EPIS-AKI

EPIdemiology of Surgical
induced Acute Kidney Injury
Part of ESAIC Research Group
Renal Protective Network
(RAPNet)
 EPIS-AKI
INclusion
• Age ≥ 18 years
• Major surgery with a duration of at least 2 hours
• (Un-)Planned admission to ICU, IMC after surgery
• Written informed consent
EXclusion
• Pre-existing AKI
• AKI within last 3 months
• End stage renal disease with dialysis dependency
• Kidney transplant

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 EPIS-AKI
Primary endpoint: Occurrence of AKI within first 72 h after surgery
according to KDIGO criteria

Secondary endpoints: Identification and effect of risk factors

Biomarkers of AKI
Outcomes: RRT, length of stay etc.
Survival
MAKE90 (major adverse kidney events day 90)

Observational period: First post-operative 72 h

Day-90-Follow-Up telephonically
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How to …

… RedCap.

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How to …
• … include patients staying less than 72 hrs in the ICU?
• Patients must stay at least 1 day/24 h on ICU/IMC/PACU
• Documentation will continue until 72 hrs are reached regardless of the ward

• … measure SCr-levels and urine output?

• SCr are needed before OP (baseline)
• For ideal conditions, if possible: daily on 1st, 2nd, 3rd post-OP day and on day 90
• Urin output should be measured as far and detailed as possible until 72 h

• … count post-OP days?

• Depending on documentation of study cite, therefore consistency is important
• Usually: day of operation until next morning 05:59 - 1st - 2nd - 3rd

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How to …
• … define crystalloids?
• Everything except classical colloids (HES, albumine etc.)

• … count fluid balance?

• If vomitting can be measured, please substract this amount (i.e. gastral tube is used)
• Diarrhea is not recorded

• … count fluid balance with oral intake?

• Amount added to crystalloids

• … count fluid balance with parenteral nutrition?

• Amount added to crystalloids

• … use a Cell Saver?

• Just click the check box
• No extra calculation needed for fluids
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RedCap – General Information
• Rules
• You will only see patients of your own site.

• Only enter patients who are eligible for the study.

• Use your provided site ID to code patients.

• Please be as detailed as possible (i.e. if possible daily SCr in 72 h)

• Please use drop down menu at the end of each eCRF form to state if form is in-/complete.

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RedCap – eCRF Platform

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RedCap – New Patient

Please use your provided site ID to generate patient IDs

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RedCap – Patient ID

49-YY-ZZZZ XX-YY-ZZZZ
country code - site code - ongoing patient number

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 RedCap – Entering data
Be advised „0“ is a value!
If something is unavailable please
leave blank and use comment function
(speech bubble).

Sometimes, if numbers are too

low/high there will be an alert
message: „Out of range“
Then please re-check the entered
value and correct or accept.
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 RedCap – Follow Up
Day 90 Follow Up
• To be done telephonically
• General practioneer (GP)
(clarify whether patient is alive or not,
creatinine level)
• If no recent information contact patient

SCr level on Day 90

• Please enter the value that is closest to Day
90
• but after hospital discharge.
• This might be SCr value measured by GP or
readmission
• Please state the date with the use of the
speech bubble (if not in Day 90 period). 12
 RedCap – Follow Up

Complete?
• Please state at the end whether a eCRF is
complete or not.

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 Go to epis-aki.ukmuenster.de

Thank you for your support!