GENERIC NAME: DOSAGE/ FREQUENCY/
Rifampin ROUTE:
600mg/day, 10 kg /day PO,
IV
BRAND NAME: INDICATION:
Rifadin, Rimactane Active tuberculosis and
DRUG ILLUSTRATION: meningococcal carriers.
Prevention of disease caused
by haemophilus influenza
type B in close contact
CLASSIFICATION: CONTRAINDICATION:
Antibiotic, Antituberculars Hypersensitivity,
MECHANISM OF ACTION: Concurrent indinavir,
Inhibits RNA synthesis by blocking RNA nelfinavir, pyrazinamide, or
transcription in susceptible organisms, saquinavir
Therapeutic Effects:
Against susceptible organisms
DRUG STUDY
GENERIC NAME: DOSAGE/ FREQUENCY/
ROUTE:
SIDE EFFECTS/ NURSING
ADVERSE REACTION RESPONSIBILITIES
 Upset stomach  Administer on an empty
 Heartburn  stomach, 1 hr. before or
 Nausea 2 hr. after meals.
 menstrual changes,  Administer in a single
or headache daily dose.
 may cause urine,  Consult pharmacist for
sweat, saliva, or tears rifamoin suspension for
to change color patients unable to
(yellow, orange, red, or swallow capsules
brown).  Prepare patient for the
 diarrhea reddish-orange coloring
of body fluids (urine,
Sweat, sputum, tears,
feces, saliva), soft
contact lenses may be
stained permanently
stained; advise patients
not to wear them during
therapy
 Warning: arrange for
follow-up visits for
liver and renal function
tests, CBC, and
ophthalmic examination
SIDE EFFECTS/ NURSING
ADVERSE REACTION RESPONSIBILITIES
 Pyrazinamide Adults: 15 to 30 mg/kg PO
Children: 15 to 30 mg/ kg
PO
BRAND NAME: INDICATION:
pyznia Initial treatment of active
TB in adults and children
DRUG ILLUSTRATION:
with other anti TB drugs
after primary treatment has
failed
CLASSIFICATION: CONTRAINDICATION:
Anti-Tuberculotic, Antibiotic Hypersensitivity to PZA
MECHANISM OF ACTION: Acute hepatic disease
Bacteriastatic/bactericidal against Lactation
Mycobacterium TB
Acute gout
Converted to pyrazinoic acid susceptible to
strains of mycobacterium which lowers the
PG level of the environment
GENERIC NAME:  DOSAGE/ FREQUENCY/
Ethambutol ROUTE:
 Allergic reactions  Monitor periodic liver
Loss of appetite function tests
 Monitor serum uric acid
 Nausea and vomiting level
Increased uric acid  Assess patient’s
condition before therapy
 Joint pain
and regularly thereafter
 Sideroblastic to monitor drug
 Anemia effectiveness.
 Pellagra  Monitor serum uric acid
 Siezures which may be elevated
 Low platelet count and cause gout
 Nephritis symptoms.
 Gouty arthritis  Regularly assess for
 Drug induced Hepatitis hepatoxicity.
 Regularly assessrenal
status.
 Instruct patient to take
drug continuously as
prescribed.
 Remind patient to report
with follow-up schedule.
SIDE EFFECTS/ NURSING
ADVERSE REACTION RESPONSIBILITIES
 1200mg, Daily, PO
BRAND NAME: INDICATION:  Headache  Perform visual acuity
Myambutol,Etibi, Servambutol,  Loss of appetite and
DRUG ILLUSTRATION: Active tuberculosis or other color discrimination
 Upset stomach
mycobacterial diseases (with tests before and during
 Nausea/ vomiting
at least one other drug). therapy.
 vision changes (such as
blurred/decreased visio  Assess liver and renal
n, color blindness) status and function
 symptoms of liver before and during
disease (such as therapy.
persistent  Assess patient
nausea/vomiting, for visual disturbance
unusual that may indicate optic
tiredness/weakness, neuritis.
severe stomach/abdomi  Advise patient that
CLASSIFICATION: CONTRAINDICATION: nal pain, compliance with
yellowing eyes/skin, da dosage schedule and
antibiotic Hypersensitivity; Optic duration is necessary
rk urine)
neuritis.  numbness/tingling of to eradicate disease.
MECHANISM OF ACTION:
arms/legs, toe/joint  Remind patient to
It works by obstructing the formation pain. come for follow up
of cell wall. Mycolic acids attach to the consultations including
5'-hydroxyl groups of D- ophthalmic
arabinose residues appointments.
of arabinogalactan and form mycolyl-
arabinogalactan-peptidoglycan complex
in the cell wall. It disrupts
arabinogalactan synthesis by inhibiting
the enzyme arabinosyl transferase.
Disruption of the arabinogalactan
synthesis inhibits the formation of this
complex and leads to increased
permeability of the cell wall.

GENERIC NAME: DOSAGE/ FREQUENCY/ SIDE EFFECTS/ NURSING

ROUTE: ADVERSE REACTION RESPONSIBILITIES:
Streptomycin
 Adults:
Daily 115mg/kg IM qDay;
no more than 1 g/day
Twice 25-30 mg/kg IM
2times/ week; no more than
1.5g/day
Pediatric:
Daily therapy: 20-40 mg/kg
IM qDay; no more than 1
g/day   
Twice wekly therapy: 20-40
mg/kg IM 2 times/week; no
more than 1.5 g/day
BRAND NAME: INDICATION:
Ambistryn, pyznia In combination with other
DRUG ILLUSTRATION: agents in the management of
active tuberculosis.
  vestibular ototoxicity  Lab tests: Obtain C&S
(nausea, vomiting, tests prior to and
and vertigo) periodically during
 paresthesia of face course of therapy
 rash  Be alert for and report
 fever immediately symptoms
 urticaria of ototoxicity.
 angioneurotic edema  Early damage to
 eosinophilia. vestibular portion of
 cochlear ototoxicity eighth cranial nerve
(deafness) (higher incidence than
 exfoliative dermatitis auditory toxicity) is
anaphylaxis initially manifested by
 azotemia moderately severe
 Leucopenia headache, nausea,
 thrombocytopenia vomiting, vertigo in
 pancytopenia upright position,
 hemolytic anemia difficulty in reading,
 muscular weakness unsteadiness, and
positive Romberg sign.
 amblyopia.
 Be aware that auditory
nerve damage is
usually preceded by
vestibular symptoms
and high-pitched
tinnitus, roaring noises,
impaired hearing
(especially to high-
pitched sounds), sense
of fullness in ears.
 Monitor Input and
Output.
 CLASSIFICATION:
Aminoglycoside antibiotics
MECHANISM OF ACTION:
Streptomycin is a protein synthesis
inhibitor. It binds to the small 16S rRNA
of the 30S subunit of the bacterial
ribosome, interfering with the binding of
formyl-methionyl-tRNA to the 30S
subunit.
CONTRAINDICATION:
A history of clinically
significant hypersensitivity
to streptomycin is
a contraindication to its use.
Clinically significant
hypersensitivity to other
aminoglycosides
may contraindicate the use
of streptomycin because of
the known cross-sensitivity
of patients to drugs in this
class.

GENERIC NAME: DOSAGE/FREQUENCT/RO SIDE EFFECTS/ NURSING

Isoniazid UTE: ADVERSE REACTION RESPONSIBILITY
Adults 5mg/kg/day (max
300mg daily)
PO,IM
BRAND NAME: INDICATION:  Nausea/vomiting  Advise patient to take
Niazid First-line therapy of active  Numbness/ Tingling of medication once daily,
DRUG ILLUSTRATION: tuberculosis in combination arms/ Legs as indicated, and not to
with other agents. skip dose or double up
 Prevention of tuberculosis
in patients exposed to active
disease
CLASSIFICATION: CONTRAINDICATION:
Antibiotic Allergy to the drug
MECHANISM OF ACTION: Liver disease
Inhibits mycobacterial cell wall synthesis Alcohol use
and interferes with metabolism. HIV infection
Bacteriostatic, bactericidal action. Kidney disease
Bacterial action against susceptible Diabetes
organism. Recent child birth
 Painful/ swollen joints on missed dose
 Increased thirst/  Emphasize the
urination importance of
 Vision changes continuing therapy
 Easy bruising/bleeding even after symptoms
 Mental/ mood changes subside.
 Seizures  Caution patient to
avoid alcohol during
 Fever
this therapy, as this
 New or worsening
may increase the risk of
lymph nodes swelling
hepatotoxicity.
 Rash  Advise patient to notify
 Itching/ swelling (face/ physician promptly if
throat/ tongue) s/sx of hepatitis or
 Severe dizziness peripheral neuritis
 Trouble breathing occur

References:
https://www.webmd.com/drugs/2/drug-8665/isoniazid-oral/details
https://www.scribd.com/document/67413718/isoniazid
https://www.webmd.com/drugs/2/drug-1744/rifampin-oral/details
https://www.scribd.com/document/66658737/rifampicin
https://www.scribd.com/document/255459903/Drug-Ana-Rifampicin-Isoniazid-Pyrazinamide-Ethambutol-Streptomycin
https://www.webmd.com/drugs/2/drug-11249/streptomycin-intramuscular/details
https://en.wikipedia.org/wiki/Streptomycin
https://reference.medscape.com/drug/streptomycin-342682
https://www.scribd.com/document/255459903/Drug-Ana-Rifampicin-Isoniazid-Pyrazinamide-Ethambutol-Streptomycin
https://www.rxlist.com/streptomycin-drug.htm#precautions
https://www.scribd.com/document/44646401/Pyrazinamide-Drug-Study
https://www.webmd.com/drugs/2/drug-7398/pyrazinamide-oral/details
https://www.rxlist.com/pyrazinamide-drug.htm#dosage
https://www.scribd.com/document/255459903/Drug-Ana-Rifampicin-Isoniazid-Pyrazinamide-Ethambutol-Streptomycin
https://www.scribd.com/doc/132567037/Ethambutol
https://www.scribd.com/document/255459903/Drug-Ana-Rifampicin-Isoniazid-Pyrazinamide-Ethambutol-Streptomycin
https://www.webmd.com/drugs/2/drug-8082/ethambutol-oral/details
https://en.wikipedia.org/wiki/Ethambutol#Mechanism_of_action