P1182 Poster Presentations: Tuesday, July 18, 2017
P3-532 GASTROENTERITIS AND COLITIS AND
SUBSEQUENT RISK OF PARKINSON’S
DISEASE
G€ultekin Tamg€ uney1, Michael Nerius2,
Gabriele Doblhammer3,4,5, 1German Center for
Neurodegenerative Diseases (DZNE), Bonn, Germany; 2German
Center for Neurodegenerative Diseases, Rostock, Germany; 3Max
Planck Institute for Demographic Research, Rostock, Germany;
4
German Center for Neurodegenerative Diseases, Germany,
Rostock, Germany; 5University of Rostock, Rostock, Germany.
Contact e-mail: erdem@dzne.de
Background: It is hypothesized that Parkinson’s disease (PD) may
be caused by chronic systemic inflammation, and previous
studies have shown that inflammatory bowl disease (IBD) or
gastrointestinal infection with Helicobacter pylori causing
gastritis and peptic ulcers may increase the risk for PD. We
investigated the risk of PD in patients who were diagnosed
with gastroenteritis and colitis and hypothesized that not only
chronic but also acute systemic inflammation may be associated
with a higher risk for PD. Methods: We used a longitudinal sam-
ple of 238,721 persons aged 50 and older from claims data of the
largest German health insurer, containing 5,361 incident PD diag-
noses between 2006 and 2013. We used Cox regression to
compute hazard ratios (HRs) for PD and corresponding 95 % con-
fidence intervals (CIs), adjusting for potential confounders.
Results: Risk of PD was increased in patients with viral infections
(HR 1.28; 95 % CI 1.10–1.48), with gastroenteritis and colitis of
infectious and unspecified origin (HR 1.23; 95 % CI 1.14–1.34),
with bacterial intestinal infections (HR 1.24; 95 % CI 1.04–
1.49), and with noninfective gastroenteritis and colitis other
than IBD (HR 1.08; 95 % CI 1.00–1.16) when compared to the
general population cohort. Conclusions: Gastroenteritis and colitis
of infectious and non-infectious origin is associated with an
increased risk for subsequent PD.
P3-533 COGNITIVE FRAILTY AND INCIDENCE OF
DEMENTIA IN OLDER PERSONS
Hiroyuki Shimada1, Hyuma Makizako1, Kota Tsutsumimoto1,
Takehiko Doi1, Sangyoon Lee1, Takao Suzuki2, 1National Center
for Geriatrics and Gerontology, Obu, Japan; 2J.F. Oberlin
University Graduate School, Tokyo, Japan. Contact e-mail:
shimada@ncgg.go.jp
Background: Previous studies have identified the relationship be-
tween physical and cognitive frailty and limitation of activities
in daily living. However, the impact of physical and cognitive
frailty on dementia incidence is unknown. The aim of this study
was to examine the relationship between physical and cognitive
frailty and the incidence of dementia in community-living older
persons. Methods: A total of 4072 persons aged 65 years and over
who were enrolled in the NCGG-Study of Geriatric Syndromes.
We characterized physical frailty as 3 of the following criteria:
slow walking speed, muscle weakness, exhaustion, low physical
activity, and weight loss. We used the National Center for Geri-
atrics and Gerontology-Functional Assessment Tool, which in-
cludes tests of word list memory, attention, and executive
function, and processing speed to screen for cognitive frailty.
The presence of
2 cognitive impairments, indicated by an
age-adjusted score of at least 1.5 standard deviations below
the reference threshold, was defined as cognitive frailty. The
incidence of dementia was determined using data collected by
the Japanese Health Insurance System over 24 months. Results:
The overall prevalence rates of physical frailty, cognitive impair-
ment, and cognitive frailty (i.e., coexistence of frailty and cogni-
tive impairment) were 5.1%, 5.5%, and 1.1%, respectively.
During the follow-up period, 81 participants (2.0%) developed de-
mentia. We found significant relationships between the incidence
of dementia and cognitive impairment (hazard ratio (HR): 3.85,
95% confidence interval (95% CI): 2.09–7.10) and cognitive
frailty (HR: 6.19, 95% CI: 2.7–13.99). However, the association
between dementia and physical frailty did not reach significance
(HR: 1.95, 95% CI: 0.97–3.91). Conclusions: Individuals with
cognitive frailty had the highest risk of dementia. Future research
should implement dementia prevention strategies among older
persons with cognitive frailty.
P3-534 BLOOD MERCURY LEVEL AND RISKS OF
AMNESTIC MILD COGNITIVE
IMPAIRMENT AND ALZHEIMER’S
DISEASE: A CASE-CONTROL STUDY
Jaelim Cho1, Juhwan Noh2, Seong-Kyung Cho2, Jee Eun Choi2,
Changsoo Kim2, 1Institute of Psychiatry, Psychology and Neuroscience,
King’s College London, London, United Kingdom; 2Yonsei University
College of Medicine, Seoul, Republic of South Korea. Contact e-mail:
jaelim.cho@kcl.ac.uk
Background: Long-term high exposure to mercury has known to
affect central nervous system. Evidence on the effect of mercury
exposure mainly focuses on neurodevelopment, so ageing popu-
lation has been marginalised. A few studies have suggested that
high blood mercury is associated with lower cognitive function
including memory in adults. However, they restricted to areas
contaminated by mercury or individuals at risk of exposure,
leading to relatively high blood mercury level. Moreover, there
are no studies on the effect of mercury exposure on cognitive
disorder such as mild cognitive impairment and dementia.
Thus, this study aimed to examine the association of blood mer-
cury level with amnestic mild cognitive impairment (aMCI) and
Alzheimer’s disease (AD). Methods: A matched case-control
study was performed. Patients who diagnosed aMCI (n¼89) and
AD (n¼121) were recruited from a university-based hospital in
2014-2016 in Seoul, Korea. After excluding missing values, 82
aMCI patients and 108 AD patients were included. Among com-
munity cohorts in Seoul and Incheon recruited in 2014-2016
(n¼1,041), four healthy controls for each aMCI patient (n¼328)
and two for each AD (n¼216) were randomly selected via fre-
quency matching based on age group (60-69 or
70 year-old),
gender and education level (0-11 or
12 years). Blood mercury
level was divided into tertile. Conditional logistic regression
method was used, adjusting for age, education level, obesity, total
cholesterol, triglyceride, high-density lipoprotein cholesterol,
smoking and drinking. Results: The geometric means of blood
mercury were 2.525 (standard error, 0.226) mg/L in aMCI, and
2.210 (0.074) in it controls, 1.914 (0.140) in AD and 2.184
(0.073) in its controls. In reference to the lowest tertile (tertile
1), the odds ratios of aMCI were 0.933 (0.504-1.726) for tertile
2 and 1.768 (1.002-3.119) for tertile 3. The trend of the odds ratios
was statistically significant (p¼0.039). The odds ratios of AD
were 0.682 (0.423-1.101) for tertile 2 and 0.892 (0.551-1.443)
for tertile 3. Conclusions: Blood mercury level was postively asso-
ciated with risk of aMCI, but the association with AD was not sig-
nificant.