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High alcohol intake for many years - approximately one drink per
day for women and two drinks per day for men over many years
Other forms of chronic liver disease, such as non-alcoholic fatty
liver disease (NAFLD) or chronic hepatitis B or C
A few cases - around 1 in 100 - are caused by poisoning with
industrial chemicals called 'nanoparticles. Liver disease cirrhosis
leads to scarring (fibrosis) of liver tissue that impairs its function.