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Nutraceutical
Formulations and
Challenges
9
Raj K. Keservani*, Rajesh K. Kesharwani**, Anil K. Sharma†,
Surya P. Gautam‡, Santosh K. Verma‡
*School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya,
Bhopal, India; **Department of Biotechnology, NIET, NIMS University, Shobha Nagar,
Jaipur, India; †Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences
and Research, New Delhi, India; ‡CT Institute of Pharmaceutical Sciences, Sahapur Campus,
Jalandhar, India
9.1 INTRODUCTION
The term “nutraceutical” was introduced as a hybrid of nutrition and pharmaceutical
in 1989 by Dr. Stephen DeFelice, Chairperson of the Foundation for Innovation in
Medicine. A nutraceutical is any material that may be considered a food or com-
ponent of a food and offers medical or health advantages, encompassing prophy-
laxis and cure of diseases (Brower, 1998; Kalra, 2003; Biesalski, 2001; Keservani
et al., 2010). Functional foods are any food or food ingredient that may provide a
health benefit beyond the traditional nutrients it contains (Keservani et al., 2015d).
The safety of what is proposed and promising nutritional and therapeutic influences
have generated an appreciable curiosity in nutraceuticals and functional foods. This
has rendered the nutraceutical and functional food industry in a special place to focus
on the benefits of their terminal users, that is, the consumers.
Nutraceuticals offer several advantages, but the current review emphasizes the
role of nutraceuticals in the maintenance of health. Nutraceuticals are believed to
provide physiological benefit or immunity against ensuing diseases/disorders such as
cardiovascular disorders (Rissanen et al., 2003; Choudhary and Tomer, 2013), obesity
(Boozer et al., 2001; Kaur et al., 2015), diabetes (Singh et al., 2012), cancer (Temple
and Gladwin, 2003; Ahmad et al., 2015), stress, Parkinson’s and Alzheimer’s dis-
eases (Latif et al., 2007; Keservani et al., 2015a), neurological diseases (Keservani
et al., 2015b), pulmonary and respiratory disorder (Keservani et al., 2015c), and may
function as immunomodulators (Keservani et al., 2015d).