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ABSTRACT
In Ayurveda, Agadatantra being the sixth branch of Ashtaanga Ayurveda which deals with
the study of Jaangam (animate) and (Sthavara) inanimate poisons, their symptoms and their
management. In ancient era animate poisoning is common phenomenon as they reside in
forests. Comprehensive description of Sarpa (Snake), it’s bite and remedies are elaboratively
described in texts. Being an agronomic country death due to snake poisoning is common in
rural areas due to lack of traveling and medical facilities. Material and methods – all the
available major and minor classics of Ayurveda been referred for literature review. Past
studies and researches regarding the topic have been probed. Objectives- To present a
comprehensive account of snakes in classics of Ayurveda. Discussion- present study is an
effort to compile and analyze all the data related to Ayurvedic perspective of snake poison
scattered in different treaties of Ayurveda and arrange it systematically for the convenience
of UG, PG Scholars and researchers, zoologists for easy referencing. Snake bite management
through different antidotes mentioned as Agadas in classics and Lexicons. Conclusion- There
is huge significance of Agadas and role of Agadatantra in snakebite management as a first
aid.
Corresponding Author
Email: pravinmjawanjal@gmail.com
Table 1.
Divya Ananta, Takshaka, Vaasuki, Gulika, Karkotaka, shamkhapala, they exert their visha through their mere sight
Sarpa-8 Padma, Mahapadma or exhalation
Bhauma Darvikaara, mandali, Rajimana, Nirvish, Vyantara poison in their fangs and they bite
Sarpa
different sexes the sight or the pupils of vi) Parisheka-Sprinkling, hot or cold
the eyes of a person bitten by a male vii) Avagaha – Tub Bath (merging in
snake, is turned upwards. A bite by a medicated decoction)
female serpent exhibits such as downcast b) Eliminative Therapy--
eyes and appearance of vein on the viii) Raktamokshana- Blood-letting
forehead while that by a hermaphrodite ix) Vamana - Emesis
(Napunsaka) snake makes the patient look
x) Virechana-purgation
sideways.[12]
xi) Nasya-Snuffing
In addition, depending upon the c) Symptomatic Therapy --
appearance Sushruta categorizes the xii) Hridayavarana- Protection of heart
snakes into Brahmana, Kshatriya, Vaishya xiii) Sangyasthapana-Resuscitation
and Kshudra. This division may be seen as xiv) Mritasanjivana- Revitalization
the influence of ‘Chaturvarnya’- The d) Counteracting Measures-
deep-rooted caste system of ancient xv) Mantra - Incantation
INDIA. Practically no significance can be xvi) Ousadha- medicament
found in this arrangement. Biologist and xvii) Prativisha -Antidotes
zoologist may search for logic in this e) Pacificatory Measures
context. xviii) Lepa- Pastes
xix) Pratisarana- Local application
Significance of the Vega the signs and xx) Anjana - Collyrium
symptoms expressed in each Vega (stage) xxi) Pradhamana- Blowing up powder
denotes the spread of the poison from one through nose
tissue to the other and is also xxii) Dhuma-Dhumapana- Fumigation
therapeutically significant because the xxiii) Leha - Linctus
management depends on the stage at xxiv) Upadhana-Medication on incised
which the poison has spread in the body. scalp [15]
When the poison has affected deeper
tissues such as Majja and Shukra, it turns Treatment of hooded snake bites.i.e
to be Asadhya (incurable). It is mandatory i. Root of Sinduvaraka macerated in its
for a Vishavaidya to have thorough own juice, added with Madhu and
knowledge of seven Vegas or stages to consumed is the recipe for poison of
bring about effective therapy.[14] hooded snakes. Root of Sinduvaraka
and Shvetagirikarnika made into paste
Treatment (with water) and consumed, Pakala
1) General Treatment (kustha) and honey made use of as
The twenty-four remedial measures for the nasal drops are for the person bitten by
poisoning can be understood in the hooded snake.[16]
following way. ii. If bitten by a Krishnasarpa the blood
a) To check Entry and Circulation of should be removed from the site and
Blood-- paste of Charati and Nakuli or of
i) Arista bhandana - Binding powerful root poison should be
ii) Utakartana- Incision applied.
iii) Nishapidana - Compression iii. Ghrita added with Madhu, Manjishtha
iv) Chushana-Sucking and Gruhadhuma (kitchen soot) should
v) Agni – Heating, cauterization be drunk.
Table 7. Symptoms of the different stages of poisoning from the bite of a Darvikarasarpa ,
Mandali dansha, Rajimanta dansha
Vega Darvikarasarpa dansha Mandali dansha Rajimanta dansha
1 st In first impulse (prathamavega)rakta(blood) gets vitiated, Spreads in the rakta Affects the Rakta Dhatu ;
becomes blackish and there by produce darkish complexion of dhatu, and changes the and changes the colour to
the body. The person feels as though ants are running all over colour to yellow. burning dull white. Horipillations,
his body.[13] sensation all over the person becomes pale,
body, oedema on the
bitten limb,
2 In second impulse (dvitiyavega)masadhatu (muscular tissue) Vitiates Maamsa dhatu, spreads in maamsa dhatu,
gets vitiated. Swelling occurs on the bitten site. deepening of yellowish Heaviness of body, becomes
discoloration; burning more pale,fatigue, oedema
sensation all over the in the head.
body, edema on the bitten
site.
3 In third impulse (trutiyavega) medodhatu (adipose tissue) gets Affects Medo dhatu, spreads in
vitiated. Heaviness of the head, loss of vision, moistness at the blurring of vision, intense medodhatu,dimness of
site of bite. thrust, putrefaction at the vision,
site, sweating Putrefaction at the site,
excessive secretion of
mucus from the nose, eyes,
mouth etc.
4 In fourth impulse (chaturthavega) the poison enters into Enters koshtha and spreads in koshtha, stiffness
Kostha and vitiates the Kaphadosha there and produces produces fever. (in of neck, Heaviness of head,
symptoms such as excessive salivation, vomiting, joints pains addition to the above stiffness of neck (in
and lethargy lakshanas) addition)
5 In fifth impulse (Panchamavega) the poison enters into Burning sensation all difficulty in
Asthidhatu (osseous tissue) and vitiates the Pranavayu and above the body (in speaking(dysphonia),
Agni. This causes joints pains, hiccups and burning sensation. addition to the above (dysarthria); fever (in
Lakshanas) addition)
6 In sixth impulse (shashthavega) the poison enters into same as treat of same as that of
majjadhatu (bone marrow) and also vitiates the grahani Darvikarasarpa dansha Darvikarasarpa dansha
(pittadharakala) causes severe pain in the chest, heaviness in
the chest, delirium and diarrhea.
The following formula is for bite by Vasuki (snake king): soot, Haridra, Daruhardra,
Tanduliyaka with [its own] root + plenty of honey and Ghee,
5 Kalyanakaghrita 13 Sleshmatakadichurna
6 Kshara agada 14 Tarkshya agada
7 Mahasugandhi agada 15. TrivrutadiMahagada
8 Panchashirisha agada
According to Acharya Bhavamishra [22]- hermitage, temple, on the last days of the
Mrityupashachedighrita fortnight, in noon and on the 8th day of the
For Vyantara Sarpa - special fortnight, in midnight, and also in places of
“Sarvakarmika Agada” is mentioned by Tantrika practices do not recover.
Vagbhata. Fatality of Asivisa Snakes:( dreadful
According to sarpas- snakes with poisoned vision and breath):
1.Darvikar Sinduvar Mula And Honeys People inflicted by Asivisa serpents with
2.Mandali- Himvaan Agada poisons through vision [being looked at by
3. Rajimaan- Gonus, -Ashtaang Agada the snake], breath, excrements and touch
4. All types of snakes- Rushabha Agada and also bitten in all vital parts die soon. [
and Taarkshya Agada if the person is bitten in any of the vital
parts (i.e., heart, head, bladder) he will die
Prognosis: soon. But if he has been bitten on a non-
Fatal Times and Locales: vital part (i.e., a leg) he may recover.] This
The person bitten in cremation ground, rule is true of both snakes as well as
religious tree, ant hill, sacrifices,
insects born of them [including spiders, adhere to the surface of a lotus leaf, but
centipedes and scorpions]. roles right off. So, it is the time need to
evaluate the Anti venom activity of
Importance of Hema- Suvarna (Gold) medicinal plant. Since ancient time many
for Treatment of Poisoning: Hema herbs are use in the treatment of scorpion
controls all poisons and poisonous bite and it is also scientifically proved.
combinations. Poison does not adhere in there are so many plants which has a
the body of the person taking Hema therapeutic value in the scorpion bite
(Swarna bhasma), just like water does not treatment.
.
Table 10. snake venom constituents and their important clinical features,
Constituents Mechanism Clinical effects
neurotoxins act on the pre and post synaptic area of Paralysis of muscles causing respiratory failure, weakness
nerves and myoneural junctions. etc.
cardiotoxins Affects cardiac musculatures Contraction of the heart musc es and cardiac arrest.
Reduces BP
Haemolysin act on RBC Contraction of the heart musc -es and cardiac arrest.
Reduces BP
coagulinity converts fibrinogen to fibrin and pro derangeed clotting cascade, bleeding from the site of bite,
thrombin to thrombinis gums, aall orifices, hair follicles etc.
Crotamine proteases acts on nerve endings proteolytic and paralysis of muscles, Deranged clotting mechanism;
esterase activity necrosis
phospholipase A act on RBC and hydrolyze lecithin to erythrolysis
lysolecithin
Cholinesterase hydrolyzes acetyl choline Block transmission of nerve impulses resulting in curare-
like actions
Ophio amino acid activate proteases and peptides in the cells cell autolysis and suppuration
oxidase
Nucleases (DNAse & Hydrolyzes phosphodiester bonds of DNA enhance the activity of other enzymes
RNAse) & RNA
Hyaluronidase Hydrolyzes hyaluronic acid which is the Reduces natural resistance of tissues and increases the
cementing material between the cells permeability; helps spread of other factors; local swelling
Ayurvedic classification of snake bite marks- Many of the ancient books show difference of
opinion in describing bite marks as follows-,
Other Preventative Routines: bind a tourniquet above the sight of the bite.
One should always walk with a umbrella He should also excise the part or cauterize it.
and a rattle in hand day and night. By the
shade of the umbrella and the sound of the Vega, literally means speed. According to
rattle, the serpents get frightened and flee Vishjyotshnika,’ Vega is the ability of
away. One should wear diamond, emerald, (poison) Visha to invade the dhatus
Sara, Picuka, Visamusika, ruby, snake’s quickly and consecutively. In other words,
gem, cat’s eye, elephant pearl and anti- it is the stages of subsequent invasion of
poison stone or excellent anti-poison the dhatus by poison. In Sushruta Samhita
herbs. Birds such as Sarika, Demoisella instead of Dhatus,’ Kalaa’ is used. So,
Crane, Peacock, Swan, Parrot etc. should “Vega is the ability of Visha supported by
be kept. [Perhaps these birds kill snakes Vayu to spread into the Kalaas one by one
and poisonous insects or alert their owners and manifestation of the particular signs
about these intruders.] and symptoms”.
Further Emergency Treatment for Bites
[by Snake]: The science of toxicology is so developed
If bitten, one should immediately bite the at that time they observed seven Vegas
same serpent. [Yes, apparently this says to with different symptoms and treatment for
bite the snake back who just bit.] Or he
poisoning is also prescribed as per Vegas.
should bite a clod of earth. He should also
Here is huge scope for further research.
Table comparison of Vegas wise signs and symptoms of Darveekar Sarpa (Cobra)
vega Sushruta Ashtanga samgraha Ashtanga Hridaya
1 spreads in the dhatus; and changes the colour spreads in the rakta dhatu and spreads in the Rakta Dhatu; eyes,
to black, tingling sensation and the black changes the colour(cyanosis) so mouth, urine etc. appear with into
discoloration at the site of bite cyanosis in the face and all over blackish tinge. Coloration at the
the sensation tingling sensation.
2 vitiates Mamsa dhatu, discoloration, edema enlargement of lymph nodes enlargement of lymph nodes
enlargement of lymph glands
3 Affects Meda Dhatu, suppuration at the site , heaviness of head, dimness of heaviness of head, dimness of vision
sweating,. heaviness of head, blurring of vision, putrefaction at the site.
vision
4 Enters Koshtha and increases ka pha , fatigue excessive salivation, vomiting, excessive salivation, vomiting,
, salivation , pain in the joints. weakness of joint, fatigue weakness of joint,
5 enters Asthi Dhatu and vitiates Praana and pain in the joints, burning pain in the joints, burning sensations,
Agni. Arthralgia, burning sensat- ion all over sensations, hiccough hiccough
the body hiccough,
6 Enters Majja Dhatu, and affect Grahani, Chest pain, heaviness of body, Chest pain, heaviness of body,
heaviness of body, diarrhea loss of consciousness; indigestion, diarrhea, giddiness.
indigestion; diarrhea
7 Enters Shukradhatu vitiates Vyaana; spreads in Shukradhatu; spreads in Shukradhatu; paralysis/
increases secretions resulting in excessive paralysis/ weakness of muscles weakness of muscles of shoulder,back
salivation; sweating incoordination of of shoulder,back.later complete and low back. Later complete and low
movements; paralysis of muscles of back and paralysis back. Later complete and low back.
low back regions dyspnoea and arrest of later complete paralysis
respiration
Due to over expansion of the article same of Rajimanta and Mandali are not
comparative charts in major classicsg ( presented here.
charaka, sushruta, Vagbhata) of Ayurveda
Probable mode of action