DOBUTAMINE

a. Drug Name
 Generic Name: Dobutamine
 Brand names: Dobutrex
 Chemical name: 4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol

b. Drug Classifications
 Therapeutic:
Inotropics that change the force of your heart contractions.
 Pharmacologic:
Adrenergics are medications that stimulate certain nerves in your body.

c. Pregnancy Category
 Pregnancy Category B

d. Mechanism of Action
 Stimulates beta1 (myocardial) - adrenergic receptors with relatively minor effect on heart rate
or peripheral blood vessels.

Therapeutic Effects:
 Increased cardiac output without significantly increased heart rate.

e. Pharmacokinetics

 Metabolized: we are readily metabolised by COMT in the liver, even though tissue MAO has
no way of handling our bizarrely elongated amine substituent group. COMT is actually very
good at this; our half-life is about 2-3 minutes.
 Absorption: Orally administered dobutamine is rapidly metabolised in the GI tract. Following
IV administration, our onset of action occurs within 2 minutes. Our peak plasma concentrations
and peak effects occur within 10 minutes after initiation of an IV infusion.
And we are then eliminated in human urine, the major excretion products are our conjugates and 3-O-
methyl dobutamine.

f. Indications
 We are indicated for patients who require a positive inotropic support in the treatment of
cardiac decompensation due to depressed contractility.

g. Contraindications
 Dobutamine hydrochloride is contraindicated in patients with idiopathic hypertrophic subaortic
stenosis ( is a disease characterized by marked hypertrophy of the left ventricle,) and in
patients who have shown previous manifestations of hypersensitivity to dobutamine injection.

h. Side and Adverse Effects (categorize per body system)

 Increased Heart Rate, Blood Pressure, And Ventricular Ectopic Activity
 Hypotension
 Reactions At Sites Of Intravenous Infusion
 The adverse effects have been reported in 1% to 3% of patients which experienced: nausea,
headache, anginal pain, nonspecific chest pain, palpitations, and shortness of breath.
 i. Nursing Responsibilities (Before, During and After)
 Nurses should observe IV site closely and avoid extravasation. for we can cause inflammatory
response and tissue ischemia (ischemia is a condition in which the blood flow (and thus
oxygen) is restricted or reduced)
 Monitor for adverse reactions
 Continuous blood pressure monitoring
 Continuous cardiorespiratory monitoring
 Document vital signs hourly and PRN
 Monitor fluid balance