Appendix

Family
Total
Patient Smoking Age Age Packs Occupationa history
gender Age weight height BMI pack
number status started quit per day l exposure of
years
cancer
P.1 M 55 58 159 22.94 previous 16 55 1.5 58 yes Yes
P.2 M 78 72 172 24.3 previous 20 53 1.5 49.5 yes Yes
P.3 M 53 66 173 22 previous 15 53 1.5 57 No No

P.4 M 65 106 186 30.7 previous 20 41 3 63 yes Yes

P.5 F 83 60 151 26.3 previous 25 84 1.25 74 No Yes

P.6 M 62 68 172 23.1 previous 17 25 1.5 12 No Yes

P.7 M 58 48 173 16 current 12 - 3 138 yes No

P.8 M 77 56 165 20.5 previous 18 57 1 58.5 No No

P.9 F 46 45 154 18.9 previous 18 45 1 27 yes No
P.10 M 50 83 178 26.1 current 16 - 1.5 51 yes Yes
P.11 M 56 66 169 23.1 previous 18 49 2 62 yes No

P.12 M 74 94 170 32.5 previous 35 54 0.2 4 No No

P.13 F 66 50 159 19.7 previous 15 65 0.75 37.5 yes Yes

P.14 M 60 61 166 22.1 current 15 3 135 No Yes

P.15 M 67 88 168 31.1 previous 18 65 1.5 71 No No

P.16 M 62 70 176 22.5 previous 20 62 2 84 No No

P.17 F 73 74 168 26.2 current 20 1 54 No Yes

P.18 M 62 71 170 24.5 previous 18 50 2 64 No No

P.19 M 75 64 167 22.94 previous 18 54 3 108 No No
P.20 M 65 74 178 23.35 previous 16 40 0.7 16.8 No No
P.21 M 36 ? ? ? current ? ? ? ? No No
P.22 M 59 63 165 23.14 current 14 - 1.25 50 No Yes
P.23 M 66 80 178 25.24 previous 16 66 1 50 yes No
P.24 M 59 92 170 31.83 previous 19 59 1.5 64.5 yes No
P.25 M 68 76 170 16.29 previous 16 40 0.5 12 yes yes

P.26 M 47 50 165 18.36 previous 17 47 2.5 75 yes Yes

P.27 M 43 107 186 30.9 never - - - 0 yes No

P.28 F 61 68 170 23.5 never - - - 0 No Yes
P.29 M 65 89 174 29.3 previous 20 62 1 42 yes No
P.30 F 54 56 161 21.6 previous 18 54 1 36 No Yes

P.31 M 84 70 163 26.3 never - - - 0 No Yes

P.32 M 66 66 164 24.53 never - - - 0 No No

P.33 M 49 91 167 32.62 previous 17 48 1 41 yes No
P.34 M 65 70 168 24.8 current 13 - 3 154 yes Yes
P.35 M 56 84 170 29.06 previous 14 16 1.5 63 yes Yes
P.36 F 76 43 147 19.89 previous 16 76 1 60 No Yes
P.37 M 64 85 168 30.11 previous 15 51 1 36 yes Yes
P.38 M 55 70 179 21.84 previous 18 55 2 74 yes Yes
P.39 F 70 65 160 25.39 never - - - 0 No No
Patient
group histology Staging Type of therapy Protocol in followup period*
number
P.1 NSCLC adeno 4 chemo Carboplatin+ pemetrexed
P.2 NSCLC adeno 4 chemo pemetrexed
P.3 NSCLC squamous 3b chemo Cisplatin+ vinorelbine
Cisplatin+ pemetrexed, then erlotinib, then
P.4 NSCLC adeno 4 Chemo/ biologic/ chemo
chemo because of PD under erlotinib
P.5 NSCLC adeno 4 chemo Carboplatin+ pemetrexed
Carboplatin+ pemetrexed, then only
P.6 NSCLC adeno 4 chemo
pemetrexed
Carboplatin+ pemetrexed, then only
P.7 NSCLC adeno 4 chemo
pemetrexed
P.8 NSCLC adeno 4 chemo pemetrexed
P.9 NSCLC adeno 4 chemo Cisplatin+ pemetrexed
P.10 NSCLC NOS 4 chemo Cisplatin+ vinorelbine
P.11 NSCLC adeno 3B chemo Carboplatin+ vinorelbine
Carboplatin+ pemetrexed, then erlotinib, then
P.12 NSCLC adeno 4 Chemo /biologic/ chemo
chemo because of PD under erlotinib
Cisplatin+ pemetrexed, then carboplatin instead
P.13 NSCLC adeno 4 chemo
of cisplatin
P.14 SCLC - 3A chemo Cisplatin+ etoposide
P.15 NSCLC NOS 4 biologic Tarceva
first Cisplatin+ etoposide, then carboplatin
P.16 SCLC - 4 chemo
instead of cisplatin
Cisplatin+ etoposide, then carboplatin instead of
P.17 SCLC - 4 chemo
cisplatin
P.18 NSCLC squamous 3A chemo Cisplatin+ vinorelbine
P.19 NSCLC adeno 4 chemo Cisplatinum + pemetrexed
P.20 NSCLC adeno 4 chemo Cisplatin + pemetrexed
P.21 NSCLC adeno 4 biologic gefitinib
P.22 SCLC - 4 chemo Carboplatin+ etoposide
P.23 SCLC - 3A chemo Cisplatin+ etoposide
P.24 NSCLC squamous 3B chemo Carboplatin + Gemcitabine
P.25 NSCLC adeno 4 chemo Cisplatinum + pemetrexed + Avastin
 Cisplatin, then carbo+ pemetrexed, then
P.26 NSCLC NOS 4 chemo
gefitinib
P.27 NSCLC adeno 4 biologic Cisplatin+ pemetrexed, then crizotinib
P.28 NSCLC adeno 4 chemo and then biologic Cisplatin+ pemetrexed, then gefitinib
P.29 NSCLC adeno 4 chemo Carboplain+ pemetrexed, then only pemetrexed
P.30 NSCLC adeno 4 chemo Cisplatin+ pemetrexed
Carboplatin+ pemetrexed, then only
P.31 NSCLC adeno 4 chemo
pemetrexed
P.32 NSCLC adeno 4 biologic erlotinib
P.33 SCLC - 4 chemo Carboplatin+ etoposide
P.34 NSCLC adeno 4 chemo and then biologic pemetrexed, then gefitinib
P.35 NSCLC squamous 3A chemo Carboplatin+ pemetrexed
P.36 NSCLC undifferentiated 3A chemo Carboplatin+gemcitabine
P.37 NSCLC adeno 4 chemo pemetrexed
P.38 NSCLC NOS 3A chemo Cisplatin+ vinorelbine
P.39 NSCLC adeno 4 chemo Carboplatin + pemetrexed

*Does not include therapies undergone outside the follow-up period, e.g. radiation.