Oabel, Xenia May C.

2Nur- 6

GENERIC BRAND INDICATIONS MECHANISM OF CONTRAINDICA NURSING

NAME NAMES ACTION TION/S RESPONSIBILITIES
Rifampicin Rifadin, Active tuberculosis Inhibits RNA synthesis Hypersensitivity; Administer on an empty
Rimactane, (with other agents). by blocking RNA Concurrent stomach, 1 hr before or 2
Rofact Elimination of transcription in indinavir, nelfinavir, hr after meals.
meningococcal susceptible organisms. pyrazinamide, or
carriers. Unlabeled Therapeutic Effects: saquinavir. Administer in
Use: Prevention of Bactericidal action a single daily dose.
disease caused by against susceptible
Haemophilus organisms. Consult pharmacist for
influenza type B in rifamoin suspension for
close contacts. patients unable to swallow
capsules.

Prepare patient for the

reddish-orange coloring of
body fluids (urine, sweat,
sputum, tears, feces,
saliva); soft contact lenses
may be permanently
stained; advise patients not
to wear them during
therapy.

Warning: arrange for

follow-up visits for liver
and renal function tests,
CBC,
and ophthalmic examinati
on.
Isoniazid INH First-line therapy of Inhibits mycobacterial Hypersensitivity; Assess laboratory
active tuberculosis, in cell wall synthesis and Acute liver disease; examinations.
combination with interferes with Previous hepatitis
other agents. metabolism. from isoniazid. Monitor liver/renal
Prevention of Therapeutic Effects: function.
tuberculosis in Bacteriostatic or
patients exposed to bactericidal action Instruct patient that
active disease against susceptible compliance with dosage
(alone). mycobacteria. schedule for duration is
necessary to gain benefits.

Caution patient in
alcohol while in therapy
may increase risk of liver
damage.

Tell patient to report

peripheral neuritis
Pyrazinamide Zynaphar Used in combination Mechanism not known. Hypersensitivity; Assess patient’s condition
with other agents in Therapeutic Effects: Cross-sensitivity before therapy and
the treatment of Bacteriostatic action with ethionamide, regularly thereafter to
active tuberculosis. against susceptible isoniazid, niacin, or monitor drug
mycobacteria. nicotinic acid may effectiveness.
exist; Severe liver
impairment. Monitor serum uric acid
which may be elevated
and cause gout symptoms.

Regularly assess for

hepatoxicity.

Regularly assessrenal
status.
 Instruct patient to take
drug continuously as
prescribed.

Remind patient to report

with follow-up schedule.
Ethambutol Myambutol Active tuberculosis or Inhibits the growth of Hypersensitivity; Perform visual acuity and
other mycobacterial mycobacteria. Optic neuritis. color discrimination tests
diseases (with at least Therapeutic Effects: before and during therapy.
one other drug). Tuberculostatic effect
against susceptible Assess liver and renal
organisms. status and function before
and during therapy.

Assess patient for visual

disturbance that may
indicate optic neuritis.

Advise patient that

compliance with dosage
schedule and duration is
necessary to eradicate
disease.

Remind patient to come

for follow up consultations
including ophthalmic
appointments.
Streptomycin Generic only In combination with Inhibits protein Hypersensitivity to Lab tests: Obtain C&S
other agents in the synthesis in bacteria at aminoglycosides; tests prior to and
management of active level of 30S ribosome. Most parenteral periodically during course
tuberculosis. Therapeutic Effects: products contain of therapy
Bactericidal action. bisulfites and should
be avoided in Be alert for and report
patients with known immediately symptoms of
intolerance; Pedi: ototoxicity.
Products containing
benzyl alcohol Early damage to vestibular
should be avoided in portion of eighth cranial
neonate; Intestinal nerve (higher incidence
obstruction than auditory toxicity) is
(neomycin only). initially manifested by
moderately severe
headache, nausea,
vomiting, vertigo in
upright position, difficulty
in reading, unsteadiness,
and positive Romberg
sign.

Be aware that auditory

nerve damage is usually
preceded by vestibular
symptoms and high-
pitched tinnitus, roaring
noises, impaired hearing
(especially to high-pitched
sounds), sense of fullness
in ears.

Monitor Input and Output.