Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices

Pharm 201L

Name: De jesus, Esmeria, Estanislao Group: 05

Year/Section: Q2A Final Rating:

PREPARATION No. “18”

“LEMON PEEL TINCTURE, USP”

A. WRAP-UP GUIDE QUESTIONS:

Synonym/s: Citrus limon peel tincture

Uses of Preparation: Antimicrobial
Method/s of Preparation used: Percolation & Maceration
Method/s of Administration: Sublingual
Packaging material/s used in the preparation: Light resistant container / Amber glass bottle
Particular Equipment (if any): Beaker, Funnel, Filter paper, Graduated cylinder, Chopping
devices (Knife, Spatula, Chopping board)
Ideal temperature and storage conditions: Preserve in tight, light-resistant containers, and avoid
exposure to direct sunlight and to excessive heat. Store at controlled room temperature.
Description of Finished Product: A clear pale yellow or brownish color, Liquid preparation. have
strong, fragrant, and characteristics odor with an aromatic, bitter taste.

B. Facsimile label:
 Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L
Formula based on preparation:
Raw Materials Quantity Physical Appearance Uses
Lemon peel 15 g It has strong and resistant Contains antibacterial
skin. Shiny, brightly substances that may
colored, and textured. inhibit
microorganism
growth.
Alcohol, qs. ad 30 mL Is a clear, colorless liquid It is widely used as a
with a characteristic solvent and
pleasant odor and burning preservative in
taste. pharmaceutical
preparations.

C. Calculation(s):

Ingredients Original Amount Computed Amount

Lemon peel 500 g 15 g

Alcohol, qs. ad 1000 mL 30 mL

To make 1000 mL 30 mL

Solution:
500g / 1000mL = x / 30mL = 15g
1000mL / 1000mL = x / 30mL = 30mL

D. Attachment(s) of actual laboratory activity: (if any)

 Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L

ASSIGNMENT
1. Define tincture based on USP.
- According to the USP, tinctures are defined as alcoholic or hydroalcoholic solutions
prepared from vegetable materials or from chemical substances. Made by extracting
the valuable principles from drugs by the use of appropriate menstrua or solvents.
Tinctures are made by percolation with few exceptions. Maceration or solution is
preferred when from its physical character the drug is not suitable for percolation.
2. What is the difference between tincture and extracts?
- The difference is in the liquid that is used. An extract might use any liquid such as
glycerin, vinegar, oil, or even water. A tincture is an extract that uses alcohol as a
liquid or solvent. Liquid extracts are more concentrated than tinctures. In other
words: all tinctures are extracts, but not all extracts are tinctures.
3. Why is it necessary to remove the rind of the lemon before maceration?
- Because only lemon peel is needed in this preparation. When fruit is macerated, it
softens and releases some of its flavors.
4. What is the principle behind maceration or process M?
- Maceration is the process by which organized tissue is transformed into a suspension
of intact cells, resulting in pulpy products used as a base material for pulpy juices and
nectars, as baby foods, and as ingredients for dairy products such as puddings and
yoghurts.