Minutes of Meeting for Pharmaceutical Organic Chemistry-III

Date and Platform: 28th January 2021 on Google Meet

Purpose: To discuss the plan of action for the subject of Pharm. Organic Chemistry-III for
Sem IV, in a post COVID-19 scenario.

Attendees: Faculty Members from several Colleges affiliated to University of Mumbai

Resolutions and Suggestions:

1. The number of hours available for teaching and the number of lectures required for
completion of syllabus were projected. In light of the lesser time available, the
following sub-topics were unanimously agreed upon to be given to the students for self-
study:
UNIT I, Subunit v: Racemic modification and resolution of a racemic mixture
UNIT I, Subunit vi: Asymmetric synthesis: partial and absolute
UNIT II, Subunit ii: Methods of determination of configuration of geometric
isomers
UNIT III: Furan
UNIT IV: Synthesis and medicinal uses of Pyrimidine, purine, Azepine and their
derivatives.
However, the notes of these topics will have to be provided by the subject teachers
and an overview should be given in the class, following which these sub topics can
be assigned for self-study.
2. The depth of teaching for the remaining topics will continue to remain the same as was
discussed in the orientation meeting held by VES College of Pharmacy on 30th August
2019.
3. In order to map course objective 3 of the syllabus, it was decided that the following
table will be shared with the students:

Sr Heterocycle Medicinal agent Use

No.
1. Furan Ranitidine Antihistaminic
2. Pyrrole Atorvastatin Antilipidemic
3. Thiophene Pyrantel pamoate Anti-infective
4. Pyrazole Celecoxib Anti-inflammatory
5 Imidazole Clonidine Antihypertensive
6 Thiazole Sulphathiazole Antibacterial
7 Quinoline Quinine Antimalarial
8 Acridine Tacrine Cholinesterase inhibitor or treatment of
Alzheimer’s disease
9 Indole Indomethacin Anti-inflammatory
10 Pyrimidine Zidovudine Anti-HIV

4. The blue prints for the MCQ and subjective questions were discussed. These are as
given:
 BLUEPRINT FOR MCQs (20 MCQs, level: high, Intermediate, Low)
UNIT SUBUNIT HOURS MARKS MCQs CO Weightage
of each CO
I i 10 9  relationship between pairs of molecules 2 1= 40%
ii  Chiral/ Achiral
iii  Nomenclate the given structure/ structure of given 2= 40%
nomenclature
iv  Any question from unit iv, v 3= 10%
v
vi
II i 10 9  Nomenclate the given structure/ structure of given 2
nomenclature
ii  Any question from unit ii, iii, iv
iii
iv
v
III, IV Nomenclature 10 + 8 9+ 7  Nomenclate the given structure/ structure of given
nomenclature
Resonance 1
Acidity/basicity Any 6 MCQs from these sections
Methods of synthesis
EAS, NAS
V Reduction 7 6  Reagent for the reduction/ product of the reaction 1
Rearrangements  Any innovative question based on rearrangements 1
mentioned in the syllabus
IDENTIFY THE  3
HETEROCYCLE IN
THE GIVEN
MOLECULE
GIVE THE MEDICINAL  3
USE OF
BLUEPRINT FOR SUBJECTIVE PAPER (7 questions, Choice between Q1 and Q2, both of which are of high level of difficulty. Attempt
any 4 from the remaining 5, of which 2 are of intermediate and 3 are of low level of difficulty)

UNIT SUBUNIT HOURS MARKS LEVEL CO

I I Opt. act., enantio, diastereo, meso 10 9 2

Ii Elements of symmetry
Iii DL , RS
Iv Reactions at chiral C HIGH
V Racemic modification INTERMEDIATE
Vi Asymmetric synthesis LOW
II I EZ, Cis trans, Anti and Syn 10 9 2
Ii Methods of determination of config.
Of geometric isomers
Iii Conformational isomers INTERMEDIATE
Iv Atropisomerism INTERMEDIATE
V Stereospecific and stereoselective HIGH
reactions
III, IV Nomenclature 10 + 8 9+7 1, 3
Resonance, aromaticity, reactivity HIGH A question on: Predict the order of…… can be
Acidity/basicity asked
Methods of synthesis
EAS, NAS INTERMEDIATE/ LOW
V Reduction 7 6 LOW 1
Rearrangements INTERMEDIATE/ LOW
5. Reactions to be covered under UNIT II, subunit v: STEREOSPECIFIC AND
STEREOSELECTIVE REACTIONS: ALL STEREOCHEMICAL ASPECTS AND
MECHANISM TO BE DISCUSSED ELABORATELY
a. REACTION OF BROMINE WITH ALKENE (Ref: Morrison and Boyd)
b. ADDITON OF HBr, IN PRESENCE AND ABSENCE OF H2O2 (Ref. Morrison
and Boyd)
c. DIOL FORMATION: EPOXIDATION, OsO4, KMnO4 (Ref. Morrison and Boyd,
Peter Sykes, Clayden)
6. These proposals were unanimously accepted by the participants. Some types of
questions of different difficulty levels were discussed so that uniformity could be
maintained through the clusters.