic Class:  Always check
Anticoagulants compatibilities
with other IV
solutions.
Dosage, Frequency  Monitor VS
and Route:  Do not add
low intensity heparin heparin to
infusion (UFH infusion lines
50,000units/5mL of other
infusion rate of 12 drugs, and do
units/kg/hr.) for 48 not piggyback
hours, IV other drugs
into heparin
line. If this
must be done,
ensure drug
compatibility.
 Drugs Mechanism of Indications and Contraindications Common Side Effects Nursing
Action Rationale Considerations
Generic Name: Hinders bacterial to treat and prevent Contraindicated in  Fever  Monitor BP
Vancomycin cell-wall synthesis, various bacterial patients  Headache and heart rate
damaging the infections caused by hypersensitive to  Fatigue continuously
Brand Name: bacterial plasma gram-positive drug.  Nausea through period
Vancocin membrane and bacteria.  Abdominal of drug
making the cell pain administration.
Classifications: more vulnerable to Rationale: To  Dyspnea  Monitor
Therapeutic Class: osmotic pressure. prevent potentially  red-man patient
Antibiotics life-threatening syndrome carefully for
infections in patient. (with rapid IV red-man
Pharmacologic infusion) syndrome
Class:  nephrotoxicit which can
Glycopeptides y occur if drug is
infused too
Dosage, Frequency rapidly.
and Route:  Monitor
500 mg IV every patient’s fluid
6hrs. balance and
watch for
oliguria and
cloudy urine
 Carefully
monitor serum
concentrations
of vancomycin
to adjust IV
dosage
requirements.
 Drugs Mechanism of Indications and Contraindications Common Side Effects Nursing
Action Rationale Considerations
Generic Name: Inhibits cell-wall Moderate to severe Contraindicated in  headache >Before giving
Piperacillin synthesis during infections from patients  insomnia drug, ask pt. about
bacterial piperacillin- hypersensitive to  fever allergic reactions to
Brand Name: multiplication. resistant; producing drug and other  Diarrhea/constipation penicillin,
Zosyn strains of penicillin,  nausea cephalosporins, or
microorganisms in cephalosporins, or  vomiting beta- lactamase
Classifications: peritonitis. beta-lactamase  dyspepsia, inhibitors.
Therapeutic Class: inhibitors.  pseudomembranous
Antibiotics Rationale: To treat colitis. >Monitor pt. for
and prevent  pruritus diarrhea and
Pharmacologic infections.  hypersensitivity initiate therapeutic
Class: reactions measures as
Extended-spectrum needed. Drug may
penicillin-beta- need to be stopped
lactamase
inhibitors >Monitor
hematologic and
Dosage, Frequency coagulation
and Route: parameters
3.375 g every 6hrs.
by IV infusion >Monitor patient’s
sodium intake and
electrolyte levels;
drug contains 65mg
of sodium