Klebsiella

General character skis :

•
Gram -
ne bacilli

•
Facultative anaerobes

•
Nonmotile

Encapsulated
short chains
•

Single ,
in
pairs or

Form mucoid
•

large ,
colonies .

Major pathogenic species : Klebsiella

pneumoniae
•

Biochemistry :

lactose
fern enters
o

Pink colonies Mac

Conkey agar
-

on

• Unease + ve

•
Oxidase - ve

Virulence Factors :

Evades
T phagocytosis
"i Polysaccharide capsule &
Kz most virulent
1- K ,
types are

in
Hypermucoviscosity
(
iiit
lipopolysaccharide
Iron chela tors
(in
siderophores
-

Mediate
(v )
Piti ( fimbria e) -
adherence

- Formation of Treatment - resistant biofilms .

 Infectious Manifestations :

( is
Pneumonia

- 7.6% of Hospital -

acquired

community acquired mainly posterior

-

In in
,

segments of Right upper lobe .

Currant
jelly sputum
-
-

-
Fever ,
cough .
dyspnea .
pleuritic chest
pain
abscess
-

Complication e- lung
1-
Empyema

Tract
cii ,
Urinary Infection ( UT Is ) :

3rd
-

leading cause

can cause cystitis

&
pyelonephritis
Liii ,
Meningitis -

usually associated with

Neurosurgical
procedures .

civ > Endocarditis

cus End ophthalmitis

(
ri ) skin &
soft tissue
infections .

Mnemonic
ci , Aspiration Pneumonia

ciii Alcohol -
use disorde
5A 's
of Klebsiella iiiis Abscesses in
lungs
& lives

in Dia # betes

evi Currant Jelly Sputum

 Antibiotics Resistance :

Some strains Extended

•

produce -

spectrum B- lactamases
( ESBL )
•
Resistance to most B- lactam antibiotics

Resistance
• Some strains are
Multidrug
Mediated that P
by Plasmids encode lactamases
• -
.

Plasmids
•

exchanged via Piti

Identification :

( is Gram stain :
sputum -

sensitivity
about 50%

Iii , Cultures : -
Blood
- Urine

Body Fluids

-
Abscess aspirates

C
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