E.

coli
General characters leis :

Gram -
ve

•
Bacillus trod )

• Facultative anaerobic

• Either nonmotile or motile

( flagellated )
• Catalase + ve

•
Ferments lactose

colonies
Mac
Conkey agar Grows as
pink
•

• Indole test → + ve

Pathogenesis :

Virulence
structures
-
•

0
antigen ( component of
lipopolysaccharide )
H
antigen ( flagellar protein )

K
antigen ( polysaccharide capsule )

Adherence E coli
factors specific
•
& toxins are to .
 Reservoir :

Humans
primary
•
are reservoir

Avirulent variants Normal

•
are
part of gut flora .

Transmission :

cis Fecal-oral route

iii , contaminated meat or

produce

Associated Diseases :

Tract infections
its
Urinary :

E coli is
leading cause
of UT Is in women
•

Bacterium ascends urethra to infection

•

cause

•
More common in Homen or with catheter use

Type 1-
fimbria e ( pili ) -
virulence
factor that allows

bacterial attachment to cero

epithelial cells .

Diagnosis & Treatment :

with culture
•

Urinalysis urine

Antibiotics ( Nitro furantoin TMP smx

)
-

•
.

Neonatal
(2)
Meningitis :

E. coli and
can cause
meningitis sepsis
 •

Signs &
Symptoms :

-
Fever
-
Fullfontanelles
-

Vomiting
- Coma

Convulsion

Poor absent
-
or Moro
reflex
-

Hypertonic or
Hypotonia

Diagnosis :

CSF
analysis showing leukocytes is and low
glucose
-

and bacteria stain

gram
on .

Treatment

-
Antibiotics ( ceftriaxone )

(3) Diarrhea :
c
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