CONFIDENTIAL

Placement plan for confirmed cases according to SNP PCR profile

N501Y T478K E484K L452R E484A S371L/F S373P Variants Patient placement#
Cohort with other
cases with all targeted
Not detected Not detected Not detected Not detected Not detected Not detected N/A mutations not
detected
Cohort with other cases with
Insufficient viral load for mutation analysis* N/A insufficient viral load for
mutation analysis
Single room or cohort
Detected Detected @ @ N/A N/A
with other cases with the
Detected / Insufficient viral Detected / Insufficient viral Omicron same PCR profile under
N/A N/A @ Detected tight isolation capacity
load for mutation analysis load for mutation analysis
Single room or cohort with other
@ Detected ^ @ Detected @ @ Delta cases with same PCR profile
Single room or cohort with other
Detected Not detected Not detected @ @ @ Alpha cases with same PCR profile
Beta, Gamma, Single room or cohort with other
Detected Not detected Detected @ @ @ cases with same PCR profile
Mu, Theta
Single room or cohort with other
Not detected Not detected Detected @ @ @ Eta, Iota, Zeta cases with same PCR profile

@ “Not detected”, “To follow” or “Insufficient viral load for mutation analysis” ^ “Detected”, “To follow” or “Insufficient viral load for mutation analysis”
# Irrespective of their disease stage including possible “re-positive” cases
* Ensuring persistently very low viral load that is insufficient for mutation analysis by increasing trend of CT value with at least 2 consecutive specimens taken at 1
least 12 hours apart