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306 IEEE REVIEWS IN BIOMEDICAL ENGINEERING, VOL.

11, 2018

Noncontact Wearable Wireless ECG Systems


for Long-Term Monitoring
Sumit Majumder , Leon Chen , Ognian Marinov, Member, IEEE,
Chih-Hung Chen, Senior Member, IEEE, Tapas Mondal, and M. Jamal Deen , Fellow, IEEE

Abstract—Electrocardiography (ECG) is the most com-


mon and extensively used vital sign monitoring method
in modern healthcare systems. Different designs of am-
bulatory ECG systems were developed as alternatives to
the commonly used 12-lead clinical ECG systems. These
designs primarily focus on portability and user conve-
nience, while maintaining signal integrity and lowering
power consumption. Here, a wireless ECG monitoring
system is developed using flexible and dry capacitive
electrodes for long-term monitoring of cardiovascular
health. Our capacitive-coupled dry electrodes can measure
ECG signals over a textile-based interface material between
the skin and electrodes. The electrodes are connected to a
data acquisition system that receives the raw ECG signals
from the electrodes and transmits the data using Bluetooth
to a computer. A software application was developed to
process, store, and display the ECG signal in real time. ECG Fig. 1. Basic features in the waveform of an ECG signal.
measurements were obtained over different types of textile
materials and in the presence of body movements. Our
experimental results show that the performance of our ECG disease, the electrocardiogram (also, ECG) is also useful in di-
system is comparable to other reported ECG monitoring
systems. In addition, to put this research into perspec- agnosing the disorders in the cardiac rhythm and evaluating
tive, recent ambulatory ECG monitoring systems, ECG syncope. Other common uses of the ECG include evaluation of
systems-on-chip, commercial ECG monitoring systems, metabolic disorders, direct and side effects of pharmacotherapy,
and different state-of-the-art ECG systems are reviewed, and primary and secondary cardiomyopathy.
compared, and critically discussed. In the early days, realizing a highly sensitive ECG system
Index Terms—Capacitive coupling, ECG sensors, flexible was a significant challenge. The electrical heart signals attenu-
electrodes, wearable ECG sensing system. ate while traveling through the body tissues and become weak
at the skin’s surface. However, Einthoven [1] managed to im-
prove the sensitivity of ECG sensing systems by using a string
I. INTRODUCTION
galvanometer. Einthoven’s improvement was considered to be a
LECTROCARDIOGRAPHY (ECG) has been proven to
E be among the most useful diagnostic tests in clinical
medicine, and is now routinely used in the evaluation of pa-
giant leap forward for ECG, since the characteristic peaks of the
ECGs, now familiar as P, Q, R, S, and T waves, were apparently
defined (see Fig. 1), while the scientists previously had demon-
tients with implanted defibrillators and pacemakers, as well as strated only ventricular depolarization and repolarization [2].
to detect myocardial injury, ischemia, and the presence of prior Different types of ECG systems [3]–[6] have been introduced
infarction. In addition to its usefulness in ischemic coronary so far to improve the signal quality in the clinical settings. The
conventional ECG method uses a hydrogel between the skin and
Manuscript received December 30, 2017; revised April 10, 2018; ac- the electrodes to increase the conductivity of the signal path.
cepted May 3, 2018. Date of publication May 29, 2018; date of current However, the wet electrode method uses conductive gels that
version July 24, 2018. This work was supported in part by the National contain toxic materials, which can cause irritation to the skin of
Sciences and Engineering Research Council of Canada (NSERC) and
the Canada Research Chair (CRC) program. (Corresponding author: M. the patients. Some patients may even be allergic to the nickel
Jamal Deen.) particles or the acrylic adhesive present in the popular disposable
S. Majumder, L. Chen, O. Marinov, C.-H. Chen, and M. J. Deen are conductive hydrogel based ECG electrodes [7]–[11]. Therefore,
with the Department of Electrical and Computer Engineering, McMas-
ter University, Hamilton, ON L8S 4K1, Canada (e-mail: majums3@m the wet electrode method is not suitable for ambulatory and
cmaster.ca; chenl79@mcmaster.ca; omarinov@yahoo.com; chench@ long-term monitoring of the ECG.
mcmaster.ca; jamal@mcmaster.ca). In this paper, a dry capacitive-coupled flexible electrode is de-
T. Mondal is with the Department of Pediatrics, McMaster University,
Hamilton, ON L8S 4K1, Canada (e-mail: mondalt@mcmaster.ca). signed and used to develop a portable wireless ECG monitoring
Digital Object Identifier 10.1109/RBME.2018.2840336 system. The capacitive dry electrode method [3], [4] requires
1937-3333 © 2018 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission.
See http://www.ieee.org/publications standards/publications/rights/index.html for more information.

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MAJUMDER et al.: NONCONTACT WEARABLE WIRELESS ECG SYSTEMS FOR LONG-TERM MONITORING 307

neither a conductive interfacial medium, nor any direct contact


to the skin, thus making it suitable for long-term monitoring.
Despite having a layer of interfacial material between the skin
and electrodes, the proposed electrode still allows the detection
of the ECG signals from the skin’s surface through capacitive
coupling, thus making the system suitable for long-term moni-
toring of ECG in an ambulatory environment.
The interface material for capacitive electrodes can be a thin
layer of textile material, such as cotton, which is tightly at-
tached to the skin to ensure an optimal signal quality. Cotton is
a common fabric for clothes, which-in comparison with other
materials, such as, wool, silk, or nylon-has a higher dielectric
constant, thus resulting in better capacitive coupling [12]. These Fig. 2. General architecture of the ambulatory ECG monitoring system.
capacitive electrodes can potentially be integrated with the smart
textiles [13]–[15] to realize a wearable and comfortable long-
term ECG monitoring system. Both the capacitive dry electrodes 1) Flexible Electrodes: In the conventional 12-lead clin-
and smart textiles are increasingly being studied and developed ical ECG systems, the heart’s electrical activities are sensed
for flexible and wearable ECG monitoring systems. using conventional Ag-AgCl gel electrodes. Although, the con-
In this paper, a detailed and comparative review on the current ductive gel offers superior signal quality and motion tolerance,
state of research and developments in ambulatory ECG moni- it is, however, toxic and may cause skin irritation if used for a
toring systems is presented. A wearable wireless ECG system prolonged period of time, making it inappropriate for long-term
based on a flexible and capacitive-coupled active dry electrode ambulatory monitoring. Researchers in [18] integrated a minia-
is also proposed, which is designed for both inpatient and outpa- ture water reservoir in the Ag and Ti coated polyethylene tereph-
tient monitoring of the ECG. The capacitive-coupled electrode- thalate yarn-based textile electrode to moisturize the electrodes
based system is capable of obtaining ECG signals over a thin with the water vapor. Although the ECG signals thus obtained
layer of cloth, which is transmitted in real-time over the Blue- were of good quality, the presence of the water reservoir may
tooth platform for storage and further processing [16]. cause reliability issues, for example, in the case of a leakage.
The water level in the reservoir needs to be monitored regularly
II. AMBULATORY ECG SYSTEMS in the case of long-term monitoring. A superabsorbent polymer
was exploited in [19] to regulate the humidity around a conduc-
The primary purpose of the ambulatory ECG systems
tive polymer-based flexible fabric electrode thus enabling faster
is to facilitate monitoring the heart’s activity outside the
discharge of any accumulated charges and resulting shorter sta-
clinical setting. It also allows for continuous monitoring of
bilization time for the signal. These electrodes showed high
cardiovascular health, thus enabling detection and diagnosis
signal quality at rest and short stabilization time. However, the
of any heart-related issues at their early onset. Unlike the
motion tolerance of these electrodes was not evaluated.
ten-electrode clinical ECG systems, ambulatory ECG systems
“Dry” electrodes, on the other hand, do not rely on any con-
are small, portable, and generally exploit two to three electrodes
ductive gel or additional moisturizer and, therefore, are suitable
to measure and record the electrical signals. Some systems
for long-term ambulatory monitoring systems. However, dry
also incorporate wireless communication technologies, such
electrodes usually suffer from high electrode-tissue impedance
as Bluetooth, Bluetooth low energy (BLE), and ZigBee to
(ETI) owing to the poor contact between the skin and the elec-
facilitate real-time data transmission. Ambulatory ECG systems
trode and, thereby, are prone to noise and motion artifacts. The
with inherent wireless transmission capability can thereby play
electrode contact can be improved by using flexible substrates,
a key role in a smart home-based long-term and remote health
which makes it highly conformable to the skin. Some researchers
monitoring system [17]. A general architecture of ambulatory
used polymer materials, such as polydimethylsiloxane (PDMS)
ECG monitoring system is shown in Fig. 2.
[20], [21] and ethylene propylene diene monomer [22], ure-
thane [23], [24] as the substrate to improve the contact between
A. ECG Systems in the Literature
the electrode and the skin. The wearable dry electrodes can be
One of the key problems in the ambulatory ECG systems realized by embedding conductive nanomaterials, such as Ag-
evolves from the contamination of the electrical signals by the nanowire [20], [25], carbon nanoparticle [22], Ag-coated glass
electrode motion artifacts (MA). The impedance of the interface composite [26], and carbon nanotube (CNT) [21], in the flexi-
between the electrode and the skin is disturbed with the move- ble polymers or by employing a coating of conductive material,
ment of the body that corrupts the ECG signal and decreases such as Ni, Cu, and Au, on the polymer substrate [23], [24].
the SNR. Therefore, many researchers put their efforts in im- With an adequate concentration of nanomaterials in the PDMS,
proving the motion tolerance and the noise performance of the these electrodes may achieve similar order of ETI to Ag-AgCl
ambulatory ECG systems by exploiting flexible electrodes, im- wet electrodes at lower frequencies. These flexible electrodes
proved analog front ends (AFE) and on-chip signal processing are tolerant to MA to some extent. In [25], an additional ca-
techniques. pacitive strain sensor was cofabricated with the electrode on a

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308 IEEE REVIEWS IN BIOMEDICAL ENGINEERING, VOL. 11, 2018

self-adhesive, stretchable platinum silicone rubber-based sub- There has also been a growing interest among the researchers
strate to estimate and minimize the MA through an adaptive in using textile materials for developing wearable, unobtrusive,
filtering approach. These dry wearable electrodes are suitable and comfortable health monitoring systems. Textile-based sen-
for long-term monitoring systems. The signal quality, however, sors exploit conventional fabric manufacturing techniques, such
may degrade due to possible oxidation of the metal nanopar- as weaving, knitting, embroidery, and stitching, as well as ad-
ticles over time. For the CNT-based electrodes, achieving ho- vanced methods, such as inkjet-printing, coating, lithography,
mogenous dispersion of the CNT in PDMS may cause addi- and chemical vapor deposition. Researchers in [33] fabricated
tional fabrication challenges due to the presence of strong van a textile-based flexible and conformable electrode by screen
der Waals interactions in CNT. A novel concentric flexible mul- printing Ag/AgCl-based conductive ink on the propylene-based
tiring electrode was presented in [27], which consists of four elastomeric nonwoven fabric. The dry electrode showed higher
hook-shaped silver electrodes and an inner disc fabricated on a ETI than the commercial wet electrode as well as some MA.
flexible polyester substrate. The potential differences between The impedance and MA, however, reduced significantly with
the rings and the central disc contribute to achieving higher the increase of the electrode area as well as with the applica-
spatial resolution compared to the traditional disc electrodes. tion of hydrogel on the electrode. A similar electrode, based
Some researchers exploited microstructures to reduce the ETI on nanofiber web textiles, was also reported in [34]. Another
by enhancing the adhesion, flexibility, and conformability of textile-based electrode was proposed in [35], where a flexible
the electrodes. A 3-D printed surface electrode was presented but unstretchable textile was coated with the conductive PE-
in [28]. An array of conical needles was printed on a truncated DOT/PSS. A soft foam layer was introduced in the electrode to
conical support by jetting thin layers of polymeric material and improve the contact pressure and keep the electrode wet, thus
curing each layer by ultraviolet light. The developed model lowering the contact impedance. The dry electrodes showed sim-
was then coated with Ti and Au to lower the ETI and pre- ilar order of ETI to the conventional Ag/AgCl gel electrodes but
vent oxidation and corrosion. In [29], researchers exploited a poor performance in terms of baseline stability. The impedance
microelectro-mechanical system process to fabricate a highly and signal quality, however, improves when the electrodes are
thin and flexible capacitive electrode. The electrode consists of wet. Although the electrodes are low-cost and follow a simple
two insulating layers, an active shield plate, and a Ni sensing fabrication process, they require regular moistening to maintain
plate, forming a parallel-plate capacitor with the body, which a low ETI and high SNR, especially in the presence of move-
enables sensing ECG over the cloth. In both works, the re- ment. One may find several early implementations of textile
searchers reported to achieve ECG measurements comparable electrodes in [36]–[39].
to the signal measured using wet electrodes. However, the im- 2) ECG Systems: Ambulatory ECG systems are small in
pact of the MA on the measured signal was not reported. A size and by using only a few electrodes compared to the clinical
filamentary serpentine mesh layout was exploited in [30] to re- ECG systems can still provide limited yet useful information
alize a flexible and reusable epidermal capacitive sensor. Three about the cardiovascular health. A wearable ECG system can
such gold electrodes were embedded into silicone and con- facilitate continuous and long-term monitoring of cardiovascu-
nected to the anisotropic conductive film-based bonding pads. lar health without affecting the daily activities and comfort of
The stretchable membrane-like structure, with the aid of van- the user.
der Waals interaction, offers high conformability and ensures Researchers mostly used polymer [23], [27], [40], [41] and
intimate contact to the skin. In addition, its low modulus and textile [42]–[47] based flexible- and direct-contact electrodes
elastic properties allow the sensor to readily adapt to the skin to realize the sensing part of the wearable ECG systems. The
deformation, thus, making it less sensitive to MA compared to noncontact electrodes are capacitive in nature and capable of
the traditional capacitive flat electrodes. sensing bio-potential over the cloth without having any direct
Researchers in [31] fabricated Si microneedles array (MNA) contact to the skin. Such noncontact electrodes are embedded in
and bonded it over a PDMS substrate to realize a flexible struc- chairs [44], [46] and bed covers [46] to measure the ECG at rest
ture of the electrode. The conductive PEDOT/PSS coated sharp or during sleep. Direct-contact electrodes are usually embedded
MNA can penetrate the skin layer and thus can make intimate in textiles by using snap buttons [40], [41], [47]–[49], Velcro
contact to the skin. An interesting microstructure, inspired from [50] or by means of conventional sewing, weaving or packaging
the gecko’s toe pad was exploited in [32] to design a conduc- techniques [43], [44], [3], [46].
tive dry adhesives (CDA) electrode. The CDA was fabricated by The sensed bio-potential is fed to the AFE, which filters and
growing mushroom-shaped micropillar structures of conductive amplifies the ECG signal. The noise in a battery-operated ambu-
elastomer on a Si platform, where the conductive elastomer was latory ECG system is primarily caused by the movement of the
composed of 1-D–2-D hybrid carbon nano-fillers and PDMS. body. The flexible electrodes, due to their high conformability to
The structure showed a good adhesion force (∼ 1.3 N/ cm2 ) on the skin, can greatly reduce the MA. The noise can be further re-
and conformity to the human skin. In addition, the surface of duced by designing the AFE with high input impedance and high
the pad showed superhydrophobic property, and thereby, having common mode rejection ratio (CMRR). The input impedance
self-cleaning capability. Both structures showed close attach- of the AFE can be improved by using resistors [3], [45], [51],
ment and high conformability to the skin even in the presence [52] or two antiparallel diodes for biasing [50], [53]. However,
of movement, making them useful for long-term ambulatory antiparallel diodes are preferred due to their low thermal noise
monitoring systems with reduce MA. and faster recovery time. Researchers also exploited advanced

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MAJUMDER et al.: NONCONTACT WEARABLE WIRELESS ECG SYSTEMS FOR LONG-TERM MONITORING 309

amplifier topologies, for example, differential difference ampli- In order to realize seamless monitoring of the cardiovascular
fier [41] to achieve high input impedance, high CMRR, low- health from a remote facility, some researchers exploited cloud-
power and low-noise performance. The filtered ECG signal is based computing platform [44], [65]–[67]. Cloud-based moni-
then digitized, which can be stored in a SD card and/or transmit- toring systems allow the clinicians, designated family members
ted to a nearby computing platform, such as computer, smart- and the users to share and access health information through a
phone, and tablet, preferably over a wireless media. common web-based platform. In [44], researchers developed a
Another key concern for the ambulatory ECG systems is mobile application for their ECG monitoring system, which can
achieving high energy efficiency and low-power consumption. analyze, summarize, and monitor the health status of the user. It
Lower power consumption increases the battery life, which is can also communicate and share resources with the healthcare
critical for long-term monitoring systems. Some researchers professional through a common web-based cloud computing
exploited energy harvesting techniques [54], [55] to meet the server over the Internet. Similar cloud-based ECG monitoring
power requirements of the ambulatory systems. Power con- systems were also reported in [65]. Instead of analyzing the
sumption can also be minimized by using low-power electronic ECG in the local computing machine (e.g., smartphone, laptop,
components [40] and wireless communication technologies, and tablet), the system presented in [66] periodically transmits
such as Bluetooth [23], [27], [44], [50], Bluetooth LE [42], the measured ECG to the web server via a smartphone. The web
[43], [47], ZigBee [40], [49], and ANT [3]. Researchers in [49] server runs an algorithm that evaluates and enhances the quality
developed a dynamic power adjustment method to optimize the of the ECG, displays and analyzes the signal in real time. It also
power consumption of the transmitter by analyzing the distance functions as a common communication platform between the
between the transmitter and the receiver. The system periodi- user and the healthcare professionals. Researchers in [67] also
cally computes the relative received signal strength (RSSI) and developed a cloud-based wearable ECG monitoring system, par-
automatically adjust the transmitter power until the RSSI falls ticularly for women. They installed two gold-nanowire-based
within −60 and −70 dBm. In [56], the human body was ex- electrodes, electronic and transmission modules at the bottom
ploited as the low-power communication medium for transmit- layer of a brassiere. Unlike most ambulatory systems presented
ting ECG signal. They used impulse radio (IR) type human above, they employed GPRS communication technology for di-
body communication (HBC) technology to transmit ECG data. rect and long-range communication with the remote server, thus
HBC generally operates in the megahertz (MHz) regime. The eliminating the need of any intermediate gateway, however, at
HBC transmitter generates a quasi-static electric field around the cost of increased power consumption. Table I presents a
and close to the body through capacitive coupling. As a result, comparison among several ambulatory ECG monitoring sys-
HBC offers minimum interference with other wireless systems tems presented in the literature recently.
as well as high data security. The researchers reported to achieve 3) Integrated Circuits: There have been growing interests
low bit error rate (BER) at a data rate as high as 1.25 Mbps. The in developing fully integrated ECG measurement system to re-
ECG data can be readily transferred to a computer by touching duce the power requirements, cost, and size of the overall sys-
the receiver connected to the computer. tem. A typical ECG system-on-chip (SoC) comprises an AFE, an
After receiving the ECG data, the computing platform can analog-to-digital converter (ADC), a power management unit,
perform further processing, store and display the result in real and a digital signal processing (DSP) unit. The on-chip DSP
time. The system can exploit signal processing techniques, such unit performs some preliminary signal processing, such as fea-
as adaptive filtering [57], [58], wavelet decomposition [59]- ture detection, data compression, and noise and artifact reduc-
[62], and empirical mode decomposition [61], [63], [64] tech- tion. The processed signal or information is then sent to an
niques to further reduce the noise and improve the SNR. The off-chip or, occasionally, an on-chip transceiver unit to transmit
platform can also make use of artificial intelligence technolo- the data to a more powerful computing machine, such as smart-
gies, such as machine learning, deep learning, and neural net- phone, laptop, or tablet. One of the key design concerns for
work to learn and evaluate the health status of the user. An the ECG SoC is to lower the power consumption to cope with
Android-based mobile application was developed in [43] that the energy constraint of the wearable and long-term monitoring
can display the ECG traces and calculate the heart rate (HR) in systems. The reduction in power consumption in an ECG SoC is
real time with high accuracy. In [50], the researchers addition- generally achieved by lowering the supply voltage, minimizing
ally included an alert generation mechanism in their application. the data rate and employing low-power communication tech-
The system is capable of detecting arrhythmia with high accu- nologies [68]. In addition, an AFE with high input impedance,
racy, and high sensitivity and can inform the user by a text large dc electrode offset (DEO), high CMRR, and low noise
message. The H-shirt system presented in [42] includes a mo- floor is critical for achieving superior signal quality and
bile phone application, which can detect six types of anomalous high SNR.
ECG. The application can evaluate the user’s health status by In the ECG SoC, the DSP unit, owing to its complex func-
analyzing the ECG signal and warn the user about a potential tionalities, generally consumes a significant proportion of total
health problem by sending voice messages to the phone. In [40], power [69], [70]. Researchers in [71] integrated a microcon-
the researchers proposed and implemented a single integration troller and SRAM blocks to enable specific DSP features in
platform to serve multiple ECG monitoring systems in a smart the SoC. Both the microcontroller and SRAM blocks are ca-
home, thus enabling management and long-term monitoring of pable of operating in the subthreshold region that lowers the
multiple users at a reduced cost. total power consumption. An automatic gain control (AGC)

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310 IEEE REVIEWS IN BIOMEDICAL ENGINEERING, VOL. 11, 2018

TABLE I
COMPARISON AMONG AMBULATORY ECG MONITORING SYSTEMS

mechanism was employed in [72] to achieve an optimal SNR conversion’s power efficiency. The overall power consumption
by adjusting the input level of the ADC. The AGC in [72] does as well as the size of the DSP units can also be minimized by
not depend on the power-hungry DSP unit for its operation. In exploiting modern scaled-down technology nodes and lowering
addition, the low-power sigma-delta ADC only activates after the supply voltage [74].
the completion of the AGC operation, which further reduces the In order to minimize the overall power consumption of the
overall power consumption. A current-multiplexed buffer and ECG SoC, researchers proposed different low-power AFE archi-
self-synchronized ADC were used in [73] to improve the data tectures with power requirements ranging from several hundreds

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MAJUMDER et al.: NONCONTACT WEARABLE WIRELESS ECG SYSTEMS FOR LONG-TERM MONITORING 311

of nW to several tens of µW [68], [75]–[78]. Low-power con- or on-chip [69], [78] DAC in the feedback loop to program the
sumption was achieved by exploiting several topologies, such cutoff frequency of the HPF, and thus removing the DEO.
as ac-coupled amplifiers [75], [78], [79], complementary dif- Some ECG SoCs incorporate on-chip ECG noise reduction
ferential input amplifiers [80], [81], and chopper stabilization and feature extraction mechanisms. In [72], a Haar-wavelet-
amplifiers [76], [82], [83]. An ac-coupled amplifier along with based discrete wavelet transform method was used to remove
a dc-servo loop (DSL) was proposed in [75], where the input the high frequency and baseline wander noise and also to detect
transistors were biased in weak inversion to reduce the power the characteristic peaks and the cycle boundaries of the ECG
consumption. Researchers in [76] and [82] exploited a chopper in real time. An on-chip baseline stabilizer was introduced in
stabilization amplifier and operated it in the subthreshold region [68], which monitors the offset voltage at the input of a pro-
to lower the power consumption as well as the flicker noise. grammable gain amplifier (PGA) and resets the PGA when the
Although these low-power solutions are favorable for wearable, input signals are much higher than the common mode voltage.
ambulatory, and long-term ECG monitoring systems, the rel- The baseline drift of the ECG signal is thus eliminated by reset-
atively low input impedance of these topologies makes them ting the PGA, which brings the baseline down to the common
susceptible to noise and MA. Since the ETI of the Ag/AgCl mode voltage by shorting the input and output of the PGA.
based wet electrodes are much smaller than the dry ones, these In [76], a DSP unit is integrated in an implantable ECG SoC,
low-power designs are particularly suitable for the former ones which facilitates on-chip arrhythmia detection by performing
[84]. The detrimental impact of the large ETI on the ECG signal QRS-peak detection and fast Fourier-transform in real time. Re-
can be mitigated by increasing the input impedance of the AFE. searcher in [79] implemented an algorithm on the SoC that can
The input impedance and thus the SNR can be improved by simultaneously perform QRS detection and lossless ECG com-
employing a positive feedback in an ac-coupled amplifier [75], pression using shared hardware resources, thus lowering the
[76], [85] or by using a dc-coupled amplifier [68], [86]. The overall power consumption.
noise floor of the capacitive feedback amplifier can be further A switched-capacitor-based HPF was used in [73] to facil-
lowered by employing current scaling, current splitting, current itate QRS feature extraction in the analog domain that lowers
reuse, and source degeneration techniques in a folded cascade the power consumption by reducing the computational load on
amplifier topology [81]. Researchers in [81] exploited floating- the DSP. Although the switched capacitor HPF increases the
gate transistors to realize the common mode feedback in a com- size of the chip, it provides larger input impedance, which is
plementary differential pair architecture and used current reuse beneficial in terms of noise performance. Researchers in [77]
technique to lower the noise floor. designed an ultralow-power SoC for cardiovascular monitoring.
In order to avoid amplifier saturation, the AFE needs to They employed one QRS amplifier and one baseline amplifier
be capable of eliminating the large DEO effectively. Accord- to isolate QRS complex from the baseline drift. The QRS com-
ing to the International Electrotechnical Commission (Geneva, plex is detected by comparing the QRS voltage with an adaptive
Switzerland), the ECG system should tolerate an electrode off- threshold. The QRS detection is performed in the analog do-
set of at least +/−300 mV [87]. A suitable compensation tech- main and, thereby, does not involve any DSP unit. As a result,
nique is required to deal with the large electrode offset caused by the power consumption is brought down to as low as 58 nW.
skin-electrode interface [68], [88]. DEO can be removed by em- An on-chip implementation of the Pan-Tomkins algorithm was
ploying ac-coupled amplifiers, capacitive feedback amplifiers presented in [94] that can calculate HR in real time by em-
[71], [73], [81], [89], or DSLs [75], [90]. As discussed ear- ploying time windowing and thresholding techniques. In [95],
lier, ac-coupled amplifiers suffer from poor input impedance. an ECG processor was proposed, which was capable of de-
In addition, the mismatch in the capacitors may result into tecting R-peaks and monitoring instantaneous HR by perform-
poor CMRR [91]. Researchers utilized the DSL technique in ing correlation between a template signal and the measured
chopper-modulated amplifiers [91] and ac-coupled amplifiers signal. They used the ECG processor along with a three-axis
[75] to improve the DEO rejection range. However, the DEO accelerometer and near-field communication technology to re-
rejection range of the DSL-based AFE typically remains within alize a wearable system for monitoring cardiovascular health
several tens of mV [91], [92]. In [91], the researchers used through a smartphone. In [96], researchers implemented a for-
two current feedback instrumentation amplifiers (CFIA) in the ward search algorithm in an integrated ECG signal processor
forward path and a DSL feedback, which feeds the unwanted to detect the characteristic features of the ECG. They also de-
dc-offset to the negative terminal of the CFIAs to cancel the veloped an android-based application to detect various phases
offset voltage. In the capacitive feedback amplifiers, a large ca- of myocardial infarction and AV block with high accuracy and
pacitor along with a resistor in parallel forms a high-pass filter sensitivity.
(HPF), which removes the DEO voltage. Thick-oxide PMOS- Some researchers also integrated wireless communication
based pseudoresistors [71], [79], [89], floating-gate transistors technologies to realize a compact and fully integrated wireless
[81] are exploited to realize the HPF with a cutoff frequency as ECG monitoring system. The ECG SoC presented in [71] incor-
low as several hundreds of millihertz, thereby eliminating the porates a medical implantation communication service (MICS)
need of large capacitors in the HPF. However, the pseudore- band RF-transceiver. The binary frequency-shift keying and on–
sistors may cause nonlinearity [81], [93]. Additionally, the low- off keying (OOK) modulation schemes were used in the trans-
frequency cutoff set by the pseudoresistors is process dependent mitter and receiver, respectively. In [97], an RF front end was
and not configurable [81]. Researchers made use of off-chip [86] integrated in a bio-signal acquisition SoC to facilitate low-power

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312 IEEE REVIEWS IN BIOMEDICAL ENGINEERING, VOL. 11, 2018

TABLE II
COMPARISON AMONG ECG SOCS

ECG acquisition and wireless transmission on a single integrated raw ECG data. Some researchers exploited asymmetric radio
circuit (IC). The SoC includes a two-channel ECG front end and IR UWB to integrate low-power wireless transmission in
with an 8-bit successive approximation-ADC, a ZigBee com- the SoC [98], [99]. A bio-potential acquisition SoC with an inte-
munication processor with offset quadrature phase-shift keying grated low-power RF transmitter was presented in [94]. In order
modulation, and a RF transceiver unit. The chip can acquire to meet the power requirements of the SoC, the researchers also
ECG signal and transmit it in real time over the ZigBee plat- integrated the thermoelectric energy-harvesting technique in the
form. The chip consumes 37 mW for acquiring and transmitting IC. The system can harvest energy from the body heat, which

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MAJUMDER et al.: NONCONTACT WEARABLE WIRELESS ECG SYSTEMS FOR LONG-TERM MONITORING 313

enables the system to run continuously. The low power con-


sumption (19 µW) was achieved by utilizing subthreshold DSP
and heavy duty-cycle RF transmission of the HR information.
However, for transmitting raw ECG signal, the SoC requires the
power of 397 µW. Table II presents a comparison among several
ECG SoCs proposed in the literature recently.
4) Commercial Portable ECG Systems: The 12-lead clin-
ical ECG systems are expensive, bulky, and require trained per-
sonnel to operate, making them infeasible for in-home monitor-
ing of the electrical activities of heart. Recent developments in
flexible dry electrodes, low-power electronics, and short-range
communication technologies coupled with high market pene-
tration of computing devices, such as smart phones, tablets, Fig. 3. Block diagram of the ECG sensing system with a photograph
of a designed capacitive electrode.
and laptops, have propelled the medical product industries to-
ward developing small, light-weight, and portable wireless ECG
measurement systems in an effort to enable continuous in-home
monitoring of basic cardiac activities and arrhythmias. Several
portable and small-size ECG monitoring systems are currently
available in the market [100]–[111]. Some ECG monitoring sys-
tems, such as HeartCheck PEN (CardioComm Solutions, Inc.,
North York, ON, Canada) [104], can be bought over-the-counter.
Most of the systems, however, are sold with a doctor’s prescrip-
tion.
These portable systems are compact, affordable and can mea-
sure basic I-lead ECG by using two to three electrodes [100]– Fig. 4. Electrode–body interface with capacitive coupling of ECG bio-
[107], [110]. However, some systems are capable of providing potential.
three-lead ECG measurement [108], [109], [111]. Most sys-
tems are capable of measuring and recording the ECG signal power, and transmits the ECG data to a personal computer over
for only a short period of time, usually 30 s. Some advanced the low-power Bluetooth communication medium [13].
systems facilitate continuous monitoring of the ECG signal up A computer software was developed that upon receiving the
to 48 h [101], [105], [107], [109]–[111]. The measured ECG ECG data performs filtering of the raw data, stores and displays
data are stored either in a flash memory embedded in the sys- the filtered ECG signal. This entire system is designed to allow
tem [102]–[105], [108]–[111] or in an external SD card [107], the user to carry the ECG device throughout the day, thereby
[109], which is later transmitted to a computing and storage enabling long- term monitoring of cardiac activities.
platform over a wired communication protocol, for example,
Universal Serial Bus (USB) [102]–[105], [107]–[109],- [111].
Some systems also incorporate low-power wireless communica- B. Capacitive Electrodes
tion technologies, such as Bluetooth, BLE to facilitate wireless The capacitive electrodes sense the bio-potential through the
transmission of ECG signal in real time [100], [101], [106], capacitance between the electrode and skin surfaces [3], [4], as
[107], [110]. A comparison among different currently available shown in Fig. 4. Capacitive electrodes allow measuring the ECG
ECG monitoring systems is presented in Table III. over the cloth. In practice, the patient wears the electrodes over
a thin layer of textile material such as cotton. The layer of the
III. PROPOSED ECG SYSTEM cotton material is expected to be thin and remain in tight contact
to the skin for optimal pickup of the ECG signals.
A. Overview Fig. 5 presents the schematic of the designed capacitive elec-
The purpose of using the proposed dry ECG electrode is to trode. The sensing area of the electrode is 6 cm², providing about
obtain the ECG traces in the presence of a textile material be- 20 pF capacitive coupling to the skin. A 3 V coin battery serves
tween the skin and the electrodes. The electrodes do not require as the power source for the operational amplifiers (op-amps).
any conductive gel or direct contact to the skin, thus prevent- The power switches ON when the electrode is connected with
ing any skin irritations or possible allergies. Fig. 3 presents the the cable of the portable ECG device. Thus, the battery charge
block diagram of the proposed wireless ECG monitoring sys- starts draining only when the wire is plugged into the electrode.
tem, which includes the designed capacitive electrodes, data The coin battery has a capacity of 40 mAh, allowing for the elec-
acquisition and transmission system, and a computer software. trode to last for up to 2 weeks using the micropower AD8617
Two capacitive electrodes, one for the left arm (LA) and an- CMOS dual op-amp.
other for the right arm (RA), are placed on the forearms and The op-amp AD8617 is selected for its low input bias current
connected to the portable ECG device by flexible wires. The (<5 pA) and low current consumption (<0.1 mA). This op-amp
portable data acquisition device is small in size, consumes low also has a low offset voltage, a low input voltage, and current

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314 IEEE REVIEWS IN BIOMEDICAL ENGINEERING, VOL. 11, 2018

TABLE III
COMPARISON AMONG COMMERCIAL ECG MONITORS

noise. The electrometric amplifier AD8617 is very suitable systems, initial signal conditioning, and lead-off detection. The
for portable medical devices. One of the op-amps is used for safety requirements ask for very small or no current to keep the
splitting the battery voltage symmetrically around the virtual heart beating. Overall, the advantages of the proposed electrodes
ground (RET). The other op-amp is used for impedance buffer- come from their small size and low power consumption, which
ing in the signal path, providing high impedance (50 GΩ) at the enables both portability and long-term monitoring.
input and low impedance (few kΩ) at the output. The high input
impedance of the electrodes makes them more tolerant to noise
and artifacts. Shielding and guarding are carefully considered C. Portable ECG Device
in the layout in order to prevent external interferences being The Biometrics DataLog (Biometrics Ltd., Newport, U.K.)
coupled to the sensitive input of the electrode. [112] is used as the data acquisition and transmission module
Resistors and a capacitor are added at the output of the sen- for the portable ECG system. The size of the device is 104 ×
sor in order to comply with safety requirements for the ECG 6 × 22 mm3 , weight is 129 g. The device is powered by two

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MAJUMDER et al.: NONCONTACT WEARABLE WIRELESS ECG SYSTEMS FOR LONG-TERM MONITORING 315

Fig. 7. ECG acquisitions in the time domain without body movement.


(a) With electrodes on bare dry skin. (b) With electrodes on cotton fabric
Fig. 5. Schematic diagram of the capacitive electrode. covered dry skin.

is stopped by the user. Therefore, the duration of the record is


practically unlimited, or until the free disk space of the computer
is consumed.

IV. PERFORMANCE EVALUATION


The proposed ECG monitoring system was used to measure
the ECG from three different healthy subjects. The LA and RA
electrodes were placed on the forearms of the left and right
Fig. 6. Photograph of the ECG measurement setup. hand, respectively. The experiment was conducted in a stan-
dard room environment. A formal consent was taken from the
McMaster Research Ethics Board (REB) to conduct the exper-
AA batteries and can run continuously for about 24 h. The iments. A simple questionnaire was prepared for the subjects
device is capable of transferring data in real time from up to to collect information about any known cardiac or significant
24 programmable channels. However, only one channel is used health problems. The impact of different interface materials and
to realize the developed ECG system. The device also supports body movements on the signal quality are also evaluated with
automatic data backup on a Micro SD card. experiments.
A photograph of the ECG measurement setup is shown in
Fig. 6. The electrodes are about 3 cm in diameter (see Fig. 3) A. Experimental Results
and connected to the Biometrics DataLog device with flexible
The ECG monitoring system was first tested by measuring
wires, which provides enhanced convenience to the user and
the ECG signal at rest. The first set of measurements was taken
also prevent the displacement of the electrodes in the case of
by attaching the electrodes directly to the dry skin without ap-
body movement.
plying any conductive gel or liquid [see Fig 7(a)]. ECG was also
measured by placing a thin cotton cloth between the electrodes
D. Computer Monitoring System
and the skin [see Fig 7(b)]. Reasonably good ECG signals with
The Biometrics DataLog device acquires the ECG signals distinguishable QRS complexes, P and T waves were observed
using the proposed capacitive-coupled electrodes. The portable in both cases. However, as shown in Fig. 7(a), the bare skin
ECG device transmits the measured ECG data over the Blue- causes better coupling of signals to the electrodes compared to
tooth platform in real time to a wireless receiver connected to the textile-covered dry skin, thus, resulting in signal with higher
the USB port of the computer. The ECG data received from amplitude. However, since the ECGs were measured at rest,
the portable ECG device are processed by an infinite impulse both signals were observed to be affected by a similar level of
response notch (60 Hz) and a bandpass (1–30 Hz) filter imple- noise.
mented in the software application to minimize the noise in the A second set of the experiments was performed to evaluate
ECG traces. After performing the filtering, the ECG readings the impact of body movements on the ECG signals. Signals
are displayed in real time. The software can also store the ECG were measured with body movements, which include slow and
readings in comma separated value (CSV) format. Each CSV fast abduction/adduction of hands, body rotation, and normal
file contains 10 s of ECG data. Consecutive acquisitions are walking. First, the ECG signals were measured by keeping the
automatically stored in files with filenames containing sequen- electrodes in direct contact with the dry skin. In the later exper-
tially incremented numbers. Thus, the stored files contain the iments, the ECG signals were acquired by placing a thin cotton
whole record of the ECG acquisition, until the storing function cloth between the electrodes and the dry skin. Figs. 8 and 9

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316 IEEE REVIEWS IN BIOMEDICAL ENGINEERING, VOL. 11, 2018

TABLE IV
EFFECTS OF INTERFACE MATERIALS AND MOISTURE ON THE
QUALITY OF THE ECG ACQUISITION

show the ECG signals obtained by the direct-contact and con-


tactless methods, respectively, with different patterns of body
movements. It was observed that the movement of the body
contaminates the ECG signals in all cases, which is attributed
to the displacement of the electrodes with movements.
It can also be seen that the ECG signals obtained with a
thin cotton cloth at the electrode-skin interface (see Fig. 9) are
more affected by the motion-induced noise compared to the
signals measured by direct-contact method (see Fig. 8). The
textile material at the interface experiences faster and larger
Fig. 8. ECG measured from the bare dry skin with body movements. displacement with the movements of the body, thus increasing
(a) Slow abduction–adduction of both hands. (b) Fast abduction– the noise in the measured ECG signals. The QRS complex is,
adduction of both hands. (c) Body rotation. (a) Normal walking.
however, maintained in all cases although the P and T waves are
heavily distorted by the movements.
More experiments were performed at rest with the proposed
electrode by placing different dry and moisturized (by water)
textile materials at the interface. In Table IV, a summary of
the results of the electrodes integrated on skin and different
types of cotton interface materials is provided. A good re-
sult denotes waveforms with distinguishable QRS complex, P
and T wave with a typical period of 5 s. The amplitude of
the waveform varies depending on proximity of the electrodes
to the heart. A stronger signal with higher amplitude of the
waveform can be detected by placing the electrodes closer to
the heart. On the contrary, a poor result refers to either no
signal (flat) or waveform with significant fluctuations due to
noise.

B. Comparison With Existing Results


As discussed in Section II, many ECG systems have been
developed so far by the researchers by integrating different
technologies, such as capacitive ECG electrodes, AFEs, com-
munication systems, and data processing techniques. Table V
presents a comparison of key features between ten different
state-of-the-art ECG systems, including the proposed system.
Compared to the technologies reported in these publications,
the proposed ECG system presents a good balance among signal
quality, size, and power consumption. Although our proposed
electrode is slightly larger than the electrodes presented in [5],
Fig. 9. ECG measured from the textile covered dry skin with body
movements. (a) Slow abduction–adduction of both hands. (b) Fast [13], and [113], it provides better flexibility in terms of integra-
abduction–adduction of both hands. (c) Body rotation. (a) Normal tion with clothes. Additionally, the quality of the ECG signals
walking. obtained by the proposed system is similar to those reported in

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MAJUMDER et al.: NONCONTACT WEARABLE WIRELESS ECG SYSTEMS FOR LONG-TERM MONITORING 317

TABLE V
COMPARISON BETWEEN THE PROPOSED METHODS AND RECENT ALTERNATIVES FOR ECG SENSING SYSTEMS

[4]–[14], [16], [23], and [114]–[116]. The system also has lower [13], [113], and [114], it was suggested to develop mobile ECG
power consumption and smaller size, which ensure better porta- monitoring applications in Android platforms for cell phones.
bility. In comparison with [5], [6], [13]–[15], [23], and [116], However, cell phone consumes a significant amount of power
our proposed method has better signal integrity primarily due to during RF communications, which is an issue toward long-
the flexible nature of the sensing material and better design of term ECG monitoring. For long-term monitoring, an application
the capacitive electrode. specific transmitting device is preferred so that the battery can
Different wireless technologies have been adopted in different last for a minimum of one day of continuous operation of the
publications [5], [13], [16], [113]–[115]. For example, in [5], portable unit.

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318 IEEE REVIEWS IN BIOMEDICAL ENGINEERING, VOL. 11, 2018

The developed ECG monitoring system is tested, as routinely The major features and performance characteristics of recently
done, in an outpatient environment. Using our system, we aim published state-of-the-art ECG systems are compared and de-
to identify Tachy and Brady arrhythmias including atrial fib- scribed. For long-term monitoring, electrodes integrated on skin
rillation, ventricular and supraventricular tachycardia (narrow and different types of interface clothing materials are desired.
complex and wide complex), sick sinus syndrome, episodic Therefore, a comparison of the advantages and limitations be-
syncope, which are particularly intermittent and may not be tween the method proposed in this paper and recent alternatives
evident in short-term ECGs. The low power consumption al- for ECH sensing systems is presented and discussed.
lows the prototype system to monitor the ECG for prolonged
periods. Apart from the long-term monitoring of ECG, one can ACKNOWLEDGMENT
also measure single lead short-term ambulatory ECGs using the
proposed system. The authors would like to thank the Canada Research Chair
Program, NSERC of Canada as well as the Canada Foundation
for Innovation and the Ministry of Research and Innovation
V. CONCLUSION for supporting this paper. They would also like to thank their
An ECG monitoring system has been developed to achieve colleagues at Celestica for help in developing another version
improved signal detection, portability, and reduced power con- of the ECG electrode system as a possible commercial product.
sumption by addressing the tradeoffs among size, power re-
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MAJUMDER et al.: NONCONTACT WEARABLE WIRELESS ECG SYSTEMS FOR LONG-TERM MONITORING 321

[112] “DataLOG for portable data acquisition and monitoring,” Biometrics Ognian Marinov (M’10) received the M.Sc. and Ph.D. degrees in elec-
Ltd., Ynysddu, U.K. [Online]. Available: http://www.biometricsltd.com/ tronics from the Technical University of Sofia, Sofia, Bulgaria, in 1986
datalog.htm. Accessed: May 9, 2018. and 1996, respectively.
[113] C. Y. Chen et al., “A low-power bio-potential acquisition system with He joined the Faculty of Electronics, Technical University of Sofia in
flexible PDMS dry electrodes for portable ubiquitous healthcare appli- 1987. He visited ENSEA, Cergy, France, from 1994 to 1995, RWTH,
cations,” Sensors, vol. 13, pp. 3077–3091, 2013. Aachen, Germany, in 1998, and UVR, Tarragona, Spain, in 2009. Since
[114] P. C. Hii and W. Y. Chung, “A comprehensive ubiquitous healthcare 2000, he has been with McMaster University, Hamilton, ON, Canada.
solution on an Android mobile device,” Sensors, vol. 11, pp. 6799–6815, He has authored or co-authored 80 papers in journals and conferences.
2011. His current research interests include noise in devices, breakdown and
[115] B. Jin et al., “Walking-age analyzer for healthcare applications,” IEEE instrumentation, micropower circuit design, organic electronics, technol-
J. Biomed. Health Inform., vol. 18, no. 3, pp. 1034–1042, May 2014. ogy, automation of measurements and characterization, and micro- and
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dry surface wireless sensor node for healthcare monitoring application,”
in Proc. IEEE Ninth Int. Conf. Wireless Mobile Comput. Netw. Commun.,
Lyon, France, Oct. 7–9, 2013, pp. 189–195.
[117] F. Miao, Y. Cheng, Y. He, Q. He, and Y. Li, “A wearable context-aware Chih-Hung Chen (S’95–M’03–SM’08) received the B.Sc. degree from
ECG monitoring system integrated with built-in kinematic sensors of the the National Central University, Taiwan, in 1991, the M.A.Sc. degree
smartphone,” Sensors, vol. 15, no. 5, pp. 11465–11484, 2015. from Simon Fraser University, Burnaby, BC, Canada, in 1997, and the
Ph.D. degree from the McMaster University, Hamilton, ON, Canada, in
2002. He is an Associate Professor with the Department of Electrical and
Computer Engineering, McMaster University, Hamilton, ON, Canada.
His current research interests include the noise characterization and
modeling of nanoscale MOSFETS, designs of low-noise radio-frequency
integrated circuits (RFIC) for wireless applications, and low-noise, low-
power biomedical integrated circuits and systems.
Sumit Majumder received the B.Sc. degree in electrical and electronic
engineering from the Bangladesh University of Engineering and Tech-
nology, Dhaka, Bangladesh, and the M.A.Sc. degree in electrical and Tapas Mondal is a Pediatric Cardiologist and Associate Professor of
computer engineering from McMaster University, Hamilton, ON, Canada, pediatrics and a member of the Faculty of Engineering with McMaster
in 2007 and 2011, respectively. He is currently working toward the Ph.D. University, Hamilton, ON, Canada. He is also an Associate Member
degree in electrical and computer engineering at McMaster University. of Staff with the Hospital for Sick Children, Toronto, ON, Canad. His
His research interests include biomedical signal processing, machine research interests focus on imaging techniques for children, including
learning, and pattern recognition. fetuses and low-cost health monitoring systems, especially as related to
cardiac health.

M. Jamal Deen (F’02) was born in Georgetown, British Guiana (now


Guyana), South America. He is currently a Distinguished University Pro-
fessor, Senior Canada Research Chair in Information Technology, and
the Director of the Micro- and Nano-Systems Laboratory, McMaster Uni-
Leon Chen received the B.A.Sc. degree in electrical engineering from versity, Hamilton, ON, Canada. His research records include more than
the University of Waterloo, Waterloo, ON, Canada, and the M.Eng. de- 560 peer-reviewed articles and 2 textbooks Silicon Phonics: Fundamen-
gree in electrical and computer engineering from McMaster University, tals and Devices (Wiley, 2002) and Fiber Optic Communications: Funda-
Hamilton, ON, Canada, in 2012 and 2014, respectively. mentals and Applications (Wiley, 2014). His current research interests
He joined Intel Corporation, Santa Clara, CA, USA, in 2014, and has include nano-/opto-electronics, nanotechnology, and their emerging ap-
been involved in backend designs for the next generation high-speed plications in health and environment.
SerDes research and development with Intel’s advanced technology Prof. Deen was elected to fellow in ten national academies and pro-
processes. fessional societies, including RSC, APS, ECS, and AAAS.

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