Immunology and Serology

Study online at quizlet.com/_59ntsy

1. Accumulation of Hallmark of autoimmunity 29. Acquired Resistance characterized by Specificty of

immune complexesin Immunity each individual pathogen and the ability to
your tissues remeber prior exposure which result to
increase response upon repeated exposure
2. Jenner Founder of immunology
30. Natural Use pattern recognition molecules
3. Jenner Discovered cross immunity in 1798
immunity
4. Pasteur Fater of Immunology
31. Acquired Use antigen-recognition molecules
5. Pasteur Discovered live, attenuated cicken immunity
cholera and anthrax vaccine;
32. Mycoplasma Lysozyme Attacks bacterial cell wall except
therapeutic vaccination
and
6. Metchnikoff Cellular immunity thru phagocytosis Ureaplasma
7. Koch Cutaneous (delayed-type) 33. Helicobacter Resistant to stomach acidity
hypersensitivity pylori
8. Emil Roux Passive immunity 34. 1st line of Skin, cilia, mucus membranes, secretions,
9. Rudolf kraus Precipitins in 1897 defense physiologic factors

10. Ehrlich Antibody formation theory; immunity 35. 2nd line of Phagocytic cells, nk cells, complement
defense (alternate), cytokines, interferons, Il,
11. Salk, sabin Polio vaccine
phagocytosis and inflammation
12. Edelman and Porter Identification of antibody molecule
36. 3rd line of T cells, B cells, Apc (macrophage,
(1972)
defense monocytes, dendritic, b cells), antibodies,
13. Frazer Discovery oF HPV vaccine in 2005 classic, cytokines
14. Murray Kidney transplant 37. Large In the peripheral blood, lymphocytes are
15. Thomas Bone marrow transplant granular sometimes seen with granules. What are
lymphocytes they?
16. Emil von Behring First noble prize winner in 1901 (NK cell)
17. Jules bordet Discovered complement in 1894; 38. Neutrophils Principal leukocyteassociated with
nobel prize winner in 1919 phagocytosis and localized inflammatory
18. Rosalyn Yalow Nobel Prize winner of 1977: response
Radioimmunoassay Granules contain bactericidal enzymes and
responds to chemotaxis
19. Susumu Tonegawa Antibody diversity
39. Eosinophil Wbc that increases during allergies; produces
20. Stanley Prusiner Prions
histaminase; anti helminthic
21. Gunter Blobel Signal Transduction
40. Basophils Granules contain histamine and heparin
22. Montagu Variolation (1718)
41. Kupffer cells Macrophages in liver
23. 1890 Declaration of complete eradication
42. Alveolar Macrophage in lungs
of Polio
macrophage
24. 1984 Year of doscovery of T cell receptor
43. Histiocytes Macrophage in connective tissues
gene
44. Mesanglial Macrophage in kidney
25. Christopher Travelled from old word to new
cells
Columbus world
45. Microglial Macrophage in brain
26. Smallpox Old world to new world
cells
27. Syphilis New world to old world
46. Osteoclast Macrophage in bone
28. Natural immunity Ability of an individual to resist
47. Synovial Macrophage in joint
infection by means of normally
cells
present body functions
48. Splenic Macrophage in spleen
macrophages
49. Nk cells/ null First line of defense against tumor cells 73. Fibroblast and epith cells Main producer of Ifn
cells and cells infected with viruses beta
50. Lymphokine Use Il-2 to help lyse tumor 74. Leukocyte interferon Ifn alpha is also known
activated killer as
cells
75. Fibroblast/epithelial/fibroepithelial Ifn beta is also known
51. ADCC Lyse antibody(IgG) coated target cells interferon as
52. CD 16, CD 56 Markers of NK CELLS 76. Type 2 Ifn Immune, produced as a
component of the
53. CD 56 unique marker of NK cells
specific immune
54. Neutro, mono, Phagocytes response to viral and
macro, other pathogens
eosinophils
77. Ifn gamma Produced by
55. 15-20% nk cells in peripheral blood immunologically
56. Baso, mast Cells of inflammation stimulated
lymphocytes
57. Porphyrins Produces by ADCC that is important in
killing cancer cells 78. t cells Main producer of
interferon gamma
58. Secreted PRRs Molecules that circulate in blood and
lymph that bind to PAMPs 79. Immune interferon Other name of ifn
gamma
59. Phagocytosis Cell surface receptors taht bind to
receptors pathogen, initiating a signal leading to the 80. Tnf Cytotoxic against
release of effector molecules tumor cells and virally
infected cells
60. Tlrs Set of transmembran receptors that
recognize diff types of PAMPS 81. Tnf alpha Produced by
macrophages
61. Macropgae, TLRs are found in?
dendritic cells, 82. Tnf beta Produced by cd4+ and
epithelial cells cd8+

62. Acute Phase Proteins that increase due to infection, 83. Cachetin Tnf alpha
Reactants injury or trauma 84. Lymphotoxin Tnf beta
63. C-reactive Increases up to 1000x when there is 85. Complement Mediation of
protein and infection inflammation
serum amyloid
86. 123456789 Order of discover of
A
complement
64. Hepatocytes Produces CRP
87. 142356789 Order of activation of
65. IL1 and TNF Causes inflammation and hypothalamic complement
fever
88. Activation of immune response, Functions of
66. IL 12 Produces interferon gamma opsonization, lysis Complement
67. Classical Pathway activated by crp 89. H. Influenza, N. Meningitidis, S. Inhibits phagocytosis
pathway Pneumoniae due to large capsule
68. Interferons Family of glycoproteins produced by all 90. Properdin or Factor P Serum protein that
animal cells that exert virus nonspecific exerts bactericidal and
but host specific antiviral activity viricidal effects in the
69. Type 1 Non immune, produced primarily in the presence of c3 and Mg
Interferon initial innate response to viral infection 91. Beta-lysin Released by ruptured
70. IFN-alpha Produced by virus induced leukocyte platelets during clot
formation; heat stable
71. Nk/Null Main producer ocpf IFN Alpha
cationic substance
lymphocyte
Bactericidal for G+
72. ifn beta Producd by dsRNA fibroblast except strptococcus
92. CR3 Receptors of phagocytes 115. Spleen Secondary lymphoid tissue
Laminin Receptor Lymph nodes Storgae and proliferation
Leucyl Formyl MALT
Methionyl
116. Peyers patches MALT
Phenylalanine Receptor
Tonsils
93. Diapedesis Squeezing movement of WBCs Appendix
from the blood vessels to the site Adenoids
of tissue damage
117. Blood, thoracic T cells are found in
94. Chemotaxis Movement toward duct fluid, lymph
chemoattractant node
95. C5a Most common chemotaxin 118. Cd2 Antigen of tcell which can react with
RBCs to form rosette formation
96. C3b Most common opsonin
119. Lymphokines End product of T cell activation
97. RANDOM movement Withouth the influence of
chemotactic substances, cell 120. Cd2, cd3, cd4, Antigens of t cells
motion is cd8, t cell
receptor
98. Defensins, lactoferrin Components of lysosomes
and lysozyme 121. Double negative Stages in T cell development
lymphocyte
99. Nitric Oxide Produced by activated
Double positive
macrophage which is toxic to
lymphocyte
microorganism
Mature t cell
100. Hydrogen Peroxide Most potent reactive oxygen Activated t cell
intermediate Sensitized T cell
101. Job's syndrome Normal random activity, 122. Double negative Lymphocyte precursor enter the thymic
abnormak chemotactic activity lymphocyte cortex and develop cd 2, cd5, cd7 and
102. Lazy Leukocyte Abnormal random and cd45R antigens
Syndrome chemotactic activity 123. Double positive Thymocytes expresses cd3, cd4 and cd8
103. Rubor Redness lymphocyte

104. Calor Heat; effects of Il 1 and TNF 124. Mature T cell T cell becomes single positive

105. Dolor Pain 125. Cd25 T cell growth factor

106. Tumor Swelling due to edema 126. Cd25 Receptor of Il 2

107. Functio laesa Loss of function 127. Sensitized T Secrete lymphokines

cells
108. Peyer's patches Antigen trapping site when
ingested 128. T cells Paracortex

109. Lymph nodes Antigen trapping site in 129. B cells Cortex

subcutaneous 130. Bone marrow T cells derive from cells in
110. Spleen Antigen trapping site- iv and 131. Thymus T cells develop T cell specific surface
intraperitoneal antigens in
111. Vascular response, Stages in inflammation 132. 60-80% Percent of peripheral lymphocytes
cellular response,
133. T helper cell Orchestrates cell mediated immunity
resolution and repair
134. T Helper cell Activates b cells, cytotocpxic cells and
112. Totally repaired Results of tissue repair
Nk cells
Formation of abscess
Granuloma 135. Class II MHC T helper cells recognize foreign antigen
molecules in association with?
113. Il2 Activates 3rd line of defense
136. Cd4+ Th
114. Bone marrow Primary lymphoid organs
Thymus Where development and 137. 55-70 % of T helper cells in peripheral T cells
maturation occurs
138. 1000/uL or 500- NormL CD4 161. Concanavalin ConA Mitogens of T cells
1300/uL Phytohemagglutin
PHA
139. <200/uL In aids, t helper cells is
POkeweed
140. T suppressor Inhibit T helper cells mitogen PWM
cells
162. Lps Mitogens of B cells
141. t cytotoxic cells Kill other cells, t cell subset Pwm
142. Class I mhc T cytotoxic cells recognize foreign 163. Plasma cells Cells responsible for ab production
molecules antigen on association with
164. Few days Plasma cells in peripheral lymphoid
143. Cd8+ T suppressor cells organs die in?
144. 25-40 % of Tsuppressor in peripheral T 165. Months to years Lifespan of memory cells
lymphocytes
166. Cd10 Marjer for pre-B CALLA
145. 2:1 Thelper: T suppressor/ cd4:cd8
167. Cd34 Marker of hematopoietic stem cells
146. <0.5:1 Cd4:cd8 in aids
168. Cytokines Small protein hormones that stimulate
147. Bone marrow, B cells is found in or inhibit many normal cell functions
spleen, lymph
169. Il 1 Hypothalamic fever
nodes
170. Il 2 Lak cells
148. Cortex, germinal Storage of b cells
center 171. Il 3 Differentiation of hematopoietic stem
cells, mast cells
149. Sufrace B cells are identified by
immunoglobulin 172. Il 4 B cell growth factor 1
150. Antibody End product of B cell activation 173. Il 5 B cell growth factor 2
151. Cd19, cd20, cd21, antigens of B cells 174. Il 10 Potent suppressor of macrophage
cd40, MHC II function
152. Pro B cell Stages of B cell development 175. Il 12 Activates nk cells
Pre B cell
176. Steel factor Stem cell division (c-kit gland)
immature B cell
mature B cell 177. Antibodies Humoral components
Activated B cell Complement:
Plasma cell classical
Cytokines
153. Pro b cell Rearrangement of genes coding for the
heavy chains take place at this stage 178. Macrophages and Cytokines are mainly produced by
Tcells and Bcells
154. Pre-b cell Characterize by the presence of mu
chains in cytoplasm 179. Mono/macrophages Antigen presenting crlls
Dendritic cells
155. Pre b cell Rearrangement if light chains begins
B cells
156. Immature B cells Expression of IgM on the surface
180. Langerhan cell In skin, dendritic cells are known as
157. Mature B cell igD and IgM in surface and incepreased
181. Dendritic Most efficient ag presenting cells
density
These are released in bmarrow and seek 182. Short arm of Mhc is located at
peripheral lymphoid organs chromosome 6

158. Plasma cells Has abundant cytoplasmic 183. hla Product of MHC
immunoglobulins which is excreted in 184. Hla A B C Genetic loci of Class I hla
the bloodstream
185. Hla DP DQ DR Genetic loci of class 2 hla
159. IGD igM can class switch with all
186. Alpha chain and Chain structure of Class 1 hla
immunoglobulins except
Beta 2
160. Mitogens Polyclonal activators microglobulin
Substances that cause cells to divide
187. Alpha chain and Chain structure of class 2 hla
Beta chains
188. On all Cell distribution of class 1 hla 212. Immunogen Any substance that is capable of imducing
nucleated cells an immune response
189. Apcs Cell distribution of class 2 hla 213. Hapten Low molecular weight substance taht can
bind to an antibody once it is formed, but
190. Cd8+ Class I hla presents antigen to
that is incapable of stimulating antibody
191. Cd4+ Class 2 hla presents antigen to production unless bound to a larger
192. C2, c4, factor B Class 3 hla carrier molecule
and TNF 214. Foreigness Factors affectinf immunogenicity
193. Tnf Cytokine for cancer Size
Chemical
194. Cd3 Phenotypiv marker that is important for
composition
TCR to be expressed
and
195. Chromosome14 Chromosome location of heavy chains complexity
196. Chromosome 2 Chromosomal location of kappa light Route, dosage
chain and timing
Degradability
197. Chromosome Chromosomal location of lambda light Adjuvants
22 chain
215. Heterophile Antigens in unrelated plants and animals
198. IgD Immune regulator, stops antibdoy antigens
production
216. Potential Has MW OF > 10000 Daltons
199. Monomeric IgM B cell antigen receptor antigen
or IgD
217. Good MW of 40000 daltons
200. fab portion of Two identical antigen binding pockets pf b immunogen
an antibody crll surface receptors
mono er 218. Excellent Mw of >1000000 daltons
immunogen
201. T cell receptor Consists of twon nonidentical peptides
and CD3 219. Protein Most immunogenic

202. IgM First antibody produced 220. Lipids Least immunogenic

Acute, present infection 221. Proteins Immunogenicity highest to lowest
203. IgG Produced due to class switching Polysaccharide composition
Persist longer Lipids
Chronic, past infection Nucleic acid

204. T cells Cell mediated 222. Adjuvant Substance added to vaccines and less
mmunogenic substance to enhance
205. B cells amd Antibody mediated immune response
plasma cells Defense against bacteria
223. Complete Water in oil emulsion and killed
206. Active natural An individual infected with microorganism freud's mycobacterium butyriu or mycobacterium
produces an antibody adjuvant tuberculosis
207. Active artificial An individual xposed to an antigen thru a 224. Alum adjuvant Only adjuvant utilized within human being
vaccine develops immunity without having
the infection 225. Squalene from Adjuvant in HIV Vaccin
shark's oil
208. Passive natural An individual is protected by abs MF 59
produced by another individual
226. Fab Part of antbody which has amino terminal
209. Passive An individual receives an immune globulin
artificial containing antibodies produced in another 227. Fc Portion of antibody which has carboxyl
individual terminal

210. Adv: long term Advantage of active immunity 228. IgA, IgG, IgD Antibodies with 4 domains
Disadv: not 229. IgM, IgE Abs with xtra CH4 domain
immediate
230. Ch2 (IgG) Part of antibody na dumikit sa complement
211. Epitope Determinant site on an antigen Ch3 (IgM) (classical)
231. Isotype Entire heavy chain
232. Allotype Constant region of heavy and light 262. Opsonization Major functions of complement system
chains Inflammation
Cytotoxic
233. Idiotype Variable region
234. IgM, IgA2 Has J chains
235. IgM, IgD Found in surface of Beta cells
236. IgG and IgM Immunoglobulins that act as opsonins
237. 65%:35% Kappa: Lambda ratio
2:1
238. IgG Immune antibody
239. IgG Has the longest half life (23 days)
240. IgG3 Most capable IgG of activating
complement
241. IgM Most primitive, naturally occurring
242. IgM Heaviest (900000 Daltons)
243. IgA Ig found in secretions
244. Malt Secretory igA is synthesized in the
plasma cells found mainly in?
245. IgD Antiidiotypic antibody
Switch off B cells
246. IgE Least abundant immunoglobulin in thr
serum
247. IgE Heat labile antibody
248. Reagin IGe is also known as
249. IgG Most abundant Ig (70-75%)
250. IgM Has the longest sediment coefficient
(19S)
251. IgM Most efficient in complement fixation
252. GAMDE Abundance of Ig in serum
253. GMADE abundance of ig in plasma
254. Papain Cleaves the molecule into 2 Fab
fragments and 1 Fc fragment
255. Directly Papain cleaves ______ on the honge region
256. Pepsin Cleaves the molecules into 2 Fab
fragments
257. Below Papain cleaves ______ the hinge region
258. Dithiotreitol IgM pentamer--> monomer
2-
Mercaptoethanol
(2-Me)
259. Hybridoma cell Plasma cell + myeloma cell
260. Polyethylene In monoclonal antibody production,
glycol spleen cells are combined with
myeloma cells in the presence of?
261. hat medium Medium used in monoclonal antibody
production