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MODULE 1
INTRODUCTION TO
PHARMACOLOGY
DISCLAIMER:
The content of this module are curated from different sources, citations and
references that are indicated in every part of the module.
ACKNOWLEDGEMENT:
Acknowledging the effort of the clinical instructors who work tirelessly for
every module that each students receives. For the Level II Clinical Instructors.
The work of this module was through the approval of the Level II Chairman,
Ms Divina T. Villarin and assistant Level Chairman Mrs. Ma Carmila I Rama.
TABLE OF CONTENTS:
This module aims to make the recipients to identify the principles of Drug
administration which contains basic learning material for the administration of
the medications, describes the “ten rights” in drug administration, drug orders,
drug distribution, drug charts, drug administration guidelines, and drug
administration routes. (Pharmacology, A nursing process approach, 6th edition)
LESSON CONTENT:
generally called excipients, are used
in drug preparation to allow the drug
to take on a particular size and shape
to enhance drug dissolution.
Disintegration is the
breakdown of a tablet into smaller
particles while dissolution is the
dissolving of the smaller particles in
the GI fluid before absorption. Rate
(Click on the link for the video) limiting is the time it takes the drug
to disintegrate and dissolve to
A drug taken by mouth goes through become available for the body to
3 different phases—pharmaceutic absorb it.
(dissolution), pharmacokinetic, and
pharmacodynamics as drug actions
occur.
Pharmaceutic Phase
Also known as dissolution, it
is the first phase of drug action. A
drug in a solid form (tablet or
capsule) must disintegrate into
smaller particles to dissolve into a
liquid, a process known as
dissolution.
Tablets are not 100% drug,
fillers and inert substances,
Pharmacokinetic Phase
Absorption
Distribution
1 3 325 50
PHARMACOLOGIC
EFFECT 2 6 162 25
3 9 81 12.5
4 12 40 6.25
Figure 1.3 Drug Distribution
5 15 20 3.1
Metabolism, (or Biotransformation)
6 18 10 1.55
Drugs can be metabolized in both
the GI tract and liver; however, the A drug goes through several half-
liver is the primary site of lives before more than 90% of the
metabolism. Most drugs are drug is eliminated. If the client takes
inactivated by the liver enzymes and 650 mg of aspirin and the half-life is
are then converted or transformed by 3 hours, it takes 3 hours for the first
hepatic enzymes to inactive half-life to eliminate 325 mg, 6
metabolites or water-soluble hours for the second half-life to
substances for excretion. (Joyce eliminate an additional 162 mg, and
LeFever Kee, Evelyn R. Hayes, so on until the sixth half-life (or 18
Linda E. McCuistion, 2015) hours), when 10 mg is left in the
body.
What is the half-life (t ½) of a drug?
PHARMACOLOGY CCMC-CN LEVEL II
R epubl i c of the Phi l i ppi nes
CE B U TEC HNOLOG IC AL U NIVE R SITY
Mai n Campu s
i n consort i um wi t h
C EB U C ITY ME D IC AL CE NTER - C OLLEG E OF NU R SING
N. Bacalso Avenue corner Panganiban Street, Cebu City, Cebu, 6000 Philippines
Tel. Nos. +63-032 – 3161987 or 3165128
Email address: ctuccmc_cn@ymail.com
Excretion, (or Elimination)
4. Irritation
Loading Dose
Placebo effect
Evaluation
Drug administration
schedule may
sometimes be adjusted
to fit the schedule of the
client’s lifestyle,
activities, tolerances, or
preferences.
It is the nurse’s
responsibility to check
whether the client is
scheduled for any
diagnostic procedures
An Example of Computerized such as endoscopy or
medication management system fasting blood test that would
contraindicate the
4. The right time administration of medications.
Is the time at which the prescribed Check the institutions policy.
dose should be administered. Check the expiration date.
Nursing implications are as follows: Discard the medication or
Administer drugs at the return it to the pharmacy
specified times. Drugs may be (depending on hospital policy)
given 30 minutes before or if the date has passed.
after the time prescribed if the Antibiotics should be
administration interval is administered at even intervals
>2hours. Refer to agency (e.g. q8h rather than TID)
policy. throughout a 2-hour period so
Administer drugs that are therapeutic blood levels are
affected by food maintained.
(Tetracylcine) before meals.
Administers drugs that can 5. The right route
irritate the stomach (gastric It is necessary for adequate or
mucosa) for example appropriate absorption.
Cholinergic receptors are located in the bladder, heart, blood vessels, stomach,
bronchi, and eyes
ADDITIONAL
POWERPOINT
PRESENTATION IS
ATTACHED TO YOUR
STREAM BOARD FOR:
MEDICATION
PREPARATIONS
AND SUPPLIES
ROUTES OF
SUPPLLEMENTAL VIDEOS ADMINISTRATION
PHARMACOKINETICS-INTRO
PHARMACOLOGY
(PHARMACOKINETICS)
MADES EASY
PHARMACOKINETICS-
ABSROPTION
PHARMACODYNAMICS
(MADE EASY)
PHARMACOLOGY CCMC-CN LEVEL II
R epubl i c of the Phi l i ppi nes
CE B U TEC HNOLOG IC AL U NIVE R SITY
Mai n Campu s
i n consort i um wi t h
C EB U C ITY ME D IC AL CE NTER - C OLLEG E OF NU R SING
N. Bacalso Avenue corner Panganiban Street, Cebu City, Cebu, 6000 Philippines
Tel. Nos. +63-032 – 3161987 or 3165128
Email address: ctuccmc_cn@ymail.com
PHARMACOKINETICS-
METABOLISM
SUPPLEMENTAL VIDEOS
PHARMACOKINETICS-
DISTRIBUTION
PHARMACOKINETICS-
DISTRIBUTION
LEARNING ACTIVITIES:
REFERENCES AND
SUPPLEMENTARY
REFERENCES:
TEXTBOOK:
INTERNET SOURCE:
https://drive.google.com/file/d/1sYYJ8mAbUtrCHdw2iF7gc3D2FpE9VXe6/
view?fbclid=IwAR1laLEA8McnkQAEpvueugfX0qMIDMOGp-
ht92HURbhdHMgryd22IlEXuzk
https://www.ted.com/talks/
celine_valery_how_does_your_body_process_medicine#t-12242